Aliases for SLC7A8 Gene
- Solute Carrier Family 7 Member 8 2 3 4 5
- Solute Carrier Family 7 (Amino Acid Transporter Light Chain, L System), Member 8 2 3
- L-Type Amino Acid Transporter 2 3 4
- LAT2 3 4
- Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 8 3
- Solute Carrier Family 7 (Amino Acid Transporter, L-Type), Member 8 3
External Ids for SLC7A8 Gene
Previous GeneCards Identifiers for SLC7A8 Gene
GeneCards Summary for SLC7A8 Gene
SLC7A8 (Solute Carrier Family 7 Member 8) is a Protein Coding gene. Diseases associated with SLC7A8 include Lysinuric Protein Intolerance. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Gene Ontology (GO) annotations related to this gene include peptide antigen binding and antiporter activity. An important paralog of this gene is SLC7A10.
UniProtKB/Swiss-Prot for SLC7A8 Gene
Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.