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Aliases for RHOBTB2 Gene

Aliases for RHOBTB2 Gene

  • Rho Related BTB Domain Containing 2 2 3 5
  • Deleted In Breast Cancer 2 Gene Protein 3 4
  • DBC2 3 4
  • P83 3 4
  • Rho-Related BTB Domain-Containing Protein 2 3
  • Rho-Related BTB Domain Containing 2 2
  • KIAA0717 4

External Ids for RHOBTB2 Gene

Previous GeneCards Identifiers for RHOBTB2 Gene

  • GC08P022626
  • GC08P023198
  • GC08P022866
  • GC08P022880
  • GC08P022900
  • GC08P021389
  • GC08P022844

Summaries for RHOBTB2 Gene

Entrez Gene Summary for RHOBTB2 Gene

  • The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for RHOBTB2 Gene

RHOBTB2 (Rho Related BTB Domain Containing 2) is a Protein Coding gene. Diseases associated with RHOBTB2 include Epileptic Encephalopathy, Early Infantile, 64 and Acrodermatitis Chronica Atrophicans. Among its related pathways are Ubiquitin mediated proteolysis and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is RHOBTB1.

Gene Wiki entry for RHOBTB2 Gene

Additional gene information for RHOBTB2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOBTB2 Gene

Genomics for RHOBTB2 Gene

GeneHancer (GH) Regulatory Elements for RHOBTB2 Gene

Promoters and enhancers for RHOBTB2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J022998 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 659 +14.4 14406 5.9 HDGF ATF1 ARID4B SIN3A YY1 GLIS2 ZNF143 RUNX3 SP3 YY2 RHOBTB2 PEBP4 EGR3 ENSG00000251034 PIR37908 ENSG00000245025
GH08J022979 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 657.9 -1.4 -1357 12 HDGF PKNOX1 ATF1 FOXA2 ARID4B SIN3A BRCA1 ZNF48 ELK1 ATF7 RHOBTB2 ENSG00000253200 FAM160B2 C8orf58 ENTPD4 ENSG00000245025 BIN3 LOXL2 CHMP7 BMP1
GH08J023017 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 11.5 +33.3 33348 6.8 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 CBX5 E2F8 ENSG00000245025 PIR53150 PIR51638 FAM160B2 ENSG00000253200 BMP1 RHOBTB2 POLR3D SORBS3 CCAR2
GH08J022915 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.3 -70.2 -70191 4.1 PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 ZNF766 ZNF143 FOS DEK PEBP4 LOC101929237 RHOBTB2 BIN3 CHMP7 ENSG00000253142 GC08P022948
GH08J022927 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 11.2 -59.2 -59193 1 SP1 RXRA HLF HNF4A PEBP4 RHOBTB2 LOC101929237 BIN3 GC08P022948 ENSG00000253142
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RHOBTB2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RHOBTB2 gene promoter:
  • CUTL1
  • Egr-3
  • RORalpha2
  • YY1
  • POU2F1a
  • POU2F1
  • POU2F1b
  • POU2F1c
  • NF-1
  • NF-1/L

Genomic Locations for RHOBTB2 Gene

Genomic Locations for RHOBTB2 Gene
32,942 bases
Plus strand
32,783 bases
Plus strand

Genomic View for RHOBTB2 Gene

Genes around RHOBTB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOBTB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOBTB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOBTB2 Gene

Proteins for RHOBTB2 Gene

  • Protein details for RHOBTB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho-related BTB domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K9Z8
    • D3DSR8
    • E9PBU2
    • E9PEI7
    • O94825
    • Q8N4A8
    • Q9BZK6

    Protein attributes for RHOBTB2 Gene

    727 amino acids
    Molecular mass:
    82626 Da
    Quaternary structure:
    • Interacts with HSP90AA1 and HSP90AB1 (PubMed:26517842).
    • Sequence=AAH34917.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA34437.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RHOBTB2 Gene


neXtProt entry for RHOBTB2 Gene

Post-translational modifications for RHOBTB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOBTB2 Gene

No data available for DME Specific Peptides for RHOBTB2 Gene

Domains & Families for RHOBTB2 Gene

Gene Families for RHOBTB2 Gene

Suggested Antigen Peptide Sequences for RHOBTB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rho family.
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOBTB2: view

Function for RHOBTB2 Gene

Phenotypes From GWAS Catalog for RHOBTB2 Gene

Gene Ontology (GO) - Molecular Function for RHOBTB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 26517842
GO:0005525 GTP binding IEA --
GO:0019901 protein kinase binding IBA --
genes like me logo Genes that share ontologies with RHOBTB2: view
genes like me logo Genes that share phenotypes with RHOBTB2: view

Animal Model Products

CRISPR Products

miRNA for RHOBTB2 Gene

miRTarBase miRNAs that target RHOBTB2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOBTB2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RHOBTB2 Gene

Localization for RHOBTB2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHOBTB2 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 2
cytoskeleton 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RHOBTB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005938 cell cortex IBA --
genes like me logo Genes that share ontologies with RHOBTB2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RHOBTB2 Gene

Pathways & Interactions for RHOBTB2 Gene

genes like me logo Genes that share pathways with RHOBTB2: view

Pathways by source for RHOBTB2 Gene

3 Reactome pathways for RHOBTB2 Gene
1 KEGG pathway for RHOBTB2 Gene

Gene Ontology (GO) - Biological Process for RHOBTB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IBA --
GO:0007163 establishment or maintenance of cell polarity IBA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007266 Rho protein signal transduction IBA --
GO:0008360 regulation of cell shape IBA --
genes like me logo Genes that share ontologies with RHOBTB2: view

No data available for SIGNOR curated interactions for RHOBTB2 Gene

Drugs & Compounds for RHOBTB2 Gene

No Compound Related Data Available

Transcripts for RHOBTB2 Gene

mRNA/cDNA for RHOBTB2 Gene

Unigene Clusters for RHOBTB2 Gene

Rho-related BTB domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOBTB2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RHOBTB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18
SP1: - - - - - -
SP2: - - - -
SP3: - -
SP6: - - - - -
SP7: -
SP8: -

Relevant External Links for RHOBTB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RHOBTB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RHOBTB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RHOBTB2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RHOBTB2 Gene

Protein tissue co-expression partners for RHOBTB2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RHOBTB2 Gene:


SOURCE GeneReport for Unigene cluster for RHOBTB2 Gene:


mRNA Expression by UniProt/SwissProt for RHOBTB2 Gene:

Tissue specificity: Ubiquitous, with highest levels in neural tissues. Expression is also detected in fetal lung, heart, and brain.

Evidence on tissue expression from TISSUES for RHOBTB2 Gene

  • Nervous system(4.8)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with RHOBTB2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RHOBTB2 Gene

Orthologs for RHOBTB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RHOBTB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RHOBTB2 34 33
  • 99.64 (n)
(Bos Taurus)
Mammalia -- 34
  • 97 (a)
RHOBTB2 34 33
  • 92.1 (n)
(Monodelphis domestica)
Mammalia RHOBTB2 34
  • 97 (a)
(Canis familiaris)
Mammalia RHOBTB2 34 33
  • 92.02 (n)
(Rattus norvegicus)
Mammalia Rhobtb2 33
  • 90.64 (n)
(Mus musculus)
Mammalia Rhobtb2 16 34 33
  • 90.59 (n)
(Ornithorhynchus anatinus)
Mammalia RHOBTB2 34
  • 79 (a)
(Gallus gallus)
Aves RHOBTB2 34 33
  • 81.89 (n)
(Anolis carolinensis)
Reptilia RHOBTB2 34
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rhobtb2 33
  • 71.91 (n)
(Danio rerio)
Actinopterygii rhobtb2b 34 33
  • 72.31 (n)
Dr.16408 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3851 33
fruit fly
(Drosophila melanogaster)
Insecta RhoBTB 34 33
  • 55.03 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006474 33
  • 53.03 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
CSA.4181 34
  • 38 (a)
Species where no ortholog for RHOBTB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RHOBTB2 Gene

Gene Tree for RHOBTB2 (if available)
Gene Tree for RHOBTB2 (if available)
Evolutionary constrained regions (ECRs) for RHOBTB2: view image

Paralogs for RHOBTB2 Gene

Paralogs for RHOBTB2 Gene

(18) SIMAP similar genes for RHOBTB2 Gene using alignment to 4 proteins:

  • E5RI44_HUMAN
genes like me logo Genes that share paralogs with RHOBTB2: view

Variants for RHOBTB2 Gene

Sequence variations from dbSNP and Humsavar for RHOBTB2 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs193920745 uncertain-significance, Malignant tumor of prostate 23,006,055(+) C/G coding_sequence_variant, missense_variant
rs1000041077 -- 23,015,120(+) TCCCTTAATCCC/TCCC intron_variant
rs1000178284 -- 23,008,996(+) G/A intron_variant
rs1000209745 -- 23,009,365(+) G/C intron_variant
rs1000241315 -- 22,987,250(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RHOBTB2 Gene

Variant ID Type Subtype PubMed ID
dgv7138n100 CNV gain 25217958
esv2663907 CNV deletion 23128226
esv2759604 CNV loss 17122850
esv3616620 CNV loss 21293372
nsv1017570 CNV gain 25217958
nsv1025672 CNV gain 25217958
nsv1027718 CNV gain 25217958
nsv1119171 CNV deletion 24896259
nsv522436 CNV loss 19592680
nsv524231 CNV loss 19592680
nsv526377 CNV loss 19592680
nsv8323 CNV gain 18304495

Variation tolerance for RHOBTB2 Gene

Residual Variation Intolerance Score: 9.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RHOBTB2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOBTB2 Gene

Disorders for RHOBTB2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for RHOBTB2 Gene - From: HGMD, OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
epileptic encephalopathy, early infantile, 64
  • eiee64
acrodermatitis chronica atrophicans
  • herxheimer disease
sporadic breast cancer
  • sporadic breast carcinoma
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RHOBTB2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RHOBTB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHOBTB2 Gene

Publications for RHOBTB2 Gene

  1. Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants. (PMID: 26517842) Prince TL … Neckers L (PloS one 2015) 3 4 58
  2. A novel tumor suppressor gene RhoBTB2 (DBC2): frequent loss of expression in sporadic breast cancer. (PMID: 19937980) Mao H … Zhang L (Molecular carcinogenesis 2010) 3 22 58
  3. Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population. (PMID: 19714462) Loizidou MA … Kyriacou K (Breast cancer research and treatment 2010) 3 44 58
  4. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 44 58
  5. DBC2 gene is silenced by promoter methylation in bladder cancer. (PMID: 18640857) Shi Y … Xiao CG (Urologic oncology 2008) 3 22 58

Products for RHOBTB2 Gene

Sources for RHOBTB2 Gene

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