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Aliases for FCGR2A Gene

Aliases for FCGR2A Gene

  • Fc Fragment Of IgG Receptor IIa 2 3 5
  • Fc Fragment Of IgG, Low Affinity IIa, Receptor (CD32) 2 3
  • Immunoglobulin G Fc Receptor II 2 3
  • IgG Fc Receptor II-A 3 4
  • Fc-Gamma-RIIa 3 4
  • FcRII-A 3 4
  • FCGR2A1 3 4
  • CDw32 3 4
  • IGFR2 3 4
  • FCG2 3 4
  • CD32 3 4
  • Low Affinity Immunoglobulin Gamma Fc Region Receptor II-A 3
  • Fc Fragment Of IgG, Low Affinity IIa, Receptor For (CD32) 2
  • Fc Gamma Receptor IIa 2
  • Fc-Gamma RII-A 4
  • CD32 Antigen 4
  • CD32A 3
  • FCGR2 3
  • FcGR 3

External Ids for FCGR2A Gene

Previous HGNC Symbols for FCGR2A Gene

  • FCG2
  • FCGR2A1
  • FCGR2

Previous GeneCards Identifiers for FCGR2A Gene

  • GC01P159191
  • GC01P157207
  • GC01P158252
  • GC01P158744
  • GC01P158743
  • GC01P158288
  • GC01P159741
  • GC01P161475
  • GC01P132800

Summaries for FCGR2A Gene

Entrez Gene Summary for FCGR2A Gene

  • This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]

CIViC summary for FCGR2A Gene

GeneCards Summary for FCGR2A Gene

FCGR2A (Fc Fragment Of IgG Receptor IIa) is a Protein Coding gene. Diseases associated with FCGR2A include Cystic Fibrosis and Systemic Lupus Erythematosus. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and GPCR Pathway. Gene Ontology (GO) annotations related to this gene include IgG binding. An important paralog of this gene is FCGR2C.

UniProtKB/Swiss-Prot for FCGR2A Gene

  • Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.

Gene Wiki entry for FCGR2A Gene

Additional gene information for FCGR2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGR2A Gene

Genomics for FCGR2A Gene

GeneHancer (GH) Regulatory Elements for FCGR2A Gene

Promoters and enhancers for FCGR2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J161504 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 650.7 +0.7 689 3.4 HDGF PKNOX1 ATF1 TCF12 POLR2B ZNF766 ATF7 RUNX3 ZNF263 SP5 GC01P161506 FCGR2A PPOX FCGR2C USP21 DUSP12 B4GALT3 FCRLA HSPA7 ENSG00000273112
GH01J161066 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 38.6 -436.8 -436800 5.1 HDGF PKNOX1 BMI1 ZBTB40 KLF5 IRF4 ZNF207 ZNF143 ATF7 ETV6 ARHGAP30 FCGR2A TSTD1 DUSP12 USP21 PPOX F11R DEDD NECTIN4 ENSG00000232879
GH01J161011 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.3 -488.2 -488202 11.7 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 F11R DUSP12 USP21 ENSG00000228606 DEDD PPOX TSTD1 LOC148430 B4GALT3 ARHGAP30
GH01J161528 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 16.5 +25.7 25745 4.7 PKNOX1 ARNT SIN3A FEZF1 ZNF2 IRF4 YY1 ZNF213 ZNF207 ZNF143 TRL-CAG1-6 TRG-TCC2-6 USP21 DUSP12 PPOX FCGR2C DEDD FCGR2A B4GALT3 FCRLA
GH01J161738 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 15.6 +234.7 234727 3.5 PKNOX1 ATF1 ARNT SIN3A YBX1 ZNF2 IRF4 YY1 TCF12 ZNF213 FCRLA FCGR2A DUSP12 ATF6 HSPA6 FCGR3A RN7SL466P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FCGR2A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FCGR2A gene promoter:
  • STAT3
  • AML1a
  • p53
  • FOXD1
  • STAT1
  • TBP
  • Hlf
  • Hand1
  • E47
  • Evi-1

Genomic Locations for FCGR2A Gene

Genomic Locations for FCGR2A Gene
chr1:161,505,415-161,524,048
(GRCh38/hg38)
Size:
18,634 bases
Orientation:
Plus strand
chr1:161,475,205-161,493,803
(GRCh37/hg19)
Size:
18,599 bases
Orientation:
Plus strand

Genomic View for FCGR2A Gene

Genes around FCGR2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCGR2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCGR2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCGR2A Gene

Proteins for FCGR2A Gene

  • Protein details for FCGR2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12318-FCG2A_HUMAN
    Recommended name:
    Low affinity immunoglobulin gamma Fc region receptor II-a
    Protein Accession:
    P12318
    Secondary Accessions:
    • Q8WUN1
    • Q8WW64

    Protein attributes for FCGR2A Gene

    Size:
    317 amino acids
    Molecular mass:
    35001 Da
    Quaternary structure:
    • Interacts with INPP5D/SHIP1 and INPPL1/SHIP2, regulating its function. Interacts with APCS and FGR. Interacts with HCK.
    SequenceCaution:
    • Sequence=AAA35932.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FCGR2A Gene

    Alternative splice isoforms for FCGR2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCGR2A Gene

Post-translational modifications for FCGR2A Gene

  • Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK.
  • Glycosylation at Asn178 and Asn97
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for FCGR2A (Fc gamma RII/CD32)
  • R&D Systems Antibodies for FCGR2A (Fc gamma RIIA/CD32a)

No data available for DME Specific Peptides for FCGR2A Gene

Domains & Families for FCGR2A Gene

Gene Families for FCGR2A Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FCGR2A Gene

Suggested Antigen Peptide Sequences for FCGR2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FCGR2A: view

No data available for UniProtKB/Swiss-Prot for FCGR2A Gene

Function for FCGR2A Gene

Molecular function for FCGR2A Gene

UniProtKB/Swiss-Prot Function:
Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.
GENATLAS Biochemistry:
immunoglobulin G,low affinity Fc receptor 2A (see IGFCR@),primarily expressed by cells of the myeloid lineage

Phenotypes From GWAS Catalog for FCGR2A Gene

Gene Ontology (GO) - Molecular Function for FCGR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019864 IgG binding IEA --
genes like me logo Genes that share ontologies with FCGR2A: view
genes like me logo Genes that share phenotypes with FCGR2A: view

Animal Models for FCGR2A Gene

MGI Knock Outs for FCGR2A:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FCGR2A

Clone Products

  • R&D Systems cDNA Clones for FCGR2A (Fc gamma RIIA/CD32a)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FCGR2A Gene

Localization for FCGR2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCGR2A Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCGR2A gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 2
cytoskeleton 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
endosome 1

Gene Ontology (GO) - Cellular Components for FCGR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane NAS,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030667 secretory granule membrane TAS --
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with FCGR2A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FCGR2A Gene

Pathways & Interactions for FCGR2A Gene

genes like me logo Genes that share pathways with FCGR2A: view

Gene Ontology (GO) - Biological Process for FCGR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with FCGR2A: view

No data available for SIGNOR curated interactions for FCGR2A Gene

Drugs & Compounds for FCGR2A Gene

(57) Drugs for FCGR2A Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adalimumab Approved Pharma Target 521
Cetuximab Approved Pharma Target EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 784
Etanercept Approved, Investigational Pharma Target 413
Trastuzumab Approved, Investigational Pharma Target HER2 antagonist, HER2 Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 848
rituximab Approved Pharma Target Therapeutic Antibodies 1808

(12) Additional Compounds for FCGR2A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FCGR2A: view

Transcripts for FCGR2A Gene

Unigene Clusters for FCGR2A Gene

Fc fragment of IgG, low affinity IIa, receptor (CD32):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FCGR2A

Clone Products

  • R&D Systems cDNA Clones for FCGR2A (Fc gamma RIIA/CD32a)

Alternative Splicing Database (ASD) splice patterns (SP) for FCGR2A Gene

No ASD Table

Relevant External Links for FCGR2A Gene

GeneLoc Exon Structure for
FCGR2A
ECgene alternative splicing isoforms for
FCGR2A

Expression for FCGR2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCGR2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCGR2A Gene

This gene is overexpressed in Whole Blood (x36.4).

Protein differential expression in normal tissues from HIPED for FCGR2A Gene

This gene is overexpressed in Serum (22.9), Peripheral blood mononuclear cells (19.4), and Plasma (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCGR2A Gene



NURSA nuclear receptor signaling pathways regulating expression of FCGR2A Gene:

FCGR2A

SOURCE GeneReport for Unigene cluster for FCGR2A Gene:

Hs.352642

mRNA Expression by UniProt/SwissProt for FCGR2A Gene:

P12318-FCG2A_HUMAN
Tissue specificity: Found on monocytes, neutrophils and eosinophil platelets.

Evidence on tissue expression from TISSUES for FCGR2A Gene

  • Blood(4.5)
  • Lung(4.5)
  • Spleen(3.1)
  • Lymph node(2.6)
  • Nervous system(2.6)
  • Heart(2.5)
  • Bone marrow(2.4)
  • Intestine(2.3)
  • Kidney(2)
genes like me logo Genes that share expression patterns with FCGR2A: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCGR2A Gene

Orthologs for FCGR2A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCGR2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCGR2A 34 33
  • 98.95 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fcgr3 16 34 33
  • 72.3 (n)
Fcgr2b 34
  • 43 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC100912061 33
  • 69.6 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 48 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FCGR2C 34
  • 43 (a)
ManyToMany
FCGR2 34
  • 41 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 42 (a)
ManyToMany
-- 34
  • 40 (a)
ManyToMany
-- 34
  • 34 (a)
ManyToMany
-- 34
  • 33 (a)
ManyToMany
-- 34
  • 25 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 25 (a)
OneToMany
Species where no ortholog for FCGR2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCGR2A Gene

ENSEMBL:
Gene Tree for FCGR2A (if available)
TreeFam:
Gene Tree for FCGR2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FCGR2A: view image

Paralogs for FCGR2A Gene

(11) SIMAP similar genes for FCGR2A Gene using alignment to 5 proteins:

  • FCG2A_HUMAN
  • F5GX41_HUMAN
  • F5GXY9_HUMAN
  • V9GY55_HUMAN
  • V9GY83_HUMAN

Pseudogenes.org Pseudogenes for FCGR2A Gene

genes like me logo Genes that share paralogs with FCGR2A: view

Variants for FCGR2A Gene

Sequence variations from dbSNP and Humsavar for FCGR2A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1801274 risk-factor, drug-response, benign, Lupus nephritis, susceptibility to, Pseudomonas aeruginosa, susceptibility to chronic infection by, in cystic fibrosis, Malaria, severe, susceptibility to, trastuzumab response - Efficacy, not specified 161,509,955(+) A/C/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs11810143 benign, not specified 161,510,859(+) A/C/G coding_sequence_variant, intron_variant, non_coding_transcript_variant, synonymous_variant
rs12029217 benign, not specified 161,518,073(+) C/T 3_prime_UTR_variant, coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs7529425 benign, not specified 161,509,809(+) G/A intron_variant
rs9427397 benign, not specified 161,506,414(+) C/T coding_sequence_variant, non_coding_transcript_variant, stop_gained

Structural Variations from Database of Genomic Variants (DGV) for FCGR2A Gene

Variant ID Type Subtype PubMed ID
dgv17n21 CNV loss 19592680
dgv22n16 CNV deletion 17901297
dgv447n100 CNV gain 25217958
dgv4n68 CNV gain+loss 17160897
dgv5e203 CNV gain+loss 21179565
dgv74e199 CNV deletion 23128226
dgv8e55 CNV gain 17911159
esv2718873 CNV deletion 23290073
esv2758972 CNV gain+loss 17122850
esv28122 CNV gain+loss 19812545
esv33393 CNV gain+loss 17666407
esv3587729 CNV loss 21293372
esv3587730 CNV gain 21293372
esv997087 CNV loss 20482838
nsv1161730 CNV duplication 26073780
nsv3243 CNV deletion 18451855
nsv428257 CNV loss 18775914
nsv464173 CNV gain 19166990
nsv482137 CNV gain 20164927
nsv519779 CNV loss 19592680
nsv820341 CNV duplication 20802225
nsv825176 CNV gain 20364138
nsv8502 CNV loss 18304495
nsv946463 CNV duplication 23825009
nsv946464 CNV duplication 23825009

Variation tolerance for FCGR2A Gene

Residual Variation Intolerance Score: 75.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.83; 67.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FCGR2A Gene

Human Gene Mutation Database (HGMD)
FCGR2A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCGR2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCGR2A Gene

Disorders for FCGR2A Gene

MalaCards: The human disease database

(20) MalaCards diseases for FCGR2A Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cystic fibrosis
  • cf
systemic lupus erythematosus
  • sle
malaria
  • malaria, susceptibility to
asymptomatic dengue
infective endocarditis
  • endocarditis, infective
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FCGR2A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FCGR2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCGR2A Gene

Publications for FCGR2A Gene

  1. FcgammaRIIa genotype is associated with acute coronary syndromes as first manifestation of coronary artery disease. (PMID: 19232413) Raaz D … Garlichs CD (Atherosclerosis 2009) 3 22 44 58
  2. FcgammaRIIa (CD32) polymorphism and anti-malarial IgG subclass pattern among Fulani and sympatric ethnic groups living in eastern Sudan. (PMID: 19284648) Nasr A … Berzins K (Malaria journal 2009) 3 22 44 58
  3. CRP and FCGR2A genes have an epistatic effect on carotid artery intima-media thickness: the Cardiovascular Risk in Young Finns Study. (PMID: 19055599) Pessi T … Hurme M (International journal of immunogenetics 2009) 3 22 44 58
  4. FcgammaRIIa, IIIa and IIIb gene polymorphisms in Behçet's disease: do they have any clinical implications? (PMID: 19026120) Aksu K … Doganavsargil E (Clinical and experimental rheumatology 2008) 3 22 44 58
  5. FcgammaRIIa polymorphism and clinical response to rituximab in non-Hodgkin lymphoma patients. (PMID: 18474295) Paiva M … Medeiros R (Cancer genetics and cytogenetics 2008) 3 22 44 58

Products for FCGR2A Gene

Sources for FCGR2A Gene

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