Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPRC1 Gene

Aliases for PPRC1 Gene

  • Peroxisome Proliferator-Activated Receptor Gamma, Coactivator-Related 1 2 3 5
  • PGC-1-Related Coactivator 3 4
  • PRC 3 4
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator-Related Protein 1 3
  • Peroxisome Proliferative Activated Receptor, Gamma, Coactivator-Related 1 2
  • KIAA0595 4

External Ids for PPRC1 Gene

Previous GeneCards Identifiers for PPRC1 Gene

  • GC10P103558
  • GC10P103882
  • GC10P097524

Summaries for PPRC1 Gene

Entrez Gene Summary for PPRC1 Gene

  • The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

GeneCards Summary for PPRC1 Gene

PPRC1 (Peroxisome Proliferator-Activated Receptor Gamma, Coactivator-Related 1) is a Protein Coding gene. Diseases associated with PPRC1 include Epithelial Recurrent Erosion Dystrophy and Prosopagnosia. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is PPARGC1A.

UniProtKB/Swiss-Prot for PPRC1 Gene

  • Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes.

Gene Wiki entry for PPRC1 Gene

Additional gene information for PPRC1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPRC1 Gene

Genomics for PPRC1 Gene

GeneHancer (GH) Regulatory Elements for PPRC1 Gene

Promoters and enhancers for PPRC1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J102131 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.6 572 3.5 CLOCK MLX ZFP64 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 PPRC1 NOLC1 HPS6 SFXN2 OGA ARL3 KCNIP2-AS1 BORCS7 PIR37499 GC10M102134
GH10J101828 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 112.1 -302.0 -302011 4.4 HDGF PKNOX1 CLOCK SMAD1 ARNT SIN3A ZNF2 ZBTB7B ZNF766 ZNF416 PPRC1 LDB1 GBF1 LZTS2 MRPL43 HPS6 NOLC1 SUFU ENSG00000272572 SLF2
GH10J102418 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 45.6 +288.0 287952 5.1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 SP3 FBXL15 PSD PPRC1 PDCD11 LDB1 PCGF6 GBF1 SFXN2 OGA NOLC1
GH10J101692 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 40.7 -438.6 -438647 3.1 HDGF ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF143 SP3 SP5 FBXW4 PPRC1 GBF1 MRPL43 LDB1 ENSG00000272572 HPS6 OGA TWNK SLF2
GH10J101814 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 31.5 -315.9 -315885 5.9 CLOCK MLX FEZF1 YY1 ZNF213 ZNF143 SP3 SSRP1 GLIS1 NBN KCNIP2-AS1 OGA PPRC1 HPS6 LDB1 GBF1 MRPL43 TWNK SUFU NPM3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPRC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPRC1 gene promoter:
  • CREB
  • deltaCREB
  • Pax-5
  • E47
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • YY1
  • USF-1

Genomic Locations for PPRC1 Gene

Genomic Locations for PPRC1 Gene
17,340 bases
Plus strand
17,304 bases
Plus strand

Genomic View for PPRC1 Gene

Genes around PPRC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPRC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPRC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPRC1 Gene

Proteins for PPRC1 Gene

  • Protein details for PPRC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peroxisome proliferator-activated receptor gamma coactivator-related protein 1
    Protein Accession:
    Secondary Accessions:
    • Q5VV66
    • Q6P3U5
    • Q6P3W1
    • Q76N31
    • Q9BUJ3
    • Q9BZE5
    • Q9Y4E0

    Protein attributes for PPRC1 Gene

    1664 amino acids
    Molecular mass:
    177544 Da
    Quaternary structure:
    • Interacts with CREB1 and NRF1.
    • Sequence=AAH02561.2; Type=Frameshift; Positions=1643; Evidence={ECO:0000305}; Sequence=BAA25521.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PPRC1 Gene


neXtProt entry for PPRC1 Gene

Post-translational modifications for PPRC1 Gene

  • Ubiquitination at posLast=16451645
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PPRC1 Gene

Domains & Families for PPRC1 Gene

Gene Families for PPRC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PPRC1 Gene

Suggested Antigen Peptide Sequences for PPRC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PPRC1: view

No data available for UniProtKB/Swiss-Prot for PPRC1 Gene

Function for PPRC1 Gene

Molecular function for PPRC1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes.
UniProtKB/Swiss-Prot Induction:
Up-regulated by serum (at protein level).

Phenotypes From GWAS Catalog for PPRC1 Gene

Gene Ontology (GO) - Molecular Function for PPRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003712 transcription coregulator activity IEA --
GO:0003723 RNA binding IEA,HDA 22658674
GO:0008134 transcription factor binding IBA,IEA --
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IBA --
genes like me logo Genes that share ontologies with PPRC1: view
genes like me logo Genes that share phenotypes with PPRC1: view

Animal Models for PPRC1 Gene

MGI Knock Outs for PPRC1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPRC1 Gene

Localization for PPRC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPRC1 Gene

Nucleus. Note=Colocalizes with NRF1. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPRC1 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2
endosome 2
plasma membrane 1
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PPRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm IDA,TAS --
genes like me logo Genes that share ontologies with PPRC1: view

Pathways & Interactions for PPRC1 Gene

genes like me logo Genes that share pathways with PPRC1: view

Pathways by source for PPRC1 Gene

Gene Ontology (GO) - Biological Process for PPRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007005 mitochondrion organization TAS --
GO:0045944 positive regulation of transcription by RNA polymerase II IBA --
GO:0051091 positive regulation of DNA binding transcription factor activity IBA --
genes like me logo Genes that share ontologies with PPRC1: view

No data available for SIGNOR curated interactions for PPRC1 Gene

Drugs & Compounds for PPRC1 Gene

No Compound Related Data Available

Transcripts for PPRC1 Gene

Unigene Clusters for PPRC1 Gene

Peroxisome proliferator-activated receptor gamma, coactivator-related 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPRC1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: -
SP7: - - - -
SP8: - - - - - -
SP9: - -
SP11: -

ExUns: 14a · 14b ^ 15a · 15b ^ 16 ^ 17
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -

Relevant External Links for PPRC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPRC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPRC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPRC1 Gene

This gene is overexpressed in Retina (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPRC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PPRC1 Gene:


SOURCE GeneReport for Unigene cluster for PPRC1 Gene:


mRNA Expression by UniProt/SwissProt for PPRC1 Gene:

Tissue specificity: Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors.

Evidence on tissue expression from TISSUES for PPRC1 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with PPRC1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPRC1 Gene

Orthologs for PPRC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PPRC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPRC1 34 33
  • 98.82 (n)
(Canis familiaris)
Mammalia PPRC1 34 33
  • 87.9 (n)
(Bos Taurus)
Mammalia PPRC1 34 33
  • 86.76 (n)
(Rattus norvegicus)
Mammalia Pprc1 33
  • 81.99 (n)
(Mus musculus)
Mammalia Pprc1 16 34 33
  • 81.32 (n)
(Ornithorhynchus anatinus)
Mammalia PPRC1 34
  • 45 (a)
(Monodelphis domestica)
Mammalia PPRC1 34
  • 42 (a)
(Gallus gallus)
Aves PPRC1 34
  • 37 (a)
(Anolis carolinensis)
Reptilia PPRC1 34
  • 34 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10020 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.19433 33
(Danio rerio)
Actinopterygii pprc1 34
  • 30 (a)
sbcb478 33
fruit fly
(Drosophila melanogaster)
Insecta Spargel 34
  • 18 (a)
Species where no ortholog for PPRC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPRC1 Gene

Gene Tree for PPRC1 (if available)
Gene Tree for PPRC1 (if available)
Evolutionary constrained regions (ECRs) for PPRC1: view image

Paralogs for PPRC1 Gene

Paralogs for PPRC1 Gene

genes like me logo Genes that share paralogs with PPRC1: view

Variants for PPRC1 Gene

Sequence variations from dbSNP and Humsavar for PPRC1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs193920990 uncertain-significance, Malignant tumor of prostate 102,139,412(+) A/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000093356 -- 102,143,986(+) A/T intron_variant
rs1000194324 -- 102,150,419(+) T/G downstream_transcript_variant
rs1000266996 -- 102,132,124(+) G/A upstream_transcript_variant
rs1000304010 -- 102,137,542(+) C/T intron_variant

Variation tolerance for PPRC1 Gene

Residual Variation Intolerance Score: 2.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.64; 65.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPRC1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PPRC1 Gene

Disorders for PPRC1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PPRC1 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
epithelial recurrent erosion dystrophy
  • ered
- elite association - COSMIC cancer census association via MalaCards
Search PPRC1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PPRC1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PPRC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPRC1 Gene

Publications for PPRC1 Gene

  1. Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells. (PMID: 11340167) Andersson U … Scarpulla RC (Molecular and cellular biology 2001) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  3. Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study. (PMID: 19209188) Reiling E … Dekker JM (European journal of human genetics : EJHG 2009) 3 44 58
  4. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PMID: 18660489) Lu Y … Boer JM (Journal of lipid research 2008) 3 44 58
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58

Products for PPRC1 Gene

Sources for PPRC1 Gene

Loading form....