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Aliases for F2R Gene

Aliases for F2R Gene

  • Coagulation Factor II Thrombin Receptor 2 3 5
  • Proteinase-Activated Receptor 1 3 4
  • PAR-1 3 4
  • CF2R 3 4
  • PAR1 3 4
  • TR 3 4
  • Coagulation Factor II (Thrombin) Receptor 2
  • Coagulation Factor II Receptor 4
  • Protease-Activated Receptor 1 3
  • Protease Activated Receptor 1 2
  • Thrombin Receptor 4
  • HTR 3

External Ids for F2R Gene

Previous GeneCards Identifiers for F2R Gene

  • GC05P074817
  • GC05P076246
  • GC05P076050
  • GC05P076095
  • GC05P076047
  • GC05P071219

Summaries for F2R Gene

Entrez Gene Summary for F2R Gene

  • Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

GeneCards Summary for F2R Gene

F2R (Coagulation Factor II Thrombin Receptor) is a Protein Coding gene. Diseases associated with F2R include Chromosome 5Q Deletion Syndrome and Leukocyte Adhesion Deficiency, Type Iii. Among its related pathways are cAMP signaling pathway and Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G-protein alpha-subunit binding. An important paralog of this gene is F2RL1.

UniProtKB/Swiss-Prot for F2R Gene

  • High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.

Tocris Summary for F2R Gene

  • Protease-activated receptors (PARs, also known as thrombin receptors) are G-protein-coupled receptors, activated by cleavage of their N-terminal domains by serine proteases. Hydrolysis reveals a tethered peptide ligand, which affects transmembrane signaling.

Gene Wiki entry for F2R Gene

Additional gene information for F2R Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for F2R Gene

Genomics for F2R Gene

GeneHancer (GH) Regulatory Elements for F2R Gene

Promoters and enhancers for F2R Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J076714 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 617.5 +1.1 1119 4.4 ZFX ZNF148 NKRF MLLT1 GTF2F1 ZNF687 CTCF YY1 SP7 SP5 F2R ENSG00000225407 F2RL2 F2RL1 POC5 RPL7P23 GC05P076755
GH05J076715 Promoter/Enhancer 0.8 Ensembl dbSUPER 600.7 -1.3 -1342 0.2 ZNF664 ENSG00000225407 ENSG00000278237 F2R
GH05J076735 Enhancer 1.6 FANTOM5 ENCODE dbSUPER 44.5 +22.2 22173 5.1 SP1 CC2D1A ELF3 MNT CBFA2T2 ZNF148 CEBPG CSDE1 ZNF687 ZSCAN21 F2R RPL7P23 ENSG00000225407 IQGAP2 GC05P076755
GH05J076818 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 20.3 +104.9 104909 5.6 ELF3 ZNF121 MAFK YY1 SP7 POLR2A SP1 KLF14 PRDM1 ZNF384 F2RL1 GC05P076819 GC05P076820 F2R ENSG00000225407 RN7SL208P GC05P076755
GH05J076786 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 23 +73.7 73704 5.8 CBFA2T2 MAFK SP7 SP1 SP5 KLF14 CREM PRDM1 SMARCA4 IKZF1 F2RL1 F2R ENSG00000225407 CRHBP GC05P076755
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around F2R on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the F2R gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • CREB
  • deltaCREB
  • Nkx2-5
  • Sp1

Genomic Locations for F2R Gene

Genomic Locations for F2R Gene
chr5:76,716,043-76,735,770
(GRCh38/hg38)
Size:
19,728 bases
Orientation:
Plus strand
chr5:76,011,868-76,031,606
(GRCh37/hg19)
Size:
19,739 bases
Orientation:
Plus strand

Genomic View for F2R Gene

Genes around F2R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
F2R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for F2R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for F2R Gene

Proteins for F2R Gene

  • Protein details for F2R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25116-PAR1_HUMAN
    Recommended name:
    Proteinase-activated receptor 1
    Protein Accession:
    P25116
    Secondary Accessions:
    • Q53XV0
    • Q96RF7
    • Q9BUN4

    Protein attributes for F2R Gene

    Size:
    425 amino acids
    Molecular mass:
    47441 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for F2R Gene

neXtProt entry for F2R Gene

Post-translational modifications for F2R Gene

  • A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
  • Phosphorylated in the C-terminal tail; probably mediating desensitization prior to the uncoupling and internalization of the receptor.
  • Glycosylation at isoforms=259, posLast=250250, isoforms=75, posLast=3535, and isoforms=62
  • Modification sites at PhosphoSitePlus

Other Protein References for F2R Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for F2R

No data available for DME Specific Peptides for F2R Gene

Domains & Families for F2R Gene

Gene Families for F2R Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for F2R Gene

GenScript: Design optimal peptide antigens:
  • Thrombin receptor (PAR1_HUMAN)
  • Thrombin receptor (Q6LCF1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P25116

UniProtKB/Swiss-Prot:

PAR1_HUMAN :
  • The cleaved signal peptide may not be degraded and may function as an intracellular angiogenesis inhibitor peptide known as parstatin.
  • Belongs to the G-protein coupled receptor 1 family.
Domain:
  • The cleaved signal peptide may not be degraded and may function as an intracellular angiogenesis inhibitor peptide known as parstatin.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with F2R: view

Function for F2R Gene

Molecular function for F2R Gene

UniProtKB/Swiss-Prot Function:
High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.
GENATLAS Biochemistry:
coagulation factor II (thrombin) receptor,proteinase activated receptor 1 (centromeric to the common proximal breakpoint and unlikely involved in 5q- syndrome), G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for F2R Gene

Gene Ontology (GO) - Molecular Function for F2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding ISS --
GO:0004930 G protein-coupled receptor activity TAS 17848177
GO:0005102 signaling receptor binding IPI 1672265
GO:0005515 protein binding IPI 17299037
GO:0015057 thrombin-activated receptor activity IBA,IDA 1672265
genes like me logo Genes that share ontologies with F2R: view
genes like me logo Genes that share phenotypes with F2R: view

Animal Models for F2R Gene

MGI Knock Outs for F2R:
  • F2r F2r<tm1Pago>
  • F2r F2r<tm1.1Cgh>
  • F2r F2r<tm1Ajc>
  • F2r F2r<tm2Cgh>
  • F2r F2r<tm1Cgh>

Animal Model Products

  • Taconic Biosciences Mouse Models for F2R

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for F2R - Now 50% OFF >
  • * F2R as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * F2R tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for F2R

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for F2R Gene

Localization for F2R Gene

Subcellular locations from UniProtKB/Swiss-Prot for F2R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for F2R gene
Compartment Confidence
plasma membrane 5
endosome 5
extracellular 4
golgi apparatus 4
cytoskeleton 2
cytosol 2
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for F2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005623 cell IEA --
GO:0005769 early endosome IDA 22547407
GO:0005770 late endosome IDA 24732013
GO:0005794 Golgi apparatus TAS 7961693
genes like me logo Genes that share ontologies with F2R: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for F2R Gene

Pathways & Interactions for F2R Gene

genes like me logo Genes that share pathways with F2R: view

SIGNOR curated interactions for F2R Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for F2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity ISS --
GO:0002248 connective tissue replacement involved in inflammatory response wound healing IDA 9639571
GO:0003105 negative regulation of glomerular filtration ISS --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 10692450
GO:0006954 inflammatory response IEA,ISS --
genes like me logo Genes that share ontologies with F2R: view

Drugs & Compounds for F2R Gene

(94) Drugs for F2R Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vorapaxar Approved Pharma Target, antagonist PAR-1 antagonist,potent and orally active 16
Streptokinase Approved, Investigational Pharma Target, cleavage 19
Thrombin Approved, Investigational Pharma Target 369
Argatroban Approved, Investigational Pharma Thrombin mediated fibrinogen cleavage inhibitor 24
SR-123781A Investigational Pharma Target 0

(56) Additional Compounds for F2R Gene - From: Novoseek and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>3</sup>H]haTRAP
Agonist
RWJ-56110
Antagonist
SCH530348
Antagonist
TFLLR-NH<sub>2</sub>
Full agonist, Agonist

(5) Tocris Compounds for F2R Gene

Compound Action Cas Number
AY-NH2 Selective PAR4 agonist 352017-71-1
SLIGKV-NH2 PAR2 receptor agonist 190383-13-2
SLIGRL-NH2 PAR2-activating peptide 171436-38-7
TFLLR-NH2 PAR1-activating peptide 197794-83-5
Thrombin Receptor Agonist Peptide Causes platelet aggregation and secretion 137339-65-2

(20) ApexBio Compounds for F2R Gene

Compound Action Cas Number
APC 366 Selective tryptase inhibitor 158921-85-8
Argatroban Thrombin mediated fibrinogen cleavage inhibitor 74863-84-6
Axitinib (AG 013736) VEGFR1/ c-Kit inhibitor 319460-85-0
BIBR 953 (Dabigatran, Pradaxa) Thrombin inhibitor,potent,reversible and direct 211914-51-1
BIBR-1048 Thrombin inhibitor 211915-06-9
FR 171113 173904-50-2
FSLLRY-NH2 245329-02-6
ML161 PAR1 inhibitor 423735-93-7
Parstatin (human) 1065755-99-8
Q94 hydrochloride 1052076-77-3
RLLFT-NH2 447408-68-6
RWJ 56110 252889-88-6
SCH 79797 dihydrochloride 1216720-69-2
tcY-NH2 327177-34-4
TFLLR-NH2 PAR1 selective agonist 197794-83-5
Thrombin Receptor Activator for Peptide 5 (TRAP-5) 141685-53-2
Thrombin Receptor Agonist Peptide 137339-65-2
TRAP-6 PAR1 agonist 141136-83-6
VKGILS-NH2 control peptide for SLIGKV-NH2, PAR1 agonist 942413-05-0
Vorapaxar PAR-1 antagonist,potent and orally active 618385-01-6
genes like me logo Genes that share compounds with F2R: view

Drug Products

Transcripts for F2R Gene

mRNA/cDNA for F2R Gene

(2) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(117) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for F2R Gene

Coagulation factor II (thrombin) receptor:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for F2R - Now 50% OFF >
  • * F2R as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * F2R tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for F2R

Alternative Splicing Database (ASD) splice patterns (SP) for F2R Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for F2R Gene

GeneLoc Exon Structure for
F2R
ECgene alternative splicing isoforms for
F2R

Expression for F2R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for F2R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for F2R Gene

This gene is overexpressed in Minor Salivary Gland (x4.6) and Artery - Aorta (x4.4).

Protein differential expression in normal tissues from HIPED for F2R Gene

This gene is overexpressed in Testis (31.6), Breast (23.2), and Platelet (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for F2R Gene



Protein tissue co-expression partners for F2R Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of F2R Gene:

F2R

SOURCE GeneReport for Unigene cluster for F2R Gene:

Hs.482562

mRNA Expression by UniProt/SwissProt for F2R Gene:

P25116-PAR1_HUMAN
Tissue specificity: Platelets and vascular endothelial cells.

Evidence on tissue expression from TISSUES for F2R Gene

  • Nervous system(4.1)
  • Eye(4)
  • Blood(2.9)
  • Heart(2.8)
  • Muscle(2.5)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with F2R: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for F2R Gene

Orthologs for F2R Gene

This gene was present in the common ancestor of chordates.

Orthologs for F2R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia F2R 35 34
  • 99.53 (n)
OneToOne
dog
(Canis familiaris)
Mammalia F2R 35 34
  • 86.41 (n)
OneToOne
cow
(Bos Taurus)
Mammalia F2R 35 34
  • 80.55 (n)
OneToOne
mouse
(Mus musculus)
Mammalia F2r 17 35 34
  • 79.87 (n)
rat
(Rattus norvegicus)
Mammalia F2r 34
  • 79.01 (n)
oppossum
(Monodelphis domestica)
Mammalia F2R 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves F2R 35 34
  • 63.18 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia F2R 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia f2r 34
  • 59.49 (n)
African clawed frog
(Xenopus laevis)
Amphibia f2r-A-prov 34
zebrafish
(Danio rerio)
Actinopterygii f2r 35 34
  • 56.88 (n)
OneToOne
Species where no ortholog for F2R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for F2R Gene

ENSEMBL:
Gene Tree for F2R (if available)
TreeFam:
Gene Tree for F2R (if available)
Aminode:
Evolutionary constrained regions (ECRs) for F2R: view image

Paralogs for F2R Gene

(7) SIMAP similar genes for F2R Gene using alignment to 2 proteins:

  • PAR1_HUMAN
  • G3XAL6_HUMAN
genes like me logo Genes that share paralogs with F2R: view

Variants for F2R Gene

Sequence variations from dbSNP and Humsavar for F2R Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000009737 -- 76,731,777(+) C/A/T intron_variant
rs1000197474 -- 76,734,293(+) G/A 3_prime_UTR_variant
rs1000200777 -- 76,722,193(+) C/T intron_variant
rs1000302704 -- 76,735,447(+) C/T 3_prime_UTR_variant
rs1000476355 -- 76,716,193(+) C/T 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for F2R Gene

Variant ID Type Subtype PubMed ID
esv2730323 CNV deletion 23290073
esv2730324 CNV deletion 23290073
nsv1035135 CNV gain 25217958

Variation tolerance for F2R Gene

Residual Variation Intolerance Score: 28.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for F2R Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
F2R
Human Gene Mutation Database (HGMD)
F2R

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for F2R Gene

Disorders for F2R Gene

MalaCards: The human disease database

(13) MalaCards diseases for F2R Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chromosome 5q deletion syndrome
  • 5q- syndrome
leukocyte adhesion deficiency, type iii
  • lad
ariboflavinosis
  • riboflavin deficiency
melanoma metastasis
blood platelet disease
  • qualitative platelet deficiency
- elite association - COSMIC cancer census association via MalaCards
Search F2R in MalaCards View complete list of genes associated with diseases

Additional Disease Information for F2R

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with F2R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for F2R Gene

Publications for F2R Gene

  1. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. (PMID: 10079109) Kahn ML … Coughlin SR (The Journal of clinical investigation 1999) 3 4 23 58
  2. The protease-activated receptor 1 possesses a functional and cleavable signal peptide which is necessary for receptor expression. (PMID: 22659187) Zampatis DE … Schülein R (FEBS letters 2012) 3 4 58
  3. New gene functions in megakaryopoiesis and platelet formation. (PMID: 22139419) Gieger C … Soranzo N (Nature 2011) 3 45 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 58
  5. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PMID: 20140262) Ryckman KK … Jacobsson B (PloS one 2010) 3 45 58

Products for F2R Gene

Sources for F2R Gene

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