Aliases for FCER1A Gene
External Ids for FCER1A Gene
Previous HGNC Symbols for FCER1A Gene
Previous GeneCards Identifiers for FCER1A Gene
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]
GeneCards Summary for FCER1A Gene
FCER1A (Fc Fragment Of IgE Receptor Ia) is a Protein Coding gene. Diseases associated with FCER1A include Allergic Urticaria and Dermatographia. Among its related pathways are Immune response Fc epsilon RI pathway and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include IgE binding and IgE receptor activity. An important paralog of this gene is FCGR3A.
UniProtKB/Swiss-Prot for FCER1A Gene
Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.