Aliases for PDS5B Gene
External Ids for PDS5B Gene
Previous HGNC Symbols for PDS5B Gene
Previous GeneCards Identifiers for PDS5B Gene
This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015]
GeneCards Summary for PDS5B Gene
PDS5B (PDS5 Cohesin Associated Factor B) is a Protein Coding gene. Among its related pathways are Mitotic Telophase/Cytokinesis and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is PDS5A.
UniProtKB/Swiss-Prot for PDS5B Gene
Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.