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Aliases for TDRD7 Gene

Aliases for TDRD7 Gene

  • Tudor Domain Containing 7 2 3 5
  • PCTAIRE2-Binding Protein 3 4
  • PCTAIRE2BP 3 4
  • Tudor Repeat Associator With PCTAIRE 2 3
  • Tudor Repeat Associator With PCTAIRE-2 4
  • Tudor Domain-Containing Protein 7 3
  • CATC4 3
  • TRAP 3
  • Trap 4

External Ids for TDRD7 Gene

Previous GeneCards Identifiers for TDRD7 Gene

  • GC09P095555
  • GC09P097253
  • GC09P099214
  • GC09P100174
  • GC09P069775

Summaries for TDRD7 Gene

Entrez Gene Summary for TDRD7 Gene

  • The protein encoded by this gene belongs to the Tudor family of proteins. This protein contains conserved Tudor domains and LOTUS domains. It is a component of RNA granules, which function in RNA processing. Mutations in this gene have been associated with cataract formation in mouse and human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

GeneCards Summary for TDRD7 Gene

TDRD7 (Tudor Domain Containing 7) is a Protein Coding gene. Diseases associated with TDRD7 include Cataract 36 and Cataract. Among its related pathways are Aurora A signaling. Gene Ontology (GO) annotations related to this gene include protein N-terminus binding and mRNA binding.

UniProtKB/Swiss-Prot for TDRD7 Gene

  • Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.

Gene Wiki entry for TDRD7 Gene

Additional gene information for TDRD7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TDRD7 Gene

Genomics for TDRD7 Gene

GeneHancer (GH) Regulatory Elements for TDRD7 Gene

Promoters and enhancers for TDRD7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J097411 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.6 595 2.3 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 ZNF766 ZNF207 ZNF143 KLF13 TDRD7 NCBP1 ZNF782 MFSD14C ZNF322P1 NUTM2G LOC441454 FAM220CP CCDC180 TMOD1
GH09J097631 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.7 +221.5 221464 4 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 NCBP1 TSTD2 MFSD14C ZNF782 LOC441454 NUTM2G ZNF322P1 ENSG00000224848 ZNF510 ENSG00000254633
GH09J096856 Enhancer 1.2 Ensembl ENCODE 11 -554.2 -554202 3 HDGF ATF1 PKNOX1 SMAD1 FOXA2 ARNT ARID4B FEZF1 ZNF2 ZNF48 ENSG00000224848 TDRD7 LOC100132781 ZNF510 ZNF782
GH09J097524 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.2 +115.6 115555 5.8 BATF IRF4 BRCA1 RFX5 ZNF143 RCOR1 ATF7 FOS ETV6 IKZF2 TMOD1 LOC105376168 TDRD7 ANKRD18CP ENSG00000203279 AAED1 CCDC180 PIR34153
GH09J097380 Enhancer 1 ENCODE dbSUPER 11.5 -29.7 -29717 2.5 ELF3 FOXA2 ARID4B RAD21 RARA YY1 ZNF614 IKZF2 THAP11 MIXL1 CCDC180 TDRD7 VN1R51P LOC105376167 MIR1302-8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TDRD7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TDRD7 gene promoter:
  • NF-kappaB
  • NF-kappaB1
  • RP58
  • AREB6
  • Lmo2
  • CUTL1
  • USF-1
  • USF1
  • MyoD

Genomic Locations for TDRD7 Gene

Genomic Locations for TDRD7 Gene
84,176 bases
Plus strand
84,176 bases
Plus strand

Genomic View for TDRD7 Gene

Genes around TDRD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TDRD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TDRD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TDRD7 Gene

Proteins for TDRD7 Gene

  • Protein details for TDRD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tudor domain-containing protein 7
    Protein Accession:
    Secondary Accessions:
    • A6NCI6
    • B2RBX3
    • B4DG99
    • B4DXF7
    • E7EQD4
    • Q5VV27
    • Q96JT1
    • Q9UFF0
    • Q9Y2M3

    Protein attributes for TDRD7 Gene

    1098 amino acids
    Molecular mass:
    123586 Da
    Quaternary structure:
    • Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for TDRD7 Gene

    Alternative splice isoforms for TDRD7 Gene


neXtProt entry for TDRD7 Gene

Post-translational modifications for TDRD7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TDRD7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TDRD7 Gene

Domains & Families for TDRD7 Gene

Gene Families for TDRD7 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for TDRD7 Gene

Suggested Antigen Peptide Sequences for TDRD7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TDRD7 family.
  • Belongs to the TDRD7 family.
genes like me logo Genes that share domains with TDRD7: view

Function for TDRD7 Gene

Molecular function for TDRD7 Gene

UniProtKB/Swiss-Prot Function:
Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.

Gene Ontology (GO) - Molecular Function for TDRD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0003729 mRNA binding IDA 21436445
GO:0005515 protein binding IPI 14603251
GO:0047485 protein N-terminus binding IEA --
genes like me logo Genes that share ontologies with TDRD7: view
genes like me logo Genes that share phenotypes with TDRD7: view

Human Phenotype Ontology for TDRD7 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TDRD7 Gene

MGI Knock Outs for TDRD7:

Animal Model Products

miRNA for TDRD7 Gene

miRTarBase miRNAs that target TDRD7

Clone Products

  • Addgene plasmids for TDRD7

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for TDRD7 Gene

Localization for TDRD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TDRD7 Gene

Cytoplasm. Note=Localizes to cytoplasmic RNA granules. Present in chromatoid body (CB) of spermatids (mammalian counterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called intermitochondrial cementin) in pachytene spermatocytes and as a single perinuclear CB in haploid round spermatids (By similarity). {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TDRD7 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TDRD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005759 mitochondrial matrix IEA --
GO:0033391 chromatoid body ISS --
GO:0035770 ribonucleoprotein granule IDA 21436445
genes like me logo Genes that share ontologies with TDRD7: view

Pathways & Interactions for TDRD7 Gene

SuperPathways for TDRD7 Gene

SuperPathway Contained pathways
1 Aurora A signaling
genes like me logo Genes that share pathways with TDRD7: view

Pathways by source for TDRD7 Gene

1 BioSystems pathway for TDRD7 Gene

Gene Ontology (GO) - Biological Process for TDRD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002089 lens morphogenesis in camera-type eye IMP 21436445
GO:0007283 spermatogenesis ISS --
GO:0010608 posttranscriptional regulation of gene expression IMP 21436445
GO:0030154 cell differentiation IEA --
GO:0070306 lens fiber cell differentiation IMP 21436445
genes like me logo Genes that share ontologies with TDRD7: view

No data available for SIGNOR curated interactions for TDRD7 Gene

Drugs & Compounds for TDRD7 Gene

No Compound Related Data Available

Transcripts for TDRD7 Gene

mRNA/cDNA for TDRD7 Gene

Unigene Clusters for TDRD7 Gene

Tudor domain containing 7:
Representative Sequences:

Clone Products

  • Addgene plasmids for TDRD7

Alternative Splicing Database (ASD) splice patterns (SP) for TDRD7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18
SP1: - -
SP2: -

Relevant External Links for TDRD7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TDRD7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TDRD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TDRD7 Gene

This gene is overexpressed in Breast (14.7), Ovary (12.0), Retina (11.5), and Testis (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TDRD7 Gene

NURSA nuclear receptor signaling pathways regulating expression of TDRD7 Gene:


SOURCE GeneReport for Unigene cluster for TDRD7 Gene:


Evidence on tissue expression from TISSUES for TDRD7 Gene

  • Nervous system(4.3)
  • Eye(2.9)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TDRD7 Gene

Germ Layers:
  • ectoderm
  • nervous
Head and neck:
  • eye
  • head
genes like me logo Genes that share expression patterns with TDRD7: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TDRD7 Gene

Orthologs for TDRD7 Gene

This gene was present in the common ancestor of animals.

Orthologs for TDRD7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TDRD7 34 33
  • 99.54 (n)
(Canis familiaris)
Mammalia TDRD7 34 33
  • 91.5 (n)
(Bos Taurus)
Mammalia TDRD7 34 33
  • 90.5 (n)
(Rattus norvegicus)
Mammalia Tdrd7 33
  • 84.38 (n)
(Mus musculus)
Mammalia Tdrd7 16 34 33
  • 83.61 (n)
(Monodelphis domestica)
Mammalia TDRD7 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia TDRD7 34
  • 46 (a)
(Gallus gallus)
Aves TDRD7 34 33
  • 62.83 (n)
(Anolis carolinensis)
Reptilia TDRD7 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tdrd7 33
  • 61.69 (n)
Str.16511 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3586 33
(Danio rerio)
Actinopterygii tdrd7b 33
  • 57.71 (n)
  • 48 (a)
tdrd7 34
  • 43 (a)
wufi12c12 33
fruit fly
(Drosophila melanogaster)
Insecta papi 34
  • 12 (a)
Species where no ortholog for TDRD7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TDRD7 Gene

Gene Tree for TDRD7 (if available)
Gene Tree for TDRD7 (if available)
Evolutionary constrained regions (ECRs) for TDRD7: view image

Paralogs for TDRD7 Gene

No data available for Paralogs for TDRD7 Gene

Variants for TDRD7 Gene

Sequence variations from dbSNP and Humsavar for TDRD7 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs10982012 likely-benign, Congenital cataract 97,412,112(+) C/G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs115297535 likely-benign, Congenital cataract 97,472,420(+) A/G coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs12552100 benign, uncertain-significance, not specified, Congenital cataract 97,472,351(+) T/C coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs13290426 likely-benign, Congenital cataract 97,432,252(+) G/A intron_variant
rs1381532 benign, not specified, Congenital cataract 97,428,498(+) A/G 5_prime_UTR_variant, coding_sequence_variant, intron_variant, non_coding_transcript_variant, synonymous_variant

Variation tolerance for TDRD7 Gene

Residual Variation Intolerance Score: 4.64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.75; 46.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TDRD7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TDRD7 Gene

Disorders for TDRD7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TDRD7 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cataract 36
  • ctrct36
  • cataracts
- elite association - COSMIC cancer census association via MalaCards
Search TDRD7 in MalaCards View complete list of genes associated with diseases


  • Cataract 36 (CTRCT36) [MIM:613887]: An opacification of the crystalline lens of the eye becoming evident at birth. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. {ECO:0000269 PubMed:21436445}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TDRD7

genes like me logo Genes that share disorders with TDRD7: view

No data available for Genatlas for TDRD7 Gene

Publications for TDRD7 Gene

  1. Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. (PMID: 21436445) Lachke SA … Maas RL (Science (New York, N.Y.) 2011) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Identification of tudor repeat associator with PCTAIRE 2 (Trap). A novel protein that interacts with the N-terminal domain of PCTAIRE 2 in rat brain. (PMID: 10727952) Hirose T … Okada M (European journal of biochemistry 2000) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for TDRD7 Gene

Sources for TDRD7 Gene

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