Aliases for FOXE1 Gene
External Ids for FOXE1 Gene
Previous HGNC Symbols for FOXE1 Gene
Previous GeneCards Identifiers for FOXE1 Gene
This intronless gene encodes a protein that belongs to the forkhead family of transcription factors. Members of this family contain a conserved 100-amino acid DNA-binding 'forkhead' domain. The encoded protein functions as a thyroid transcription factor that plays a role in thyroid morphogenesis. Mutations in this gene are associated with the Bamforth-Lazarus syndrome, and with susceptibility to nonmedullary thyroid cancer-4. [provided by RefSeq, Nov 2016]
GeneCards Summary for FOXE1 Gene
FOXE1 (Forkhead Box E1) is a Protein Coding gene. Diseases associated with FOXE1 include Hypothyroidism, Thyroidal Or Athyroidal, With Spiky Hair And Cleft Palate and Thyroid Cancer, Nonmedullary, 4. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXE3.
UniProtKB/Swiss-Prot for FOXE1 Gene
Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression.