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Aliases for LCTL Gene

Aliases for LCTL Gene

  • Lactase Like 2 3 5
  • Klotho/Lactase-Phlorizin Hydrolase-Related Protein 3 4
  • KL Lactase Phlorizin Hydrolase 2 3
  • Klotho Gamma 2 3
  • KLPH 3 4
  • Lactase-Like Protein 3
  • KLG 3

External Ids for LCTL Gene

Previous GeneCards Identifiers for LCTL Gene

  • GC15M064628
  • GC15M066840
  • GC15M043675

Summaries for LCTL Gene

Entrez Gene Summary for LCTL Gene

  • This gene encodes a member of family 1 glycosidases. Glycosidases are enzymes that hydrolyze glycosidic bonds and are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved glutamic acid residues, which are required for enzymatic activity. The mouse ortholog of this protein has been characterized and has a domain structure of an N-terminal signal peptide, glycosidase domain, transmembrane domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

GeneCards Summary for LCTL Gene

LCTL (Lactase Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity, hydrolyzing O-glycosyl compounds. An important paralog of this gene is LCT.

Additional gene information for LCTL Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LCTL Gene

Genomics for LCTL Gene

GeneHancer (GH) Regulatory Elements for LCTL Gene

Promoters and enhancers for LCTL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J066565 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 656.4 -0.4 -369 2.3 YBX3 PKNOX1 ARNT ARID4B SIN3A DMAP1 NFXL1 BATF IRF4 RAD21 LCTL TIPIN ENSG00000261351 LINC01169
GH15J066654 Enhancer 1.2 Ensembl ENCODE dbSUPER 6.2 -89.2 -89189 2.3 SIX4 CTCF PKNOX1 KLF1 RB1 RFX5 CCNT2 ZFHX2 CTBP1 NCOR1 TIPIN ZWILCH LCTL GC15P070014 LINC01169
GH15J066577 Enhancer 1 FANTOM5 Ensembl ENCODE 0.4 -12.4 -12383 0.9 JUND RBAK JUN ZMYM3 ZNF24 MYC ENSG00000260773 INTS14 RPL4 ZWILCH SNORD18A SNORD16 SNAPC5 MAP2K1 TIPIN DIS3L
GH15J066582 Enhancer 0.7 ENCODE 0.4 -15.8 -15819 0.2 HDGF MEIS2 PKNOX1 FOXA2 ARNT GTF2E2 CC2D1A POLR2A AFF1 L3MBTL2 LINC01169 TIPIN LCTL
GH15J066573 Enhancer 0.5 ENCODE 0.4 -8.2 -8222 2 PKNOX1 IKZF1 PRDM10 ZNF24 RPL4 ZWILCH SNORD16 SNORD18A SNAPC5 TIPIN LCTL LINC01169
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LCTL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LCTL gene promoter:
  • PPAR-alpha
  • XBP-1
  • AP-1
  • c-Myb
  • Elk-1
  • AREB6
  • C/EBPalpha
  • MRF-2
  • USF1
  • Bach2

Genomic Locations for LCTL Gene

Genomic Locations for LCTL Gene
18,801 bases
Minus strand
18,801 bases
Minus strand

Genomic View for LCTL Gene

Genes around LCTL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LCTL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LCTL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCTL Gene

Proteins for LCTL Gene

  • Protein details for LCTL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lactase-like protein
    Protein Accession:
    Secondary Accessions:
    • B3KQY0

    Protein attributes for LCTL Gene

    567 amino acids
    Molecular mass:
    65088 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LCTL Gene


neXtProt entry for LCTL Gene

Post-translational modifications for LCTL Gene

  • Glycosylation at posLast=245245, posLast=171171, and isoforms=80
  • Modification sites at PhosphoSitePlus

Other Protein References for LCTL Gene

Antibody Products

  • R&D Systems Antibodies for LCTL (Lactase-like Protein/LCTL)
  • Boster Bio Antibodies for LCTL

No data available for DME Specific Peptides for LCTL Gene

Domains & Families for LCTL Gene

Gene Families for LCTL Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.
  • Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.
genes like me logo Genes that share domains with LCTL: view

Function for LCTL Gene

Phenotypes From GWAS Catalog for LCTL Gene

Gene Ontology (GO) - Molecular Function for LCTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008422 beta-glucosidase activity IBA --
genes like me logo Genes that share ontologies with LCTL: view
genes like me logo Genes that share phenotypes with LCTL: view

Animal Models for LCTL Gene

MGI Knock Outs for LCTL:

Animal Model Products

  • Taconic Biosciences Mouse Models for LCTL

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LCTL Gene

Localization for LCTL Gene

Subcellular locations from UniProtKB/Swiss-Prot for LCTL Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LCTL gene
Compartment Confidence
endoplasmic reticulum 4
peroxisome 2
plasma membrane 1
extracellular 1
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LCTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005903 brush border IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LCTL: view

Pathways & Interactions for LCTL Gene

No Data Available

Gene Ontology (GO) - Biological Process for LCTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:1901657 glycosyl compound metabolic process IBA --
genes like me logo Genes that share ontologies with LCTL: view

No data available for Pathways by source and SIGNOR curated interactions for LCTL Gene

Drugs & Compounds for LCTL Gene

(5) Drugs for LCTL Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2s)-Hydroxy(4-Hydroxyphenyl)Ethanenitrile Experimental Pharma Target 0
2,4-Dihydroxy-7-(Methyloxy)-2h-1,4-Benzoxazin-3(4h)-One Experimental Pharma Target 0
Beta-D-Glucose Experimental Pharma Target 0
Nojirimycine Tetrazole Experimental Pharma Target 0
genes like me logo Genes that share compounds with LCTL: view

Transcripts for LCTL Gene

mRNA/cDNA for LCTL Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LCTL Gene

Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LCTL Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -
SP2: - -

Relevant External Links for LCTL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LCTL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LCTL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LCTL Gene

This gene is overexpressed in Nerve - Tibial (x23.4) and Brain - Spinal cord (cervical c-1) (x7.6).

NURSA nuclear receptor signaling pathways regulating expression of LCTL Gene:


SOURCE GeneReport for Unigene cluster for LCTL Gene:


Evidence on tissue expression from TISSUES for LCTL Gene

  • Eye(4.6)
  • Pancreas(3.5)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with LCTL: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LCTL Gene

Orthologs for LCTL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LCTL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LCTL 34 33
  • 99.53 (n)
(Canis familiaris)
Mammalia LCTL 34 33
  • 89.01 (n)
(Bos Taurus)
Mammalia LCTL 34 33
  • 88.75 (n)
(Mus musculus)
Mammalia Lctl 16 34 33
  • 83.24 (n)
(Monodelphis domestica)
Mammalia LCTL 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia LCTL 34
  • 67 (a)
(Anolis carolinensis)
Reptilia LCTL 34
  • 36 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lctl 33
  • 70.19 (n)
(Danio rerio)
Actinopterygii lctlb 34 33
  • 68.74 (n)
lctla 34
  • 64 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006425 33
  • 54.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9701 34
  • 39 (a)
(Caenorhabditis elegans)
Secernentea klo-1 34
  • 33 (a)
klo-2 34
  • 32 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons BGLU40 33
  • 50.84 (n)
(Oryza sativa)
Liliopsida Os03g0212800 33
  • 53.2 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00130 33
  • 49.93 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
Species where no ortholog for LCTL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LCTL Gene

Gene Tree for LCTL (if available)
Gene Tree for LCTL (if available)
Evolutionary constrained regions (ECRs) for LCTL: view image

Paralogs for LCTL Gene

Paralogs for LCTL Gene

(3) SIMAP similar genes for LCTL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LCTL: view

Variants for LCTL Gene

Sequence variations from dbSNP and Humsavar for LCTL Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000012831 -- 66,552,667(-) C/A/T intron_variant
rs1000356251 -- 66,553,653(-) G/T intron_variant
rs1000478294 -- 66,547,148(-) T/A downstream_transcript_variant
rs1000815299 -- 66,548,784(-) A/G intron_variant
rs1000831007 -- 66,565,477(-) G/A 5_prime_UTR_variant, intron_variant

Variation tolerance for LCTL Gene

Residual Variation Intolerance Score: 61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.00; 68.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LCTL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LCTL Gene

Disorders for LCTL Gene

Additional Disease Information for LCTL

No disorders were found for LCTL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LCTL Gene

Publications for LCTL Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  4. Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure. (PMID: 12084582) Ito S … Nabeshima Y (Biochimica et biophysica acta 2002) 2 3 58
  5. Short hairpin RNA screen indicates that Klotho beta/FGF19 protein overcomes stasis in human colonic epithelial cells. (PMID: 22020932) Kim J … Wright WE (The Journal of biological chemistry 2011) 3 58

Products for LCTL Gene

Sources for LCTL Gene

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