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Aliases for PLD5 Gene

Aliases for PLD5 Gene

  • Phospholipase D Family Member 5 2 3 5
  • Inactive Phosphatidylcholine-Hydrolyzing Phospholipase D5 3 4
  • Inactive Choline Phosphatase 5 3 4
  • Inactive PLD 5 3 4
  • Phospholipase D Family, Member 5 2
  • Inactive Phospholipase D5 3
  • PLDC 3
  • PLDc 4

External Ids for PLD5 Gene

Previous GeneCards Identifiers for PLD5 Gene

  • GC01M238579
  • GC01M240318
  • GC01M242251
  • GC01M212711

Summaries for PLD5 Gene

GeneCards Summary for PLD5 Gene

PLD5 (Phospholipase D Family Member 5) is a Protein Coding gene. An important paralog of this gene is PLD3.

Gene Wiki entry for PLD5 Gene

Additional gene information for PLD5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLD5 Gene

Genomics for PLD5 Gene

GeneHancer (GH) Regulatory Elements for PLD5 Gene

Promoters and enhancers for PLD5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J242523 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 650.4 +6.0 6013 1.4 KLF17 MZF1 ZNF2 YY1 ZNF335 GLIS2 SCRT2 ZNF548 ZNF202 ZNF398 PLD5 ENSG00000227230 LOC105373234
GH01J242449 Promoter 0.5 EPDnew 650.2 +81.1 81056 0.1 PLD5 GC01M242468 LOC100421344
GH01J242529 Enhancer 0.2 ENCODE 650.7 -0.3 -312 1.9 PLD5 PIR49041
GH01J243251 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.4 -723.9 -723892 6.7 CLOCK FEZF1 IRF4 YY1 ZNF213 ZNF143 SP3 NFYC MEF2D ZNF610 SDCCAG8 CEP170 AKT3 ENSG00000236031 PLD5 ENSG00000232085
GH01J241603 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +922.0 922048 10.5 ATF1 PKNOX1 FOXA2 ARNT ZFP64 SIN3A YBX1 YY1 TCF12 ARID2 KMO CHML WDR64 PLD5 OPN3 GC01M241589 LOC105373233
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLD5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLD5 gene promoter:
  • Nkx2-5
  • CUTL1
  • MRF-2
  • SRY
  • POU2F1b
  • E47
  • Hand1
  • POU2F1
  • POU2F1a
  • POU2F1c

Genomic Locations for PLD5 Gene

Genomic Locations for PLD5 Gene
447,559 bases
Minus strand
441,711 bases
Minus strand

Genomic View for PLD5 Gene

Genes around PLD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLD5 Gene

Proteins for PLD5 Gene

  • Protein details for PLD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive phospholipase D5
    Protein Accession:
    Secondary Accessions:
    • A1KXV0
    • B7Z324
    • Q494U9
    • Q8NB22

    Protein attributes for PLD5 Gene

    536 amino acids
    Molecular mass:
    61312 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI01374.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI01375.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI01376.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PLD5 Gene


neXtProt entry for PLD5 Gene

Post-translational modifications for PLD5 Gene

  • Glycosylation at isoforms=2, 3, 4302 and isoforms=2, 4121
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PLD5 Gene

Domains & Families for PLD5 Gene

Gene Families for PLD5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PLD5 Gene

Suggested Antigen Peptide Sequences for PLD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the phospholipase D family.
  • Belongs to the phospholipase D family.
genes like me logo Genes that share domains with PLD5: view

Function for PLD5 Gene

Phenotypes From GWAS Catalog for PLD5 Gene

Gene Ontology (GO) - Molecular Function for PLD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
genes like me logo Genes that share ontologies with PLD5: view
genes like me logo Genes that share phenotypes with PLD5: view

Animal Models for PLD5 Gene

MGI Knock Outs for PLD5:
  • Pld5 Pld5<tm1b(KOMP)Wtsi>
  • Pld5 Pld5<tm1a(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for PLD5

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLD5

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLD5 Gene

Localization for PLD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLD5 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLD5 gene
Compartment Confidence
cytosol 4
mitochondrion 3
nucleus 2
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLD5: view

Pathways & Interactions for PLD5 Gene

No Data Available

Interacting Proteins for PLD5 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000440896 for PLD5 Gene via STRING

Gene Ontology (GO) - Biological Process for PLD5 Gene


No data available for Pathways by source and SIGNOR curated interactions for PLD5 Gene

Drugs & Compounds for PLD5 Gene

No Compound Related Data Available

Transcripts for PLD5 Gene

mRNA/cDNA for PLD5 Gene

Unigene Clusters for PLD5 Gene

Phospholipase D family, member 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLD5

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLD5 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: - -
SP2: -
SP3: - -

Relevant External Links for PLD5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLD5 Gene

This gene is overexpressed in Artery - Aorta (x8.9) and Brain - Cerebellar Hemisphere (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLD5 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLD5 Gene:


SOURCE GeneReport for Unigene cluster for PLD5 Gene:


Evidence on tissue expression from TISSUES for PLD5 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with PLD5: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLD5 Gene

Orthologs for PLD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLD5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLD5 34 33
  • 99.5 (n)
(Bos Taurus)
Mammalia PLD5 34 33
  • 93.06 (n)
(Canis familiaris)
Mammalia PLD5 34 33
  • 91.97 (n)
(Rattus norvegicus)
Mammalia Pld5 33
  • 89.86 (n)
(Mus musculus)
Mammalia Pld5 16 34 33
  • 88.99 (n)
(Monodelphis domestica)
Mammalia PLD5 34
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia PLD5 34
  • 78 (a)
(Gallus gallus)
Aves PLD5 34 33
  • 76.75 (n)
(Anolis carolinensis)
Reptilia PLD5 34
  • 72 (a)
(Danio rerio)
Actinopterygii LOC100535478 33
  • 57.99 (n)
PLD5 (1 of 2) 34
  • 47 (a)
CABZ01084700.1 34
  • 37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9248 34
  • 31 (a)
CG43345 34
  • 29 (a)
(Caenorhabditis elegans)
Secernentea T05C3.6 34
  • 24 (a)
Species where no ortholog for PLD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PLD5 Gene

Gene Tree for PLD5 (if available)
Gene Tree for PLD5 (if available)
Evolutionary constrained regions (ECRs) for PLD5: view image

Paralogs for PLD5 Gene

Paralogs for PLD5 Gene

(2) SIMAP similar genes for PLD5 Gene using alignment to 6 proteins:

  • F5H329_HUMAN
  • F8W7H1_HUMAN
  • J3KP61_HUMAN
genes like me logo Genes that share paralogs with PLD5: view

Variants for PLD5 Gene

Sequence variations from dbSNP and Humsavar for PLD5 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000000350 -- 242,220,629(-) T/G intron_variant
rs1000012708 -- 242,202,645(-) T/G intron_variant
rs1000026077 -- 242,426,707(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000026176 -- 242,103,196(-) T/C intron_variant
rs1000027212 -- 242,461,559(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLD5 Gene

Variant ID Type Subtype PubMed ID
dgv16e55 CNV gain 17911159
dgv20e215 CNV deletion 23714750
dgv595n100 CNV gain 25217958
dgv875n54 CNV gain 21841781
esv1006418 CNV insertion 20482838
esv1038787 CNV insertion 17803354
esv1110378 CNV insertion 17803354
esv1505070 CNV deletion 17803354
esv1676362 CNV deletion 17803354
esv1979417 CNV deletion 18987734
esv2089690 CNV deletion 18987734
esv25405 CNV gain 19812545
esv2658344 CNV deletion 23128226
esv2658863 CNV deletion 23128226
esv2726296 CNV deletion 23290073
esv2726307 CNV deletion 23290073
esv2726318 CNV deletion 23290073
esv2726329 CNV deletion 23290073
esv2726340 CNV deletion 23290073
esv2726351 CNV deletion 23290073
esv2726363 CNV deletion 23290073
esv2764195 CNV loss 21179565
esv3305846 CNV mobile element insertion 20981092
esv3389198 CNV insertion 20981092
esv3408183 CNV insertion 20981092
esv3549621 CNV deletion 23714750
esv3578513 CNV loss 25503493
esv3578514 CNV loss 25503493
esv3589365 CNV loss 21293372
esv3589367 CNV gain 21293372
esv992990 CNV insertion 20482838
esv998142 CNV gain 20482838
esv998850 CNV insertion 20482838
nsv1002309 CNV gain 25217958
nsv1003844 CNV gain 25217958
nsv1068994 CNV deletion 25765185
nsv1110157 CNV duplication 24896259
nsv1111016 CNV tandem duplication 24896259
nsv1113232 CNV deletion 24896259
nsv1118152 CNV deletion 24896259
nsv1122469 CNV deletion 24896259
nsv1127069 CNV deletion 24896259
nsv1127070 CNV deletion 24896259
nsv1133954 CNV deletion 24896259
nsv159213 CNV insertion 16902084
nsv160878 CNV insertion 16902084
nsv468672 CNV gain 19166990
nsv470788 CNV gain 18288195
nsv476062 CNV novel sequence insertion 20440878
nsv5077 CNV deletion 18451855
nsv508703 CNV deletion 20534489
nsv5088 CNV deletion 18451855
nsv515604 CNV loss 19592680
nsv528016 CNV gain 19592680
nsv549462 CNV gain 21841781
nsv549465 CNV gain 21841781
nsv945408 CNV duplication 23825009
nsv945409 CNV duplication 23825009
nsv945411 CNV duplication 23825009
nsv998804 CNV loss 25217958

Variation tolerance for PLD5 Gene

Residual Variation Intolerance Score: 35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 14.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLD5 Gene

Disorders for PLD5 Gene

Additional Disease Information for PLD5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PLD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLD5 Gene

Publications for PLD5 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. A genome-wide scan for common alleles affecting risk for autism. (PMID: 20663923) Anney R … Hallmayer J (Human molecular genetics 2010) 3 44 58
  3. Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis. (PMID: 19626040) McCauley JL … Haines JL (Genes and immunity 2009) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Genome-wide association study of ancestry-specific TB risk in the South African Coloured population. (PMID: 24057671) Chimusa ER … Hoal EG (Human molecular genetics 2014) 3 58

Products for PLD5 Gene

Sources for PLD5 Gene

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