Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DUSP1 Gene

Aliases for DUSP1 Gene

  • Dual Specificity Phosphatase 1 2 3 5
  • Mitogen-Activated Protein Kinase Phosphatase 1 3 4
  • Dual Specificity Protein Phosphatase HVH1 3 4
  • Protein-Tyrosine Phosphatase CL100 3 4
  • MAP Kinase Phosphatase 1 3 4
  • PTPN10 3 4
  • CL100 3 4
  • MKP-1 3 4
  • MKP1 3 4
  • Serine/Threonine Specific Protein Phosphatase 3
  • Dual Specificity Protein Phosphatase 1 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • CL 100 3
  • HVH1 3
  • VH1 4

External Ids for DUSP1 Gene

Previous HGNC Symbols for DUSP1 Gene

  • PTPN10

Previous GeneCards Identifiers for DUSP1 Gene

  • GC05M172450
  • GC05M172896
  • GC05M172130
  • GC05M172176
  • GC05M172127
  • GC05M167290
  • GC05M172195

Summaries for DUSP1 Gene

Entrez Gene Summary for DUSP1 Gene

  • The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017]

GeneCards Summary for DUSP1 Gene

DUSP1 (Dual Specificity Phosphatase 1) is a Protein Coding gene. Diseases associated with DUSP1 include Multiple Cranial Nerve Palsy and Amyotrophic Lateral Sclerosis 9. Among its related pathways are Immune response Fc epsilon RI pathway and RET signaling. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP4.

UniProtKB/Swiss-Prot for DUSP1 Gene

  • Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both Thr-183 and Tyr-185, regulating its activity during the meiotic cell cycle.

Gene Wiki entry for DUSP1 Gene

Additional gene information for DUSP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP1 Gene

Genomics for DUSP1 Gene

GeneHancer (GH) Regulatory Elements for DUSP1 Gene

Promoters and enhancers for DUSP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J172763 Promoter/Enhancer 3.1 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 682 -1.0 -999 16.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 DUSP1 CREBRF KLF3P1 ERGIC1 SH3PXD2B ENSG00000253628 ENSG00000253172 SMIM23 BOD1 EFCAB9
GH05J172884 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 20.4 -115.5 -115547 4.7 FOXA2 SIN3A RAD21 RARA ETS1 YY1 EGR1 THAP11 RXRA CEBPB DUSP1 ENSG00000253445 ERGIC1 ENSG00000254295 RPL26L1 LOC100268168 CREBRF
GH05J172877 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19.1 -109.6 -109565 6.5 HDGF PKNOX1 ATF1 IRF4 ZNF766 ZNF207 ZNF143 ZFP91 FOS ATF7 DUSP1 CREBRF ERGIC1 ENSG00000254295 RPL26L1 LOC100268168 SH3PXD2B BNIP1
GH05J172832 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.8 -64.5 -64494 6.5 PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A FEZF1 YY1 ZNF143 PAF1 ERGIC1 CREBRF DUSP1 RPL26L1
GH05J172894 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 16.4 -129.7 -129748 12.7 CLOCK MLX FEZF1 IRF4 YY1 E2F8 ZNF416 MEF2D SSRP1 GLIS1 KLF3P1 BOD1 BNIP1 UBTD2 ERGIC1 DUSP1 ENSG00000253628 ENSG00000253172 FBXW11 EFCAB9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUSP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DUSP1 gene promoter:
  • CREB
  • deltaCREB
  • Sp1
  • Elk-1
  • STAT3

Genomic Locations for DUSP1 Gene

Genomic Locations for DUSP1 Gene
chr5:172,768,090-172,771,200
(GRCh38/hg38)
Size:
3,111 bases
Orientation:
Minus strand
chr5:172,195,093-172,198,203
(GRCh37/hg19)
Size:
3,111 bases
Orientation:
Minus strand

Genomic View for DUSP1 Gene

Genes around DUSP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP1 Gene

Proteins for DUSP1 Gene

  • Protein details for DUSP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28562-DUS1_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 1
    Protein Accession:
    P28562
    Secondary Accessions:
    • D3DQL9
    • Q2V508

    Protein attributes for DUSP1 Gene

    Size:
    367 amino acids
    Molecular mass:
    39298 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP1 Gene

neXtProt entry for DUSP1 Gene

Post-translational modifications for DUSP1 Gene

  • Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation.
  • Ubiquitination at posLast=280280
  • Modification sites at PhosphoSitePlus

Other Protein References for DUSP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP1 Gene

Domains & Families for DUSP1 Gene

Gene Families for DUSP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

P28562

UniProtKB/Swiss-Prot:

DUS1_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP1: view

Function for DUSP1 Gene

Molecular function for DUSP1 Gene

UniProtKB/Swiss-Prot Function:
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both Thr-183 and Tyr-185, regulating its activity during the meiotic cell cycle.
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Induction:
By oxidative stress and heat shock.
GENATLAS Biochemistry:
dual specificity (tyr/thr) phosphatase 1,reversing the activation of mitogen-activated protein (MAP) kinase family,vaccinia virus phosphatase VH1-like 1,induced by EGF,predominantly expressed in lung,placenta,pancreas,involved in signal transduction

Enzyme Numbers (IUBMB) for DUSP1 Gene

Phenotypes From GWAS Catalog for DUSP1 Gene

Gene Ontology (GO) - Molecular Function for DUSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity TAS 1406996
GO:0005515 protein binding IPI 10617468
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IDA 17498703
genes like me logo Genes that share ontologies with DUSP1: view
genes like me logo Genes that share phenotypes with DUSP1: view

Animal Models for DUSP1 Gene

MGI Knock Outs for DUSP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for DUSP1

Clone Products

  • Addgene plasmids for DUSP1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP1 Gene

Localization for DUSP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP1 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 2
extracellular 2
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DUSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 7593328
GO:0005737 cytoplasm IDA 7593328
genes like me logo Genes that share ontologies with DUSP1: view

Pathways & Interactions for DUSP1 Gene

SuperPathways for DUSP1 Gene

SuperPathway Contained pathways
1 RET signaling
2 MAPK signaling pathway
3 Developmental Biology
4 Cytokine Signaling in Immune system
5 Innate Immune System
genes like me logo Genes that share pathways with DUSP1: view

SIGNOR curated interactions for DUSP1 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for DUSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity ISS --
GO:0001706 endoderm formation IBA --
GO:0006470 protein dephosphorylation IEA,IBA --
GO:0006979 response to oxidative stress TAS 1406996
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with DUSP1: view

Drugs & Compounds for DUSP1 Gene

(36) Drugs for DUSP1 Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Salbutamol Approved, Vet_approved Pharma Partial agonist, Agonist 0
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Sanguinarine chloride Pharma Inhibitor of PP2C and MKP-1 0

(21) Additional Compounds for DUSP1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14265-44-2
genes like me logo Genes that share compounds with DUSP1: view

Transcripts for DUSP1 Gene

mRNA/cDNA for DUSP1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(622) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DUSP1 Gene

Dual specificity phosphatase 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for DUSP1

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2:
SP3: - -
SP4:

Relevant External Links for DUSP1 Gene

GeneLoc Exon Structure for
DUSP1
ECgene alternative splicing isoforms for
DUSP1

Expression for DUSP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUSP1 Gene

mRNA differential expression in normal tissues according to GTEx for DUSP1 Gene

This gene is overexpressed in Whole Blood (x5.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DUSP1 Gene



NURSA nuclear receptor signaling pathways regulating expression of DUSP1 Gene:

DUSP1

SOURCE GeneReport for Unigene cluster for DUSP1 Gene:

Hs.171695

mRNA Expression by UniProt/SwissProt for DUSP1 Gene:

P28562-DUS1_HUMAN
Tissue specificity: Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.

Evidence on tissue expression from TISSUES for DUSP1 Gene

  • Nervous system(4.8)
  • Lung(4.3)
  • Eye(3.9)
  • Muscle(3.9)
  • Heart(3.5)
  • Kidney(3.5)
  • Blood(3.4)
  • Liver(3.4)
  • Intestine(3.3)
  • Pancreas(3.3)
  • Bone marrow(3)
  • Skin(3)
  • Adrenal gland(2.9)
  • Spleen(2.9)
  • Thyroid gland(2.7)
  • Lymph node(2.6)
  • Gall bladder(2.5)
  • Stomach(2.5)
  • Bone(2.3)
genes like me logo Genes that share expression patterns with DUSP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP1 Gene

Orthologs for DUSP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DUSP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP1 34 33
  • 99.73 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DUSP1 34 33
  • 92.82 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp1 16 34 33
  • 90.19 (n)
rat
(Rattus norvegicus)
Mammalia Dusp1 33
  • 89.55 (n)
oppossum
(Monodelphis domestica)
Mammalia DUSP1 34
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUSP1 34 33
  • 84.83 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP1 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUSP1 34 33
  • 80.37 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP1 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp1 33
  • 70.59 (n)
Str.6379 33
zebrafish
(Danio rerio)
Actinopterygii dusp1 34 33
  • 68.53 (n)
OneToOne
Dr.2413 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPS1 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
OneToMany
Cin.5253 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5253 33
Species where no ortholog for DUSP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP1 Gene

ENSEMBL:
Gene Tree for DUSP1 (if available)
TreeFam:
Gene Tree for DUSP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DUSP1: view image

Paralogs for DUSP1 Gene

Paralogs for DUSP1 Gene

(8) SIMAP similar genes for DUSP1 Gene using alignment to 1 proteins:

  • DUS1_HUMAN
genes like me logo Genes that share paralogs with DUSP1: view

Variants for DUSP1 Gene

Sequence variations from dbSNP and Humsavar for DUSP1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000222677 -- 172,772,183(-) C/T upstream_transcript_variant
rs1000517485 -- 172,771,375(-) C/T upstream_transcript_variant
rs1000685993 -- 172,770,999(-) G/T 5_prime_UTR_variant
rs1000823494 -- 172,771,213(-) G/A upstream_transcript_variant
rs1001351105 -- 172,767,879(-) T/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP1 Gene

Variant ID Type Subtype PubMed ID
esv2759393 CNV gain 17122850
nsv600294 CNV loss 21841781

Variation tolerance for DUSP1 Gene

Residual Variation Intolerance Score: 34.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 52.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP1 Gene

Human Gene Mutation Database (HGMD)
DUSP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP1 Gene

Disorders for DUSP1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for DUSP1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
multiple cranial nerve palsy
  • multiple cranial nerve palsies
amyotrophic lateral sclerosis 9
  • als9
amyotrophic lateral sclerosis 7
  • als7
- elite association - COSMIC cancer census association via MalaCards
Search DUSP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DUSP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DUSP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP1 Gene

Publications for DUSP1 Gene

  1. Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene. (PMID: 8106404) Kwak SP … Dixon JE (The Journal of biological chemistry 1994) 3 4 22 58
  2. Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase. (PMID: 1406996) Keyse SM … Emslie EA (Nature 1992) 2 3 4 58
  3. Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients. (PMID: 20805296) Coulthard LR … McDermott MF (Annals of the rheumatic diseases 2011) 3 44 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Angiotensin II signaling via type 2 receptors in a human model of vascular hyporeactivity: implications for hypertension. (PMID: 19797979) Calò LA … Pessina AC (Journal of hypertension 2010) 3 22 58

Products for DUSP1 Gene