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Aliases for WDR37 Gene

Aliases for WDR37 Gene

  • WD Repeat Domain 37 2 3 5
  • WD Repeat-Containing Protein 37 3
  • KIAA0982 4

External Ids for WDR37 Gene

Previous GeneCards Identifiers for WDR37 Gene

  • GC10P001056
  • GC10P001085
  • GC10P001092
  • GC10P001041
  • GC10P001095

Summaries for WDR37 Gene

Entrez Gene Summary for WDR37 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR37 Gene

WDR37 (WD Repeat Domain 37) is a Protein Coding gene. An important paralog of this gene is COPA.

Gene Wiki entry for WDR37 Gene

Additional gene information for WDR37 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR37 Gene

Genomics for WDR37 Gene

GeneHancer (GH) Regulatory Elements for WDR37 Gene

Promoters and enhancers for WDR37 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J001054 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 669.5 +7.0 7020 4.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B WDR37 IDI1 LARP4B GTPBP4 IDI2 IDI2-AS1
GH10J001047 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 663.6 -0.2 -186 4.3 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 WDR37 IDI1 LARP4B GTPBP4 IDI2-AS1 IDI2
GH10J001042 Enhancer 0.9 ENCODE dbSUPER 19.7 -4.9 -4899 4.1 FOXA2 MAX CEBPG PAX8 SCRT2 ATF7 ETV6 RUNX3 ZNF687 SMAD5 WDR37 IDI2-AS1 GTPBP4 ENSG00000205740 IDI2 IDI1
GH10J000968 Enhancer 1.1 Ensembl ENCODE 13.8 -78.6 -78646 4.9 PKNOX1 FOXA2 MLX ARID4B ZNF48 NCOA2 YY1 ZNF207 ATF7 NFKBIZ PIR35547 WDR37 GTPBP4 LOC101927762 IDI2 LOC105376341 LARP4B ENSG00000205740
GH10J001109 Enhancer 0.8 ENCODE 17.2 +60.9 60933 1.5 TAF9B SIN3A BATF RAD21 ZNF143 FOS ETV6 RUNX3 CREM ZNF654 WDR37 ADARB2 IDI2 GC10P001101 PIR40136
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WDR37 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDR37 gene promoter:
  • NF-kappaB2
  • NF-kappaB1
  • NF-kappaB
  • LHX3b
  • Lhx3a
  • Elk-1
  • CUTL1
  • Hlf
  • aMEF-2

Genomic Locations for WDR37 Gene

Genomic Locations for WDR37 Gene
82,760 bases
Plus strand
82,760 bases
Plus strand

Genomic View for WDR37 Gene

Genes around WDR37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR37 Gene

Proteins for WDR37 Gene

  • Protein details for WDR37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 37
    Protein Accession:
    Secondary Accessions:
    • A8K976
    • D3DRQ7
    • Q5SW03
    • Q8WVG2
    • Q9NTJ6

    Protein attributes for WDR37 Gene

    494 amino acids
    Molecular mass:
    54665 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA76826.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR37 Gene


neXtProt entry for WDR37 Gene

Post-translational modifications for WDR37 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR37 Gene

No data available for DME Specific Peptides for WDR37 Gene

Domains & Families for WDR37 Gene

Gene Families for WDR37 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WDR37 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR37: view

No data available for UniProtKB/Swiss-Prot for WDR37 Gene

Function for WDR37 Gene

Phenotypes From GWAS Catalog for WDR37 Gene

Gene Ontology (GO) - Molecular Function for WDR37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with WDR37: view
genes like me logo Genes that share phenotypes with WDR37: view

Animal Models for WDR37 Gene

MGI Knock Outs for WDR37:
  • Wdr37 Wdr37<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR37

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WDR37 Gene

Localization for WDR37 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR37 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (1)
  • Cytosol (1)
  • Intermediate filaments (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDR37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030687 preribosome, large subunit precursor IBA --
GO:0070545 PeBoW complex IBA --
genes like me logo Genes that share ontologies with WDR37: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WDR37 Gene

Pathways & Interactions for WDR37 Gene

SuperPathways for WDR37 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000460 maturation of 5.8S rRNA IBA --
GO:0000470 maturation of LSU-rRNA IBA --
genes like me logo Genes that share ontologies with WDR37: view

No data available for Pathways by source and SIGNOR curated interactions for WDR37 Gene

Drugs & Compounds for WDR37 Gene

No Compound Related Data Available

Transcripts for WDR37 Gene

mRNA/cDNA for WDR37 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(126) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WDR37 Gene

WD repeat domain 37:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WDR37

Alternative Splicing Database (ASD) splice patterns (SP) for WDR37 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: - - - - -
SP7: - - -
SP8: - - - -
SP9: -
SP10: -

ExUns: 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c ^ 19
SP1: -
SP5: -

Relevant External Links for WDR37 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR37 Gene

Protein differential expression in normal tissues from HIPED for WDR37 Gene

This gene is overexpressed in Cervix (20.8), Peripheral blood mononuclear cells (9.4), and Frontal cortex (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WDR37 Gene

Protein tissue co-expression partners for WDR37 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR37 Gene:


SOURCE GeneReport for Unigene cluster for WDR37 Gene:


Evidence on tissue expression from TISSUES for WDR37 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with WDR37: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR37 Gene

Orthologs for WDR37 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR37 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDR37 34 33
  • 99.8 (n)
(Ornithorhynchus anatinus)
Mammalia WDR37 34
  • 94 (a)
(Monodelphis domestica)
Mammalia WDR37 34
  • 94 (a)
(Canis familiaris)
Mammalia WDR37 34 33
  • 87.99 (n)
(Mus musculus)
Mammalia Wdr37 16 34 33
  • 87.92 (n)
(Rattus norvegicus)
Mammalia Wdr37 33
  • 87.84 (n)
(Bos Taurus)
Mammalia WDR37 34 33
  • 86.3 (n)
(Gallus gallus)
Aves WDR37 34 33
  • 79.28 (n)
(Anolis carolinensis)
Reptilia WDR37 34
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr37 33
  • 76.79 (n)
(Danio rerio)
Actinopterygii wdr37 34 33
  • 74.63 (n)
Dr.7221 33
fruit fly
(Drosophila melanogaster)
Insecta CG12333 34 33
  • 57.68 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004374 33
  • 55.18 (n)
(Caenorhabditis elegans)
Secernentea C05D2.10 34 33
  • 51.71 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YTM1 34
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
Species where no ortholog for WDR37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR37 Gene

Gene Tree for WDR37 (if available)
Gene Tree for WDR37 (if available)
Evolutionary constrained regions (ECRs) for WDR37: view image

Paralogs for WDR37 Gene

Paralogs for WDR37 Gene

(1) SIMAP similar genes for WDR37 Gene using alignment to 4 proteins:

  • E7EQ49_HUMAN
genes like me logo Genes that share paralogs with WDR37: view

Variants for WDR37 Gene

Sequence variations from dbSNP and Humsavar for WDR37 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000045348 -- 1,077,018(+) G/C/T intron_variant
rs1000047493 -- 1,074,719(+) A/G intron_variant
rs1000072887 -- 1,068,734(+) A/G intron_variant
rs1000119451 -- 1,080,169(+) G/A intron_variant
rs1000124905 -- 1,105,529(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR37 Gene

Variant ID Type Subtype PubMed ID
esv1009406 CNV deletion 20482838
esv1356116 CNV deletion 17803354
esv2573324 CNV deletion 19546169
esv2660097 CNV deletion 23128226
esv2662183 CNV deletion 23128226
esv2729406 CNV deletion 23290073
esv2729417 CNV deletion 23290073
esv2729428 CNV deletion 23290073
esv2729439 CNV deletion 23290073
esv3622096 CNV gain 21293372
esv3891735 CNV gain 25118596
nsv1041498 CNV gain 25217958
nsv1046220 CNV gain 25217958
nsv1054432 CNV gain 25217958
nsv1161922 CNV duplication 26073780
nsv476445 CNV novel sequence insertion 20440878
nsv521885 CNV loss 19592680
nsv549765 CNV gain 21841781
nsv549768 CNV gain 21841781
nsv951232 CNV duplication 24416366

Variation tolerance for WDR37 Gene

Residual Variation Intolerance Score: 4.97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR37 Gene

Disorders for WDR37 Gene

Additional Disease Information for WDR37

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for WDR37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR37 Gene

Publications for WDR37 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 44 58
  4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 44 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for WDR37 Gene

Sources for WDR37 Gene

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