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Aliases for DRG2 Gene

Aliases for DRG2 Gene

  • Developmentally Regulated GTP Binding Protein 2 2 3 5
  • Developmentally-Regulated GTP-Binding Protein 2 3
  • Developmentally Regulated GTP-Binding Protein 2 2
  • DRG-2 4

External Ids for DRG2 Gene

Previous GeneCards Identifiers for DRG2 Gene

  • GC17P018236
  • GC17P019363
  • GC17P017934
  • GC17P018191
  • GC17P017932
  • GC17P017992
  • GC17P017744

Summaries for DRG2 Gene

Entrez Gene Summary for DRG2 Gene

  • This gene encodes a GTP-binding protein known to function in the regulation of cell growth and differentiation. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jan 2012]

GeneCards Summary for DRG2 Gene

DRG2 (Developmentally Regulated GTP Binding Protein 2) is a Protein Coding gene. Diseases associated with DRG2 include Smith-Magenis Syndrome and Potocki-Lupski Syndrome. Gene Ontology (GO) annotations related to this gene include GTP binding and ferrous iron transmembrane transporter activity.

UniProtKB/Swiss-Prot for DRG2 Gene

  • May play a role in cell proliferation, differentiation and death.

Gene Wiki entry for DRG2 Gene

Additional gene information for DRG2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRG2 Gene

Genomics for DRG2 Gene

GeneHancer (GH) Regulatory Elements for DRG2 Gene

Promoters and enhancers for DRG2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J018087 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 737 +0.3 349 1.9 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 DRG2 ENSG00000264885 ZNF286B RAI1 FOXO3B SMCR8 LOC100419436 ENSG00000265511 SMCR5 ACTG1P24
GH17J018313 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 41.8 +227.9 227883 5.2 HDGF PKNOX1 CLOCK ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 E2F8 SMCR8 TOP3A DRG2 FLII SHMT1 FOXO3B ENSG00000262202 ENSG00000264885 TVP23B CCDC144B
GH17J018780 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 41.6 +693.4 693442 2.2 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 POLR2B TVP23B MAPK7 FOXO3B SMCR8 DRG2 ENSG00000262202 ENSG00000264885 ENSG00000264932 TOP3A ZNF286B
GH17J017590 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 32.9 -495.9 -495898 3.7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 PEMT ENSG00000264666 DRG2 USP32P2 SMCR8 SMCR5 MPRIP ENSG00000265511 TOP3A LOC644422
GH17J018410 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 48.7 +323.9 323934 2.8 SIN3A GLI4 ZNF2 YY1 KLF7 KLF13 SP3 YY2 REST TSHZ1 LINC02076 MAPK7 FOXO3B DRG2 SMCR8 SMCR5 SHMT1 ENSG00000264885 ZNF286B ENSG00000262202
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DRG2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DRG2 gene promoter:
  • NF-Y
  • CBF(2)
  • POU2F1c
  • POU2F1b
  • POU2F1a
  • POU2F1
  • HNF-3beta
  • HNF-1

Genomic Locations for DRG2 Gene

Genomic Locations for DRG2 Gene
20,119 bases
Plus strand
20,093 bases
Plus strand

Genomic View for DRG2 Gene

Genes around DRG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DRG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DRG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRG2 Gene

Proteins for DRG2 Gene

  • Protein details for DRG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Developmentally-regulated GTP-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • B2R8G5
    • Q53Y50
    • Q9BWB2

    Protein attributes for DRG2 Gene

    364 amino acids
    Molecular mass:
    40746 Da
    Quaternary structure:
    • Interacts with RWDD1.

neXtProt entry for DRG2 Gene

Post-translational modifications for DRG2 Gene

  • Polyubiquitinated; which induces proteolytic degradation and is impaired by interaction with RWDD1.
  • Ubiquitination at Lys341, Lys161, and Lys127
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DRG2 Gene

Domains & Families for DRG2 Gene

Gene Families for DRG2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DRG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
genes like me logo Genes that share domains with DRG2: view

Function for DRG2 Gene

Molecular function for DRG2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in cell proliferation, differentiation and death.
GENATLAS Biochemistry:
developmentally regulated GTP-binding protein,41kDa,expressed in normal but not virally transformed fibroblasts

Phenotypes From GWAS Catalog for DRG2 Gene

Gene Ontology (GO) - Molecular Function for DRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with DRG2: view
genes like me logo Genes that share phenotypes with DRG2: view

Animal Models for DRG2 Gene

MGI Knock Outs for DRG2:
  • Drg2 Drg2<tm1a(EUCOMM)Wtsi>

Animal Model Products

miRNA for DRG2 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DRG2 Gene

Localization for DRG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRG2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DRG2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol IDA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with DRG2: view

Pathways & Interactions for DRG2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 7929244
genes like me logo Genes that share ontologies with DRG2: view

No data available for Pathways by source and SIGNOR curated interactions for DRG2 Gene

Drugs & Compounds for DRG2 Gene

(1) Drugs for DRG2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with DRG2: view

Transcripts for DRG2 Gene

Unigene Clusters for DRG2 Gene

Developmentally regulated GTP binding protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DRG2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - - - - - - - - - -
SP2: - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - -
SP8: - -

Relevant External Links for DRG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DRG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DRG2 Gene

Protein differential expression in normal tissues from HIPED for DRG2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.9) and Salivary gland (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DRG2 Gene

Protein tissue co-expression partners for DRG2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DRG2 Gene:


SOURCE GeneReport for Unigene cluster for DRG2 Gene:


mRNA Expression by UniProt/SwissProt for DRG2 Gene:

Tissue specificity: Highest levels in skeletal muscle, heart and kidney. Low levels in colon, thymus, spleen, small intestine, lung and Leukocytes.

Evidence on tissue expression from TISSUES for DRG2 Gene

  • Nervous system(4.4)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with DRG2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DRG2 Gene

Orthologs for DRG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DRG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia DRG2 34
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia DRG2 34
  • 97 (a)
(Pan troglodytes)
Mammalia DRG2 34 33
  • 93.59 (n)
(Canis familiaris)
Mammalia DRG2 34 33
  • 92.03 (n)
(Bos Taurus)
Mammalia DRG2 34 33
  • 91.3 (n)
(Mus musculus)
Mammalia Drg2 16 34 33
  • 90.93 (n)
(Rattus norvegicus)
Mammalia Drg2 33
  • 90.75 (n)
(Gallus gallus)
Aves DRG2 34 33
  • 81.23 (n)
(Anolis carolinensis)
Reptilia DRG2 34
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia drg2 33
  • 79.76 (n)
Str.7109 33
African clawed frog
(Xenopus laevis)
Amphibia MGC69136 33
(Danio rerio)
Actinopterygii drg2 34 33
  • 75.92 (n)
wufb96a09 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.773 33
fruit fly
(Drosophila melanogaster)
Insecta CG6195 34 35 33
  • 73.09 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002185 33
  • 72.82 (n)
(Caenorhabditis elegans)
Secernentea C02F5.3 34 35 33
  • 63.83 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL134W 33
  • 61.25 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RBG2 36 34 33
  • 57.05 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F14993g 33
  • 56.96 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons DRG1 33
  • 62.64 (n)
(Oryza sativa)
Liliopsida Os05g0357600 33
  • 62.27 (n)
Os.7201 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 73 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gtp1 33
  • 60.7 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01183 33
  • 60.6 (n)
Species where no ortholog for DRG2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DRG2 Gene

Gene Tree for DRG2 (if available)
Gene Tree for DRG2 (if available)
Evolutionary constrained regions (ECRs) for DRG2: view image

Paralogs for DRG2 Gene

(6) SIMAP similar genes for DRG2 Gene using alignment to 10 proteins:

  • J3QL90_HUMAN
  • J3QR71_HUMAN
genes like me logo Genes that share paralogs with DRG2: view

No data available for Paralogs for DRG2 Gene

Variants for DRG2 Gene

Sequence variations from dbSNP and Humsavar for DRG2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000210526 -- 18,105,177(+) G/C intron_variant
rs1000268454 -- 18,098,855(+) C/A intron_variant
rs1000325226 -- 18,092,717(+) T/C intron_variant
rs1000395212 -- 18,094,431(+) C/T intron_variant
rs1000706461 -- 18,106,449(+) G/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for DRG2 Gene

Variant ID Type Subtype PubMed ID
nsv155 OTHER inversion 15895083
nsv457697 CNV loss 19166990
nsv499114 OTHER inversion 21111241
nsv574527 CNV loss 21841781
nsv953839 CNV deletion 24416366

Variation tolerance for DRG2 Gene

Residual Variation Intolerance Score: 23.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.25; 40.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DRG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRG2 Gene

Disorders for DRG2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DRG2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
smith-magenis syndrome
  • sms
potocki-lupski syndrome
  • ptls
- elite association - COSMIC cancer census association via MalaCards
Search DRG2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DRG2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DRG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DRG2 Gene

Publications for DRG2 Gene

  1. A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts. (PMID: 7929244) Schenker T … Trueb B (The Journal of biological chemistry 1994) 2 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. DRG represents a family of two closely related GTP-binding proteins. (PMID: 10760581) Li B … Trueb B (Biochimica et biophysica acta 2000) 3 22 58

Products for DRG2 Gene

Sources for DRG2 Gene

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