Aliases for GRIP1 Gene
External Ids for GRIP1 Gene
Previous GeneCards Identifiers for GRIP1 Gene
This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]
GeneCards Summary for GRIP1 Gene
GRIP1 (Glutamate Receptor Interacting Protein 1) is a Protein Coding gene. Diseases associated with GRIP1 include Fraser Syndrome 3 and Fraser Syndrome 1. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and beta-catenin binding. An important paralog of this gene is GRIP2.
UniProtKB/Swiss-Prot for GRIP1 Gene
May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed:10197531). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).