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Aliases for MAST3 Gene
Aliases for MAST3 Gene
External Ids for MAST3 Gene
- HGNC: 19036
- Entrez Gene: 23031
- Ensembl: ENSG00000099308
- OMIM: 612258
- UniProtKB: O60307
Previous GeneCards Identifiers for MAST3 Gene
- GC19P018069
- GC19P018208
- GC19P017772
- GC19P018137
- GC19P018196
- GC19P020495
- GC19P020636
- GC19P020742
- GC19P022249
- GC19P018364
- GC19P018384
- GC19P018716
- GC19P019027
- GC19P019342
- GC19P019676
- GC19P020041
- GC19P020354
Summaries for MAST3 Gene
GeneCards Summary for MAST3 Gene
MAST3 (Microtubule Associated Serine/Threonine Kinase 3) is a Protein Coding gene. Diseases associated with MAST3 include Inflammatory Bowel Disease 6 and Mega-Corpus-Callosum Syndrome With Cerebellar Hypoplasia And Cortical Malformations. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAST4.
Additional gene information for MAST3 Gene
- HGNC(19036)
- Entrez Gene(23031)
- Ensembl(ENSG00000099308)
- OMIM(612258)
- UniProtKB(O60307)
- Open Targets Platform(ENSG00000099308)
- Search for MAST3 at DataMed
- Search for MAST3 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAST3 Gene
Genomics for MAST3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MAST3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MAST3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAST3
- Top Transcription factor binding sites by QIAGEN in the MAST3 gene promoter:
-
- ATF
- Bach1
- HEN1
- HSF2
- STAT1
- STAT3
- STAT5A
- XBP-1
Genomic Locations for MAST3 Gene
Genomic Locations for MAST3 Gene
- chr19:18,097,764-18,151,692
- (GRCh38/hg38)
- Size:
- 53,929 bases
- Orientation:
- Plus strand
- chr19:18,208,603-18,262,502
- (GRCh37/hg19)
- Size:
- 53,900 bases
- Orientation:
- Plus strand
Genomic View for MAST3 Gene
Genes around MAST3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.11 by HGNC
- 19p13.11 by Entrez Gene
- 19p13.11 by Ensembl
MAST3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAST3 Gene
Proteins for MAST3 Gene
-
Protein details for MAST3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60307-MAST3_HUMAN
- Recommended name:
- Microtubule-associated serine/threonine-protein kinase 3
- Protein Accession:
- O60307
- Q7LDZ8
- Q9UPI0
Protein attributes for MAST3 Gene
- Size:
- 1309 amino acids
- Molecular mass:
- 143137 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Interacts with PTEN.
- SequenceCaution:
-
- Sequence=AAC62830.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for MAST3 Gene
Selected DME Specific Peptides for MAST3 Gene
- O60307:
-
- RFSKVYSS
- MFCSFET
- AETVLALEYLH
- LYEFLVGCVPFFGDTPEELFGQV
- LTDFGLSK
- RPRSRSL
- CSFETRRHLCMVMEYVEGGDCATL
- CGTPEYIAPE
- KLTDFGL
- TIKLISNGAYGAVYLVRHRDTRQRFA
- ELARDCL
- SSTLSSSSS
- ESDFETIKLISNGAYGAVY
- DNEIVMMNHVY
- DELHFLSKHF
- RSLSPGR
- GHIKLTD
- GKPVDWWA
- RPARLLECLEF
- GHIKLTDFGLSK
- KELSLPRRG
- IKLTDFG
- WPEGDEALP
- GIVHRDLKPDN
- FVERDILTFAENPFVV
- VHRDLKP
- IVHRDLK
Post-translational modifications for MAST3 Gene
Other Protein References for MAST3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_005259880.1
- XP_005259881.1
- XP_005259882.1
- XP_005259883.1
- XP_005259884.1
- XP_006722761.1
- XP_006722762.2
- XP_006722763.1
- XP_011526125.1
- XP_016881995.1
- XP_016881996.1
- XP_016881997.1
- XP_016881998.1
- XP_016881999.1
- XP_016882000.1
- XP_016882001.1
- XP_016882002.1
- XP_016882003.1
- XP_016882004.1
- XP_016882005.1
- NP_055831.1
Antibody Products
- LifeSpan BioSciences MAST3 Antibody
- G Biosciences Immunotag™ MAST3 Antibody
- Novus Biologicals Antibodies for MAST3
-
Abcam antibodies for MAST3
- Invitrogen Antibodies for MAST3 (AFLGC-MAST3)
- antibodies-online: Show 9 available MAST3 Antibodies ranked by validation data
-
Biorbyt antibodies for MAST3
-
Boster Bio Antibodies for MAST3
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MAST3
- Origene Custom Protein Services for MAST3
- Novus Biologicals proteins for MAST3
-
Abcam proteins for MAST3
Assay Products
-
Boster Bio ELISA Kits for MAST3
-
Signalway ELISA kits for MAST3
Domains & Families for MAST3 Gene
Gene Families for MAST3 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for MAST3 Gene
- InterPro:
- Blocks:
-
- PDZ/DHR/GLGF domain
- Protein kinase C-terminal domain
- ProtoNet:
Suggested Antigen Peptide Sequences for MAST3 Gene
- GenScript: Design optimal peptide antigens:
-
- Microtubule-associated serine/threonine-protein kinase 3 (MAST3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O60307UniProtKB/Swiss-Prot:
MAST3_HUMAN :- Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
- Family:
-
- Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Function for MAST3 Gene
Molecular function for MAST3 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
Enzyme Numbers (IUBMB) for MAST3 Gene
Phenotypes From GWAS Catalog for MAST3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0000287 | magnesium ion binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 15951562 |
Phenotypes for MAST3 Gene
- MGI mutant phenotypes for MAST3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MAST3:
-
- Increased cell death HMECs cells
- Decreased viability ratio
- shRNA abundance <= 25%
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased cell migration
- Decreased shRNA abundance
- Decreased viability
- Increased transferrin (TF) endocytosis
- Increased HPV18 LCR reporter activity
- Increased human cytomegalovirus (HCMV) strain AD169 replication
- Decreased BPV1 E2 protein expression
- Decreased replication of vaccinia virus (VACV)
- Decreased mitotic index
- Paclitaxel antagonistic effect
- Increased colony dispersion (increased number of colonies and decreased number of cells per colony)
Animal Models for MAST3 Gene
- MGI Knock Outs for MAST3:
-
- Mast3 Mast3<tm1.1(KOMP)Wtsi>
Animal Model Products
-
Taconic Biosciences Mouse Models for MAST3
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MAST3 - Select products 50% OFF >
- * MAST3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MAST3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAST3
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAST3
miRNA for MAST3 Gene
- miRTarBase miRNAs that target MAST3
-
- hsa-miR-484 (MIRT042385)
- hsa-miR-30a-5p (MIRT150758)
- hsa-miR-30c-5p (MIRT150760)
- hsa-miR-30d-5p (MIRT150761)
- hsa-miR-30b-5p (MIRT150763)
- hsa-miR-30e-5p (MIRT150765)
- hsa-miR-7848-3p (MIRT496490)
- hsa-miR-449b-5p (MIRT496491)
- hsa-miR-449a (MIRT496492)
- hsa-miR-34c-5p (MIRT496493)
- hsa-miR-34a-5p (MIRT496494)
- hsa-miR-449c-5p (MIRT496495)
- hsa-miR-34b-5p (MIRT496496)
- hsa-miR-2682-5p (MIRT496497)
- hsa-miR-940 (MIRT496498)
- hsa-miR-6893-5p (MIRT496499)
- hsa-miR-6808-5p (MIRT496500)
- hsa-miR-6511a-5p (MIRT496501)
- hsa-miR-1910-3p (MIRT496502)
- hsa-miR-4704-5p (MIRT496503)
- mmu-miR-466o-3p (MIRT578306)
- mmu-miR-466m-3p (MIRT578307)
- mmu-miR-466f-3p (MIRT578308)
- mmu-miR-329-3p (MIRT578309)
- mmu-miR-466i-3p (MIRT578310)
- mmu-miR-362-3p (MIRT578311)
- hsa-miR-7156-3p (MIRT649646)
- hsa-miR-5196-5p (MIRT649647)
- hsa-miR-3178 (MIRT649648)
- hsa-miR-4747-5p (MIRT649649)
- hsa-miR-566 (MIRT649650)
- hsa-miR-6720-3p (MIRT649651)
- hsa-miR-4691-3p (MIRT649652)
- hsa-miR-3614-5p (MIRT649653)
- hsa-miR-6826-3p (MIRT696074)
- hsa-miR-6820-3p (MIRT696075)
- hsa-miR-3164 (MIRT696076)
- hsa-miR-6505-3p (MIRT696077)
- hsa-miR-617 (MIRT696078)
- hsa-miR-676-5p (MIRT696079)
- hsa-miR-372-5p (MIRT696080)
- hsa-miR-6795-3p (MIRT696081)
- hsa-miR-6887-3p (MIRT696082)
- hsa-miR-6729-3p (MIRT696083)
- hsa-miR-125a-3p (MIRT696084)
- hsa-miR-7853-5p (MIRT696085)
- hsa-miR-105-5p (MIRT696086)
- hsa-miR-552-3p (MIRT696087)
- hsa-miR-4506 (MIRT696088)
- hsa-miR-4786-5p (MIRT696089)
- hsa-miR-6849-3p (MIRT696090)
- hsa-miR-4293 (MIRT696091)
- hsa-miR-6771-3p (MIRT696092)
- hsa-miR-32-5p (MIRT727242)
- hsa-miR-92b-3p (MIRT727243)
- hsa-miR-92a-3p (MIRT727244)
- hsa-miR-25-5p (MIRT764235)
- hsa-miR-3160-3p (MIRT765129)
- hsa-miR-377-5p (MIRT767427)
- hsa-miR-4459 (MIRT769299)
- hsa-miR-4487 (MIRT769666)
- hsa-miR-455-3p (MIRT770363)
- hsa-miR-558 (MIRT774840)
- hsa-miR-6086 (MIRT775558)
- hsa-miR-6087 (MIRT775676)
- hsa-miR-6499-3p (MIRT776304)
- hsa-miR-6516-5p (MIRT777160)
- hsa-miR-658 (MIRT777351)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAST3
- Browse OriGene Inhibitory RNA Products For MAST3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAST3
Clone Products
- Applied Biological Materials (abm): Clones for MAST3 - Select products 50% OFF >
- * MAST3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MAST3
- Addgene plasmids for MAST3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAST3
Cell Line Products
-
Horizon Cell Lines for MAST3
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAST3 Gene
Localization for MAST3 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nuclear speckles (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAST3 Gene
Pathways & Interactions for MAST3 Gene
Interacting Proteins for MAST3 Gene
Selected Interacting proteins:
O60307-MAST3_HUMAN
ENSP00000262811
for MAST3 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for MAST3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0007010 | cytoskeleton organization | IBA | 21873635 |
| GO:0016310 | phosphorylation | IEA | -- |
| GO:0018105 | peptidyl-serine phosphorylation | IBA | 21873635 |
| GO:0035556 | intracellular signal transduction | IBA | 21873635 |
No data available for Pathways by source for MAST3 Gene
Drugs & Compounds for MAST3 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
Transcripts for MAST3 Gene
mRNA/cDNA for MAST3 Gene
- 1 REFSEQ mRNAs :
- 5 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000262811 5896 nts (view in UCSC)
- ENST00000601226 451 nts (view in UCSC)
- ENST00000608648 1760 nts (view in UCSC)
- ENST00000609076 449 nts (view in UCSC)
- ENST00000609494 354 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MAST3 - Select products 50% OFF >
- * MAST3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MAST3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAST3
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAST3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAST3
- Browse OriGene Inhibitory RNA Products For MAST3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAST3
Clone Products
- Applied Biological Materials (abm): Clones for MAST3 - Select products 50% OFF >
- * MAST3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MAST3
- Addgene plasmids for MAST3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAST3
Relevant External Links for MAST3 Gene
- GeneLoc Exon Structure for
- MAST3
Expression for MAST3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for MAST3 Gene
This gene is overexpressed in Whole Blood (x6.4) and Brain - Cortex (x4.9).
This gene is overexpressed in Saliva (25.1), Blymphocyte (12.9), and Peripheral blood mononuclear cells (8.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAST3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAST3
SOURCE GeneReport for Unigene cluster for MAST3 Gene:
Hs.466184Evidence on tissue expression from TISSUES for MAST3 Gene
- Nervous system(4.6)
- Liver(4.3)
- Kidney(2)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs for MAST3
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAST3 Gene
Orthologs for MAST3 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MAST3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MAST3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MAST3 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mast3 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Mast3 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MAST3 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Chicken (Gallus gallus) |
Aves | MAST3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MAST3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mast3 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC100535762 30 |
|
||
| MAST3 (1 of 2) 31 |
|
OneToMany | |||
| BX004890.2 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG6498 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | kin-4 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | KIN82 31 |
|
ManyToMany | |
| FPK1 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for MAST3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MAST3 Gene
- ENSEMBL:
- Gene Tree for MAST3 (if available)
- TreeFam:
- Gene Tree for MAST3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MAST3: view image
Paralogs for MAST3 Gene
Paralogs for MAST3 Gene
(18) SIMAP similar genes for MAST3 Gene using alignment to 2 proteins:
- MAST3_HUMAN
- V9GYV0_HUMAN
Variants for MAST3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAST3 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 769963 | Benign: not provided | 18,135,783(+) | C/T | SYNONYMOUS_VARIANT | |
| 781463 | Benign: not provided | 18,134,696(+) | G/A | SYNONYMOUS_VARIANT | |
| rs35945810 | - | p.Arg203Gln | |||
| rs369960905 | - | p.Gly883Ser | |||
| rs8108738 | - | p.Gly861Ser |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2658066 | CNV | deletion | 23128226 |
| esv2718285 | CNV | deletion | 23290073 |
| esv3556132 | CNV | deletion | 23714750 |
| nsv1130730 | CNV | deletion | 24896259 |
| nsv1138675 | CNV | deletion | 24896259 |
| nsv1151018 | CNV | deletion | 26484159 |
| nsv1160591 | CNV | deletion | 26073780 |
| nsv1160592 | CNV | deletion | 26073780 |
| nsv2429 | CNV | deletion | 18451855 |
| nsv470130 | CNV | loss | 18288195 |
| nsv833773 | CNV | loss | 17160897 |
| nsv833774 | CNV | loss | 17160897 |
| nsv833775 | CNV | loss | 17160897 |
| nsv952420 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
4.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.65;
65.72% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAST3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MAST3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAST3 Gene
Disorders for MAST3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| inflammatory bowel disease 6 |
|
|
| mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations |
|
|
Search MAST3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MAST3
No data available for UniProtKB/Swiss-Prot and Genatlas for MAST3 Gene
Publications for MAST3 Gene
- Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases. (PMID: 15951562) Valiente M … Pulido R (The Journal of biological chemistry 2005) 3 4
- The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
- Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4
- Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation. (PMID: 30344098) Weith M … Meyer H (Molecular cell 2018) 3
- RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3
ExternalLinks
Products for MAST3 Gene
- Custom Antibody Services
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