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Aliases for AGTR1 Gene

Aliases for AGTR1 Gene

  • Angiotensin II Receptor Type 1 2 3 5
  • AGTR1B 3 4
  • AT1AR 3 4
  • AT1BR 3 4
  • AT2R1 3 4
  • AT1 3 4
  • Type-1B Angiotensin II Receptor 3
  • Type-1 Angiotensin II Receptor 3
  • Angiotensin II Type-1 Receptor 4
  • Angiotensin Receptor 1B 2
  • AGTR1A 4
  • AT2R1B 4
  • HAT1R 3
  • AG2S 3
  • AT1B 3
  • AT1R 3

External Ids for AGTR1 Gene

Previous HGNC Symbols for AGTR1 Gene

  • AGTR1B

Previous GeneCards Identifiers for AGTR1 Gene

  • GC03P145407
  • GC03P149300
  • GC03P149697
  • GC03P149736
  • GC03P149898
  • GC03P148415
  • GC03P145788

Summaries for AGTR1 Gene

Entrez Gene Summary for AGTR1 Gene

  • Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for AGTR1 Gene

AGTR1 (Angiotensin II Receptor Type 1) is a Protein Coding gene. Diseases associated with AGTR1 include Renal Tubular Dysgenesis and Hypertension, Essential. Among its related pathways are Apelin signaling pathway and Development Angiotensin activation of ERK. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and angiotensin type II receptor activity. An important paralog of this gene is AGTR2.

UniProtKB/Swiss-Prot for AGTR1 Gene

  • Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Tocris Summary for AGTR1 Gene

  • The angiotensin1 receptor (AT1) is a member of the angiotensin group of G-protein-coupled receptors that also includes AT2 and AT4. They are located primarily in the liver, kidney, adrenal gland and lung. AT1 receptors preferentially bind angiotensin II.

Gene Wiki entry for AGTR1 Gene

Additional gene information for AGTR1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGTR1 Gene

Genomics for AGTR1 Gene

GeneHancer (GH) Regulatory Elements for AGTR1 Gene

Promoters and enhancers for AGTR1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J148697 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 664.9 +0.2 154 1.3 DRAP1 PKNOX1 USF1 TAF1 MAX ARID4B SIN3A ZNF48 RAD21 YY1 AGTR1 GC03M148696 RPL38P1 CPB1
GH03J148648 Enhancer 0.7 Ensembl ENCODE 19.3 -48.8 -48799 1.4 JUND FOSL2 FOS MAFK AGTR1 GC03M148696 LOC105374150
GH03J148723 Enhancer 0.7 Ensembl ENCODE 11.5 +26.0 26045 1 SP1 JUND SMAD4 FOSL2 FOS HOMEZ RARA AGTR1 RPL38P1 CPB1
GH03J148643 Enhancer 0.8 Ensembl ENCODE 8.5 -54.1 -54054 1.3 BACH1 CEBPB NR2F2 SP1 FOSL2 NFE2 MAFK NFE2L2 AGTR1 GC03M148696 LOC105374150
GH03J148642 Enhancer 0.5 Ensembl ENCODE 8.5 -54.9 -54917 0.3 POLR2A AGTR1 GC03M148696 LOC105374150
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AGTR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AGTR1 gene promoter:
  • AP-2alpha isoform 3
  • AP-2alpha isoform 2
  • AP-2alpha
  • AP-2alphaA

Genomic Locations for AGTR1 Gene

Genomic Locations for AGTR1 Gene
45,225 bases
Plus strand
45,225 bases
Plus strand

Genomic View for AGTR1 Gene

Genes around AGTR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGTR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGTR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGTR1 Gene

Proteins for AGTR1 Gene

  • Protein details for AGTR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Type-1 angiotensin II receptor
    Protein Accession:
    Secondary Accessions:
    • Q13725
    • Q8TBK4

    Protein attributes for AGTR1 Gene

    359 amino acids
    Molecular mass:
    41061 Da
    Quaternary structure:
    • Interacts with MAS1 (Probable) (PubMed:15809376). Interacts with ARRB1 (By similarity). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (PubMed:26460884).

    Three dimensional structures from OCA and Proteopedia for AGTR1 Gene

neXtProt entry for AGTR1 Gene

Post-translational modifications for AGTR1 Gene

  • C-terminal Ser or Thr residues may be phosphorylated.
  • Glycosylation at Asn188, posLast=176176, and Asn4
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for AGTR1 Gene

Domains & Families for AGTR1 Gene

Gene Families for AGTR1 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with AGTR1: view

Function for AGTR1 Gene

Molecular function for AGTR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
GENATLAS Biochemistry:
angiotensin II (type-1) receptor,G protein coupled receptor superfamily,including two subtypes AT1A and AT1B,major blood pressure regulator (activation of vascular growth),inhibiting adenylate cyclase,activating phospholipase C and A2,contributing in association with ACE to the risk of coronary disease,localized in the substantia nigra, the caudate nucleus and putamen (neuromodulator),blood vessels ,heart (conduction system) and kidney (renal medullary interstitial cells)

Phenotypes From GWAS Catalog for AGTR1 Gene

Gene Ontology (GO) - Molecular Function for AGTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001596 angiotensin type I receptor activity IPI 1378723
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004945 angiotensin type II receptor activity IDA,IEA 1567413
GO:0005515 protein binding IPI 1378723
genes like me logo Genes that share ontologies with AGTR1: view
genes like me logo Genes that share phenotypes with AGTR1: view

Human Phenotype Ontology for AGTR1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for AGTR1 Gene

MGI Knock Outs for AGTR1:

Animal Model Products

Clone Products

  • Addgene plasmids for AGTR1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for AGTR1 Gene

Localization for AGTR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGTR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGTR1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
mitochondrion 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for AGTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IC 1378723
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,NAS 8135787
genes like me logo Genes that share ontologies with AGTR1: view

Pathways & Interactions for AGTR1 Gene

genes like me logo Genes that share pathways with AGTR1: view

SIGNOR curated interactions for AGTR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for AGTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 17159080
GO:0001822 kidney development IMP 16116425
GO:0002018 renin-angiotensin regulation of aldosterone production NAS 17159080
GO:0002034 regulation of blood vessel diameter by renin-angiotensin IC 10993080
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin IC 1378723
genes like me logo Genes that share ontologies with AGTR1: view

Drugs & Compounds for AGTR1 Gene

(155) Drugs for AGTR1 Gene - From: DrugBank, PharmGKB, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Angiotensin II Approved, Investigational Pharma Full agonist, Agonist, Target, agonist Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex. 1217
Losartan Approved Pharma Antagonist, antagonist, Target 295
Olmesartan Approved, Investigational Pharma Antagonist, antagonist, Target 128
Valsartan Approved, Investigational Pharma Antagonist, antagonist, Target Angiotensin II AT1 receptor antagonist, High affinity, selective AT1 antagonist 306
Irbesartan Approved, Investigational Pharma Antagonist, antagonist, Target Angiotensin II inhibitor 102

(50) Additional Compounds for AGTR1 Gene - From: Novoseek, HMDB, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
angiotensin I
  • I, angiotensin
Full agonist, Agonist
Full agonist, Agonist
Full agonist, Agonist

(5) Tocris Compounds for AGTR1 Gene

Compound Action Cas Number
Azilsartan Potent AT1 receptor inverse agonist; antihypertensive 147403-03-0
EMD 66684 Potent, selective non-peptide AT1 antagonist 1216884-39-7
Losartan potassium Selective, non-peptide AT1 antagonist 124750-99-8
Valsartan High affinity, selective AT1 antagonist 137862-53-4
ZD 7155 hydrochloride Selective non-peptide AT1 antagonist 146709-78-6
genes like me logo Genes that share compounds with AGTR1: view

Transcripts for AGTR1 Gene

mRNA/cDNA for AGTR1 Gene

Unigene Clusters for AGTR1 Gene

Angiotensin II receptor, type 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for AGTR1

Alternative Splicing Database (ASD) splice patterns (SP) for AGTR1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - - - -
SP3: -
SP4: - - - - -
SP5: -

Relevant External Links for AGTR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AGTR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AGTR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGTR1 Gene

This gene is overexpressed in Adipose - Subcutaneous (x7.4), Liver (x7.0), Adipose - Visceral (Omentum) (x4.5), and Adrenal Gland (x4.1).

Protein differential expression in normal tissues from HIPED for AGTR1 Gene

This gene is overexpressed in Cerebrospinal fluid (61.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AGTR1 Gene

Protein tissue co-expression partners for AGTR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of AGTR1 Gene:


SOURCE GeneReport for Unigene cluster for AGTR1 Gene:


mRNA Expression by UniProt/SwissProt for AGTR1 Gene:

Tissue specificity: Liver, lung, adrenal and adrenocortical adenomas.

Evidence on tissue expression from TISSUES for AGTR1 Gene

  • Blood(4.6)
  • Liver(4.6)
  • Nervous system(4.5)
  • Kidney(3.2)
  • Heart(3.1)
  • Muscle(3)
  • Adrenal gland(2.9)

Phenotype-based relationships between genes and organs from Gene ORGANizer for AGTR1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeleton
  • urinary
Head and neck:
  • brain
  • ear
  • eye
  • face
  • head
  • skull
  • heart
  • lung
  • kidney
  • placenta
  • uterus
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
  • blood vessel
genes like me logo Genes that share expression patterns with AGTR1: view

Orthologs for AGTR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AGTR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AGTR1 34 33
  • 99.72 (n)
(Mus musculus)
Mammalia Agtr1b 34
  • 93 (a)
Agtr1a 16 34 33
  • 87 (n)
(Canis familiaris)
Mammalia AGTR1 34 33
  • 92.57 (n)
(Bos Taurus)
Mammalia AGTR1 34 33
  • 91.18 (n)
(Monodelphis domestica)
Mammalia AGTR1 34
  • 87 (a)
(Rattus norvegicus)
Mammalia Agtr1a 33
  • 86.35 (n)
(Ornithorhynchus anatinus)
Mammalia AGTR1 34
  • 71 (a)
(Gallus gallus)
Aves AGTR1 34 33
  • 73.91 (n)
(Anolis carolinensis)
Reptilia AGTR1 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia agtr1 33
  • 65.66 (n)
African clawed frog
(Xenopus laevis)
Amphibia agtr1-A 33
(Danio rerio)
Actinopterygii agtr1a 34
  • 47 (a)
agtr1b 34
  • 45 (a)
Species where no ortholog for AGTR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGTR1 Gene

Gene Tree for AGTR1 (if available)
Gene Tree for AGTR1 (if available)
Evolutionary constrained regions (ECRs) for AGTR1: view image

Paralogs for AGTR1 Gene

Variants for AGTR1 Gene

Sequence variations from dbSNP and Humsavar for AGTR1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs104893677 pathogenic, Renal dysplasia, Renal tubular dysgenesis (RTD) [MIM:267430] 148,741,880(+) C/T coding_sequence_variant, missense_variant
rs12721273 likely-benign, Renal dysplasia 148,743,014(+) T/G downstream_transcript_variant
rs12721276 likely-benign, Renal dysplasia 148,742,576(+) C/A 3_prime_UTR_variant
rs140542820 uncertain-significance, Renal dysplasia 148,741,375(+) G/A coding_sequence_variant, missense_variant
rs143432118 uncertain-significance, Renal dysplasia 148,742,043(+) G/A coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for AGTR1 Gene

Variant ID Type Subtype PubMed ID
dgv1417e212 CNV loss 25503493

Variation tolerance for AGTR1 Gene

Residual Variation Intolerance Score: 45.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AGTR1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGTR1 Gene

Disorders for AGTR1 Gene

MalaCards: The human disease database

(54) MalaCards diseases for AGTR1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search AGTR1 in MalaCards View complete list of genes associated with diseases


  • Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). {ECO:0000269 PubMed:16116425}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for AGTR1 Gene

Bartter syndrome characterized by hypokalemic alkalosis,normal or hypercalciuria,normal magnesemia,early onset and hyperreninemia,hyperaldosteronism,hyperplasia of the juxtaglomerular apparatus

Additional Disease Information for AGTR1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with AGTR1: view

Publications for AGTR1 Gene

  1. Renin-angiotensin system and alpha-adducin gene polymorphisms and their relation to responses to antihypertensive drugs: results from the GENRES study. (PMID: 19057513) Suonsyrjä T … Hiltunen TP (American journal of hypertension 2009) 3 22 44 58
  2. The association between arterial stiffness and the angiotensin II type 1 receptor (A1166C) polymorphism is influenced by the use of cardiovascular medication. (PMID: 19145770) Plat AW … Kroon AA (Journal of hypertension 2009) 3 22 44 58
  3. Impact of renin-angiotensin system polymorphisms on renal haemodynamic responsiveness to acute angiotensin-converting enzyme inhibition in type 2 diabetes mellitus. (PMID: 19286758) Volkan-Salanci B … Erbas B (Journal of the renin-angiotensin-aldosterone system : JRAAS 2009) 3 22 44 58
  4. Polymorphism in the angiotensin II type 1 receptor (AGTR1) is associated with age at diagnosis in pulmonary arterial hypertension. (PMID: 19332265) Chung WK … Morse JH (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2009) 3 22 44 58
  5. The influence of six cardiovascular polymorphisms on a first event of ischemic heart disease is modified by sex and age. (PMID: 19779330) Plat AW … Kroon AA (Coronary artery disease 2009) 3 22 44 58

Products for AGTR1 Gene

  • Addgene plasmids for AGTR1

Sources for AGTR1 Gene

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