Aliases for RHOQ Gene
External Ids for RHOQ Gene
Previous HGNC Symbols for RHOQ Gene
Previous GeneCards Identifiers for RHOQ Gene
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011]
GeneCards Summary for RHOQ Gene
RHOQ (Ras Homolog Family Member Q) is a Protein Coding gene. Among its related pathways are ERK Signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include GTP binding and profilin binding. An important paralog of this gene is RHOJ.
UniProtKB/Swiss-Prot for RHOQ Gene
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.