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Aliases for CYP4Z1 Gene

Aliases for CYP4Z1 Gene

  • Cytochrome P450 Family 4 Subfamily Z Member 1 2 3 5
  • Cytochrome P450, Family 4, Subfamily Z, Polypeptide 1 2 3
  • CYPIVZ1 3 4
  • Cytochrome P450 4Z1 3
  • EC 4
  • CYP4A20 3

External Ids for CYP4Z1 Gene

Previous GeneCards Identifiers for CYP4Z1 Gene

  • GC01P046923
  • GC01P046903
  • GC01P046902
  • GC01P047245
  • GC01P047305
  • GC01P047533
  • GC01P045649

Summaries for CYP4Z1 Gene

Entrez Gene Summary for CYP4Z1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP4Z1 Gene

CYP4Z1 (Cytochrome P450 Family 4 Subfamily Z Member 1) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4X1.

Gene Wiki entry for CYP4Z1 Gene

Additional gene information for CYP4Z1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4Z1 Gene

Genomics for CYP4Z1 Gene

GeneHancer (GH) Regulatory Elements for CYP4Z1 Gene

Promoters and enhancers for CYP4Z1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J047067 Promoter 0.5 EPDnew 650.7 0.0 -17 0.1 CYP4Z1 GC01M047004
GH01J047030 Enhancer 0.9 Ensembl ENCODE 9.1 -36.4 -36362 1.4 FOXA2 NFIB FEZF1 ZNF7 GATA3 ZBTB48 PRDM10 ZNF600 ZNF10 DPF2 POMGNT1 CYP4Z1 CYP4A22 CYP4X1 GC01M047004
GH01J047107 Enhancer 0.7 Ensembl ENCODE 10.7 +40.7 40676 2 RXRA GABPB1 CEBPG HNF4A PRDM1 CYP4A22 CYP4A22-AS1 LINC00853 CYP4Z1 GC01M047099 LOC100533626
GH01J046519 Enhancer 1.5 FANTOM5 Ensembl ENCODE 4.9 -545.8 -545841 3.6 HDGF HNRNPUL1 PKNOX1 SMAD1 FOXA2 ARNT SIN3A ZNF766 CBX5 ZNF213 EFCAB14-AS1 GPBP1L1 LRRC41 RPL7AP16 DMBX1 RPS15AP10 KNCN EFCAB14 MOB3C TEX38
GH01J047649 Enhancer 0.9 Ensembl ENCODE 5.2 +583.9 583910 3.3 JUN ZSCAN4 KLF17 BMI1 ZIC2 ZFHX2 POLR2A FOSL2 FOS ZNF600 CYP4Z1 GC01P047675 GC01P047570
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYP4Z1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CYP4Z1 gene promoter:
  • LHX3b
  • Lhx3a
  • Nkx2-2
  • ARP-1
  • Pax-5
  • Gfi-1
  • AML1a
  • RORalpha1
  • PPAR-alpha

Genomic Locations for CYP4Z1 Gene

Genomic Locations for CYP4Z1 Gene
50,873 bases
Plus strand
50,833 bases
Plus strand

Genomic View for CYP4Z1 Gene

Genes around CYP4Z1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP4Z1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP4Z1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4Z1 Gene

Proteins for CYP4Z1 Gene

  • Protein details for CYP4Z1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome P450 4Z1
    Protein Accession:
    Secondary Accessions:
    • Q5VVE4

    Protein attributes for CYP4Z1 Gene

    505 amino acids
    Molecular mass:
    59086 Da
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

neXtProt entry for CYP4Z1 Gene

Post-translational modifications for CYP4Z1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP4Z1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CYP4Z1 Gene

Domains & Families for CYP4Z1 Gene

Gene Families for CYP4Z1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for CYP4Z1 Gene

Suggested Antigen Peptide Sequences for CYP4Z1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome P450 family.
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4Z1: view

Function for CYP4Z1 Gene

Molecular function for CYP4Z1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.

Enzyme Numbers (IUBMB) for CYP4Z1 Gene

Gene Ontology (GO) - Molecular Function for CYP4Z1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
GO:0020037 heme binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CYP4Z1: view
genes like me logo Genes that share phenotypes with CYP4Z1: view

Animal Model Products

miRNA for CYP4Z1 Gene

miRTarBase miRNAs that target CYP4Z1

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP4Z1 Gene

Localization for CYP4Z1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4Z1 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP4Z1 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 2
plasma membrane 1
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CYP4Z1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with CYP4Z1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP4Z1 Gene

Pathways & Interactions for CYP4Z1 Gene

genes like me logo Genes that share pathways with CYP4Z1: view

Pathways by source for CYP4Z1 Gene

2 BioSystems pathways for CYP4Z1 Gene

Gene Ontology (GO) - Biological Process for CYP4Z1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP4Z1: view

No data available for SIGNOR curated interactions for CYP4Z1 Gene

Drugs & Compounds for CYP4Z1 Gene

(19) Drugs for CYP4Z1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citalopram Approved Pharma 526
Codeine Approved, Illicit Pharma Full agonist, Agonist 83
Estradiol Approved, Investigational, Vet_approved Pharma Sex hormone 1400
Estrone Approved Pharma Agonist Estrogenic hormone 22
Formaldehyde Approved, Vet_approved Pharma 102

(22) Additional Compounds for CYP4Z1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 11,12,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,12,15-Trihydroxyicosatrienoate
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoate
11,12-Epoxyeicosatrienoic acid
  • (+/-)11(12)-eet
  • (+/-)11(12)-epetre
  • (+/-)11,12-epetre
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • 11,14,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxyicosatrienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • 11-Hydroxy-14,15-eeta
  • 11-Hydroxy-14,15-epoxyeicosatrienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-epoxyeicosatrienoate
  • (9Z)-11-(3-Pentyloxiran-2-yl)undec-9-enoic acids
  • (9Z)-12,13-Epoxyoctadecenoic acid
  • 12(13)-EpOME
  • 12,13-cis-Epoxyoctadecenoic acid
  • 12,13-Epoxy-9(Z)-octadecenoic acid
genes like me logo Genes that share compounds with CYP4Z1: view

Transcripts for CYP4Z1 Gene

mRNA/cDNA for CYP4Z1 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYP4Z1 Gene

Cytochrome P450, family 4, subfamily Z, polypeptide 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4Z1 Gene

No ASD Table

Relevant External Links for CYP4Z1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYP4Z1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP4Z1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP4Z1 Gene

This gene is overexpressed in Breast - Mammary Tissue (x9.6) and Nerve - Tibial (x4.3).

Protein differential expression in normal tissues from HIPED for CYP4Z1 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYP4Z1 Gene

Protein tissue co-expression partners for CYP4Z1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CYP4Z1 Gene:


SOURCE GeneReport for Unigene cluster for CYP4Z1 Gene:


mRNA Expression by UniProt/SwissProt for CYP4Z1 Gene:

Tissue specificity: Preferentially detected in breast carcinoma tissue and mammary gland, whereas only marginal expression is found in all other tested tissues.
genes like me logo Genes that share expression patterns with CYP4Z1: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP4Z1 Gene

Orthologs for CYP4Z1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYP4Z1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC456834 33
  • 97.25 (n)
CYP4Z1 34
  • 97 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 53 (a)
-- 34
  • 42 (a)
(Mus musculus)
Mammalia Cyp4a12b 34
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 48 (a)
-- 34
  • 41 (a)
-- 34
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
-- 34
  • 47 (a)
-- 34
  • 46 (a)
-- 34
  • 45 (a)
Species where no ortholog for CYP4Z1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CYP4Z1 Gene

Gene Tree for CYP4Z1 (if available)
Gene Tree for CYP4Z1 (if available)
Evolutionary constrained regions (ECRs) for CYP4Z1: view image

Paralogs for CYP4Z1 Gene

(14) SIMAP similar genes for CYP4Z1 Gene using alignment to 1 proteins:

  • CP4Z1_HUMAN Pseudogenes for CYP4Z1 Gene

genes like me logo Genes that share paralogs with CYP4Z1: view

Variants for CYP4Z1 Gene

Sequence variations from dbSNP and Humsavar for CYP4Z1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000007975 -- 47,074,480(+) G/T intron_variant
rs1000386369 -- 47,079,131(+) C/T intron_variant
rs1000443346 -- 47,078,671(+) A/G intron_variant
rs1000511617 -- 47,110,035(+) A/C intron_variant
rs1000700602 -- 47,093,669(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CYP4Z1 Gene

Variant ID Type Subtype PubMed ID
dgv32e212 CNV gain 25503493
dgv80n106 CNV duplication 24896259
esv24824 CNV loss 19812545
esv2763300 CNV gain 21179565
esv3585951 CNV gain 21293372
nsv1009338 CNV gain 25217958
nsv1077760 OTHER inversion 25765185
nsv945929 CNV duplication 23825009

Variation tolerance for CYP4Z1 Gene

Residual Variation Intolerance Score: 89.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP4Z1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4Z1 Gene

Disorders for CYP4Z1 Gene

Additional Disease Information for CYP4Z1

No disorders were found for CYP4Z1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP4Z1 Gene

Publications for CYP4Z1 Gene

  1. Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma. (PMID: 15059886) Rieger MA … Weigle B (Cancer research 2004) 2 3 4 22 58
  2. Conditional regulation of the human CYP4X1 and CYP4Z1 genes. (PMID: 15797250) Savas U … Johnson EF (Archives of biochemistry and biophysics 2005) 3 22 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  4. The competing endogenous RNA network of CYP4Z1 and pseudogene CYP4Z2P exerts an anti-apoptotic function in breast cancer. (PMID: 28236635) Li C … Xi T (FEBS letters 2017) 3 58
  5. Efficient substrate screening and inhibitor testing of human CYP4Z1 using permeabilized recombinant fission yeast. (PMID: 28951277) Yan Q … Bureik M (Biochemical pharmacology 2017) 3 58

Products for CYP4Z1 Gene

Sources for CYP4Z1 Gene

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