Aliases for STOX1 Gene
External Ids for STOX1 Gene
Previous HGNC Symbols for STOX1 Gene
Previous GeneCards Identifiers for STOX1 Gene
The protein encoded by this gene may function as a DNA binding protein. Mutations in this gene are associated with pre-eclampsia/eclampsia 4 (PEE4). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
GeneCards Summary for STOX1 Gene
STOX1 (Storkhead Box 1) is a Protein Coding gene. Diseases associated with STOX1 include Preeclampsia/Eclampsia 4 and Eclampsia. Gene Ontology (GO) annotations related to this gene include RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is STOX2.
UniProtKB/Swiss-Prot for STOX1 Gene
Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (PubMed:24738702). Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity).
Isoform A: Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry (PubMed:22253775). Induces phosphorylation of MAPT/tau (PubMed:22995177).