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Aliases for CLASP2 Gene

Aliases for CLASP2 Gene

  • Cytoplasmic Linker Associated Protein 2 2 3 5
  • Protein Orbit Homolog 2 3 4
  • Cytoplasmic Linker-Associated Protein 2 4
  • Multiple Asters (Mast)-Like Homolog 2 3
  • CLIP-Associating Protein CLASP2 3
  • CLIP-Associating Protein 2 3
  • KIAA0627 4
  • HOrbit2 4

External Ids for CLASP2 Gene

Previous GeneCards Identifiers for CLASP2 Gene

  • GC03M032843
  • GC03M033384
  • GC03M033510
  • GC03M033509
  • GC03M033513
  • GC03M033512

Summaries for CLASP2 Gene

GeneCards Summary for CLASP2 Gene

CLASP2 (Cytoplasmic Linker Associated Protein 2) is a Protein Coding gene. Diseases associated with CLASP2 include Clostridium Difficile Colitis. Among its related pathways are Cell Cycle, Mitotic and Developmental Biology. Gene Ontology (GO) annotations related to this gene include binding and microtubule plus-end binding. An important paralog of this gene is CLASP1.

UniProtKB/Swiss-Prot for CLASP2 Gene

  • Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.

Gene Wiki entry for CLASP2 Gene

Additional gene information for CLASP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLASP2 Gene

Genomics for CLASP2 Gene

GeneHancer (GH) Regulatory Elements for CLASP2 Gene

Promoters and enhancers for CLASP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J033716 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE 655.6 +0.5 478 2.9 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B CBX5 CLASP2 CCR4 UBP1 FBXL2 GC03M033664 GC03M033663
GH03J033645 Promoter/Enhancer 1.6 EPDnew Ensembl dbSUPER 661.2 +73.0 72955 0.4 CEBPG ATF2 ZNF335 ATF4 PRDM6 ZNF366 POLR2A ATF7 TRIM28 CLASP2 GC03M033644 GC03M033664 GC03M033663
GH03J033790 Enhancer 1.5 FANTOM5 Ensembl ENCODE 15.4 -73.0 -72965 2.5 PKNOX1 ATF1 ARNT TCF12 ZNF766 CBX5 FOS ATF7 CAVIN1 JUNB PDCD6IP CLASP2 ENSG00000271643 ENSG00000271324 LOC105377023 SDAD1P3
GH03J033797 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.5 -81.0 -80971 3.7 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 PDCD6IP ENSG00000271020 LOC105377023 GC03M033793 LINC01811 ENSG00000227498 GLB1 TMPPE CLASP2 ENSG00000271324
GH03J033657 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 11.7 +58.9 58940 3 PKNOX1 ATF1 ARNT SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 ZNF213 CLASP2 UBP1 GC03M033664 GC03M033663 GC03M033644
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLASP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CLASP2 gene promoter:
  • Nkx6-1
  • FOXO1a
  • FOXO1
  • YY1
  • AML1a
  • Pax-3
  • Pbx1a
  • HNF-3beta
  • ATF-2
  • c-Jun

Genomic Locations for CLASP2 Gene

Genomic Locations for CLASP2 Gene
chr3:33,496,245-33,718,356
(GRCh38/hg38)
Size:
222,112 bases
Orientation:
Minus strand
chr3:33,537,737-33,759,848
(GRCh37/hg19)
Size:
222,112 bases
Orientation:
Minus strand

Genomic View for CLASP2 Gene

Genes around CLASP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLASP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLASP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLASP2 Gene

Proteins for CLASP2 Gene

  • Protein details for CLASP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75122-CLAP2_HUMAN
    Recommended name:
    CLIP-associating protein 2
    Protein Accession:
    O75122
    Secondary Accessions:
    • B2RTR1
    • F5H604
    • Q7L8F6
    • Q8N6R6
    • Q9BQT3
    • Q9BQT4
    • Q9H7A3
    • Q9NSZ2

    Protein attributes for CLASP2 Gene

    Size:
    1294 amino acids
    Molecular mass:
    141133 Da
    Quaternary structure:
    • Interacts with microtubules (PubMed:11290329, PubMed:15631994, PubMed:15955847, PubMed:26003921). Interacts with MAPRE1; probably required for targeting to the growing microtubule plus ends (PubMed:15631994, PubMed:19632184, PubMed:26003921). Interacts with CLIP2, ERC1, MAPRE3, PHLDB2 and RSN (PubMed:11290329, PubMed:15631994). The interaction with ERC1 may be mediated by PHLDB2 (PubMed:16824950). Interacts with GCC2; recruits CLASP2 to Golgi membranes (PubMed:17543864). Interacts with MACF1 (By similarity).
    SequenceCaution:
    • Sequence=BAA31602.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB14995.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CLASP2 Gene

    Alternative splice isoforms for CLASP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLASP2 Gene

Post-translational modifications for CLASP2 Gene

  • Phosphorylated by GSK3B. Phosphorylation reduces MAPRE1 binding (PubMed:26003921). Phosphorylation by GSK3B may negatively regulate binding to microtubule lattices in lamella.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CLASP2 Gene

Domains & Families for CLASP2 Gene

Gene Families for CLASP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CLASP2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O75122

UniProtKB/Swiss-Prot:

CLAP2_HUMAN :
  • The two SXIP sequence motifs mediate interaction with MAPRE1; this is necessary for targeting to growing microtubule plus ends.
  • Belongs to the CLASP family.
Domain:
  • The two SXIP sequence motifs mediate interaction with MAPRE1; this is necessary for targeting to growing microtubule plus ends.
  • Two TOG regions display structural characteristics similar to HEAT repeat domains and mediate interaction with microtubules.
Family:
  • Belongs to the CLASP family.
genes like me logo Genes that share domains with CLASP2: view

Function for CLASP2 Gene

Molecular function for CLASP2 Gene

UniProtKB/Swiss-Prot Function:
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.

Gene Ontology (GO) - Molecular Function for CLASP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002162 dystroglycan binding IPI 23940118
GO:0005488 binding IEA --
GO:0005515 protein binding IPI 11290329
GO:0008017 microtubule binding IDA 26003921
GO:0043515 kinetochore binding IEA --
genes like me logo Genes that share ontologies with CLASP2: view
genes like me logo Genes that share phenotypes with CLASP2: view

Animal Models for CLASP2 Gene

MGI Knock Outs for CLASP2:

Animal Model Products

miRNA for CLASP2 Gene

miRTarBase miRNAs that target CLASP2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLASP2 Gene

Localization for CLASP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLASP2 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cell membrane. Cell projection, ruffle membrane. Note=Localizes to microtubule plus ends (PubMed:15631994). Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase (PubMed:16866869, PubMed:16914514). In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2 (PubMed:16824950). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane. {ECO:0000269 PubMed:15631994, ECO:0000269 PubMed:16824950, ECO:0000269 PubMed:16866869, ECO:0000269 PubMed:16914514, ECO:0000269 PubMed:20937854}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLASP2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 5
golgi apparatus 5
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CLASP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 colocalizes_with kinetochore IMP 16866869
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm NAS 11290329
genes like me logo Genes that share ontologies with CLASP2: view

Pathways & Interactions for CLASP2 Gene

genes like me logo Genes that share pathways with CLASP2: view

Pathways by source for CLASP2 Gene

1 Qiagen pathway for CLASP2 Gene
1 Cell Signaling Technology pathway for CLASP2 Gene

Gene Ontology (GO) - Biological Process for CLASP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IMP 24859005
GO:0006903 vesicle targeting IMP 24859005
GO:0007020 microtubule nucleation IMP 17543864
GO:0007026 negative regulation of microtubule depolymerization NAS 11290329
GO:0007030 Golgi organization IMP 24859005
genes like me logo Genes that share ontologies with CLASP2: view

No data available for SIGNOR curated interactions for CLASP2 Gene

Drugs & Compounds for CLASP2 Gene

No Compound Related Data Available

Transcripts for CLASP2 Gene

Unigene Clusters for CLASP2 Gene

Cytoplasmic linker associated protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLASP2 Gene

No ASD Table

Relevant External Links for CLASP2 Gene

GeneLoc Exon Structure for
CLASP2
ECgene alternative splicing isoforms for
CLASP2

Expression for CLASP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLASP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CLASP2 Gene

This gene is overexpressed in Frontal cortex (14.2), Fetal Brain (11.9), Lung (7.5), Brain (6.9), and Peripheral blood mononuclear cells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CLASP2 Gene



Protein tissue co-expression partners for CLASP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CLASP2 Gene:

CLASP2

SOURCE GeneReport for Unigene cluster for CLASP2 Gene:

Hs.108614

mRNA Expression by UniProt/SwissProt for CLASP2 Gene:

O75122-CLAP2_HUMAN
Tissue specificity: Brain-specific.

Evidence on tissue expression from TISSUES for CLASP2 Gene

  • Nervous system(5)
  • Liver(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with CLASP2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLASP2 Gene

Orthologs for CLASP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CLASP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLASP2 34 33
  • 99.4 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CLASP2 34 33
  • 95.21 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CLASP2 34 33
  • 94.17 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLASP2 34
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clasp2 33
  • 90.25 (n)
mouse
(Mus musculus)
Mammalia Clasp2 16 34 33
  • 89.56 (n)
oppossum
(Monodelphis domestica)
Mammalia CLASP2 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLASP2 34 33
  • 81.22 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLASP2 34
  • 83 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii clasp2 34 33
  • 68.59 (n)
OneToOne
Dr.14760 33
fruit fly
(Drosophila melanogaster)
Insecta chb 34
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cls-2 34 33
  • 44.23 (n)
ManyToMany
cls-3 34
  • 25 (a)
ManyToMany
cls-1 34
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3398 34
  • 41 (a)
OneToMany
Cin.12093 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12093 33
Species where no ortholog for CLASP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CLASP2 Gene

ENSEMBL:
Gene Tree for CLASP2 (if available)
TreeFam:
Gene Tree for CLASP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CLASP2: view image

Paralogs for CLASP2 Gene

Paralogs for CLASP2 Gene

(3) SIMAP similar genes for CLASP2 Gene using alignment to 17 proteins:

  • CLAP2_HUMAN
  • B2RTR1_HUMAN
  • B3KR06_HUMAN
  • C9J668_HUMAN
  • D6RBU8_HUMAN
  • E3W994_HUMAN
  • E7ENG2_HUMAN
  • E7ERI8_HUMAN
  • E7EW49_HUMAN
  • E9PBA6_HUMAN
  • F5H3X0_HUMAN
  • F5H604_HUMAN
  • H7C4I5_HUMAN
  • H7C4M5_HUMAN
  • H7C4X8_HUMAN
  • H7C5M8_HUMAN
  • J3KR49_HUMAN

Pseudogenes.org Pseudogenes for CLASP2 Gene

genes like me logo Genes that share paralogs with CLASP2: view

Variants for CLASP2 Gene

Sequence variations from dbSNP and Humsavar for CLASP2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000000562 -- 33,516,916(-) A/T intron_variant
rs1000019282 -- 33,651,612(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000031055 -- 33,616,094(-) A/G intron_variant
rs1000037326 -- 33,602,340(-) T/C intron_variant
rs1000073702 -- 33,710,240(-) A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CLASP2 Gene

Variant ID Type Subtype PubMed ID
dgv2507n106 CNV deletion 24896259
esv2659678 CNV deletion 23128226
esv2725121 CNV deletion 23290073
esv2725122 CNV deletion 23290073
esv3302502 CNV tandem duplication 20981092
esv3426391 CNV duplication 20981092
esv3561718 CNV deletion 23714750
esv3595795 CNV loss 21293372
esv5412 CNV loss 18987735
esv6458 CNV loss 19470904
nsv1001132 CNV gain 25217958
nsv1006641 CNV gain 25217958
nsv1109504 CNV deletion 24896259
nsv1118698 CNV duplication 24896259
nsv1150509 CNV duplication 26484159
nsv1152886 CNV deletion 26484159
nsv236645 CNV deletion 16902084
nsv3754 CNV deletion 18451855
nsv3756 CNV insertion 18451855
nsv460487 CNV gain 19166990
nsv522881 CNV gain 19592680
nsv525628 CNV loss 19592680
nsv590051 CNV gain 21841781
nsv955541 CNV deletion 24416366
nsv999642 CNV gain 25217958

Variation tolerance for CLASP2 Gene

Gene Damage Index Score: 5.14; 69.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLASP2 Gene

Human Gene Mutation Database (HGMD)
CLASP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLASP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLASP2 Gene

Disorders for CLASP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CLASP2 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
clostridium difficile colitis
  • pseudomembranous colitis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CLASP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CLASP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLASP2 Gene

Publications for CLASP2 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  2. CLASP2 Has Two Distinct TOG Domains That Contribute Differently to Microtubule Dynamics. (PMID: 26003921) Maki T … Hayashi I (Journal of molecular biology 2015) 3 4 58
  3. Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression. (PMID: 20219685) Inkster B … Matthews PM (NeuroImage 2010) 3 44 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. (PMID: 20937854) Zaoui K … Badache A (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4 58

Products for CLASP2 Gene

Sources for CLASP2 Gene

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