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Aliases for TYSND1 Gene

Aliases for TYSND1 Gene

  • Trypsin Domain Containing 1 2 3 5
  • Trypsin Domain-Containing Protein 1 3 4
  • Peroxisomal Cysteine Endopeptidase 2 3
  • Peroxisomal Leader Peptide-Processing Protease 3
  • EC 3.4.21.- 4
  • NET41 3

External Ids for TYSND1 Gene

Previous GeneCards Identifiers for TYSND1 Gene

  • GC10M071244
  • GC10M071567
  • GC10M071897
  • GC10M065890

Summaries for TYSND1 Gene

Entrez Gene Summary for TYSND1 Gene

  • This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome. The encoded protein is also capable of removing the C-terminal peroxisomal targeting signal (PTS1) from proteins in the peroxisomal matrix. The full-length protein undergoes self-cleavage to produce shorter, potentially inactive, peptides. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

GeneCards Summary for TYSND1 Gene

TYSND1 (Trypsin Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include identical protein binding and protease binding.

UniProtKB/Swiss-Prot for TYSND1 Gene

  • Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.

Additional gene information for TYSND1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TYSND1 Gene

Genomics for TYSND1 Gene

GeneHancer (GH) Regulatory Elements for TYSND1 Gene

Promoters and enhancers for TYSND1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J070144 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.3 307 3.1 HDGF PKNOX1 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF213 AIFM2 PIR42845 TYSND1 PIR38078 GC10M070148 PPA1 SAR1A
GH10J070152 Promoter 0.5 EPDnew 650.4 -5.5 -5501 0.1 TYSND1 GC10M070161 SAR1A
GH10J069179 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 65.4 +966.1 966081 3.3 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SUPV3L1 CCAR1 DDX50 TYSND1 HNRNPH3 DDX21 SAR1A RPL26P27 VPS26A HKDC1
GH10J069315 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 24.9 +828.0 828042 7.2 HDGF PKNOX1 SMAD1 FOXA2 ARNT SIN3A ZNF2 POLR2B ZNF213 E2F8 HK1 DDX50 HNRNPH3 CCAR1 TYSND1 SAR1A DDX21 ENSG00000231748 HKDC1 FAM241B
GH10J070168 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 29.9 -23.4 -23422 2.7 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A YY1 POLR2B AIFM2 SAR1A TYSND1 PPA1 CALM2P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TYSND1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TYSND1 gene promoter:
  • AP-1
  • FOXO4
  • FOXL1
  • Pax-5
  • GATA-6
  • CREB
  • Arnt
  • AhR
  • AML1a

Genomic Locations for TYSND1 Gene

Genomic Locations for TYSND1 Gene
8,760 bases
Minus strand
8,764 bases
Minus strand

Genomic View for TYSND1 Gene

Genes around TYSND1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TYSND1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TYSND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TYSND1 Gene

Proteins for TYSND1 Gene

  • Protein details for TYSND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peroxisomal leader peptide-processing protease
    Protein Accession:
    Secondary Accessions:
    • Q5SQT4
    • Q5SQU1
    • Q8N6H2
    • Q96AR5

    Protein attributes for TYSND1 Gene

    566 amino acids
    Molecular mass:
    59309 Da
    Quaternary structure:
    • Homodimer. Forms a heterodimer with the C-terminal cleavage product (45 kDa form). Forms a heterodimer with the N-terminal cleavage product (15 kDa form). Interacts with PEX5. Interacts with LONP2.

    Alternative splice isoforms for TYSND1 Gene


neXtProt entry for TYSND1 Gene

Post-translational modifications for TYSND1 Gene

  • Self-cleavage gives rise to an N-terminal 15-kDa fragment and C-terminal 45-kDa fragment upon import into the peroxisomes. The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity.
  • Ubiquitination at posLast=389389
  • Modification sites at PhosphoSitePlus

Other Protein References for TYSND1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TYSND1 Gene

Domains & Families for TYSND1 Gene

Gene Families for TYSND1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for TYSND1 Gene


Suggested Antigen Peptide Sequences for TYSND1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1B family.
  • Belongs to the peptidase S1B family.
genes like me logo Genes that share domains with TYSND1: view

Function for TYSND1 Gene

Molecular function for TYSND1 Gene

UniProtKB/Swiss-Prot Function:
Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.

Enzyme Numbers (IUBMB) for TYSND1 Gene

Phenotypes From GWAS Catalog for TYSND1 Gene

Gene Ontology (GO) - Molecular Function for TYSND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 22002062
GO:0004252 serine-type endopeptidase activity IMP 22002062
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TYSND1: view
genes like me logo Genes that share phenotypes with TYSND1: view

Animal Models for TYSND1 Gene

MGI Knock Outs for TYSND1:

Animal Model Products

  • Taconic Biosciences Mouse Models for TYSND1

CRISPR Products

miRNA for TYSND1 Gene

miRTarBase miRNAs that target TYSND1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TYSND1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TYSND1 Gene

Localization for TYSND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TYSND1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TYSND1 gene
Compartment Confidence
peroxisome 5
cytosol 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (1)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TYSND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome IEA,IDA 22002062
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with TYSND1: view

Pathways & Interactions for TYSND1 Gene

SuperPathways for TYSND1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TYSND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IMP 22002062
GO:0016485 protein processing IMP 22002062
GO:0031998 regulation of fatty acid beta-oxidation IMP 22002062
GO:0051260 protein homooligomerization IDA 22002062
genes like me logo Genes that share ontologies with TYSND1: view

No data available for Pathways by source and SIGNOR curated interactions for TYSND1 Gene

Drugs & Compounds for TYSND1 Gene

No Compound Related Data Available

Transcripts for TYSND1 Gene

mRNA/cDNA for TYSND1 Gene

Unigene Clusters for TYSND1 Gene

Trypsin domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TYSND1

Alternative Splicing Database (ASD) splice patterns (SP) for TYSND1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: - -
SP8: - - - - - - -
SP9: - - - - -

Relevant External Links for TYSND1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TYSND1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TYSND1 Gene

Protein differential expression in normal tissues from HIPED for TYSND1 Gene

This gene is overexpressed in Adrenal (34.9) and Liver (24.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TYSND1 Gene

Protein tissue co-expression partners for TYSND1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TYSND1 Gene:


SOURCE GeneReport for Unigene cluster for TYSND1 Gene:


Evidence on tissue expression from TISSUES for TYSND1 Gene

  • Nervous system(4.3)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with TYSND1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TYSND1 Gene

Orthologs for TYSND1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TYSND1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TYSND1 34 33
  • 98.65 (n)
(Mus musculus)
Mammalia Tysnd1 16 34 33
  • 80.59 (n)
(Rattus norvegicus)
Mammalia Tysnd1 33
  • 80.18 (n)
(Canis familiaris)
Mammalia TYSND1 34
  • 78 (a)
(Bos Taurus)
Mammalia TYSND1 34
  • 76 (a)
(Monodelphis domestica)
Mammalia TYSND1 34
  • 63 (a)
(Gallus gallus)
Aves TYSND1 34 33
  • 60.28 (n)
(Anolis carolinensis)
Reptilia TYSND1 34
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tysnd1 33
  • 50.44 (n)
Str.17393 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.4078 33
(Danio rerio)
Actinopterygii tysnd1 34 33
  • 47.63 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5807 33
fruit fly
(Drosophila melanogaster)
Insecta CG3589 34
  • 26 (a)
Species where no ortholog for TYSND1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TYSND1 Gene

Gene Tree for TYSND1 (if available)
Gene Tree for TYSND1 (if available)
Evolutionary constrained regions (ECRs) for TYSND1: view image

Paralogs for TYSND1 Gene

No data available for Paralogs for TYSND1 Gene

Variants for TYSND1 Gene

Sequence variations from dbSNP and Humsavar for TYSND1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000063689 -- 70,146,300(-) C/T coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, missense_variant, upstream_transcript_variant
rs1000374411 -- 70,144,232(-) G/A intron_variant
rs1000794496 -- 70,139,050(-) T/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1000825639 -- 70,139,250(-) T/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1000843921 -- 70,137,561(-) A/ downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TYSND1 Gene

Variant ID Type Subtype PubMed ID
esv32737 CNV gain+loss 17666407
esv3397257 CNV duplication 20981092
nsv551479 CNV loss 21841781
nsv7054 CNV insertion 18451855

Variation tolerance for TYSND1 Gene

Gene Damage Index Score: 8.53; 85.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TYSND1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TYSND1 Gene

Disorders for TYSND1 Gene

Additional Disease Information for TYSND1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TYSND1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TYSND1 Gene

Publications for TYSND1 Gene

  1. Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid β-oxidation in peroxisomal matrix. (PMID: 22002062) Okumoto K … Fujiki Y (The Journal of biological chemistry 2011) 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Novel peroxisomal protease Tysnd1 processes PTS1- and PTS2-containing enzymes involved in beta-oxidation of fatty acids. (PMID: 17255948) Kurochkin IV … Okazaki Y (The EMBO journal 2007) 2 3 58
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TYSND1 Gene

Sources for TYSND1 Gene

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