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Aliases for DZIP1 Gene

Aliases for DZIP1 Gene

  • DAZ Interacting Zinc Finger Protein 1 2 3 5
  • DAZ-Interacting Protein 1/2 3 4
  • DAZ Interacting Protein 1 2 3
  • DZIP 3 4
  • Zinc Finger DAZ Interacting Protein 1 3
  • DAZ Interacting Protein Testis1 3
  • Zinc-Finger Protein DZIPt1 3
  • Zinc Finger Protein DZIP1 3
  • KIAA0996 4
  • DZIPt1 3
  • DZIP2 4

External Ids for DZIP1 Gene

Previous GeneCards Identifiers for DZIP1 Gene

  • GC13M094593
  • GC13M090620
  • GC13M095039
  • GC13M093931
  • GC13M093928
  • GC13M095028
  • GC13M096230
  • GC13M076828

Summaries for DZIP1 Gene

GeneCards Summary for DZIP1 Gene

DZIP1 (DAZ Interacting Zinc Finger Protein 1) is a Protein Coding gene. Diseases associated with DZIP1 include Acrodermatitis Enteropathica, Zinc-Deficiency Type. Among its related pathways are Signaling by Hedgehog and Signaling by GPCR. An important paralog of this gene is DZIP1L.

UniProtKB/Swiss-Prot for DZIP1 Gene

  • May participate in spermatogenesis via its interaction with DAZ (PubMed:15081113). Has a role in primary cilium formation (PubMed:19852954).

Gene Wiki entry for DZIP1 Gene

Additional gene information for DZIP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DZIP1 Gene

Genomics for DZIP1 Gene

GeneHancer (GH) Regulatory Elements for DZIP1 Gene

Promoters and enhancers for DZIP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J095642 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 662.2 +0.6 601 2.3 PKNOX1 ARID4B SIN3A ZNF48 YY1 ZEB1 ZNF335 GLIS2 ZNF366 EGR2 DZIP1 UGGT2 DNAJC3-DT CLDN10 GC13M095581
GH13J095641 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 650.7 +2.9 2876 1.2 MXI1 RFX1 RXRA SAP130 MLX ARID4B YY1 SKI SP1 RFX3 DZIP1 DNAJC3-DT DNAJC3 GC13M095581
GH13J095675 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.9 -32.3 -32264 3.7 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 DNAJC3 DNAJC3-DT DZIP1 UGGT2
GH13J096274 Enhancer 0.7 ENCODE 22.1 -630.2 -630178 1.1 ZNF473 ZBTB21 ZSCAN4 SALL2 HIC1 ZNF664 ATF7 ZNF571 ZNF621 ZFP37 DZIP1 UGGT2 GC13M096277 GC13M096146 HS6ST3
GH13J095684 Enhancer 0.7 Ensembl ENCODE 19.8 -39.8 -39795 1 CC2D1A ZNF707 SCRT2 ZNF548 PRDM10 ZBTB5 DZIP1 DNAJC3 MTND5P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DZIP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DZIP1 gene promoter:
  • Spz1
  • RREB-1
  • PPAR-gamma2
  • PPAR-gamma1
  • p53
  • Egr-4
  • C/EBPalpha
  • Evi-1
  • NF-kappaB1
  • S8

Genomic Locations for DZIP1 Gene

Genomic Locations for DZIP1 Gene
chr13:95,578,202-95,644,706
(GRCh38/hg38)
Size:
66,505 bases
Orientation:
Minus strand
chr13:96,230,456-96,296,957
(GRCh37/hg19)
Size:
66,502 bases
Orientation:
Minus strand

Genomic View for DZIP1 Gene

Genes around DZIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DZIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DZIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DZIP1 Gene

Proteins for DZIP1 Gene

  • Protein details for DZIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YF9-DZIP1_HUMAN
    Recommended name:
    Zinc finger protein DZIP1
    Protein Accession:
    Q86YF9
    Secondary Accessions:
    • Q5W078
    • Q5W079
    • Q8WY45
    • Q8WY46
    • Q9UGA5
    • Q9Y2K0

    Protein attributes for DZIP1 Gene

    Size:
    867 amino acids
    Molecular mass:
    98664 Da
    Quaternary structure:
    • Isoform 1 and isoform 2 interact with DAZ proteins. May participate in an RNA-binding complex that functions in both ES cells and germ cells.
    SequenceCaution:
    • Sequence=AAL36978.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA76840.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB43211.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DZIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DZIP1 Gene

Post-translational modifications for DZIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DZIP1 Gene

Domains & Families for DZIP1 Gene

Gene Families for DZIP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DZIP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DZIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86YF9

UniProtKB/Swiss-Prot:

DZIP1_HUMAN :
  • Belongs to the DZIP C2H2-type zinc-finger protein family.
Family:
  • Belongs to the DZIP C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with DZIP1: view

Function for DZIP1 Gene

Molecular function for DZIP1 Gene

UniProtKB/Swiss-Prot Function:
May participate in spermatogenesis via its interaction with DAZ (PubMed:15081113). Has a role in primary cilium formation (PubMed:19852954).

Phenotypes From GWAS Catalog for DZIP1 Gene

Gene Ontology (GO) - Molecular Function for DZIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 15081113
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DZIP1: view
genes like me logo Genes that share phenotypes with DZIP1: view

Animal Model Products

miRNA for DZIP1 Gene

Clone Products

  • Addgene plasmids for DZIP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DZIP1 Gene

Localization for DZIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DZIP1 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=In testis, it is predominantly nuclear, with some cytoplasmic localization in spermatogonia. Colocalizes with DAZ and DAZL in primordial germ cells. {ECO:0000269 PubMed:15081113}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DZIP1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Microtubule organizing center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DZIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 15081113
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IEA 15081113
GO:0005814 colocalizes_with centriole IDA 19852954
GO:0005815 microtubule organizing center IDA --
genes like me logo Genes that share ontologies with DZIP1: view

Pathways & Interactions for DZIP1 Gene

genes like me logo Genes that share pathways with DZIP1: view

Pathways by source for DZIP1 Gene

3 Reactome pathways for DZIP1 Gene

Gene Ontology (GO) - Biological Process for DZIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007224 smoothened signaling pathway IEA --
GO:0007275 multicellular organism development IEA --
GO:0007281 germ cell development NAS 15081113
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with DZIP1: view

No data available for SIGNOR curated interactions for DZIP1 Gene

Drugs & Compounds for DZIP1 Gene

No Compound Related Data Available

Transcripts for DZIP1 Gene

Unigene Clusters for DZIP1 Gene

DAZ interacting protein 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for DZIP1

Alternative Splicing Database (ASD) splice patterns (SP) for DZIP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - -
SP2: - -
SP3:
SP4:
SP5:
SP6: - - - - - - -
SP7: -
SP8:
SP9: -
SP10:

ExUns: 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25
SP1: - -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for DZIP1 Gene

GeneLoc Exon Structure for
DZIP1
ECgene alternative splicing isoforms for
DZIP1

Expression for DZIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DZIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DZIP1 Gene

This gene is overexpressed in Spleen (33.1), Liver (21.6), and Ovary (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DZIP1 Gene



Protein tissue co-expression partners for DZIP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DZIP1 Gene:

DZIP1

SOURCE GeneReport for Unigene cluster for DZIP1 Gene:

Hs.656580

mRNA Expression by UniProt/SwissProt for DZIP1 Gene:

Q86YF9-DZIP1_HUMAN
Tissue specificity: Predominantly expressed in testis. Also expressed in fetal brain, adult oocytes and ovary. Expressed in undifferentiated ES cells. In testis, it is probably specifically expressed in germ cells. Expressed in mature germ cells and secondary spermatocytes, while it is weakly or not expressed in primary spermatocytes.

Evidence on tissue expression from TISSUES for DZIP1 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with DZIP1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DZIP1 Gene

Orthologs for DZIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DZIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DZIP1 34 33
  • 99.34 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DZIP1 34 33
  • 85.38 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DZIP1 34 33
  • 85.15 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dzip1 33
  • 74.49 (n)
mouse
(Mus musculus)
Mammalia Dzip1 16 34 33
  • 74.34 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DZIP1 34
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DZIP1 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves DZIP1 34 33
  • 63.83 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DZIP1 34
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dzip1 33
  • 48.4 (n)
zebrafish
(Danio rerio)
Actinopterygii dzip1 34 33
  • 50.7 (n)
OneToOne
Dr.27118 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
OneToMany
Species where no ortholog for DZIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DZIP1 Gene

ENSEMBL:
Gene Tree for DZIP1 (if available)
TreeFam:
Gene Tree for DZIP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DZIP1: view image

Paralogs for DZIP1 Gene

Paralogs for DZIP1 Gene

(1) SIMAP similar genes for DZIP1 Gene using alignment to 2 proteins:

  • DZIP1_HUMAN
  • Q05D25_HUMAN
genes like me logo Genes that share paralogs with DZIP1: view

Variants for DZIP1 Gene

Sequence variations from dbSNP and Humsavar for DZIP1 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000063797 -- 95,605,098(-) T/G intron_variant
rs1000157805 -- 95,613,624(-) A/T intron_variant
rs1000233458 -- 95,607,606(-) G/T intron_variant
rs1000233710 -- 95,639,711(-) GTATGTTAGAGGT/GT genic_upstream_transcript_variant, intron_variant
rs1000281230 -- 95,594,644(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DZIP1 Gene

Variant ID Type Subtype PubMed ID
nsv7246 OTHER inversion 18451855
nsv976147 CNV duplication 23825009

Variation tolerance for DZIP1 Gene

Residual Variation Intolerance Score: 23.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.03; 84.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DZIP1 Gene

Human Gene Mutation Database (HGMD)
DZIP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DZIP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DZIP1 Gene

Disorders for DZIP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DZIP1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
acrodermatitis enteropathica, zinc-deficiency type
  • aez
- elite association - COSMIC cancer census association via MalaCards
Search DZIP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DZIP1

genes like me logo Genes that share disorders with DZIP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DZIP1 Gene

Publications for DZIP1 Gene

  1. Identification of a novel gene, DZIP (DAZ-interacting protein), that encodes a protein that interacts with DAZ (deleted in azoospermia) and is expressed in embryonic stem cells and germ cells. (PMID: 15081113) Moore FL … Reijo-Pera RA (Genomics 2004) 3 4 22 58
  2. The Zn finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis. (PMID: 19852954) Glazer AM … Reddien PW (Developmental biology 2010) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. (PMID: 12511597) Moore FL … Pera RA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 58
  5. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 58

Products for DZIP1 Gene

Sources for DZIP1 Gene

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