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Aliases for SYNPO2 Gene

Aliases for SYNPO2 Gene

  • Synaptopodin 2 2 3 5
  • Genethonin-2 3 4
  • Myopodin 3 4
  • Synaptopodin-2 3

External Ids for SYNPO2 Gene

Previous GeneCards Identifiers for SYNPO2 Gene

  • GC04P120706
  • GC04P120090
  • GC04P120203
  • GC04P120269
  • GC04P120270
  • GC04P120167
  • GC04P119809
  • GC04P115532

Summaries for SYNPO2 Gene

GeneCards Summary for SYNPO2 Gene

SYNPO2 (Synaptopodin 2) is a Protein Coding gene. Diseases associated with SYNPO2 include Myopathy, Myofibrillar, 2. Gene Ontology (GO) annotations related to this gene include actin binding and muscle alpha-actinin binding. An important paralog of this gene is SYNPO2L.

UniProtKB/Swiss-Prot for SYNPO2 Gene

  • Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:24005909, PubMed:23225103). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336).

  • Isoform 1: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body.

  • Isoform 2: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers.

  • Isoform 3: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles.

  • Isoform 4: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers.

  • Isoform 5: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro.

Gene Wiki entry for SYNPO2 Gene

Additional gene information for SYNPO2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYNPO2 Gene

Genomics for SYNPO2 Gene

GeneHancer (GH) Regulatory Elements for SYNPO2 Gene

Promoters and enhancers for SYNPO2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J118833 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.4 -15.3 -15287 4 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B SEC24D SYNPO2 METTL14 SNHG8 GC04P118831
GH04J118888 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 650.3 +39.1 39113 2.8 SIN3A ZNF2 ZNF213 ZNF143 KLF7 KLF13 SP3 REST ATF4 ZNF610 SYNPO2 METTL14 SEC24D SNHG8 LOC105377393 GC04M118904
GH04J118849 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 650.7 -0.3 -267 2 HDGF IRF2 NANOG SAP130 SIN3A STAT5A ELF1 YY1 ETS1 POLR2A SYNPO2 METTL14 SEC24D
GH04J119024 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10 +176.2 176176 3.7 MXI1 USF1 ATF1 TAF1 JUN SIN3A CEBPG BRCA1 FOSL1 POLR2A SYNPO2 LOC645513 GC04P119036 ENSG00000249002
GH04J119016 Enhancer 0.8 Ensembl ENCODE dbSUPER 6.1 +166.3 166284 1.9 SP1 POLR2A SYNPO2 ENSG00000249002 GC04P119036
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SYNPO2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SYNPO2 gene promoter:
  • TFIID
  • TBP
  • Pax-5
  • ATF-2
  • CRE-BP1
  • CHOP-10
  • C/EBPalpha
  • MIF-1
  • POU2F1a

Genomic Locations for SYNPO2 Gene

Genomic Locations for SYNPO2 Gene
chr4:118,850,688-119,061,247
(GRCh38/hg38)
Size:
210,560 bases
Orientation:
Plus strand
chr4:119,809,996-119,982,402
(GRCh37/hg19)
Size:
172,407 bases
Orientation:
Plus strand

Genomic View for SYNPO2 Gene

Genes around SYNPO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYNPO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYNPO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYNPO2 Gene

Proteins for SYNPO2 Gene

  • Protein details for SYNPO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UMS6-SYNP2_HUMAN
    Recommended name:
    Synaptopodin-2
    Protein Accession:
    Q9UMS6
    Secondary Accessions:
    • B2RWP6
    • B2Y8J9
    • C6H0M7
    • Q9UK89
    • S5XAM4

    Protein attributes for SYNPO2 Gene

    Size:
    1093 amino acids
    Molecular mass:
    117514 Da
    Quaternary structure:
    • May self-associate in muscle cells under oxidative stress. Binds F-actin (PubMed:23225103). Interacts with ACTN2; ACTN2 is proposed to anchor SYOP2 at Z lines in mature myocytes (PubMed:20554076). Interacts with AKAP6, PPP3CA and CAMK2A. Interacts (phosphorylated form) with YWHAB; YWHAB competes with ACTN2 for interaction with SYNPO2. Interacts with KPNA2; mediating nuclear import of SYNOP2; dependent on interaction with YWHAB (By similarity). Interacts with IPO13; may be implicated in SYNOP2 nuclear import (PubMed:17828378). Interacts with ZYX, FLNC, ILK (PubMed:16885336, PubMed:20554076, PubMed:21643011). Interacts with BAG3 (via WW 1 domain). May associate with the CASA complex consisting of HSPA8, HSPB8 and BAG3. Interacts with VPS18 (PubMed:23434281).

    Alternative splice isoforms for SYNPO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYNPO2 Gene

Post-translational modifications for SYNPO2 Gene

  • Phosphorylated by PKA, and by CaMK2 at multiple sites. Dephosphorylated by calcineurin; abrogating interaction with YWHAB and impairing nuclear import (By similarity). Phosphorylated by ILK.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SYNPO2 Gene

Domains & Families for SYNPO2 Gene

Gene Families for SYNPO2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SYNPO2 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SYNPO2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UMS6

UniProtKB/Swiss-Prot:

SYNP2_HUMAN :
  • The PPPY motif interacts with the WW domain 1 of BAG3.
  • Belongs to the synaptopodin family.
Domain:
  • The PPPY motif interacts with the WW domain 1 of BAG3.
Family:
  • Belongs to the synaptopodin family.
genes like me logo Genes that share domains with SYNPO2: view

Function for SYNPO2 Gene

Molecular function for SYNPO2 Gene

UniProtKB/Swiss-Prot Function:
Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:24005909, PubMed:23225103). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336).
UniProtKB/Swiss-Prot Function:
Isoform 1: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body.
UniProtKB/Swiss-Prot Function:
Isoform 2: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers.
UniProtKB/Swiss-Prot Function:
Isoform 3: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles.
UniProtKB/Swiss-Prot Function:
Isoform 4: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers.
UniProtKB/Swiss-Prot Function:
Isoform 5: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro.
UniProtKB/Swiss-Prot Induction:
Down-regulated in muscle cell lines derived from patients with Duchenne muscular dystrophy (DMD).

Phenotypes From GWAS Catalog for SYNPO2 Gene

Gene Ontology (GO) - Molecular Function for SYNPO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IBA --
GO:0005515 protein binding IEA,IPI 21643011
GO:0031005 filamin binding IDA 20554076
GO:0051371 muscle alpha-actinin binding ISS --
GO:0051393 alpha-actinin binding IDA 20554076
genes like me logo Genes that share ontologies with SYNPO2: view
genes like me logo Genes that share phenotypes with SYNPO2: view

Animal Models for SYNPO2 Gene

MGI Knock Outs for SYNPO2:
  • Synpo2 Synpo2<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for SYNPO2 Gene

miRTarBase miRNAs that target SYNPO2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SYNPO2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYNPO2 Gene

Localization for SYNPO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYNPO2 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Cell junction, focal adhesion. Note=Shuttles between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion. In undifferentiated myoblasts strongly expressed in the nucleus, after induction of myotube differentiation is located to both nucleus and cytoplasm along acting filaments, and in differentiated myotubes is located at the Z lines. Upon stress redistributes from cytoplasm of myoblasts and myotubes to the nucleus. Nuclear import is KPNA2-dependent and promoted by phosphorylation by PKA and/or CaMK2, and inhibition of calcineurin. The nuclear export is XPO1-dependent (By similarity). Localized in a fiber-like pattern, partly overlapping with filamentous actin (PubMed:18371299). {ECO:0000250 UniProtKB:Q91YE8, ECO:0000269 PubMed:18371299}.
Isoform 1: Cytoplasm, cytoskeleton. Note=Localizes to induced actin bundles with contiguous staining. {ECO:0000269 PubMed:24005909}.
Isoform 2: Cytoplasm, cytoskeleton. Note=Localizes to induced actin bundles with punctuate staining. {ECO:0000269 PubMed:24005909}.
Isoform 3: Cytoplasm, cytoskeleton. Note=Localizes to induced irregular actin bundles with contiguous and punctuated staining. {ECO:0000269 PubMed:24005909}.
Isoform 4: Cytoplasm, cytoskeleton. Note=Localizes to induced actin bundles with punctuate staining. {ECO:0000269 PubMed:24005909}.
Isoform 5: Cytoplasm, cytoskeleton. Note=Localizes to induced actin bundles with contiguous staining. {ECO:0000269 PubMed:24005909}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYNPO2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (3)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SYNPO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 20554076
GO:0005634 nucleus ISS,IBA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with SYNPO2: view

Pathways & Interactions for SYNPO2 Gene

SuperPathways for SYNPO2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYNPO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IEA --
GO:0032233 positive regulation of actin filament bundle assembly IBA --
genes like me logo Genes that share ontologies with SYNPO2: view

No data available for Pathways by source and SIGNOR curated interactions for SYNPO2 Gene

Drugs & Compounds for SYNPO2 Gene

No Compound Related Data Available

Transcripts for SYNPO2 Gene

Unigene Clusters for SYNPO2 Gene

Synaptopodin 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SYNPO2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYNPO2 Gene

No ASD Table

Relevant External Links for SYNPO2 Gene

GeneLoc Exon Structure for
SYNPO2
ECgene alternative splicing isoforms for
SYNPO2

Expression for SYNPO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SYNPO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYNPO2 Gene

This gene is overexpressed in Muscle - Skeletal (x12.5), Esophagus - Muscularis (x5.9), Colon - Sigmoid (x4.3), and Artery - Tibial (x4.2).

Protein differential expression in normal tissues from HIPED for SYNPO2 Gene

This gene is overexpressed in Colon muscle (12.1), Prostate (10.8), Rectum (7.7), Urinary Bladder (7.3), Colon (6.6), and Seminal vesicle (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SYNPO2 Gene



Protein tissue co-expression partners for SYNPO2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SYNPO2 Gene:

SYNPO2

SOURCE GeneReport for Unigene cluster for SYNPO2 Gene:

Hs.655519

mRNA Expression by UniProt/SwissProt for SYNPO2 Gene:

Q9UMS6-SYNP2_HUMAN
Tissue specificity: Expressed in heart muscle. Isoform 5 is specifically expressed in skeletal muscle.

Evidence on tissue expression from TISSUES for SYNPO2 Gene

  • Muscle(4.8)
  • Liver(4.2)
  • Intestine(2.3)
  • Heart(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with SYNPO2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SYNPO2 Gene

Orthologs for SYNPO2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYNPO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYNPO2 34 33
  • 99.58 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SYNPO2 34 33
  • 86.54 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Synpo2 16 34 33
  • 82.83 (n)
dog
(Canis familiaris)
Mammalia SYNPO2 34 33
  • 82.33 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Synpo2 33
  • 81.76 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SYNPO2 34
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SYNPO2 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves SYNPO2 34 33
  • 66.37 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYNPO2 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia synpo2 33
  • 59.48 (n)
zebrafish
(Danio rerio)
Actinopterygii SYNPO2 (2 of 2) 34
  • 41 (a)
OneToMany
SYNPO2 (1 of 2) 34
  • 32 (a)
OneToMany
Species where no ortholog for SYNPO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYNPO2 Gene

ENSEMBL:
Gene Tree for SYNPO2 (if available)
TreeFam:
Gene Tree for SYNPO2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SYNPO2: view image

Paralogs for SYNPO2 Gene

Paralogs for SYNPO2 Gene

(4) SIMAP similar genes for SYNPO2 Gene using alignment to 5 proteins:

  • SYNP2_HUMAN
  • B4E258_HUMAN
  • B9EG60_HUMAN
  • C6H0M7_HUMAN
  • H0Y9Y3_HUMAN
genes like me logo Genes that share paralogs with SYNPO2: view

Variants for SYNPO2 Gene

Sequence variations from dbSNP and Humsavar for SYNPO2 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000000983 -- 118,938,551(+) A/C/T intron_variant
rs1000008612 -- 118,914,594(+) TTTTTTT/TTTTTT intron_variant
rs1000011219 -- 118,873,671(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000018217 -- 118,894,724(+) G/C intron_variant
rs1000026019 -- 119,048,370(+) A/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SYNPO2 Gene

Variant ID Type Subtype PubMed ID
esv1280152 CNV insertion 17803354
esv2728222 CNV deletion 23290073
esv2728223 CNV deletion 23290073
esv2728224 CNV deletion 23290073
esv2728225 CNV deletion 23290073
esv2728226 CNV deletion 23290073
esv2728227 CNV deletion 23290073
esv2728229 CNV deletion 23290073
esv3357426 CNV insertion 20981092
esv3395902 CNV insertion 20981092
esv3569671 CNV loss 25503493
esv3601957 CNV gain 21293372
esv3601958 CNV gain 21293372
esv3601959 CNV gain 21293372
esv3894016 CNV gain 25118596
esv992928 CNV deletion 20482838
nsv289598 CNV deletion 16902084
nsv522652 CNV loss 19592680
nsv819746 CNV gain 19587683

Variation tolerance for SYNPO2 Gene

Residual Variation Intolerance Score: 8.88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.15; 96.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SYNPO2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYNPO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYNPO2 Gene

Disorders for SYNPO2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SYNPO2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
myopathy, myofibrillar, 2
  • mfm2
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SYNPO2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SYNPO2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SYNPO2 Gene

Publications for SYNPO2 Gene

  1. Interaction between importin 13 and myopodin suggests a nuclear import pathway for myopodin. (PMID: 17828378) Liang J … Tao T (Molecular and cellular biochemistry 2008) 2 3 4 22 58
  2. Multiple isoforms of the tumor suppressor myopodin are simultaneously transcribed in cancer cells. (PMID: 18371299) De Ganck A … Gettemans J (Biochemical and biophysical research communications 2008) 3 4 22 58
  3. Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein. (PMID: 11673475) Weins A … Mundel P (The Journal of cell biology 2001) 2 3 4 58
  4. Synaptopodin-2 induces assembly of peripheral actin bundles and immature focal adhesions to promote lamellipodia formation and prostate cancer cell migration. (PMID: 25883213) Kai F … Duncan R (Oncotarget 2015) 3 4 58
  5. Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy. (PMID: 23434281) Ulbricht A … Höhfeld J (Current biology : CB 2013) 3 4 58

Products for SYNPO2 Gene

Sources for SYNPO2 Gene

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