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Aliases for EIF4A1 Gene

Aliases for EIF4A1 Gene

  • Eukaryotic Translation Initiation Factor 4A1 2 3 5
  • ATP-Dependent RNA Helicase EIF4A-1 3 4
  • EIF-4A-I 3 4
  • EIF4A-I 3 4
  • EIF4A 3 4
  • DDX2A 3 4
  • Eukaryotic Translation Initiation Factor 4A, Isoform 1 2
  • Eukaryotic Translation Initiation Factor 4A 3
  • Eukaryotic Initiation Factor 4A-I 3
  • Eukaryotic Initiation Factor 4AI 3
  • EC 3.6.4.13 4
  • EIF-4A 3

External Ids for EIF4A1 Gene

Previous HGNC Symbols for EIF4A1 Gene

  • EIF4A

Previous GeneCards Identifiers for EIF4A1 Gene

  • GC17P007880
  • GC17P008215
  • GC17P007418
  • GC17P007676
  • GC17P007416
  • GC17P007404
  • GC17P007476

Summaries for EIF4A1 Gene

GeneCards Summary for EIF4A1 Gene

EIF4A1 (Eukaryotic Translation Initiation Factor 4A1) is a Protein Coding gene. Among its related pathways are Translation Factors and Regulation of lipid metabolism Insulin signaling-generic cascades. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is EIF4A2.

UniProtKB/Swiss-Prot for EIF4A1 Gene

  • ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.

Gene Wiki entry for EIF4A1 Gene

Additional gene information for EIF4A1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4A1 Gene

Genomics for EIF4A1 Gene

GeneHancer (GH) Regulatory Elements for EIF4A1 Gene

Promoters and enhancers for EIF4A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J007571 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE dbSUPER 684.5 +5.5 5453 14.2 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 SNORD10 EIF4A1 CD68 PIR46508 SNORA67 GC17P007772 GC17P007769 GC17P007766 GC17P007764 MPDU1
GH17J007474 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 55 -92.1 -92117 12.5 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC POLR2A ZBTB4 SLC35G6 KIAA0753 DVL2 SNORD10 PFAS CTC1 SNORA48 WRAP53
GH17J008172 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 61.7 +602.3 602261 5.2 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF416 VAMP2 GC17M008543 TMEM107 SNORD118 LOC105371520 DVL2 CNTROB CTC1 WRAP53 POLR2A
GH17J007833 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 29.3 +267.0 267023 12.5 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 KDM6B CHD3 DVL2 PFAS CTC1 WRAP53 CNTROB POLR2A SNORD10 SNORA48
GH17J007233 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 31.3 -334.0 -334047 11.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 DVL2 GABARAP PHF23 CNTROB SNORD10 WRAP53 NEURL4 POLR2A KIAA0753 KCTD11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EIF4A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EIF4A1 gene promoter:
  • AP-1
  • p53
  • PPAR-gamma1
  • PPAR-gamma2
  • CREB

Genomic Locations for EIF4A1 Gene

Genomic Locations for EIF4A1 Gene
chr17:7,572,706-7,579,006
(GRCh38/hg38)
Size:
6,301 bases
Orientation:
Plus strand
chr17:7,476,024-7,482,324
(GRCh37/hg19)
Size:
6,301 bases
Orientation:
Plus strand

Genomic View for EIF4A1 Gene

Genes around EIF4A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4A1 Gene

Proteins for EIF4A1 Gene

  • Protein details for EIF4A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60842-IF4A1_HUMAN
    Recommended name:
    Eukaryotic initiation factor 4A-I
    Protein Accession:
    P60842
    Secondary Accessions:
    • B2R6L8
    • D3DTP9
    • J3QLC4
    • P04765
    • Q5U018
    • Q61516

    Protein attributes for EIF4A1 Gene

    Size:
    406 amino acids
    Molecular mass:
    46154 Da
    Quaternary structure:
    • eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with PAIP1, EIF4E and UPF2. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. May interact with NOM1. Interacts with PDCD4; this interferes with the interaction between EIF4A and EIF4G. Interacts with RBM4. Interacts with human cytomegalovirus/HHV-5 protein UL69.

    Three dimensional structures from OCA and Proteopedia for EIF4A1 Gene

    Alternative splice isoforms for EIF4A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF4A1 Gene

Post-translational modifications for EIF4A1 Gene

  • Ubiquitination at Lys381, Lys369, isoforms=2309, isoforms=2238, Lys237, Lys177, and Lys174
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF4A1 Gene

Domains & Families for EIF4A1 Gene

Gene Families for EIF4A1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

P60842

UniProtKB/Swiss-Prot:

IF4A1_HUMAN :
  • Belongs to the DEAD box helicase family. eIF4A subfamily.
Family:
  • Belongs to the DEAD box helicase family. eIF4A subfamily.
genes like me logo Genes that share domains with EIF4A1: view

Function for EIF4A1 Gene

Molecular function for EIF4A1 Gene

UniProtKB/Swiss-Prot Function:
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Helicase activity and function in translation are inhibited by interaction with PDCD4.
GENATLAS Biochemistry:
eukaryotic,cap structure,translocation factor EIF4A,isoform1,involved in the binding of mRNA to 40S subunit of ribosome,ubiquitous with high expression in skeletal muscle,ovary,DEAD box protein family,tightly linked to CD8 in same orientation

Enzyme Numbers (IUBMB) for EIF4A1 Gene

Phenotypes From GWAS Catalog for EIF4A1 Gene

Gene Ontology (GO) - Molecular Function for EIF4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000339 RNA cap binding TAS 3215517
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA,IEA 22658674
GO:0003725 double-stranded RNA binding IDA 21266579
GO:0003729 mRNA binding TAS 3215517
genes like me logo Genes that share ontologies with EIF4A1: view
genes like me logo Genes that share phenotypes with EIF4A1: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF4A1 Gene

Localization for EIF4A1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF4A1 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EIF4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 NOT nucleus IDA 12426392
GO:0005737 cytoplasm IDA 12426392
GO:0005829 cytosol TAS --
GO:0016020 membrane HDA 19946888
GO:0016281 eukaryotic translation initiation factor 4F complex TAS 9168945
genes like me logo Genes that share ontologies with EIF4A1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF4A1 Gene

Pathways & Interactions for EIF4A1 Gene

genes like me logo Genes that share pathways with EIF4A1: view

Gene Ontology (GO) - Biological Process for EIF4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0006412 translation IEA --
GO:0006413 translational initiation TAS,IEA --
GO:0010468 regulation of gene expression IBA --
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with EIF4A1: view

No data available for SIGNOR curated interactions for EIF4A1 Gene

Drugs & Compounds for EIF4A1 Gene

(4) Drugs for EIF4A1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 202
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(2) Additional Compounds for EIF4A1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with EIF4A1: view

Transcripts for EIF4A1 Gene

mRNA/cDNA for EIF4A1 Gene

Unigene Clusters for EIF4A1 Gene

Eukaryotic translation initiation factor 4A1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4A1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - -
SP8: - - - - - - - - -
SP9: - - -
SP10: -
SP11: -
SP12: -
SP13: -
SP14: - -
SP15: - - - - - - - -
SP16: - - - -
SP17:

ExUns: 12a · 12b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for EIF4A1 Gene

GeneLoc Exon Structure for
EIF4A1
ECgene alternative splicing isoforms for
EIF4A1

Expression for EIF4A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF4A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF4A1 Gene



Protein tissue co-expression partners for EIF4A1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF4A1 Gene:

EIF4A1

SOURCE GeneReport for Unigene cluster for EIF4A1 Gene:

Hs.129673

Evidence on tissue expression from TISSUES for EIF4A1 Gene

  • Liver(5)
  • Lung(5)
  • Nervous system(5)
  • Pancreas(4.8)
  • Skin(4.8)
  • Intestine(4.7)
  • Eye(4.6)
  • Heart(4.6)
  • Bone marrow(4.5)
  • Kidney(4.5)
  • Stomach(4.2)
  • Blood(4.1)
  • Bone(3.6)
  • Muscle(3.4)
  • Spleen(2.5)
  • Lymph node(2.2)
  • Adrenal gland(2.1)
  • Gall bladder(2.1)
genes like me logo Genes that share expression patterns with EIF4A1: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF4A1 Gene

Orthologs for EIF4A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF4A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF4A1 34 33
  • 99.26 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF4A1 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF4A1 34 33
  • 92.94 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Eif4a1 16 34 33
  • 92.61 (n)
rat
(Rattus norvegicus)
Mammalia Eif4a1 33
  • 92.45 (n)
dog
(Canis familiaris)
Mammalia EIF4A1 34 34 33
  • 92.12 (n)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia EIF4A1 34
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF4A1 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif4a1 33
  • 81.03 (n)
zebrafish
(Danio rerio)
Actinopterygii eif4a1b 34
  • 89 (a)
OneToOne
eif4a1a 33
  • 78.9 (n)
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5074 33
fruit fly
(Drosophila melanogaster)
Insecta eIF-4a 34 35
  • 73 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea inf-1 34 35
  • 69 (a)
ManyToMany
F57B9.3 34 35
  • 52 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR253C 33
  • 64.57 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05731g 33
  • 62.94 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF2 33
  • 62.25 (n)
FAL1 34
  • 57 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G72730 33
  • 64.53 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.2781 33
wheat
(Triticum aestivum)
Liliopsida Ta.18 33
rice
(Oryza sativa)
Liliopsida Os.458 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10997 34
  • 80 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU07420 33
  • 70.51 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1006.07