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Aliases for DCUN1D4 Gene

Aliases for DCUN1D4 Gene

  • Defective In Cullin Neddylation 1 Domain Containing 4 2 3 5
  • Defective In Cullin Neddylation Protein 1-Like Protein 4 3 4
  • DCUN1 Domain-Containing Protein 4 3 4
  • DCN1, Defective In Cullin Neddylation 1, Domain Containing 4 (S. Cerevisiae) 2
  • DCN1, Defective In Cullin Neddylation 1, Domain Containing 4 3
  • DCN1-Like Protein 4 3
  • KIAA0276 4

External Ids for DCUN1D4 Gene

Previous GeneCards Identifiers for DCUN1D4 Gene

  • GC04P052551
  • GC04P052404
  • GC04P052709
  • GC04P048650

Summaries for DCUN1D4 Gene

GeneCards Summary for DCUN1D4 Gene

DCUN1D4 (Defective In Cullin Neddylation 1 Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is DCUN1D5.

Gene Wiki entry for DCUN1D4 Gene

Additional gene information for DCUN1D4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCUN1D4 Gene

Genomics for DCUN1D4 Gene

GeneHancer (GH) Regulatory Elements for DCUN1D4 Gene

Promoters and enhancers for DCUN1D4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J051841 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 660.9 +0.7 720 3.8 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 CBX5 DCUN1D4 PIR46111 DUTP7
GH04J051905 Enhancer 1.2 Ensembl ENCODE 19.9 +65.4 65373 5.1 PKNOX1 FOXA2 MLX ARID4B DMAP1 IRF4 YY1 SLC30A9 PAF1 SP5 DCUN1D4 GC04P051914 DUTP7
GH04J051879 Enhancer 0.8 ENCODE 21.3 +37.7 37651 2 FOXA2 ARID4B RAD21 RARA YY1 EGR1 CREM RXRA REST KAT8 DCUN1D4 LRRC66 DUTP7 GC04P051914
GH04J051895 Enhancer 1 Ensembl ENCODE 10.6 +52.9 52884 1.3 RAD21 EGR1 ZNF143 FOS ATF7 RUNX3 CREM SMARCA5 ZNF654 REST LRRC66 DCUN1D4 GC04P051914 DUTP7
GH04J052014 Promoter/Enhancer 1.1 EPDnew ENCODE 8.2 +174.7 174749 6.2 CTCF FOXA2 NFIA ZNF644 RAD21 TEAD3 XRCC5 BCL6 RXRB MIXL1 LRRC66 DCUN1D4 GC04P051994 SGCB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DCUN1D4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DCUN1D4 gene promoter:
  • Ik-2
  • HSF1short
  • HSF1 (long)
  • GATA-2
  • AhR
  • Arnt
  • TBP
  • RORalpha1
  • ATF
  • ATF-2

Genomic Locations for DCUN1D4 Gene

Genomic Locations for DCUN1D4 Gene
73,838 bases
Plus strand
73,838 bases
Plus strand

Genomic View for DCUN1D4 Gene

Genes around DCUN1D4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCUN1D4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCUN1D4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCUN1D4 Gene

Proteins for DCUN1D4 Gene

  • Protein details for DCUN1D4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DCN1-like protein 4
    Protein Accession:
    Secondary Accessions:
    • B4DH25
    • Q7Z3F3
    • Q7Z6B8

    Protein attributes for DCUN1D4 Gene

    292 amino acids
    Molecular mass:
    34068 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA13405.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD97912.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DCUN1D4 Gene

    Alternative splice isoforms for DCUN1D4 Gene


neXtProt entry for DCUN1D4 Gene

Post-translational modifications for DCUN1D4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DCUN1D4 Gene

Domains & Families for DCUN1D4 Gene

Gene Families for DCUN1D4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DCUN1D4 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCUN1D4: view

No data available for UniProtKB/Swiss-Prot for DCUN1D4 Gene

Function for DCUN1D4 Gene

Gene Ontology (GO) - Molecular Function for DCUN1D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21911577
GO:0031624 ubiquitin conjugating enzyme binding IBA --
GO:0032182 ubiquitin-like protein binding IBA --
GO:0097602 cullin family protein binding IBA --
genes like me logo Genes that share ontologies with DCUN1D4: view
genes like me logo Genes that share phenotypes with DCUN1D4: view

Animal Model Products

CRISPR Products

miRNA for DCUN1D4 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCUN1D4 Gene

Localization for DCUN1D4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCUN1D4 gene
Compartment Confidence
nucleus 5
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (3)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DCUN1D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IBA --
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with DCUN1D4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCUN1D4 Gene

Pathways & Interactions for DCUN1D4 Gene

SuperPathways for DCUN1D4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCUN1D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0045116 protein neddylation IBA --
GO:0051443 positive regulation of ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with DCUN1D4: view

No data available for Pathways by source and SIGNOR curated interactions for DCUN1D4 Gene

Drugs & Compounds for DCUN1D4 Gene

No Compound Related Data Available

Transcripts for DCUN1D4 Gene

Unigene Clusters for DCUN1D4 Gene

DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae):
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCUN1D4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - -
SP7: - - -
SP8: - - - - - - - - - - - - - - - - -
SP9: - - -
SP10: - - - - - - -
SP11: - - - - - - -
SP12: - - -
SP14: - - - - - -
SP15: -
SP16: - - - -

ExUns: 17b · 17c ^ 18 ^ 19a · 19b · 19c · 19d · 19e ^ 20
SP2: - -
SP8: - - - - - - - -

Relevant External Links for DCUN1D4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCUN1D4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCUN1D4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCUN1D4 Gene

This gene is overexpressed in Bone (48.2) and Adipocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DCUN1D4 Gene

NURSA nuclear receptor signaling pathways regulating expression of DCUN1D4 Gene:


SOURCE GeneReport for Unigene cluster for DCUN1D4 Gene:


Evidence on tissue expression from TISSUES for DCUN1D4 Gene

  • Nervous system(4.8)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with DCUN1D4: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCUN1D4 Gene

Orthologs for DCUN1D4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DCUN1D4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCUN1D4 34
  • 99 (a)
(Mus musculus)
Mammalia Dcun1d4 16 34 33
  • 91.7 (n)
(Rattus norvegicus)
Mammalia Dcun1d4 33
  • 91.11 (n)
(Canis familiaris)
Mammalia DCUN1D4 34 33
  • 88.09 (n)
(Ornithorhynchus anatinus)
Mammalia DCUN1D4 34
  • 88 (a)
(Bos Taurus)
Mammalia DCUN1D4 34
  • 81 (a)
(Monodelphis domestica)
Mammalia DCUN1D4 34
  • 78 (a)
(Gallus gallus)
Aves DCUN1D4 34 33
  • 87.02 (n)
(Anolis carolinensis)
Reptilia DCUN1D4 34
  • 93 (a)
(Danio rerio)
Actinopterygii dcun1d4 34 33
  • 74.79 (n)
Dr.16505 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002513 33
  • 60.63 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6597 34 33
  • 59.11 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCN1 34
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2971 34
  • 50 (a)
Species where no ortholog for DCUN1D4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCUN1D4 Gene

Gene Tree for DCUN1D4 (if available)
Gene Tree for DCUN1D4 (if available)
Evolutionary constrained regions (ECRs) for DCUN1D4: view image

Paralogs for DCUN1D4 Gene

Paralogs for DCUN1D4 Gene

(5) SIMAP similar genes for DCUN1D4 Gene using alignment to 12 proteins:

  • B4DH25_HUMAN
  • B4DH26_HUMAN
  • D6RB33_HUMAN
  • H0Y907_HUMAN
  • H0Y9C5_HUMAN
  • H0YA35_HUMAN
genes like me logo Genes that share paralogs with DCUN1D4: view

Variants for DCUN1D4 Gene

Sequence variations from dbSNP and Humsavar for DCUN1D4 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000043555 -- 51,879,269(+) T/G intron_variant
rs1000111279 -- 51,914,646(+) G/A 3_prime_UTR_variant, non_coding_transcript_variant
rs1000149939 -- 51,884,917(+) G/A/T intron_variant
rs1000163884 -- 51,915,016(+) G/A 3_prime_UTR_variant, non_coding_transcript_variant
rs1000227149 -- 51,898,585(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DCUN1D4 Gene

Variant ID Type Subtype PubMed ID
esv2759252 CNV gain 17122850
nsv1012793 CNV gain 25217958
nsv1073759 CNV deletion 25765185
nsv428444 CNV gain 18775914

Variation tolerance for DCUN1D4 Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCUN1D4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCUN1D4 Gene

Disorders for DCUN1D4 Gene

Additional Disease Information for DCUN1D4

No disorders were found for DCUN1D4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCUN1D4 Gene

Publications for DCUN1D4 Gene

  1. The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. (PMID: 15988528) Kurz T … Peter M (Nature 2005) 2 3 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58

Products for DCUN1D4 Gene

Sources for DCUN1D4 Gene

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