Aliases for DCN Gene
External Ids for DCN Gene
Previous GeneCards Identifiers for DCN Gene
This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]
GeneCards Summary for DCN Gene
DCN (Decorin) is a Protein Coding gene. Diseases associated with DCN include Corneal Dystrophy, Congenital Stromal and Stromal Dystrophy. Among its related pathways are TGF-beta signaling pathway (KEGG) and Chondroitin sulfate/dermatan sulfate metabolism. Gene Ontology (GO) annotations related to this gene include collagen binding. An important paralog of this gene is BGN.
UniProtKB/Swiss-Prot for DCN Gene
May affect the rate of fibrils formation.