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Aliases for TMEM26 Gene

Aliases for TMEM26 Gene

  • Transmembrane Protein 26 2 3 3 5

External Ids for TMEM26 Gene

Previous GeneCards Identifiers for TMEM26 Gene

  • GC10M062513
  • GC10M062842
  • GC10M063166
  • GC10M057155

Summaries for TMEM26 Gene

Entrez Gene Summary for TMEM26 Gene

  • This gene encodes a protein containing multiple transmembrane helices. It is a selective surface protein marker of brite/beige adipocytes, which may coexist with classical brown adipocytes in brown adipose tissue. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for TMEM26 Gene

TMEM26 (Transmembrane Protein 26) is a Protein Coding gene.

Additional gene information for TMEM26 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM26 Gene

Genomics for TMEM26 Gene

GeneHancer (GH) Regulatory Elements for TMEM26 Gene

Promoters and enhancers for TMEM26 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J061451 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 671 +0.3 315 4.1 FEZF1 ETS1 ZNF335 EGR1 RCOR1 EGR2 SP3 NR2F2 ZNF148 SP1 TMEM26 TMEM26-AS1
GH10J061829 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.6 -377.3 -377259 1.7 HNRNPUL1 SMAD1 ATF1 FOXA2 ARNT ZNF48 TCF12 ZNF766 GATA2 E2F8 TMEM26 CABCOCO1 ARID5B ENSG00000233643
GH10J061463 Enhancer 0.8 Ensembl ENCODE 20.6 -11.1 -11148 2.2 ZNF362 MAX USF2 CEBPB EP300 RFX5 PRDM6 JUND HMBOX1 STAT3 TMEM26 GC10P061456 TMEM26-AS1 GC10M061462
GH10J061475 Enhancer 0.9 ENCODE 14.9 -22.4 -22352 0.9 PKNOX1 ATF1 FEZF1 TCF12 ZNF121 ZNF766 ZNF213 ATF7 FOS TSHZ1 TMEM26 GC10P061456 GC10M061462 TMEM26-AS1
GH10J061397 Enhancer 0.8 Ensembl ENCODE 11.6 +55.6 55616 1.5 ZNF639 IRF2 NFRKB NR2F1 ZBTB11 MAFG BACH1 ZNF644 ATF2 YY1 TMEM26-AS1 TMEM26 CABCOCO1 GC10M061433 GC10P061339
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM26 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM26 gene promoter:
  • POU2F1a
  • POU2F1
  • HOXA5
  • MRF-2
  • RSRFC4
  • Ik-2
  • TBP
  • GATA-1
  • GATA-2
  • GATA-3

Genomic Locations for TMEM26 Gene

Genomic Locations for TMEM26 Gene
46,809 bases
Minus strand
46,808 bases
Minus strand

Genomic View for TMEM26 Gene

Genes around TMEM26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM26 Gene

Proteins for TMEM26 Gene

  • Protein details for TMEM26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 26
    Protein Accession:
    Secondary Accessions:
    • Q6ZVM0
    • Q8IVN9

    Protein attributes for TMEM26 Gene

    368 amino acids
    Molecular mass:
    41672 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM26 Gene


neXtProt entry for TMEM26 Gene

Post-translational modifications for TMEM26 Gene

  • Glycosylation at posLast=116116 and posLast=110110
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM26 Gene

No data available for DME Specific Peptides for TMEM26 Gene

Domains & Families for TMEM26 Gene

Gene Families for TMEM26 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM26 Gene


Suggested Antigen Peptide Sequences for TMEM26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM26: view

No data available for UniProtKB/Swiss-Prot for TMEM26 Gene

Function for TMEM26 Gene

Phenotypes From GWAS Catalog for TMEM26 Gene

genes like me logo Genes that share phenotypes with TMEM26: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM26 Gene

Localization for TMEM26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM26 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM26 gene
Compartment Confidence
plasma membrane 3
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM26: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM26 Gene

Pathways & Interactions for TMEM26 Gene

SuperPathways for TMEM26 Gene

No Data Available

Interacting Proteins for TMEM26 Gene

Gene Ontology (GO) - Biological Process for TMEM26 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM26 Gene

Drugs & Compounds for TMEM26 Gene

No Compound Related Data Available

Transcripts for TMEM26 Gene

mRNA/cDNA for TMEM26 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM26 Gene

Transmembrane protein 26:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM26 Gene

No ASD Table

Relevant External Links for TMEM26 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM26 Gene

This gene is overexpressed in Spleen (x11.2) and Breast - Mammary Tissue (x4.7).

Protein differential expression in normal tissues from HIPED for TMEM26 Gene

This gene is overexpressed in Testis (45.9) and Fetal testis (22.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM26 Gene

Protein tissue co-expression partners for TMEM26 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM26 Gene:


SOURCE GeneReport for Unigene cluster for TMEM26 Gene:


Evidence on tissue expression from TISSUES for TMEM26 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with TMEM26: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM26 Gene

Orthologs for TMEM26 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM26 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM26 34 33
  • 98.91 (n)
(Bos Taurus)
Mammalia TMEM26 34 33
  • 85.78 (n)
(Canis familiaris)
Mammalia TMEM26 34 33
  • 85.05 (n)
(Rattus norvegicus)
Mammalia Tmem26 33
  • 75.48 (n)
(Mus musculus)
Mammalia Tmem26 16 34 33
  • 75.02 (n)
(Ornithorhynchus anatinus)
Mammalia TMEM26 34
  • 70 (a)
(Monodelphis domestica)
Mammalia TMEM26 34
  • 60 (a)
(Gallus gallus)
Aves TMEM26 34 33
  • 67.04 (n)
(Anolis carolinensis)
Reptilia TMEM26 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732964 33
  • 63.88 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12342 33
(Danio rerio)
Actinopterygii LOC794507 33
  • 57.11 (n)
TMEM26 (2 of 3) 34
  • 51 (a)
TMEM26 (3 of 3) 34
  • 49 (a)
tmem26b 34
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14238 34
  • 22 (a)
(Caenorhabditis elegans)
Secernentea Y119C1B.3 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
Species where no ortholog for TMEM26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM26 Gene

Gene Tree for TMEM26 (if available)
Gene Tree for TMEM26 (if available)
Evolutionary constrained regions (ECRs) for TMEM26: view image

Paralogs for TMEM26 Gene

No data available for Paralogs for TMEM26 Gene

Variants for TMEM26 Gene

Sequence variations from dbSNP and Humsavar for TMEM26 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000030406 -- 61,446,586(-) C/A/G intron_variant
rs1000111906 -- 61,450,500(-) T/C intron_variant
rs1000141502 -- 61,441,269(-) T/C intron_variant
rs1000142677 -- 61,450,801(-) G/A intron_variant
rs1000155284 -- 61,421,802(-) C/G genic_downstream_transcript_variant, intron_variant

Variation tolerance for TMEM26 Gene

Residual Variation Intolerance Score: 10.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM26 Gene

Disorders for TMEM26 Gene

Additional Disease Information for TMEM26

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMEM26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM26 Gene

Publications for TMEM26 Gene

  1. Genome-wide association study identifies eight loci associated with blood pressure. (PMID: 19430483) Newton-Cheh C … Munroe PB (Nature genetics 2009) 3 44 58
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58

Products for TMEM26 Gene

Sources for TMEM26 Gene

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