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Aliases for PRSS55 Gene

Aliases for PRSS55 Gene

  • Serine Protease 55 2 3 3 5
  • Testis Serine Protease 1 3 4
  • Protease, Serine 55 2 3
  • T-SP1 3 4
  • TSP1 3 4
  • Probable Serine Protease UNQ9391/PRO34284 3
  • Tryptophan/Serine Protease 3
  • EC 3.4.21.- 4
  • UNQ9391 3
  • CT153 3

External Ids for PRSS55 Gene

Previous GeneCards Identifiers for PRSS55 Gene

  • GC08P010383
  • GC08P009313

Summaries for PRSS55 Gene

Entrez Gene Summary for PRSS55 Gene

  • This gene encodes a member of a group of membrane-anchored chymotrypsin (S1)-like serine proteases. The enocoded protein is primarily expressed in the Leydig and Sertoli cells of the testis and may be involved in male fertility. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

GeneCards Summary for PRSS55 Gene

PRSS55 (Serine Protease 55) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS54.

UniProtKB/Swiss-Prot for PRSS55 Gene

  • Probable serine protease.

Additional gene information for PRSS55 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS55 Gene

Genomics for PRSS55 Gene

GeneHancer (GH) Regulatory Elements for PRSS55 Gene

Promoters and enhancers for PRSS55 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J010525 Promoter 0.5 EPDnew 650.7 +0.0 39 0.1 PRSS55 PRSS51
GH08J010528 Enhancer 0.6 FANTOM5 15.4 +3.2 3154 0.1 CBFB JUNB MAFG BATF IRF4 ZNF316 MAFK EMSY RUNX3 PRSS55 PRSS51
GH08J010965 Enhancer 0.5 FANTOM5 16.6 +440.3 440279 0.2 IKZF1 EBF1 IKZF2 PIR55470 GC08P010967 C8orf74 PRSS55 ENSG00000254936 PIR49045 XKR6
GH08J010547 Enhancer 0.7 ENCODE 6.6 +22.9 22854 1 CTCF USF1 RB1 MAX SIN3A ZNF2 RAD21 EGR1 SMC3 ZNF143 PRSS51 PRSS55 ENSG00000272505 ENSG00000253678 GC08P010560
GH08J010342 Enhancer 0.7 ENCODE dbSUPER 6.4 -182.0 -182033 1.5 GATA3 NANOG POLR2A ZSCAN4 POU5F1 RCOR1 CHD2 PIR53849 PRSS55 ENSG00000255310 ENSG00000261451 PIR43128 MSRA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRSS55 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PRSS55 Gene

Genomic Locations for PRSS55 Gene
28,690 bases
Plus strand
28,621 bases
Plus strand

Genomic View for PRSS55 Gene

Genes around PRSS55 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS55 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS55 Gene

Proteins for PRSS55 Gene

  • Protein details for PRSS55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine protease 55
    Protein Accession:
    Secondary Accessions:
    • E5RJX5

    Protein attributes for PRSS55 Gene

    352 amino acids
    Molecular mass:
    38856 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRSS55 Gene


neXtProt entry for PRSS55 Gene

Post-translational modifications for PRSS55 Gene

Other Protein References for PRSS55 Gene

No data available for DME Specific Peptides for PRSS55 Gene

Domains & Families for PRSS55 Gene

Gene Families for PRSS55 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PRSS55 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS55: view

Function for PRSS55 Gene

Molecular function for PRSS55 Gene

UniProtKB/Swiss-Prot Function:
Probable serine protease.

Enzyme Numbers (IUBMB) for PRSS55 Gene

Phenotypes From GWAS Catalog for PRSS55 Gene

Gene Ontology (GO) - Molecular Function for PRSS55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PRSS55: view
genes like me logo Genes that share phenotypes with PRSS55: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS55 Gene

Localization for PRSS55 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS55 Gene

Isoform 1: Membrane; Single-pass type I membrane protein.
Isoform 2: Cytoplasm, cytosol.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRSS55 gene
Compartment Confidence
cytosol 5
extracellular 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PRSS55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PRSS55: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRSS55 Gene

Pathways & Interactions for PRSS55 Gene

SuperPathways for PRSS55 Gene

No Data Available

Interacting Proteins for PRSS55 Gene

Gene Ontology (GO) - Biological Process for PRSS55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PRSS55: view

No data available for Pathways by source and SIGNOR curated interactions for PRSS55 Gene

Drugs & Compounds for PRSS55 Gene

No Compound Related Data Available

Transcripts for PRSS55 Gene

mRNA/cDNA for PRSS55 Gene

(5) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS55 Gene

Protease, serine, 55:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS55 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: - -
SP2: -

Relevant External Links for PRSS55 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRSS55 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRSS55 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS55 Gene

This gene is overexpressed in Testis (x38.2).

Protein differential expression in normal tissues from HIPED for PRSS55 Gene

This gene is overexpressed in Plasma (67.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRSS55 Gene

Protein tissue co-expression partners for PRSS55 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRSS55 Gene:


SOURCE GeneReport for Unigene cluster for PRSS55 Gene:


mRNA Expression by UniProt/SwissProt for PRSS55 Gene:

Tissue specificity: Only detected in testis. Expressed in spermatogonia, spermatocytes, spermatids, Leydig and Sertoli cells. Expressed in prostate cancer and ovarian cancer (at protein level).

Evidence on tissue expression from TISSUES for PRSS55 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with PRSS55: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS55 Gene

Orthologs for PRSS55 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRSS55 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRSS55 34 33
  • 98.33 (n)
(Canis familiaris)
Mammalia PRSS55 34 33
  • 80.18 (n)
(Rattus norvegicus)
Mammalia Prss55 33
  • 73.04 (n)
(Mus musculus)
Mammalia Prss55 16 34 33
  • 72.37 (n)
(Bos Taurus)
Mammalia PRSS55 34
  • 61 (a)
(Monodelphis domestica)
Mammalia PRSS55 34
  • 40 (a)
(Ornithorhynchus anatinus)
Mammalia PRSS55 34
  • 34 (a)
(Gallus gallus)
Aves PRSS55 34 33
  • 55.73 (n)
(Anolis carolinensis)
Reptilia PRSS55 34
  • 33 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta CLIPD3 33
  • 46.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG18478 34
  • 27 (a)
CG31827 34
  • 27 (a)
CG4259 34
  • 24 (a)
CG18557 34
  • 23 (a)
CG3117 34
  • 23 (a)
CG14990 34
  • 22 (a)
CG5390 34
  • 20 (a)
CG9377 34
  • 19 (a)
CG40160 34
  • 19 (a)
CG8586 34
  • 19 (a)
CG13318 34
  • 19 (a)
CG18563 34
  • 19 (a)
CG8738 34
  • 17 (a)
CG6639 34
  • 17 (a)
CG18477 34
  • 15 (a)
CG31780 34
  • 15 (a)
CG4793 34
  • 10 (a)
scaf 34
  • 10 (a)
CG4998 34
  • 7 (a)
Species where no ortholog for PRSS55 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRSS55 Gene

Gene Tree for PRSS55 (if available)
Gene Tree for PRSS55 (if available)
Evolutionary constrained regions (ECRs) for PRSS55: view image

Paralogs for PRSS55 Gene

Variants for PRSS55 Gene

Sequence variations from dbSNP and Humsavar for PRSS55 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000147299 -- 10,551,701(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000188299 -- 10,548,042(+) G/A/C genic_downstream_transcript_variant, intron_variant
rs1000254746 -- 10,534,792(+) G/A 3_prime_UTR_variant, intron_variant
rs1000311002 -- 10,548,233(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000405630 -- 10,537,599(+) T/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS55 Gene

Variant ID Type Subtype PubMed ID
esv3572508 CNV loss 25503493
nsv1025557 CNV gain 25217958
nsv1026918 CNV loss 25217958
nsv1030934 CNV gain 25217958
nsv610267 CNV gain 21841781
nsv610268 CNV loss 21841781

Variation tolerance for PRSS55 Gene

Residual Variation Intolerance Score: 96.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.70; 83.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRSS55 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS55 Gene

Disorders for PRSS55 Gene

Additional Disease Information for PRSS55

No disorders were found for PRSS55 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS55 Gene

Publications for PRSS55 Gene

  1. T-SP1: a novel serine protease-like protein predominantly expressed in testis. (PMID: 18844450) Neth P … Jochum M (Biological chemistry 2008) 2 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  3. Scanning of novel cancer/testis proteins by human testis proteomic analysis. (PMID: 23436708) Liu M … Sha J (Proteomics 2013) 3 4 58
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 58
  5. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4 58

Products for PRSS55 Gene

Sources for PRSS55 Gene

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