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Aliases for TSC22D3 Gene

Aliases for TSC22D3 Gene

  • TSC22 Domain Family Member 3 2 3 5
  • Glucocorticoid-Induced Leucine Zipper Protein 3 4
  • Delta Sleep-Inducing Peptide Immunoreactor 3 4
  • DSIP-Immunoreactive Peptide 3 4
  • TSC-22-Like Protein 3 4
  • TSC-22R 3 4
  • DSIPI 3 4
  • GILZ 3 4
  • Delta Sleep Inducing Peptide, Immunoreactor 2
  • DSIP-Immunoreactive Leucine Zipper Protein 3
  • Glucocorticoid-Induced Leucine Zipper 2
  • TSC22 Domain Family, Member 3 2
  • TSC22 Domain Family Protein 3 3
  • TSC-22 Related Protein 3
  • TSC-22-Related Protein 4
  • Protein DIP 4
  • HDIP 4
  • DIP 3

External Ids for TSC22D3 Gene

Previous HGNC Symbols for TSC22D3 Gene

  • DSIPI

Previous GeneCards Identifiers for TSC22D3 Gene

  • GC0XM106763
  • GC0XM106956
  • GC0XM096580

Summaries for TSC22D3 Gene

Entrez Gene Summary for TSC22D3 Gene

  • This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor κB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for TSC22D3 Gene

TSC22D3 (TSC22 Domain Family Member 3) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and MRF binding. An important paralog of this gene is TSC22D1.

UniProtKB/Swiss-Prot for TSC22D3 Gene

  • Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).

Gene Wiki entry for TSC22D3 Gene

Additional gene information for TSC22D3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSC22D3 Gene

Genomics for TSC22D3 Gene

GeneHancer (GH) Regulatory Elements for TSC22D3 Gene

Promoters and enhancers for TSC22D3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI107708 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 578 +63.0 63030 10.9 HDGF PKNOX1 SMAD1 ARNT SIN3A YBX1 YY1 ZNF143 FOS JUNB TSC22D3 RBM41 MORC4 MID2 LOC101928335 ATG4A GC0XM107728 GC0XM107676
GH0XI107774 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.5 1512 3.3 PKNOX1 ATF1 SMAD1 ZFP64 SIN3A FEZF1 YY1 GLIS2 ARID2 ZNF143 NCBP2L TSC22D3 MID2
GH0XI107778 Enhancer 0.2 ENCODE 550.8 -1.0 -1024 0.2 TSC22D3 NCBP2L MID2
GH0XI107672 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 25.9 +100.9 100943 7.7 PKNOX1 CLOCK ARNT SIN3A FEZF1 ZNF2 IRF4 POLR2B ZNF213 ZNF143 GC0XM107676 TSC22D3 RBM41 MORC4 RNF128 GC0XM107673
GH0XI107733 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 23.2 +38.4 38445 10.9 HDGF PKNOX1 FOXA2 ARNT FEZF1 ZNF2 YY1 POLR2B E2F8 ZNF263 TSC22D3 MID2 MORC4 RBM41 GC0XM107728 NCBP2L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TSC22D3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TSC22D3 gene promoter:

Genomic Locations for TSC22D3 Gene

Genomic Locations for TSC22D3 Gene
chrX:107,713,221-107,777,342
(GRCh38/hg38)
Size:
64,122 bases
Orientation:
Minus strand
chrX:106,956,451-107,020,572
(GRCh37/hg19)

Genomic View for TSC22D3 Gene

Genes around TSC22D3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSC22D3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSC22D3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSC22D3 Gene

Proteins for TSC22D3 Gene

  • Protein details for TSC22D3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99576-T22D3_HUMAN
    Recommended name:
    TSC22 domain family protein 3
    Protein Accession:
    Q99576
    Secondary Accessions:
    • Q5H9S3
    • Q5JRI9
    • Q6FIH6
    • Q8NAI1
    • Q8WVB9
    • Q9UBN5
    • Q9UG13

    Protein attributes for TSC22D3 Gene

    Size:
    134 amino acids
    Molecular mass:
    14810 Da
    Quaternary structure:
    • Can form homodimers, however it is likely to function as a monomer. Interacts with AP1 (By similarity). Interacts with NFKB1. Isoform 1 interacts with MYOD1 (By similarity). Isoform 1 interacts with HDAC1; this interaction affects HDAC1 activity on MYOG promoter and thus inhibits MYOD1 transcriptional activity (By similarity).
    SequenceCaution:
    • Sequence=AAH18148.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA90644.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB53669.1; Type=Frameshift; Positions=4; Evidence={ECO:0000305};

    Alternative splice isoforms for TSC22D3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSC22D3 Gene

Post-translational modifications for TSC22D3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TSC22D3 Gene

Domains & Families for TSC22D3 Gene

Gene Families for TSC22D3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TSC22D3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q99576

UniProtKB/Swiss-Prot:

T22D3_HUMAN :
  • The leucine-zipper is involved in homodimerization.
  • Belongs to the TSC-22/Dip/Bun family.
Domain:
  • The leucine-zipper is involved in homodimerization.
Family:
  • Belongs to the TSC-22/Dip/Bun family.
genes like me logo Genes that share domains with TSC22D3: view

Function for TSC22D3 Gene

Molecular function for TSC22D3 Gene

UniProtKB/Swiss-Prot Function:
Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).
UniProtKB/Swiss-Prot Induction:
By glucocorticoids in lymphoid cells and upon IL4, IL10, IL13 or glucocorticoid treatment in monocyte/macrophage cells. Transiently induced by IL2 deprivation in T-cells. Isoform 1 expression is up-regulated by synthetic glucocorticoid dexamethasone in differentiating myoblasts (By similarity).

Gene Ontology (GO) - Molecular Function for TSC22D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 DNA binding transcription factor activity IEA --
GO:0043426 MRF binding IEA --
genes like me logo Genes that share ontologies with TSC22D3: view
genes like me logo Genes that share phenotypes with TSC22D3: view

Animal Models for TSC22D3 Gene

MGI Knock Outs for TSC22D3:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSC22D3 Gene

Localization for TSC22D3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSC22D3 Gene

Isoform 1: Cytoplasm. Nucleus. Note=Localization depends on differentiation status of myoblasts. In undifferentiated myoblasts, isoform 1 localizes to the cytoplasm, but in differentiating myoblasts, isoform 1 is localized to the nucleus (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSC22D3 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
golgi apparatus 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TSC22D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TSC22D3: view

Pathways & Interactions for TSC22D3 Gene

genes like me logo Genes that share pathways with TSC22D3: view

Pathways by source for TSC22D3 Gene

Gene Ontology (GO) - Biological Process for TSC22D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,TAS 8982256
GO:0006970 response to osmotic stress IEA --
GO:0034220 ion transmembrane transport TAS --
GO:0048642 negative regulation of skeletal muscle tissue development IEA --
genes like me logo Genes that share ontologies with TSC22D3: view

No data available for SIGNOR curated interactions for TSC22D3 Gene

Drugs & Compounds for TSC22D3 Gene

(6) Drugs for TSC22D3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for TSC22D3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TSC22D3: view

Transcripts for TSC22D3 Gene

Unigene Clusters for TSC22D3 Gene

TSC22 domain family, member 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSC22D3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g
SP1: - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: - - - - -
SP10: - - - -
SP11: - - -
SP12: - -
SP13: - -
SP14: -

Relevant External Links for TSC22D3 Gene

GeneLoc Exon Structure for
TSC22D3
ECgene alternative splicing isoforms for
TSC22D3

Expression for TSC22D3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSC22D3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSC22D3 Gene

This gene is overexpressed in Whole Blood (x5.0).

Protein differential expression in normal tissues from HIPED for TSC22D3 Gene

This gene is overexpressed in Ovary (18.0), Spleen (11.9), Bone marrow stromal cell (8.7), and Peripheral blood mononuclear cells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TSC22D3 Gene



NURSA nuclear receptor signaling pathways regulating expression of TSC22D3 Gene:

TSC22D3

SOURCE GeneReport for Unigene cluster for TSC22D3 Gene:

Hs.522074

mRNA Expression by UniProt/SwissProt for TSC22D3 Gene:

Q99576-T22D3_HUMAN
Tissue specificity: Expressed in brain, lung, spleen and skeletal muscle. Lower levels detected in heart and kidney. Not detected in the pancreas. In non-lymphoid tissues, in the absence of inflammation, the major source of constitutive expression is the macrophage lineage. Also expressed in cells from different hemopoietic cell lineages, including bone marrow cells, CD34+ stem cells, mature B- and T-cells, monocytes and granulocytes. Down-regulated in activated macrophages from inflammatory lesions of delayed-type hypersensitivity (DTH) reactions, such as in tuberculosis and in Crohn disease, whereas in Burkitt lymphoma, persists in macrophages involved in the phagocytosis of apoptotic malignant cells.

Evidence on tissue expression from TISSUES for TSC22D3 Gene

  • Nervous system(4.9)
  • Blood(4.8)
  • Eye(4.5)
  • Intestine(4.5)
  • Skin(4.3)
  • Pancreas(3.6)
  • Lung(3.5)
  • Spleen(2.8)
  • Adrenal gland(2.7)
  • Lymph node(2.7)
  • Bone marrow(2.6)
  • Kidney(2.6)
  • Heart(2.2)
  • Muscle(2.2)
  • Thyroid gland(2.1)
  • Gall bladder(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with TSC22D3: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSC22D3 Gene

Orthologs for TSC22D3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSC22D3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSC22D3 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSC22D3 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TSC22D3 33 34
  • 92.83 (n)
mouse
(Mus musculus)
Mammalia Tsc22d3 33 16 34
  • 86.87 (n)
oppossum
(Monodelphis domestica)
Mammalia TSC22D3 34
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSC22D3 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSC22D3 34
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSC22D3 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8142 33
zebrafish
(Danio rerio)
Actinopterygii tsc22d3 34
  • 57 (a)
OneToOne
zgc65831 33
fruit fly
(Drosophila melanogaster)
Insecta bun 34
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C30G4.7 34
  • 30 (a)
ManyToMany
T18D3.7 34
  • 15 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
OneToOne
Species where no ortholog for TSC22D3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSC22D3 Gene

ENSEMBL:
Gene Tree for TSC22D3 (if available)
TreeFam:
Gene Tree for TSC22D3 (if available)

Paralogs for TSC22D3 Gene

Paralogs for TSC22D3 Gene

Pseudogenes.org Pseudogenes for TSC22D3 Gene

genes like me logo Genes that share paralogs with TSC22D3: view

Variants for TSC22D3 Gene

Sequence variations from dbSNP and Humsavar for TSC22D3 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000072918 -- 107,754,518(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000090245 -- 107,713,646(-) T/G 3_prime_UTR_variant
rs1000238961 -- 107,716,164(-) GCCGCCGCC/GCCGCCGCCGCC intron_variant
rs1000270041 -- 107,715,673(-) A/G intron_variant
rs1000298518 -- 107,726,843(-) C/A genic_upstream_transcript_variant, intron_variant

Variation tolerance for TSC22D3 Gene

Residual Variation Intolerance Score: 22.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSC22D3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSC22D3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TSC22D3 Gene

Disorders for TSC22D3 Gene

Additional Disease Information for TSC22D3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TSC22D3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSC22D3 Gene

Publications for TSC22D3 Gene

  1. hDIP--a potential transcriptional regulator related to murine TSC-22 and Drosophila shortsighted (shs)--is expressed in a large number of human tissues. (PMID: 8982256) Vogel P … Forssmann WG (Biochimica et biophysica acta 1996) 2 3 4 22 58
  2. GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis. (PMID: 15031210) Asselin-Labat ML … Pallardy M (Blood 2004) 3 4 22 58
  3. Cloning, chromosomal assignment and tissue distribution of human GILZ, a glucocorticoid hormone-induced gene. (PMID: 11313722) Cannarile L … Riccardi C (Cell death and differentiation 2001) 3 4 22 58
  4. The glucocorticoid-induced leucine zipper gene (GILZ) expression decreases after successful treatment of patients with endogenous Cushing's syndrome and may play a role in glucocorticoid-induced osteoporosis. (PMID: 19875485) Lekva T … Jemtland R (The Journal of clinical endocrinology and metabolism 2010) 3 22 58
  5. Glucocorticoid-induced leucine zipper (GILZ) promotes the nuclear exclusion of FOXO3 in a Crm1-dependent manner. (PMID: 20018851) Latré de Laté P … Biola-Vidamment A (The Journal of biological chemistry 2010) 3 22 58

Products for TSC22D3 Gene

Sources for TSC22D3 Gene

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