Aliases for EIF4G2 Gene
External Ids for EIF4G2 Gene
Previous GeneCards Identifiers for EIF4G2 Gene
Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for EIF4G2 Gene
EIF4G2 (Eukaryotic Translation Initiation Factor 4 Gamma 2) is a Protein Coding gene. Diseases associated with EIF4G2 include Anterograde Amnesia and Amnestic Disorder. Among its related pathways are Regulation of lipid metabolism Insulin signaling-generic cascades and Translational Control. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is EIF4G1.
UniProtKB/Swiss-Prot for EIF4G2 Gene
Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.