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Aliases for TRAK1 Gene

Aliases for TRAK1 Gene

  • Trafficking Kinesin Protein 1 2 3 5
  • O-Linked N-Acetylglucosamine Transferase Interacting Protein 106 2 3
  • 106 KDa O-GlcNAc Transferase-Interacting Protein 3 4
  • Trafficking Protein, Kinesin Binding 1 2 3
  • OIP106 3 4
  • OGT(O-Glc-NAc Transferase)-Interacting Protein 106 KDa 3
  • OGT(O Glc NAc Transferase) Interacting Protein 106 KDa 2
  • Trafficking Kinesin-Binding Protein 1 3
  • Milton Homolog 1 (Drosophila) 2
  • Milton Homolog 1 3
  • KIAA1042 4
  • MILT1 3

External Ids for TRAK1 Gene

Previous GeneCards Identifiers for TRAK1 Gene

  • GC03P042108

Summaries for TRAK1 Gene

GeneCards Summary for TRAK1 Gene

TRAK1 (Trafficking Kinesin Protein 1) is a Protein Coding gene. Diseases associated with TRAK1 include Undetermined Early-Onset Epileptic Encephalopathy and Meckel Diverticulum. Among its related pathways are HIV Life Cycle and Oncogenic MAPK signaling. Gene Ontology (GO) annotations related to this gene include GABA receptor binding. An important paralog of this gene is TRAK2.

UniProtKB/Swiss-Prot for TRAK1 Gene

  • Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors.

Gene Wiki entry for TRAK1 Gene

Additional gene information for TRAK1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAK1 Gene

Genomics for TRAK1 Gene

GeneHancer (GH) Regulatory Elements for TRAK1 Gene

Promoters and enhancers for TRAK1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J042011 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 662.1 +0.6 604 5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A IRF4 YY1 POLR2B ZNF766 TRAK1 NKTR ULK4 CTNNB1 ZNF662 ENSG00000229339
GH03J042159 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 650.1 +146.8 146814 3.1 PKNOX1 FOXA2 ARID4B SIN3A ZBTB40 ZNF48 ZNF335 ZNF121 GLIS2 EGR2 TRAK1 TPMTP2 GC03P042217
GH03J042090 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 669.3 +78.0 78011 2.6 ZNF687 CBFB HLF CEBPB KLF5 ATF2 IRF4 ZBTB40 EED ZBTB33 TRAK1 ENSG00000212145 ULK4 GC03P042123 ENSG00000229339
GH03J042148 Promoter/Enhancer 1.5 EPDnew ENCODE dbSUPER 650.1 +136.2 136174 2.2 MXI1 KLF1 PKNOX1 ATF1 JUN SIN3A BMI1 RFX5 CTBP1 POLR2A TRAK1 NKTR ENSG00000212145 TPMTP2 GC03P042217
GH03J042057 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 27 +49.7 49694 12.6 PKNOX1 FOXA2 SMAD1 SIN3A IRF4 ATF7 RUNX3 DEK JUNB NFIL3 TRAK1 ULK4 NKTR KRBOX1 ENSG00000229339 GC03P042123
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRAK1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRAK1 gene promoter:
  • LCR-F1
  • E2F-1
  • E2F
  • CUTL1
  • Nkx2-5
  • AML1a
  • Chx10
  • ATF-2
  • USF1
  • USF-1

Genomic Locations for TRAK1 Gene

Genomic Locations for TRAK1 Gene
212,089 bases
Plus strand
212,088 bases
Plus strand

Genomic View for TRAK1 Gene

Genes around TRAK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAK1 Gene

Proteins for TRAK1 Gene

  • Protein details for TRAK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trafficking kinesin-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • E9PDS2
    • J3KNT7
    • Q63HR0
    • Q659B5
    • Q96B69

    Protein attributes for TRAK1 Gene

    953 amino acids
    Molecular mass:
    106040 Da
    Quaternary structure:
    • Interacts with O-GlcNAc transferase. Interacts with RHOT1/Miro-1 and RHOT2/Miro-2. Interacts with HGS. Interacts with GABRA1 (By similarity). Interacts with KIF5C.
    • Over-expressed in all investigated carcinomas, especially in gastric adenocarcinoma and signet-ring carcinoma and may serve as a marker of gastric cancer.
    • Sequence=BAA82994.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRAK1 Gene


neXtProt entry for TRAK1 Gene

Post-translational modifications for TRAK1 Gene

No data available for DME Specific Peptides for TRAK1 Gene

Domains & Families for TRAK1 Gene

Gene Families for TRAK1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TRAK1 Gene

Suggested Antigen Peptide Sequences for TRAK1 Gene

Graphical View of Domain Structure for InterPro Entry



  • The C-terminal region is required for the early endosomal and mitochondrial localization.
  • The C-terminal region is required for the early endosomal and mitochondrial localization.
genes like me logo Genes that share domains with TRAK1: view

Function for TRAK1 Gene

Molecular function for TRAK1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors.

Phenotypes From GWAS Catalog for TRAK1 Gene

Gene Ontology (GO) - Molecular Function for TRAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IBA --
GO:0005515 protein binding IPI 15644324
GO:0017022 myosin binding IBA --
GO:0030911 TPR domain binding IEA --
GO:0050811 GABA receptor binding IEA --
genes like me logo Genes that share ontologies with TRAK1: view
genes like me logo Genes that share phenotypes with TRAK1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAK1 Gene

Localization for TRAK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAK1 Gene

Cytoplasm. Nucleus. Mitochondrion. Early endosome. Endosome. Note=Predominantly associated with early endosome. The localization to early endosomes depends on its interaction with HRS. Colocalizes with MGARP at the mitochondria.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAK1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
endosome 5
cytosol 3
cytoskeleton 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA,IDA 19528298
GO:0005739 mitochondrion IEA,IDA 15644324
GO:0005768 endosome IEA --
GO:0005769 early endosome IDA,IEA 18675823
genes like me logo Genes that share ontologies with TRAK1: view

Pathways & Interactions for TRAK1 Gene

genes like me logo Genes that share pathways with TRAK1: view

Pathways by source for TRAK1 Gene

Gene Ontology (GO) - Biological Process for TRAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II ISS --
GO:0006493 protein O-linked glycosylation ISS --
GO:0006605 protein targeting ISS --
GO:0008089 anterograde axonal transport IBA --
GO:0008104 protein localization IBA --
genes like me logo Genes that share ontologies with TRAK1: view

No data available for SIGNOR curated interactions for TRAK1 Gene

Drugs & Compounds for TRAK1 Gene

No Compound Related Data Available

Transcripts for TRAK1 Gene

Unigene Clusters for TRAK1 Gene

Trafficking protein, kinesin binding 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAK1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17a · 17b ·
SP1: - - - - - -
SP2: -
SP3: -
SP4: - - - -
SP5: -
SP6: -
SP7: - -

ExUns: 17c ^ 18a · 18b ^ 19a · 19b
SP1: -
SP5: -
SP6: -

Relevant External Links for TRAK1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAK1 Gene

Protein differential expression in normal tissues from HIPED for TRAK1 Gene

This gene is overexpressed in Cervix (41.6), Heart (17.7), and Adipocyte (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRAK1 Gene

Protein tissue co-expression partners for TRAK1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRAK1 Gene:


SOURCE GeneReport for Unigene cluster for TRAK1 Gene:


mRNA Expression by UniProt/SwissProt for TRAK1 Gene:

Tissue specificity: High expression in spinal cord and moderate expression in all other tissues and specific brain regions examined. Expressed in all cell lines examined.

Evidence on tissue expression from TISSUES for TRAK1 Gene

  • Nervous system(4.8)
  • Kidney(4.2)
  • Lung(2.5)
  • Eye(2.3)
  • Heart(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with TRAK1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAK1 Gene

Orthologs for TRAK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAK1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRAK1 34 33
  • 99.55 (n)
(Canis familiaris)
Mammalia TRAK1 34 33
  • 91.82 (n)
(Monodelphis domestica)
Mammalia TRAK1 34
  • 91 (a)
(Bos Taurus)
Mammalia TRAK1 34
  • 89 (a)
-- 34
  • 88 (a)
(Mus musculus)
Mammalia Trak1 16 34 33
  • 88.45 (n)
(Rattus norvegicus)
Mammalia Trak1 33
  • 88.17 (n)
(Ornithorhynchus anatinus)
Mammalia TRAK1 34
  • 85 (a)
(Gallus gallus)
Aves TRAK1 34 33
  • 80.16 (n)
(Anolis carolinensis)
Reptilia TRAK1 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.14348 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3942 33
(Danio rerio)
Actinopterygii trak1 34
  • 69 (a)
TRAK1 (2 of 3) 34
  • 48 (a)
TRAK1 (3 of 3) 34
  • 36 (a)
Dr.26160 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008801 33
  • 48.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta milt 34 33
  • 47.72 (n)
(Caenorhabditis elegans)
Secernentea T27A3.1 34
  • 24 (a)
Species where no ortholog for TRAK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAK1 Gene

Gene Tree for TRAK1 (if available)
Gene Tree for TRAK1 (if available)
Evolutionary constrained regions (ECRs) for TRAK1: view image

Paralogs for TRAK1 Gene

Paralogs for TRAK1 Gene

(3) SIMAP similar genes for TRAK1 Gene using alignment to 5 proteins:

  • C9JC32_HUMAN
  • H7C3T3_HUMAN
genes like me logo Genes that share paralogs with TRAK1: view

Variants for TRAK1 Gene

Sequence variations from dbSNP and Humsavar for TRAK1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000040194 -- 42,095,275(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000078637 -- 42,217,663(+) T/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000080025 -- 42,131,091(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000084083 -- 42,090,457(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000092073 -- 42,095,499(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRAK1 Gene

Variant ID Type Subtype PubMed ID
dgv8295n54 CNV gain 21841781
esv2760776 CNV gain 21179565
esv32892 CNV gain 17666407
esv3595984 CNV gain 21293372
nsv1127953 CNV deletion 24896259
nsv460520 CNV gain 19166990
nsv834671 CNV gain 17160897

Variation tolerance for TRAK1 Gene

Residual Variation Intolerance Score: 24.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.44; 54.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRAK1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAK1 Gene

Disorders for TRAK1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TRAK1 Gene - From: HGMD, Orphanet, and DISEASES

Disorder Aliases PubMed IDs
undetermined early-onset epileptic encephalopathy
  • undetermined eoee
meckel diverticulum
  • meckel's diverticulum
  • startle disease, familial
- elite association - COSMIC cancer census association via MalaCards
Search TRAK1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TRAK1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TRAK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRAK1 Gene

Publications for TRAK1 Gene

  1. Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase. (PMID: 12435728) Iyer SP … Hart GW (The Journal of biological chemistry 2003) 2 3 4 22 58
  2. The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. (PMID: 16630562) Fransson S … Aspenström P (Biochemical and biophysical research communications 2006) 3 4 22 58
  3. GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin. (PMID: 15644324) Brickley K … Stephenson FA (The Journal of biological chemistry 2005) 3 4 22 58
  4. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  5. Human Miltons associate with mitochondria and induce microtubule-dependent remodeling of mitochondrial networks. (PMID: 20230862) Koutsopoulos OS … Ryan MT (Biochimica et biophysica acta 2010) 2 3 58

Products for TRAK1 Gene

Sources for TRAK1 Gene

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