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Aliases for MON2 Gene

Aliases for MON2 Gene

  • MON2 Homolog, Regulator Of Endosome-To-Golgi Trafficking 2 3 5
  • MON2 Regulator Of Endosome-To-Golgi Trafficking 3
  • MON2 Homolog (S. Cerevisiae) 2
  • Protein MON2 Homolog 3
  • MON2 Homolog (Yeast) 2
  • Protein SF21 4
  • KIAA1040 4
  • SF21 4

External Ids for MON2 Gene

Previous GeneCards Identifiers for MON2 Gene

  • GC12P061147
  • GC12P062860
  • GC12P059911

Summaries for MON2 Gene

GeneCards Summary for MON2 Gene

MON2 (MON2 Homolog, Regulator Of Endosome-To-Golgi Trafficking) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding and ARF guanyl-nucleotide exchange factor activity.

UniProtKB/Swiss-Prot for MON2 Gene

  • May be required for traffic between late Golgi and early endosomes.

Gene Wiki entry for MON2 Gene

Additional gene information for MON2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MON2 Gene

Genomics for MON2 Gene

GeneHancer (GH) Regulatory Elements for MON2 Gene

Promoters and enhancers for MON2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J062465 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.6 567 3.2 HDGF ARNT MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 MON2 FAM19A2 ENSG00000257568
GH12J062256 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 35 -207.1 -207087 6.7 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 USP15 FAM19A2 MIR6125 MON2 ENSG00000257354 RPL14P1 LINC01465 KLF17P1
GH12J062933 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21.7 +467.7 467715 2.9 PKNOX1 CLOCK SMAD1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ENSG00000252660 GC12P062936 PPM1H MON2 ENSG00000257354 RXYLT1 RNU1-83P GC12M062851
GH12J062601 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 21.7 +136.7 136719 4.5 CLOCK ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D ENSG00000257354 ENSG00000275180 GC12P062607 LINC01465 MIRLET7I MON2 USP15 FAM19A2
GH12J062817 Enhancer 1.3 FANTOM5 Ensembl ENCODE 15.3 +351.3 351268 1.2 FEZF1 ZNF2 YY1 ZNF121 ATF7 ZNF202 REST TSHZ1 ZNF488 ZNF518A RNU1-83P MON2 ENSG00000257354 ENSG00000257568 PPM1H LOC105369795 GC12M062761
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MON2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MON2 gene promoter:
  • AREB6
  • POU2F1a
  • POU2F1
  • MAZR
  • p300
  • p53
  • Arnt
  • STAT3
  • En-1
  • TGIF

Genomic Locations for MON2 Gene

Genomic Locations for MON2 Gene
133,663 bases
Plus strand
130,767 bases
Plus strand

Genomic View for MON2 Gene

Genes around MON2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MON2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MON2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MON2 Gene

Proteins for MON2 Gene

  • Protein details for MON2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein MON2 homolog
    Protein Accession:
    Secondary Accessions:
    • A5D8U7
    • A7E2Y0
    • B9EGP5
    • F8VWA6
    • F8W1Z6
    • Q86TA2
    • Q8N3I5
    • Q8NAI0
    • Q8NHE2
    • Q9UPW1

    Protein attributes for MON2 Gene

    1717 amino acids
    Molecular mass:
    190359 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA82992.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MON2 Gene


neXtProt entry for MON2 Gene

Post-translational modifications for MON2 Gene

  • Ubiquitination at isoforms=2, 5, 6288 and Lys281
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MON2 Gene

Domains & Families for MON2 Gene

Gene Families for MON2 Gene

Protein Domains for MON2 Gene

Suggested Antigen Peptide Sequences for MON2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MON2 family.
  • Belongs to the MON2 family.
genes like me logo Genes that share domains with MON2: view

Function for MON2 Gene

Molecular function for MON2 Gene

UniProtKB/Swiss-Prot Function:
May be required for traffic between late Golgi and early endosomes.

Phenotypes From GWAS Catalog for MON2 Gene

Gene Ontology (GO) - Molecular Function for MON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14743216
genes like me logo Genes that share ontologies with MON2: view
genes like me logo Genes that share phenotypes with MON2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MON2 Gene

Localization for MON2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MON2 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 2
endosome 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with MON2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MON2 Gene

Pathways & Interactions for MON2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006895 Golgi to endosome transport ISS --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with MON2: view

No data available for Pathways by source and SIGNOR curated interactions for MON2 Gene

Drugs & Compounds for MON2 Gene

No Compound Related Data Available

Transcripts for MON2 Gene

Unigene Clusters for MON2 Gene

MON2 homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MON2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a ·
SP1: - -
SP4: - - - - -
SP8: -

ExUns: 22b · 22c ^ 23a · 23b ^ 24a · 24b · 24c ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31a · 31b ^ 32a · 32b
SP2: - - -
SP3: - - - -
SP5: -
SP10: - -

Relevant External Links for MON2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MON2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MON2 Gene

Protein differential expression in normal tissues from HIPED for MON2 Gene

This gene is overexpressed in Bone (51.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MON2 Gene

Protein tissue co-expression partners for MON2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MON2 Gene:


SOURCE GeneReport for Unigene cluster for MON2 Gene:


Evidence on tissue expression from TISSUES for MON2 Gene

  • Nervous system(4.6)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with MON2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MON2 Gene

Orthologs for MON2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MON2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MON2 34 33
  • 99.77 (n)
(Canis familiaris)
Mammalia MON2 34 33
  • 94.2 (n)
(Monodelphis domestica)
Mammalia MON2 34
  • 94 (a)
(Bos Taurus)
Mammalia MON2 34 33
  • 93.71 (n)
(Ornithorhynchus anatinus)
Mammalia MON2 34
  • 92 (a)
(Rattus norvegicus)
Mammalia Mon2 33
  • 87.42 (n)
(Mus musculus)
Mammalia Mon2 16 34 33
  • 85.96 (n)
(Gallus gallus)
Aves MON2 34 33
  • 83.53 (n)
(Anolis carolinensis)
Reptilia MON2 34
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mon2 33
  • 78.2 (n)
(Danio rerio)
Actinopterygii mon2 34
  • 83 (a)
LOC100334806 33
  • 71.34 (n)
wufc16c07 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.391 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009972 33
  • 54.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta mon2 34 33
  • 54.82 (n)
(Caenorhabditis elegans)
Secernentea mon-2 34 33
  • 48.28 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MON2 34
  • 20 (a)
Species where no ortholog for MON2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MON2 Gene

Gene Tree for MON2 (if available)
Gene Tree for MON2 (if available)
Evolutionary constrained regions (ECRs) for MON2: view image

Paralogs for MON2 Gene

No data available for Paralogs for MON2 Gene

Variants for MON2 Gene

Sequence variations from dbSNP and Humsavar for MON2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000014020 -- 62,584,521(+) G/A intron_variant
rs1000035362 -- 62,478,440(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000056895 -- 62,578,336(+) A/C intron_variant
rs1000115433 -- 62,522,698(+) T/C intron_variant
rs1000149349 -- 62,584,796(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MON2 Gene

Variant ID Type Subtype PubMed ID
dgv822n106 CNV deletion 24896259
esv2658375 CNV deletion 23128226
esv2745966 CNV deletion 23290073
esv3549302 CNV deletion 23714750
esv3629738 CNV loss 21293372
nsv469418 CNV loss 19166990
nsv559156 CNV loss 21841781
nsv739 CNV insertion 18451855
nsv740 CNV insertion 18451855
nsv821671 CNV loss 15273396
nsv952196 CNV duplication 24416366

Variation tolerance for MON2 Gene

Residual Variation Intolerance Score: 5.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.08; 98.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MON2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MON2 Gene

Disorders for MON2 Gene

Additional Disease Information for MON2

No disorders were found for MON2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MON2 Gene

Publications for MON2 Gene

  1. Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus. (PMID: 16301316) Gillingham AK … Munro S (The Journal of biological chemistry 2006) 2 3 4 58
  2. Mammalian Mon2/Ysl2 regulates endosome-to-Golgi trafficking but possesses no guanine nucleotide exchange activity toward Arl1 GTPase. (PMID: 24285343) Mahajan D … Lu L (Scientific reports 2013) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for MON2 Gene

Sources for MON2 Gene

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