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Aliases for F2 Gene

Aliases for F2 Gene

  • Coagulation Factor II, Thrombin 2 3 5
  • Prepro-Coagulation Factor II 2 3
  • Coagulation Factor II (Thrombin) 2
  • Coagulation Factor II 4
  • Prothrombin B-Chain 3
  • Thrombin Factor II 3
  • Serine Protease 3
  • Prothrombin 3
  • EC 4
  • RPRGL2 3
  • THPH1 3
  • PT 3

External Ids for F2 Gene

Previous GeneCards Identifiers for F2 Gene

  • GC11M048740
  • GC11P047618
  • GC11P046772
  • GC11P046705
  • GC11P046697
  • GC11P046446

Summaries for F2 Gene

Entrez Gene Summary for F2 Gene

  • Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

GeneCards Summary for F2 Gene

F2 (Coagulation Factor II, Thrombin) is a Protein Coding gene. Diseases associated with F2 include Prothrombin Deficiency, Congenital and Stroke, Ischemic. Among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Development Angiotensin activation of ERK. Gene Ontology (GO) annotations related to this gene include calcium ion binding and serine-type endopeptidase activity. An important paralog of this gene is PLG.

UniProtKB/Swiss-Prot for F2 Gene

  • Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

Gene Wiki entry for F2 Gene

Additional gene information for F2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for F2 Gene

Genomics for F2 Gene

GeneHancer (GH) Regulatory Elements for F2 Gene

Promoters and enhancers for F2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J046717 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 650.7 -0.5 -477 1.6 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 SLC30A9 ZNF121 NFKBIZ F2 ZNF408
GH11J046844 Promoter/Enhancer 1.5 Ensembl ENCODE 10.2 +126.8 126789 2.3 SMAD1 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF207 FOS SP3 LRP4-AS1 CKAP5 ZNF408 FNBP4 ENSG00000270060 DDB2 AMBRA1 ENSG00000200090 F2 KBTBD4
GH11J046647 Enhancer 1 Ensembl ENCODE dbSUPER 10.8 -69.9 -69944 2.8 NFIA RXRA JUN RAD21 ATF2 NR2F2 SP1 JUND POLR2A ZBTB48 GC11M055307 ATG13 ZNF408 ARHGAP1 HARBI1 F2 AMBRA1 CHRM4 SNORD67 CKAP5
GH11J046639 Enhancer 0.9 ENCODE dbSUPER 11.1 -78.8 -78821 2.4 ELF3 SOX13 FOXA2 ZNF792 SAP130 ARNT MAX TEAD3 ZNF664 POLR2A ZNF408 HARBI1 ATG13 AMBRA1 F2 ARHGAP1 SNORD67 CKAP5 GC11M055307
GH11J047142 Enhancer 1.1 Ensembl ENCODE dbSUPER 8.9 +424.1 424087 1.6 CLOCK NFIB MAX SIN3A ZBTB40 ZNF664 ZNF335 CTBP1 GATA3 POLR2A LRP4 C11orf49 F2 ENSG00000255520 GC11P047160
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around F2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the F2 gene promoter:
  • c-Jun
  • ATF-2
  • deltaCREB
  • CREB
  • AP-1
  • PPAR-gamma2
  • PPAR-gamma1

Genomic Locations for F2 Gene

Genomic Locations for F2 Gene
20,327 bases
Plus strand
20,327 bases
Plus strand

Genomic View for F2 Gene

Genes around F2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
F2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for F2 Gene

Proteins for F2 Gene

  • Protein details for F2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2R7F7
    • B4E1A7
    • Q4QZ40
    • Q53H04
    • Q53H06
    • Q69EZ7
    • Q7Z7P3
    • Q9UCA1

    Protein attributes for F2 Gene

    622 amino acids
    Molecular mass:
    70037 Da
    Quaternary structure:
    • Heterodimer (named alpha-thrombin) of a light and a heavy chain; disulfide-linked. Forms a heterodimer with SERPINA5.
    • Prothrombin is activated on the surface of a phospholipid membrane that binds the amino end of prothrombin and factors Va and Xa in Ca-dependent interactions; factor Xa removes the activation peptide and cleaves the remaining part into light and heavy chains. The activation process starts slowly because factor V itself has to be activated by the initial, small amounts of thrombin.
    • It is not known whether 1 or 2 smaller activation peptides, with additional cleavage after Arg-314, are released in natural blood clotting.
    • Thrombin can itself cleave the N-terminal fragment (fragment 1) of the prothrombin, prior to its activation by factor Xa.
    • The cleavage after Arg-198, observed in vitro, does not occur in plasma.

    Three dimensional structures from OCA and Proteopedia for F2 Gene

neXtProt entry for F2 Gene

Post-translational modifications for F2 Gene

  • The gamma-carboxyglutamyl residues, which bind calcium ions, result from the carboxylation of glutamyl residues by a microsomal enzyme, the vitamin K-dependent carboxylase. The modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin.
  • N-glycosylated. N-glycan heterogeneity at Asn-121: Hex3HexNAc3 (minor), Hex4HexNAc3 (minor) and Hex5HexNAc4 (major). At Asn-143: Hex4HexNAc3 (minor) and Hex5HexNAc4 (major).
  • Glycosylation at Asn416, Asn143, and Asn121
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • THRB_HUMAN (518)

Other Protein References for F2 Gene

Antibody Products

  • R&D Systems Antibodies for F2 (Coagulation Factor II/Thrombin)
  • Invitrogen Antibodies for F2 (AFLGC-F2)

No data available for DME Specific Peptides for F2 Gene

Domains & Families for F2 Gene

Gene Families for F2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for F2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with F2: view

Function for F2 Gene

Molecular function for F2 Gene

UniProtKB/Swiss-Prot Function:
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.
UniProtKB/Swiss-Prot CatalyticActivity:
Selective cleavage of Arg- -Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by SERPINA5.
GENATLAS Biochemistry:
coagulation factor II,vitamin K-dependent (prothrombin)

Enzyme Numbers (IUBMB) for F2 Gene

Phenotypes From GWAS Catalog for F2 Gene

Gene Ontology (GO) - Molecular Function for F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IDA 20421939
GO:0004252 serine-type endopeptidase activity TAS,IEA --
GO:0005102 signaling receptor binding IPI 8626514
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 3279057
genes like me logo Genes that share ontologies with F2: view
genes like me logo Genes that share phenotypes with F2: view

Human Phenotype Ontology for F2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for F2 Gene

MGI Knock Outs for F2:
  • F2 F2<tm1Jes>
  • F2 F2<tm1Sjd>
  • F2 F2<tm1b(EUCOMM)Hmgu>

Animal Model Products

miRNA for F2 Gene

miRTarBase miRNAs that target F2

Clone Products

  • Addgene plasmids for F2

No data available for Transcription Factor Targets and HOMER Transcription for F2 Gene

Localization for F2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for F2 Gene

Secreted, extracellular space.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for F2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
golgi apparatus 5
cytosol 3
cytoskeleton 2
mitochondrion 2
nucleus 2
lysosome 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005615 extracellular space IEA,IDA 9639571
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with F2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for F2 Gene

Pathways & Interactions for F2 Gene

genes like me logo Genes that share pathways with F2: view

SIGNOR curated interactions for F2 Gene


Gene Ontology (GO) - Biological Process for F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IDA 7559487
GO:0006465 signal peptide processing TAS --
GO:0006508 proteolysis IEA,TAS 7507931
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0006953 acute-phase response IEA --
genes like me logo Genes that share ontologies with F2: view

Drugs & Compounds for F2 Gene

(212) Drugs for F2 Gene - From: DrugBank, PharmGKB, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Argatroban Approved, Investigational Pharma inhibitor, Target Thrombin mediated fibrinogen cleavage inhibitor 19
Ximelagatran Approved, Investigational, Withdrawn Pharma inhibitor, Target thrombin inhibitor,orally available 2
Bivalirudin Approved, Investigational Pharma inhibitor, Target 69
Lepirudin Approved Pharma inhibitor, Target 5
Menadione Approved Nutra inhibitor, Target, activator 257

(57) Additional Compounds for F2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with F2: view

Transcripts for F2 Gene

mRNA/cDNA for F2 Gene

Unigene Clusters for F2 Gene

Coagulation factor II (thrombin):
Representative Sequences:

Clone Products

  • Addgene plasmids for F2

Alternative Splicing Database (ASD) splice patterns (SP) for F2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - -
SP2: -
SP3: -

Relevant External Links for F2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for F2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for F2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for F2 Gene

This gene is overexpressed in Liver (x52.5).

Protein differential expression in normal tissues from HIPED for F2 Gene

This gene is overexpressed in Serum (18.4), Plasma (16.2), Synovial fluid (10.3), and Monocytes (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for F2 Gene

Protein tissue co-expression partners for F2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of F2 Gene:


SOURCE GeneReport for Unigene cluster for F2 Gene:


mRNA Expression by UniProt/SwissProt for F2 Gene:

Tissue specificity: Expressed by the liver and secreted in plasma.

Evidence on tissue expression from TISSUES for F2 Gene

  • Liver(5)
  • Blood(4.8)
  • Urine(4.5)
  • Nervous system(4.5)
  • Bone marrow(4.4)
  • Heart(3.2)
  • Intestine(3)
  • Kidney(3)
  • Lung(2.8)
  • Skin(2.6)
  • Gall bladder(2.4)
  • Adrenal gland(2.3)
  • Muscle(2.3)
  • Bone(2)
  • Eye(2)
  • Pancreas(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for F2 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeleton
Head and neck:
  • brain
  • ear
  • face
  • head
  • mouth
  • nose
  • heart
  • lung
  • intestine
  • large intestine
  • small intestine
  • stomach
  • uterus
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
  • blood
  • blood vessel
  • coagulation system
  • skin
genes like me logo Genes that share expression patterns with F2: view

Orthologs for F2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for F2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia F2 34 33
  • 99.25 (n)
(Canis familiaris)
Mammalia F2 34 33
  • 86.62 (n)
(Bos Taurus)
Mammalia F2 34 33
  • 83.52 (n)
(Mus musculus)
Mammalia F2 16 34 33
  • 82.47 (n)
(Rattus norvegicus)
Mammalia F2 33
  • 81.62 (n)
(Monodelphis domestica)
Mammalia F2 34
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia F2 34
  • 51 (a)
(Gallus gallus)
Aves F2 34 33
  • 65.4 (n)
(Anolis carolinensis)
Reptilia F2 34
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia f2 33
  • 63.21 (n)
Str.8528 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.29409 33
(Danio rerio)
Actinopterygii f2 34 33
  • 61.38 (n)
Dr.26855 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11579 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 17 (a)
Species where no ortholog for F2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for F2 Gene

Gene Tree for F2 (if available)
Gene Tree for F2 (if available)
Evolutionary constrained regions (ECRs) for F2: view image

Paralogs for F2 Gene

Paralogs for F2 Gene

(45) SIMAP similar genes for F2 Gene using alignment to 6 proteins:

  • C9JV37_HUMAN
  • Q15253_HUMAN
  • Q86WA1_HUMAN
  • Q8TD58_HUMAN
genes like me logo Genes that share paralogs with F2: view

Variants for F2 Gene

Sequence variations from dbSNP and Humsavar for F2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs121918477 pathogenic, Hereditary factor II deficiency disease, Factor II deficiency (FA2D) [MIM:613679] 46,726,563(+) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs121918478 pathogenic, Hereditary factor II deficiency disease, Factor II deficiency (FA2D) [MIM:613679] 46,728,746(+) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs121918479 pathogenic, Hereditary factor II deficiency disease, Factor II deficiency (FA2D) [MIM:613679] 46,728,138(+) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs121918480 pathogenic, Hereditary factor II deficiency disease, Factor II deficiency (FA2D) [MIM:613679] 46,739,341(+) G/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs121918481 pathogenic, Hereditary factor II deficiency disease, Factor II deficiency (FA2D) [MIM:613679] 46,728,004(+) T/C coding_sequence_variant, missense_variant, non_coding_transcript_variant

Variation tolerance for F2 Gene

Residual Variation Intolerance Score: 7.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.90; 79.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for F2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for F2 Gene

Disorders for F2 Gene

MalaCards: The human disease database

(209) MalaCards diseases for F2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prothrombin deficiency, congenital
  • hypoprothrombinemia
stroke, ischemic
  • cerebrovascular accident
pregnancy loss, recurrent 2
  • pregnancy loss, recurrent, susceptibility to, 2
thrombophilia due to thrombin defect
  • thph1
  • hypercoagulability state
- elite association - COSMIC cancer census association via MalaCards
Search F2 in MalaCards View complete list of genes associated with diseases


  • Factor II deficiency (FA2D) [MIM:613679]: A very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. The severity of the bleeding manifestations correlates with blood factor II levels. {ECO:0000269 PubMed:1349838, ECO:0000269 PubMed:1354985, ECO:0000269 PubMed:1421398, ECO:0000269 PubMed:14962227, ECO:0000269 PubMed:2719946, ECO:0000269 PubMed:3242619, ECO:0000269 PubMed:3567158, ECO:0000269 PubMed:3771562, ECO:0000269 PubMed:3801671, ECO:0000269 PubMed:6405779, ECO:0000269 PubMed:7792730, ECO:0000269 PubMed:7865694}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. {ECO:0000269 PubMed:15534175}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Thrombophilia due to thrombin defect (THPH1) [MIM:188050]: A multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation. {ECO:0000269 PubMed:2825773}. Note=The disease is caused by mutations affecting the gene represented in this entry. A common genetic variation in the 3-prime untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increased risk of venous thrombosis.
  • Pregnancy loss, recurrent, 2 (RPRGL2) [MIM:614390]: A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions. {ECO:0000269 PubMed:11506076}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for F2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with F2: view

No data available for Genatlas for F2 Gene

Publications for F2 Gene

  1. Impact of genetic polymorphisms on platelet function and aspirin resistance. (PMID: 19923980) Pamukcu B … Nisanci Y (Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2010) 3 22 44 58
  2. Causal relationship of susceptibility genes to ischemic stroke: comparison to ischemic heart disease and biochemical determinants. (PMID: 20161734) Bentley P … Sharma P (PloS one 2010) 3 22 44 58
  3. Risk factors for failure of heparin thromboprophylaxis in patients with acute traumatic spinal cord injury. (PMID: 19853891) Rubin-Asher D … Lubetsky A (Thrombosis research 2010) 3 22 44 58
  4. Thrombophilic risk factors in patients with cranial and spinal dural arteriovenous fistulae. (PMID: 18824942) Gerlach R … Marquardt G (Neurosurgery 2008) 3 22 44 58
  5. Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls. (PMID: 15534175) Casas JP … Sharma P (Archives of neurology 2004) 3 4 44 58

Products for F2 Gene