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Aliases for DYNC1LI2 Gene

Aliases for DYNC1LI2 Gene

  • Dynein Cytoplasmic 1 Light Intermediate Chain 2 2 3 5
  • Dynein, Cytoplasmic, Light Intermediate Polypeptide 2 2 3
  • Dynein Light Intermediate Chain 2, Cytosolic 3 4
  • LIC53/55 3 4
  • DNCLI2 3 4
  • LIC-2 3 4
  • LIC2 3 4
  • Cytoplasmic Dynein 1 Light Intermediate Chain 2 3

External Ids for DYNC1LI2 Gene

Previous HGNC Symbols for DYNC1LI2 Gene

  • DNCLI2

Previous GeneCards Identifiers for DYNC1LI2 Gene

  • GC16M065314
  • GC16M052629

Summaries for DYNC1LI2 Gene

Entrez Gene Summary for DYNC1LI2 Gene

  • Cytoplasmic dynein is a microtubule-associated motor protein (Hughes et al., 1995 [PubMed 7738094]). See DYNC1H1 (MIM 600112) for general information about dyneins.[supplied by OMIM, Mar 2008]

GeneCards Summary for DYNC1LI2 Gene

DYNC1LI2 (Dynein Cytoplasmic 1 Light Intermediate Chain 2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Cell cycle_Spindle assembly and chromosome separation. Gene Ontology (GO) annotations related to this gene include microtubule motor activity. An important paralog of this gene is DYNC1LI1.

UniProtKB/Swiss-Prot for DYNC1LI2 Gene

  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.

Gene Wiki entry for DYNC1LI2 Gene

Additional gene information for DYNC1LI2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYNC1LI2 Gene

Genomics for DYNC1LI2 Gene

GeneHancer (GH) Regulatory Elements for DYNC1LI2 Gene

Promoters and enhancers for DYNC1LI2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J066749 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.7 653 2.7 SMAD1 ARNT SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF207 ZNF143 KLF13 ENSG00000246777 DYNC1LI2 NAE1 ACD CTCF CES2 ENSG00000259804 TERB1 CMTM3 ENSG00000260558
GH16J066406 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.6 +343.7 343728 4.1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 SLC30A9 ARID2 LINC00920 CDH5 CMTM2 CMTM4 DYNC1LI2 ENSG00000246777 CA7 RRAD CMTM3 GC16M066396
GH16J066659 Enhancer 1.2 Ensembl ENCODE 10.4 +90.4 90408 2.8 PKNOX1 SMAD1 ARNT ARID4B YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF766 CMTM4 BEAN1 DYNC1LI2 ENSG00000246777 CA7 CES2 TK2 GC16P066646 GC16M066667
GH16J066650 Enhancer 1.1 Ensembl ENCODE 10.9 +100.7 100687 1.1 ARNT ARID4B FEZF1 ARID2 ZNF143 ATF7 RUNX3 KAT8 SSRP1 RFX3 BEAN1 CMTM4 DYNC1LI2 ENSG00000246777 TK2 CMTM3 GC16P066646 GC16M066667
GH16J066716 Enhancer 0.9 ENCODE dbSUPER 11.8 +34.0 34011 1.9 CTCF PKNOX1 RB1 TEAD4 ARID4B RAD21 RFX5 CTBP1 ZNF614 E2F8 TERB1 ENSG00000246777 DYNC1LI2 CMTM4 ENSG00000260465 GC16M066696
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DYNC1LI2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DYNC1LI2 gene promoter:
  • CUTL1
  • NF-AT4
  • NF-AT3
  • NF-AT2
  • NF-AT1
  • NF-AT
  • HSF2
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta

Genomic Locations for DYNC1LI2 Gene

Genomic Locations for DYNC1LI2 Gene
chr16:66,720,893-66,751,798
(GRCh38/hg38)
Size:
30,906 bases
Orientation:
Minus strand
chr16:66,754,796-66,785,701
(GRCh37/hg19)
Size:
30,906 bases
Orientation:
Minus strand

Genomic View for DYNC1LI2 Gene

Genes around DYNC1LI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYNC1LI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYNC1LI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNC1LI2 Gene

Proteins for DYNC1LI2 Gene

  • Protein details for DYNC1LI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43237-DC1L2_HUMAN
    Recommended name:
    Cytoplasmic dynein 1 light intermediate chain 2
    Protein Accession:
    O43237
    Secondary Accessions:
    • A8K6V1
    • B4DZP4
    • Q8TAT3

    Protein attributes for DYNC1LI2 Gene

    Size:
    492 amino acids
    Molecular mass:
    54099 Da
    Quaternary structure:
    • Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNC1H1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for DYNC1LI2 Gene

    Alternative splice isoforms for DYNC1LI2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DYNC1LI2 Gene

Post-translational modifications for DYNC1LI2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DYNC1LI2 Gene

Domains & Families for DYNC1LI2 Gene

Gene Families for DYNC1LI2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DYNC1LI2 Gene

Graphical View of Domain Structure for InterPro Entry

O43237

UniProtKB/Swiss-Prot:

DC1L2_HUMAN :
  • Belongs to the dynein light intermediate chain family.
Family:
  • Belongs to the dynein light intermediate chain family.
genes like me logo Genes that share domains with DYNC1LI2: view

Function for DYNC1LI2 Gene

Molecular function for DYNC1LI2 Gene

UniProtKB/Swiss-Prot Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.

Gene Ontology (GO) - Molecular Function for DYNC1LI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003777 microtubule motor activity IEA --
GO:0005524 ATP binding IEA --
GO:0045504 dynein heavy chain binding IBA --
genes like me logo Genes that share ontologies with DYNC1LI2: view
genes like me logo Genes that share phenotypes with DYNC1LI2: view

Animal Model Products

CRISPR Products

miRNA for DYNC1LI2 Gene

miRTarBase miRNAs that target DYNC1LI2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DYNC1LI2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DYNC1LI2 Gene

Localization for DYNC1LI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNC1LI2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DYNC1LI2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
endosome 3
lysosome 2
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DYNC1LI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0005737 cytoplasm IEA --
GO:0005764 lysosome IEA --
GO:0005770 late endosome IEA --
GO:0005813 centrosome IDA 21399614
genes like me logo Genes that share ontologies with DYNC1LI2: view

Pathways & Interactions for DYNC1LI2 Gene

genes like me logo Genes that share pathways with DYNC1LI2: view

Gene Ontology (GO) - Biological Process for DYNC1LI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0007018 microtubule-based movement IBA,IEA --
GO:0007062 sister chromatid cohesion TAS --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with DYNC1LI2: view

No data available for SIGNOR curated interactions for DYNC1LI2 Gene

Drugs & Compounds for DYNC1LI2 Gene

No Compound Related Data Available

Transcripts for DYNC1LI2 Gene

mRNA/cDNA for DYNC1LI2 Gene

Unigene Clusters for DYNC1LI2 Gene

Dynein, cytoplasmic 1, light intermediate chain 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DYNC1LI2

Alternative Splicing Database (ASD) splice patterns (SP) for DYNC1LI2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - - - - -
SP2:
SP3: -
SP4: - -
SP5:
SP6: - - -
SP7: -
SP8:

Relevant External Links for DYNC1LI2 Gene

GeneLoc Exon Structure for
DYNC1LI2
ECgene alternative splicing isoforms for
DYNC1LI2

Expression for DYNC1LI2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DYNC1LI2 Gene

mRNA differential expression in normal tissues according to GTEx for DYNC1LI2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.4).

Protein differential expression in normal tissues from HIPED for DYNC1LI2 Gene

This gene is overexpressed in Fetal Brain (7.0) and Cervix (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DYNC1LI2 Gene



Protein tissue co-expression partners for DYNC1LI2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DYNC1LI2 Gene:

DYNC1LI2

SOURCE GeneReport for Unigene cluster for DYNC1LI2 Gene:

Hs.369068

Evidence on tissue expression from TISSUES for DYNC1LI2 Gene

  • Nervous system(4.8)
  • Liver(4.3)
  • Lung(3.4)
  • Kidney(2.1)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with DYNC1LI2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DYNC1LI2 Gene

Orthologs for DYNC1LI2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DYNC1LI2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYNC1LI2 34 33
  • 97.87 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DYNC1LI2 34 33
  • 93.9 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DYNC1LI2 34 33
  • 93.27 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dync1li2 33
  • 91.98 (n)
mouse
(Mus musculus)
Mammalia Dync1li2 16 34 33
  • 90.45 (n)
oppossum
(Monodelphis domestica)
Mammalia DYNC1LI2 34
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DYNC1LI2 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves DYNC1LI2 34 33
  • 81.31 (n)
OneToMany
-- 34
  • 77 (a)
OneToMany
-- 34
  • 58 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia DYNC1LI2 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dync1li2 33
  • 73.58 (n)
zebrafish
(Danio rerio)
Actinopterygii dync1li2 34 33
  • 70.32 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000723 33
  • 54.44 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dlic 34 33
  • 52.61 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dli-1 34 33
  • 48.19 (n)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea Cin.1475 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1475 33
Species where no ortholog for DYNC1LI2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DYNC1LI2 Gene

ENSEMBL:
Gene Tree for DYNC1LI2 (if available)
TreeFam:
Gene Tree for DYNC1LI2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DYNC1LI2: view image

Paralogs for DYNC1LI2 Gene

Paralogs for DYNC1LI2 Gene

(3) SIMAP similar genes for DYNC1LI2 Gene using alignment to 10 proteins:

  • DC1L2_HUMAN
  • B4DZP4_HUMAN
  • B4E2E0_HUMAN
  • E7EPL8_HUMAN
  • H3BU48_HUMAN
  • H3BUM4_HUMAN
  • J3KRI4_HUMAN
  • J3KRZ2_HUMAN
  • J3KSD2_HUMAN
  • J3QKK5_HUMAN
genes like me logo Genes that share paralogs with DYNC1LI2: view

Variants for DYNC1LI2 Gene

Sequence variations from dbSNP and Humsavar for DYNC1LI2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000045237 -- 66,726,047(-) T/G intron_variant
rs1000284928 -- 66,747,908(-) G/C intron_variant
rs1000405177 -- 66,741,394(-) G/C intron_variant
rs1000771806 -- 66,742,993(-) T/C intron_variant
rs1000790497 -- 66,750,722(-) C/G intron_variant

Variation tolerance for DYNC1LI2 Gene

Residual Variation Intolerance Score: 13.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DYNC1LI2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DYNC1LI2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DYNC1LI2 Gene

Disorders for DYNC1LI2 Gene

Additional Disease Information for DYNC1LI2

No disorders were found for DYNC1LI2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DYNC1LI2 Gene

Publications for DYNC1LI2 Gene

  1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  3. Cytoplasmic dynein nomenclature. (PMID: 16260502) Pfister KK … Vallee RB (The Journal of cell biology 2005) 2 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for DYNC1LI2 Gene

Sources for DYNC1LI2 Gene

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