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Aliases for SSPO Gene

Aliases for SSPO Gene

  • SCO-Spondin 2 3 3 5
  • SCO Protein, Thrombospondin Domain Containing 2 3
  • SCO-Spondin Homolog (Bos Taurus) 2 3
  • Subcommissural Organ Spondin 2 3
  • EC 56
  • EC 56
  • KIAA2036 4

External Ids for SSPO Gene

Previous GeneCards Identifiers for SSPO Gene

  • GC07P148912
  • GC07P149143
  • GC07P149108
  • GC07P149473
  • GC07P143550

Summaries for SSPO Gene

GeneCards Summary for SSPO Gene

SSPO (SCO-Spondin) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and O-linked glycosylation. Gene Ontology (GO) annotations related to this gene include peptidase inhibitor activity. An important paralog of this gene is MUC5B.

UniProtKB/Swiss-Prot for SSPO Gene

  • Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system (By similarity).

Gene Wiki entry for SSPO Gene

Additional gene information for SSPO Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSPO Gene

Genomics for SSPO Gene

GeneHancer (GH) Regulatory Elements for SSPO Gene

Promoters and enhancers for SSPO Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I149775 Enhancer 0.9 Ensembl ENCODE 555.5 +0.2 193 1.3 HDAC1 CTCF MEIS2 KLF1 PKNOX1 ETV1 ZSCAN4 KLF17 HIC1 CTBP1 ZNF467 SSPO GC07P149773
GH07I149771 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 16.8 -3.2 -3162 3.5 PKNOX1 ARNT SIN3A ZBTB7B POLR2B ZNF766 ZNF213 E2F8 ZNF263 SP3 ZNF467 GC07M149505 GC07P149773 ZNF212 ZNF783 ENSG00000271664 ZNF398 ZNF767P ZNF282 LOC155060
GH07I149837 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 15.3 +62.5 62529 1.8 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF862 LOC155060 SSPO ZNF783 ZNF212 ENSG00000271664 ZNF777 ZNF398 ENSG00000280149
GH07I149883 Enhancer 1.1 Ensembl ENCODE 18.5 +108.7 108652 3.4 FOXA2 RB1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 RAD21 ETS1 YY1 ATP6V0E2 ATP6V0E2-AS1 SSPO ZNF862 ENSG00000273011 PIR51338
GH07I149690 Enhancer 1.3 Ensembl ENCODE 11.7 -85.0 -85032 1.3 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF213 E2F8 ZNF416 GC07M149692 TRC-GCA17-1 ZNF777 ZNF783 LOC155060 ZNF767P ENSG00000271664 ZNF786 ZNF398 ZNF212
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SSPO on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SSPO gene promoter:

Genomic Locations for SSPO Gene

Genomic Locations for SSPO Gene
57,938 bases
Plus strand

Genomic View for SSPO Gene

Genes around SSPO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSPO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSPO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSPO Gene

Proteins for SSPO Gene

  • Protein details for SSPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q76B61

    Protein attributes for SSPO Gene

    5147 amino acids
    Molecular mass:
    547504 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC98376.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SSPO Gene


neXtProt entry for SSPO Gene

Selected DME Specific Peptides for SSPO Gene


Post-translational modifications for SSPO Gene

  • Glycosylation at isoforms=88, posLast=130130, posLast=261261, posLast=514514, posLast=819819, posLast=911911, posLast=944944, isoforms=986, posLast=13521352, isoforms=21650, isoforms=21663, isoforms=21809, posLast=19931993, isoforms=22030, isoforms=22133, isoforms=2645, isoforms=2694, posLast=29362936, isoforms=2967, posLast=30623062, isoforms=3116, isoforms=3163, isoforms=3173, posLast=33103310, posLast=33993399, posLast=35123512, isoforms=3522, posLast=35993599, posLast=36263626, isoforms=3792, posLast=39143914, isoforms=3946, isoforms=4139, posLast=43464346, posLast=44174417, isoforms=4731, isoforms=4748, isoforms=4753, isoforms=4863, posLast=49034903, isoforms=4948, isoforms=4955, and posLast=50615061
  • Modification sites at PhosphoSitePlus

Other Protein References for SSPO Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SSPO Gene

Gene Families for SSPO Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for SSPO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the thrombospondin family.
  • Belongs to the thrombospondin family.
genes like me logo Genes that share domains with SSPO: view

Function for SSPO Gene

Molecular function for SSPO Gene

UniProtKB/Swiss-Prot Function:
Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system (By similarity).

Enzyme Numbers (IUBMB) for SSPO Gene

Gene Ontology (GO) - Molecular Function for SSPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SSPO: view
genes like me logo Genes that share phenotypes with SSPO: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SSPO

CRISPR Products

miRNA for SSPO Gene

miRTarBase miRNAs that target SSPO

Inhibitory RNA Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSPO Gene

Localization for SSPO Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSPO Gene

Secreted, extracellular space.

Gene Ontology (GO) - Cellular Components for SSPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 22261194
genes like me logo Genes that share ontologies with SSPO: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SSPO Gene

Pathways & Interactions for SSPO Gene

genes like me logo Genes that share pathways with SSPO: view

Interacting Proteins for SSPO Gene

Selected Interacting proteins: A2VEC9-SSPO_HUMAN for SSPO Gene via IID

Gene Ontology (GO) - Biological Process for SSPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007399 nervous system development IEA --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SSPO: view

No data available for SIGNOR curated interactions for SSPO Gene

Drugs & Compounds for SSPO Gene

No Compound Related Data Available

Transcripts for SSPO Gene

Unigene Clusters for SSPO Gene

SCO-spondin homolog (Bos taurus):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSPO Gene

No ASD Table

Relevant External Links for SSPO Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SSPO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SSPO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SSPO Gene

This gene is overexpressed in Brain - Cerebellum (x5.9) and Brain - Cerebellar Hemisphere (x5.0).

Protein differential expression in normal tissues from HIPED for SSPO Gene

This gene is overexpressed in Colon (46.8), Platelet (15.7), and Stomach (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SSPO Gene

Protein tissue co-expression partners for SSPO Gene

NURSA nuclear receptor signaling pathways regulating expression of SSPO Gene:


SOURCE GeneReport for Unigene cluster for SSPO Gene:

genes like me logo Genes that share expression patterns with SSPO: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSPO Gene

Orthologs for SSPO Gene

This gene was present in the common ancestor of chordates.

Orthologs for SSPO Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SSPO 33
  • 98.44 (n)
(Canis familiaris)
Mammalia SSPO 33
  • 83.67 (n)
(Bos Taurus)
Mammalia SSPO 33
  • 83.47 (n)
(Rattus norvegicus)
Mammalia Sspo 33
  • 79.55 (n)
(Mus musculus)
Mammalia Sspo 33 16
  • 79.5 (n)
(Gallus gallus)
Aves SSPO 33
  • 62.54 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497129 33
  • 57.42 (n)
(Danio rerio)
Actinopterygii scospondin 33
  • 52.3 (n)
Species where no ortholog for SSPO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSPO Gene

Gene Tree for SSPO (if available)
Gene Tree for SSPO (if available)

Paralogs for SSPO Gene

Paralogs for SSPO Gene

(1) SIMAP similar genes for SSPO Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SSPO: view

Variants for SSPO Gene

Sequence variations from dbSNP and Humsavar for SSPO Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000114805 -- 149,778,201(+) C/T intron_variant
rs1000147266 -- 149,820,584(+) C/T intron_variant
rs1000205191 -- 149,814,229(+) A/G intron_variant
rs1000257504 -- 149,784,583(+) G/C intron_variant
rs1000325957 -- 149,804,829(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SSPO Gene

Variant ID Type Subtype PubMed ID
dgv11714n54 CNV loss 21841781
dgv11715n54 CNV loss 21841781
dgv11716n54 CNV loss 21841781
dgv844n27 CNV loss 19166990
esv1010383 CNV deletion 20482838
esv1058616 CNV deletion 17803354
esv2735334 CNV deletion 23290073
esv2759571 CNV gain 17122850
esv3576480 CNV gain 25503493
esv3615438 CNV gain 21293372
nsv1033095 CNV gain 25217958
nsv469576 CNV loss 16826518
nsv517242 CNV loss 19592680
nsv521861 CNV loss 19592680
nsv608987 CNV loss 21841781
nsv824389 CNV gain 20364138
nsv831184 CNV gain 17160897
nsv951643 CNV deletion 24416366

Additional Variant Information for SSPO Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SSPO Gene

Disorders for SSPO Gene

Additional Disease Information for SSPO

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SSPO Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSPO Gene

Publications for SSPO Gene

  1. The complex multidomain organization of SCO-spondin protein is highly conserved in mammals. (PMID: 17126404) Meiniel O … Meiniel A (Brain research reviews 2007) 3 4 22 58
  2. Subcommissural organ/Reissner's fiber complex: characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth. (PMID: 11008217) Gobron S … Meiniel A (Glia 2000) 2 3 22 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. Placental expression of SCO-spondin during mouse and human development. (PMID: 15053980) Gonçalves-Mendes N … Sapin V (Gene expression patterns : GEP 2004) 3 22 58
  5. The thrombospondin type 1 repeat (TSR) and neuronal differentiation: roles of SCO-spondin oligopeptides on neuronal cell types and cell lines. (PMID: 14692680) Meiniel A … Dastugue B (International review of cytology 2003) 3 22 58

Products for SSPO Gene

Sources for SSPO Gene

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