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Aliases for ZHX2 Gene

Aliases for ZHX2 Gene

  • Zinc Fingers And Homeoboxes 2 2 3 5
  • Zinc Finger And Homeodomain Protein 2 3 4
  • Alpha-Fetoprotein Regulator 1 3 4
  • Regulator Of AFP 3 4
  • AFP Regulator 1 3 4
  • AFR1 3 4
  • RAF 3 4
  • Zinc Fingers And Homeoboxes Protein 2 3
  • Zinc-Fingers And Homeoboxes 2 2
  • Transcription Factor ZHX2 3
  • KIAA0854 4

External Ids for ZHX2 Gene

Previous GeneCards Identifiers for ZHX2 Gene

  • GC08P123462
  • GC08P123750
  • GC08P123863
  • GC08P123793
  • GC08P119119

Summaries for ZHX2 Gene

Entrez Gene Summary for ZHX2 Gene

  • The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZHX2 Gene

ZHX2 (Zinc Fingers And Homeoboxes 2) is a Protein Coding gene. Diseases associated with ZHX2 include Smallpox and Cryptococcosis. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and identical protein binding. An important paralog of this gene is ZHX1.

UniProtKB/Swiss-Prot for ZHX2 Gene

  • Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA.

Gene Wiki entry for ZHX2 Gene

Additional gene information for ZHX2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZHX2 Gene

Genomics for ZHX2 Gene

GeneHancer (GH) Regulatory Elements for ZHX2 Gene

Promoters and enhancers for ZHX2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J122779 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 665.4 +0.6 584 4.4 HDGF PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZHX2 ENSG00000272043 ENSG00000272384 DERL1 TBC1D31 C8orf76 PIR52073
GH08J122828 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.8 +47.1 47093 0.8 HDGF ATF1 ARNT TCF12 GATA2 ZFP91 ATF7 NCOA1 ZNF592 SMARCA4 ZHX2 ENSG00000253607 ENSG00000253372 GC08P122905
GH08J122798 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +17.8 17831 2.1 HDGF RB1 TARDBP IKZF1 NBN EBF1 MEF2B DPF2 PIR52073 ZHX2 C8orf76 ENSG00000253372
GH08J122830 Enhancer 1.1 Ensembl ENCODE dbSUPER 13 +48.9 48852 0.4 CTCF KLF1 ZNF644 IRF9 DIDO1 ZNF766 NFE2 ZNF639 CAVIN1 ZNF740 ZHX2 FAM91A1 ENSG00000253372 GC08P122905
GH08J122759 Enhancer 1.1 Ensembl ENCODE 11.8 -21.0 -21040 1.4 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 SLC30A9 ZNF766 FOS RXRA ZHX2 ENSG00000253607 DERL1 TBC1D31 ENSG00000238901 FAM83A-AS1 CDK5P1 GC08M122743
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZHX2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZHX2 gene promoter:
  • E2F-1
  • MyoD
  • E2F
  • IRF-2
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • SRF
  • SRF (504 AA)

Genomic Locations for ZHX2 Gene

Genomic Locations for ZHX2 Gene
193,167 bases
Plus strand
193,123 bases
Plus strand

Genomic View for ZHX2 Gene

Genes around ZHX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZHX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZHX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZHX2 Gene

Proteins for ZHX2 Gene

  • Protein details for ZHX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc fingers and homeoboxes protein 2
    Protein Accession:

    Protein attributes for ZHX2 Gene

    837 amino acids
    Molecular mass:
    92307 Da
    Quaternary structure:
    • Forms a homodimer (via homeobox domain). Forms a heterodimer with ZHX1 (via HD1 domain). Forms a heterodimer with ZHX3. Heterodimerization with ZHX1 is not necessary for repressor activity. Interacts (via homeobox domain) with NFYA (via N-terminus).
    • Sequence=BAA74877.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZHX2 Gene

neXtProt entry for ZHX2 Gene

Post-translational modifications for ZHX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZHX2 Gene

Antibody Products

  • Abcam antibodies for ZHX2

No data available for DME Specific Peptides for ZHX2 Gene

Domains & Families for ZHX2 Gene

Gene Families for ZHX2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZHX2 Gene

Suggested Antigen Peptide Sequences for ZHX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ZHX family.
  • Belongs to the ZHX family.
genes like me logo Genes that share domains with ZHX2: view

Function for ZHX2 Gene

Molecular function for ZHX2 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA.

Phenotypes From GWAS Catalog for ZHX2 Gene

Gene Ontology (GO) - Molecular Function for ZHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IDA 12741956
GO:0003714 transcription corepressor activity IDA 12741956
genes like me logo Genes that share ontologies with ZHX2: view
genes like me logo Genes that share phenotypes with ZHX2: view

miRNA for ZHX2 Gene

miRTarBase miRNAs that target ZHX2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZHX2 Gene

Localization for ZHX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZHX2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZHX2 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 12741956
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with ZHX2: view

Pathways & Interactions for ZHX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 12741956
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0006402 mRNA catabolic process IEA --
genes like me logo Genes that share ontologies with ZHX2: view

No data available for Pathways by source and SIGNOR curated interactions for ZHX2 Gene

Drugs & Compounds for ZHX2 Gene

(2) Drugs for ZHX2 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
regorafenib Approved Pharma inhibitor Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Sorafenib Approved, Investigational Pharma inhibitors, inhibitor Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 717
genes like me logo Genes that share compounds with ZHX2: view

Transcripts for ZHX2 Gene

mRNA/cDNA for ZHX2 Gene

Unigene Clusters for ZHX2 Gene

Zinc fingers and homeoboxes 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZHX2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
SP2: - - - - - -

Relevant External Links for ZHX2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZHX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZHX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZHX2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (54.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZHX2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZHX2 Gene:


SOURCE GeneReport for Unigene cluster for ZHX2 Gene:


mRNA Expression by UniProt/SwissProt for ZHX2 Gene:

Tissue specificity: Ubiquitously expressed. Expressed in podocytes.

Evidence on tissue expression from TISSUES for ZHX2 Gene

  • Liver(4.4)
  • Nervous system(4.3)
  • Kidney(4.2)
genes like me logo Genes that share expression patterns with ZHX2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZHX2 Gene

Orthologs for ZHX2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZHX2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZHX2 34 33
  • 99.24 (n)
(Canis familiaris)
Mammalia ZHX2 34 33
  • 88.77 (n)
(Bos Taurus)
Mammalia ZHX2 34 33
  • 86.94 (n)
(Mus musculus)
Mammalia Zhx2 16 34 33
  • 84.93 (n)
(Rattus norvegicus)
Mammalia Zhx2 33
  • 84.45 (n)
(Ornithorhynchus anatinus)
Mammalia ZHX2 34
  • 62 (a)
(Gallus gallus)
Aves ZHX2 34 33
  • 69.85 (n)
(Anolis carolinensis)
Reptilia ZHX2 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zhx2 33
  • 62.87 (n)
Str.1051 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.13932 33
(Danio rerio)
Actinopterygii zhx2 34 33 33
  • 56.85 (n)
Species where no ortholog for ZHX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZHX2 Gene

Gene Tree for ZHX2 (if available)
Gene Tree for ZHX2 (if available)
Evolutionary constrained regions (ECRs) for ZHX2: view image

Paralogs for ZHX2 Gene

Paralogs for ZHX2 Gene

(2) SIMAP similar genes for ZHX2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZHX2: view

Variants for ZHX2 Gene

Sequence variations from dbSNP and Humsavar for ZHX2 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs138450443 uncertain-significance, Hirschsprung disease 1 122,953,192(+) G/A coding_sequence_variant, missense_variant
rs1000004112 -- 122,939,530(+) A/G intron_variant
rs1000027319 -- 122,846,295(+) G/A/C genic_upstream_transcript_variant, intron_variant
rs1000035143 -- 122,939,291(+) G/A intron_variant
rs1000058693 -- 122,970,401(+) GGGGGGG/GGGGGGGG intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZHX2 Gene

Variant ID Type Subtype PubMed ID
esv2737525 CNV deletion 23290073
esv3544137 CNV deletion 23714750
esv3572972 CNV loss 25503493
nsv1032827 CNV gain 25217958
nsv1150054 CNV insertion 26484159

Variation tolerance for ZHX2 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.93; 79.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZHX2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZHX2 Gene

Disorders for ZHX2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZHX2 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
  • ordinary smallpox
  • busse-buschke's disease
- elite association - COSMIC cancer census association via MalaCards
Search ZHX2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZHX2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZHX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZHX2 Gene

Publications for ZHX2 Gene

  1. Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. (PMID: 12741956) Kawata H … Miyamoto K (The Biochemical journal 2003) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J … Isaacs WB (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 44 58
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58

Products for ZHX2 Gene

Sources for ZHX2 Gene

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