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Aliases for F11 Gene

Aliases for F11 Gene

  • Coagulation Factor XI 2 3 3 5
  • Plasma Thromboplastin Antecedent 2 3 4
  • FXI 3 4
  • PTA 3 4
  • EC 4

External Ids for F11 Gene

Previous GeneCards Identifiers for F11 Gene

  • GC04P188221
  • GC04P187867
  • GC04P187771
  • GC04P187883
  • GC04P187562
  • GC04P187424
  • GC04P187187
  • GC04P182938

Summaries for F11 Gene

Entrez Gene Summary for F11 Gene

  • This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]

GeneCards Summary for F11 Gene

F11 (Coagulation Factor XI) is a Protein Coding gene. Diseases associated with F11 include Factor Xi Deficiency and Hemorrhagic Disease. Among its related pathways are Complement and coagulation cascades and Formation of Fibrin Clot (Clotting Cascade). Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type aminopeptidase activity. An important paralog of this gene is KLKB1.

UniProtKB/Swiss-Prot for F11 Gene

  • Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.

Gene Wiki entry for F11 Gene

Additional gene information for F11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for F11 Gene

Genomics for F11 Gene

GeneHancer (GH) Regulatory Elements for F11 Gene

Promoters and enhancers for F11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J186264 Promoter/Enhancer 1.4 EPDnew ENCODE 656.9 +0.2 228 2.8 FOXA2 ARID4B ZNF48 YY1 RXRA SP5 ZHX2 REST PPARG KAT8 F11 GC04P186267 KLKB1 GC04M186330
GH04J186246 Enhancer 1.1 Ensembl ENCODE dbSUPER 8.2 -16.6 -16645 6.6 SOX13 TAF1 MAX YY1 POLR2A FOS EGR2 RXRA NANOG HLF KLKB1 CYP4V2 F11 GC04M186242
GH04J186240 Enhancer 0.6 ENCODE dbSUPER 7.2 -22.9 -22850 5.3 NANOG ZNF585B POLR2A GC04M186242 CYP4V2 KLKB1 F11
GH04J186260 Enhancer 0.9 ENCODE 0.4 -5.0 -5042 1.8 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 NFKBIZ RXRA SP5 NFYC KLKB1 CYP4V2 F11 GC04M186242
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around F11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the F11 gene promoter:
  • PPAR-gamma2
  • PPAR-gamma1
  • Tal-1beta
  • E47
  • Zic3
  • Cdc5
  • ZIC2
  • AP-4
  • HFH-1
  • XBP-1

Genomic Locations for F11 Gene

Genomic Locations for F11 Gene
23,737 bases
Plus strand
23,737 bases
Plus strand

Genomic View for F11 Gene

Genes around F11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
F11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for F11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for F11 Gene

Proteins for F11 Gene

  • Protein details for F11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coagulation factor XI
    Protein Accession:
    Secondary Accessions:
    • D3DP64
    • Q4W5C2
    • Q9Y495

    Protein attributes for F11 Gene

    625 amino acids
    Molecular mass:
    70109 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Forms a heterodimer with SERPINA5. After activation the heavy and light chains are also linked by a disulfide bond.

    Three dimensional structures from OCA and Proteopedia for F11 Gene

    Alternative splice isoforms for F11 Gene


neXtProt entry for F11 Gene

Post-translational modifications for F11 Gene

  • N-glycosylated on both chains. N-glycosylated sites mainly consist of nonfucosylated sialylated biantennary (in high abundance) and/or triantennary (in low abundance) complex structures. Glycosylation at Asn-163 uses a rare non-canonical Asn-X-Cys glycosite.
  • Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.
  • Glycosylation at isoforms=2491, Asn450, isoforms=2353, Asn163, Asn126, and Asn90
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • FA11_HUMAN (818)

Antibody Products

  • R&D Systems Antibodies for F11 (Coagulation Factor XI)
  • Boster Bio Antibodies for F11

No data available for DME Specific Peptides for F11 Gene

Domains & Families for F11 Gene

Gene Families for F11 Gene

Human Protein Atlas (HPA):
  • Candidate cardiovascular disease genes
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for F11 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
  • Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
genes like me logo Genes that share domains with F11: view

Function for F11 Gene

Molecular function for F11 Gene

UniProtKB/Swiss-Prot Function:
Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
UniProtKB/Swiss-Prot CatalyticActivity:
Selective cleavage of Arg- -Ala and Arg- -Val bonds in factor IX to form factor IXa.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by SERPINA5.
GENATLAS Biochemistry:
coagulation factor XI,80kDa,homodimer of two monomers (plasma thromboplastin antecedent),contact activation pathway

Enzyme Numbers (IUBMB) for F11 Gene

Phenotypes From GWAS Catalog for F11 Gene

Gene Ontology (GO) - Molecular Function for F11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity NAS 9593722
GO:0005515 protein binding IPI 2844223
GO:0008201 heparin binding IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with F11: view
genes like me logo Genes that share phenotypes with F11: view

Human Phenotype Ontology for F11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for F11 Gene

MGI Knock Outs for F11:
  • F11 F11<tm1Gjb>

Animal Model Products

Clone Products

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for F11 Gene

Localization for F11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for F11 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for F11 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for F11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 89876
GO:0005886 plasma membrane TAS --
GO:0016020 membrane NAS 9593722
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with F11: view

Pathways & Interactions for F11 Gene

genes like me logo Genes that share pathways with F11: view

Pathways by source for F11 Gene

Gene Ontology (GO) - Biological Process for F11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007596 blood coagulation NAS,IDA 9593722
GO:0007597 blood coagulation, intrinsic pathway TAS --
GO:0007599 hemostasis IEA --
GO:0030193 regulation of blood coagulation IEA --
genes like me logo Genes that share ontologies with F11: view

No data available for SIGNOR curated interactions for F11 Gene

Drugs & Compounds for F11 Gene

(25) Drugs for F11 Gene - From: DrugBank, PharmGKB, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coagulation Factor IX (Recombinant) Approved, Investigational Pharma Target, ligand 0
Coagulation Factor IX Human Approved Pharma Target, ligand 0
Conestat alfa Approved, Investigational Pharma Target, inhibitor 0
Human C1-esterase inhibitor Approved Pharma Target, inhibitor 0
Human Thrombin Approved Pharma Target, activator 0

(9) Additional Compounds for F11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with F11: view

Transcripts for F11 Gene

Unigene Clusters for F11 Gene

Coagulation factor XI:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for F11 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b
SP1: - - -
SP2: - - - -
SP3: - - -
SP5: -
SP6: -

Relevant External Links for F11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for F11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for F11 Gene

mRNA differential expression in normal tissues according to GTEx for F11 Gene

This gene is overexpressed in Liver (x42.4) and Pancreas (x7.1).

Protein differential expression in normal tissues from HIPED for F11 Gene

This gene is overexpressed in Serum (38.7) and Plasma (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for F11 Gene

Protein tissue co-expression partners for F11 Gene

NURSA nuclear receptor signaling pathways regulating expression of F11 Gene:


SOURCE GeneReport for Unigene cluster for F11 Gene:


mRNA Expression by UniProt/SwissProt for F11 Gene:

Tissue specificity: Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.

Evidence on tissue expression from TISSUES for F11 Gene

  • Liver(4.7)
  • Bone marrow(4)
  • Blood(2.9)

Phenotype-based relationships between genes and organs from Gene ORGANizer for F11 Gene

Germ Layers:
  • mesoderm
  • cardiovascular
  • blood
  • blood vessel
  • coagulation system
genes like me logo Genes that share expression patterns with F11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for F11 Gene

Orthologs for F11 Gene

This gene was present in the common ancestor of animals.

Orthologs for F11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia F11 34 33
  • 99.36 (n)
(Canis familiaris)
Mammalia F11 34 33
  • 85.1 (n)
(Bos Taurus)
Mammalia F11 34 33
  • 83.87 (n)
(Mus musculus)
Mammalia F11 16 34 33
  • 81.35 (n)
(Rattus norvegicus)
Mammalia F11 33
  • 72.69 (n)
(Monodelphis domestica)
Mammalia F11 34
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia F11 34
  • 56 (a)
(Gallus gallus)
Aves F11 33
  • 65.65 (n)
-- 34
  • 59 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klkb1 33
  • 55.9 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11824 35
  • 37 (a)
Tequila 35
  • 37 (a)
CG8170 35
  • 36 (a)
CG7829 35
  • 36 (a)
&eegr;Try 35
  • 36 (a)
CG4998 35
  • 36 (a)
CG7432 35
  • 36 (a)
CG10663 35
  • 36 (a)
CG3355 35
  • 36 (a)
CG4613 35
  • 36 (a)
BEST:GH02921 35
  • 33 (a)
CG13744 35
  • 33 (a)
CG6865 35
  • 33 (a)
(Caenorhabditis elegans)
Secernentea C07G1.1 35
  • 37 (a)
Species where no ortholog for F11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for F11 Gene

Gene Tree for F11 (if available)
Gene Tree for F11 (if available)
Evolutionary constrained regions (ECRs) for F11: view image

Paralogs for F11 Gene

Variants for F11 Gene

Sequence variations from dbSNP and Humsavar for F11 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1043836605 uncertain-significance, Hereditary factor XI deficiency disease 186,289,190(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1057516431 likely-pathogenic, Hereditary factor XI deficiency disease 186,280,320(+) CAC/C coding_sequence_variant, frameshift, non_coding_transcript_variant
rs1057516506 likely-pathogenic, Hereditary factor XI deficiency disease 186,286,414(+) G/T genic_downstream_transcript_variant, intron_variant, splice_acceptor_variant
rs1057516616 likely-pathogenic, Hereditary factor XI deficiency disease 186,267,161(+) CATT/ coding_sequence_variant, frameshift, non_coding_transcript_variant
rs1057516695 likely-pathogenic, Hereditary factor XI deficiency disease 186,275,785(+) A/G intron_variant, splice_acceptor_variant

Structural Variations from Database of Genomic Variants (DGV) for F11 Gene

Variant ID Type Subtype PubMed ID
nsv1028146 CNV gain 25217958
nsv1034638 CNV loss 25217958
nsv1131852 CNV deletion 24896259
nsv461864 CNV gain 19166990
nsv596392 CNV gain 21841781
nsv596401 CNV loss 21841781

Variation tolerance for F11 Gene

Residual Variation Intolerance Score: 15.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for F11 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for F11 Gene

Disorders for F11 Gene

MalaCards: The human disease database

(19) MalaCards diseases for F11 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
factor xi deficiency
  • f11 deficiency
hemorrhagic disease
  • hemorrhagic diathesis
von willebrand's disease
  • vascular hemophilia
hemophilia a
  • factor viii deficiency
hemophilia b
  • hemb
- elite association - COSMIC cancer census association via MalaCards
Search F11 in MalaCards View complete list of genes associated with diseases


  • Factor XI deficiency (FA11D) [MIM:612416]: A hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate. {ECO:0000269 PubMed:10027710, ECO:0000269 PubMed:10606881, ECO:0000269 PubMed:11895778, ECO:0000269 PubMed:15026311, ECO:0000269 PubMed:15180874, ECO:0000269 PubMed:1547342, ECO:0000269 PubMed:15953011, ECO:0000269 PubMed:16607084, ECO:0000269 PubMed:18005151, ECO:0000269 PubMed:21457405, ECO:0000269 PubMed:21668437, ECO:0000269 PubMed:21999818, ECO:0000269 PubMed:22016685, ECO:0000269 PubMed:22159456, ECO:0000269 PubMed:22322133, ECO:0000269 PubMed:25158988, ECO:0000269 PubMed:2813350, ECO:0000269 PubMed:7669672, ECO:0000269 PubMed:7888672, ECO:0000269 PubMed:9401068, ECO:0000269 PubMed:9787168}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for F11 Gene

bleeding diathesis,mild,inconstant

Additional Disease Information for F11

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with F11: view

Publications for F11 Gene

  1. Seven novel point mutations in the F11 gene in Iranian FXI-deficient patients. (PMID: 18005151) Fard-Esfahani P … Ala F (Haemophilia : the official journal of the World Federation of Hemophilia 2008) 3 4 22 58
  2. Factor XI deficiency in French Basques is caused predominantly by an ancestral Cys38Arg mutation in the factor XI gene. (PMID: 11895778) Zivelin A … Seligsohn U (Blood 2002) 3 4 44 58
  3. Identification of a novel mutation in a non-Jewish factor XI deficient kindred. (PMID: 10027710) Alhaq A … Savidge G (British journal of haematology 1999) 3 4 22 58
  4. Heterozygous factor XI deficiency associated with three novel mutations. (PMID: 10606881) Mitchell M … Alhaq A (British journal of haematology 1999) 3 4 44 58
  5. Expression of human blood coagulation factor XI: characterization of the defect in factor XI type III deficiency. (PMID: 1547342) Meijers JC … Chung DW (Blood 1992) 3 4 22 58

Products for F11 Gene

Sources for F11 Gene

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