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Aliases for SIN3B Gene

Aliases for SIN3B Gene

  • SIN3 Transcription Regulator Family Member B 2 3 5
  • Histone Deacetylase Complex Subunit Sin3b 3 4
  • Transcriptional Corepressor Sin3b 3 4
  • SIN3 Homolog B, Transcription Regulator (Yeast) 2
  • SIN3 Transcription Regulator Homolog B (Yeast) 2
  • SIN3 Homolog B, Transcriptional Regulator 3
  • SIN3 Transcription Regulator Homolog B 3
  • Paired Amphipathic Helix Protein Sin3b 3
  • KIAA0700 4

External Ids for SIN3B Gene

Previous GeneCards Identifiers for SIN3B Gene

  • GC19P017434
  • GC19P017332
  • GC19P016785
  • GC19P016801
  • GC19P016940
  • GC19P016509

Summaries for SIN3B Gene

GeneCards Summary for SIN3B Gene

SIN3B (SIN3 Transcription Regulator Family Member B) is a Protein Coding gene. Diseases associated with SIN3B include Cranial Nerve Malignant Neoplasm. Among its related pathways are SMAD Signaling Network and Metabolism. Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is SIN3A.

UniProtKB/Swiss-Prot for SIN3B Gene

  • Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.

Gene Wiki entry for SIN3B Gene

Additional gene information for SIN3B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIN3B Gene

Genomics for SIN3B Gene

GeneHancer (GH) Regulatory Elements for SIN3B Gene

Promoters and enhancers for SIN3B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J016828 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 663.5 +0.5 505 2.2 PKNOX1 ATF1 SIN3A YY1 GLIS2 KLF7 ATF7 KLF13 SP3 GMEB1 SIN3B ENSG00000268743
GH19J017336 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 58.7 +508.0 507969 2.5 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 GTPBP3 ANO8 CHERP ENSG00000269578 IQCN ENSG00000268743 COLGALT1 C19orf44 HAUS8 SIN3B
GH19J016063 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 33.6 -756.5 -756474 18.7 CLOCK FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 ZNF263 MCM3 SP3 TPM4 AKAP8 CHERP ENSG00000269578 ENSG00000268087 ENSG00000267904 BRD4 C19orf44 ENSG00000268743 SIN3B
GH19J017333 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 38.4 +504.9 504874 2.4 FEZF1 IRF4 YY1 ZNF213 ZNF416 ZNF143 SP3 NFYC MEF2D ZNF610 GTPBP3 ANO8 CHERP IQCN SIN3B ENSG00000269578 ENSG00000268743 ENSG00000267904 C19orf44 ENSG00000268087
GH19J017507 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 28.9 +680.8 680757 5.9 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 MEF2D ZNF610 GLIS1 RCOR2 ENSG00000269439 PGLS PIR43275 IQCN CHERP ENSG00000269578 SIN3B MED26 ENSG00000268743 HAUS8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SIN3B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SIN3B gene promoter:
  • STAT5A
  • ER-alpha

Genomic Locations for SIN3B Gene

Genomic Locations for SIN3B Gene
chr19:16,829,387-16,880,355
(GRCh38/hg38)
Size:
50,969 bases
Orientation:
Plus strand
chr19:16,940,211-16,991,164
(GRCh37/hg19)
Size:
50,954 bases
Orientation:
Plus strand

Genomic View for SIN3B Gene

Genes around SIN3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIN3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIN3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIN3B Gene

Proteins for SIN3B Gene

  • Protein details for SIN3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75182-SIN3B_HUMAN
    Recommended name:
    Paired amphipathic helix protein Sin3b
    Protein Accession:
    O75182
    Secondary Accessions:
    • Q2NL91
    • Q68GC2
    • Q6P4B8
    • Q8TB34
    • Q9BSC8

    Protein attributes for SIN3B Gene

    Size:
    1162 amino acids
    Molecular mass:
    133066 Da
    Quaternary structure:
    • Interacts with FOXK1/MNF, MXI, MAD, NCOR1 and SAP30. Interaction with SUDS3 enhances the interaction with HDAC1 to form a complex. Interacts with CRY1, HCFC1, MAD3, MAD4, MAEL, REST, RNF220 and SETDB1. Interacts with C6orf89 (PubMed:23460338). Interacts with MYT1L (By similarity).
    SequenceCaution:
    • Sequence=BAA31675.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SIN3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIN3B Gene

Post-translational modifications for SIN3B Gene

  • Ubiquitinated by RNF220 that leads to proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SIN3B Gene

Domains & Families for SIN3B Gene

Gene Families for SIN3B Gene

Protein Domains for SIN3B Gene

Suggested Antigen Peptide Sequences for SIN3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SIN3B: view

No data available for UniProtKB/Swiss-Prot for SIN3B Gene

Function for SIN3B Gene

Molecular function for SIN3B Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.

Phenotypes From GWAS Catalog for SIN3B Gene

Gene Ontology (GO) - Molecular Function for SIN3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0003714 transcription corepressor activity IEA --
GO:0004407 contributes_to histone deacetylase activity IBA --
GO:0005515 protein binding IPI 12670868
genes like me logo Genes that share ontologies with SIN3B: view
genes like me logo Genes that share phenotypes with SIN3B: view

Animal Models for SIN3B Gene

MGI Knock Outs for SIN3B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIN3B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIN3B Gene

Localization for SIN3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIN3B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIN3B gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SIN3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex IBA --
GO:0000785 chromatin IBA --
GO:0000805 X chromosome IEA --
GO:0000806 Y chromosome IEA --
GO:0001741 XY body IEA --
genes like me logo Genes that share ontologies with SIN3B: view

Pathways & Interactions for SIN3B Gene

genes like me logo Genes that share pathways with SIN3B: view

Gene Ontology (GO) - Biological Process for SIN3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016575 histone deacetylation IBA --
GO:0019216 regulation of lipid metabolic process TAS --
genes like me logo Genes that share ontologies with SIN3B: view

No data available for SIGNOR curated interactions for SIN3B Gene

Drugs & Compounds for SIN3B Gene

No Compound Related Data Available

Transcripts for SIN3B Gene

Unigene Clusters for SIN3B Gene

SIN3 transcription regulator homolog B (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIN3B

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIN3B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - -
SP4: - -
SP5:
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12:

ExUns: 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b · 25c · 25d
SP1: - - -
SP2: - - -
SP3:
SP4:
SP5: - -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for SIN3B Gene

GeneLoc Exon Structure for
SIN3B
ECgene alternative splicing isoforms for
SIN3B

Expression for SIN3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SIN3B Gene

Protein differential expression in normal tissues from HIPED for SIN3B Gene

This gene is overexpressed in Placenta (18.7), Blymphocyte (15.9), and Peripheral blood mononuclear cells (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SIN3B Gene



Protein tissue co-expression partners for SIN3B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SIN3B Gene:

SIN3B

SOURCE GeneReport for Unigene cluster for SIN3B Gene:

Hs.13999

Evidence on tissue expression from TISSUES for SIN3B Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with SIN3B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIN3B Gene

Orthologs for SIN3B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SIN3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIN3B 34 33
  • 99.24 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SIN3B 34 33
  • 90.95 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SIN3B 34 33
  • 90.7 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SIN3B 34
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SIN3B 34
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sin3b 16 34 33
  • 85.37 (n)
chicken
(Gallus gallus)
Aves SIN3B 34 33
  • 77.79 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SIN3B 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sin3b 33
  • 69.74 (n)
zebrafish
(Danio rerio)
Actinopterygii sin3b 34 33
  • 68.84 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sin3A 34
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sin-3 34
  • 12 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SIN3 34
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3742 34
  • 33 (a)
OneToMany
Species where no ortholog for SIN3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SIN3B Gene

ENSEMBL:
Gene Tree for SIN3B (if available)
TreeFam:
Gene Tree for SIN3B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SIN3B: view image

Paralogs for SIN3B Gene

Paralogs for SIN3B Gene

(1) SIMAP similar genes for SIN3B Gene using alignment to 3 proteins:

  • SIN3B_HUMAN
  • M0QYC5_HUMAN
  • M0R271_HUMAN
genes like me logo Genes that share paralogs with SIN3B: view

Variants for SIN3B Gene

Sequence variations from dbSNP and Humsavar for SIN3B Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000321579 -- 16,851,667(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000346585 -- 16,871,489(+) A/G intron_variant
rs1000486336 -- 16,845,547(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000713068 -- 16,850,437(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000764998 -- 16,855,570(+) A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SIN3B Gene

Variant ID Type Subtype PubMed ID
esv1088392 CNV deletion 17803354
esv24348 CNV loss 19812545
esv2718267 CNV deletion 23290073
esv2718268 CNV deletion 23290073
esv2718269 CNV deletion 23290073

Variation tolerance for SIN3B Gene

Residual Variation Intolerance Score: 4.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIN3B Gene

Human Gene Mutation Database (HGMD)
SIN3B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIN3B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIN3B Gene

Disorders for SIN3B Gene

MalaCards: The human disease database

(1) MalaCards diseases for SIN3B Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
cranial nerve malignant neoplasm
  • malignant neoplasm of cranial nerve
- elite association - COSMIC cancer census association via MalaCards
Search SIN3B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SIN3B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SIN3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIN3B Gene

Publications for SIN3B Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  2. C6orf89 encodes three distinct HDAC enhancers that function in the nucleolus, the golgi and the midbody. (PMID: 23460338) Lalioti VS … Sandoval IV (Journal of cellular physiology 2013) 3 4 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. The human SIN3B corepressor forms a nucleolar complex with leukemia-associated ETO homologues. (PMID: 18205948) Dhanda RS … Olsson I (BMC molecular biology 2008) 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for SIN3B Gene

Sources for SIN3B Gene

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