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Aliases for ZNF497 Gene

Aliases for ZNF497 Gene

  • Zinc Finger Protein 497 2 3 3 5
  • Zinc Finger-Like Protein 3

External Ids for ZNF497 Gene

Previous GeneCards Identifiers for ZNF497 Gene

  • GC19M063559
  • GC19M063557
  • GC19M058865
  • GC19M055174

Summaries for ZNF497 Gene

GeneCards Summary for ZNF497 Gene

ZNF497 (Zinc Finger Protein 497) is a Protein Coding gene. An important paralog of this gene is ZNF835.

UniProtKB/Swiss-Prot for ZNF497 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF497 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF497 Gene

Genomics for ZNF497 Gene

GeneHancer (GH) Regulatory Elements for ZNF497 Gene

Promoters and enhancers for ZNF497 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J058361 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.4 443 2.1 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B LOC105372483 ENSG00000268230 RNA5SP473 ZNF497 TRIM28 ZNF548 ZNF417 ZNF134 ZSCAN22 ZNF274
GH19J058364 Promoter/Enhancer 1 EPDnew ENCODE 650.7 -1.5 -1544 0.2 SMARCA5 POLR2A IKZF1 RUNX3 SPI1 ENSG00000268230 RNA5SP473 ZNF497 LOC105372483 GC19M058369
GH19J058400 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.6 -38.6 -38606 2.2 HDGF PKNOX1 ARID4B NEUROD1 SIN3A YY1 SLC30A9 POLR2B E2F8 ZNF207 ZNF584 LINC02560 GC19P058413 ZNF132 TRIM28 ZNF606 ZNF549 ENSG00000232098 MZF1 ZNF417
GH19J058403 Enhancer 0.7 ENCODE 4.9 -41.1 -41117 0.7 CTCF ELF3 KLF1 SAP130 ARID4B E4F1 RAD21 TEAD3 ZNF664 EGR1 ZNF584 ENSG00000232098 LOC100419848 ZNF497 GC19M058405 GC19P058413 PIR33627
GH19J058537 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE 2 -175.5 -175471 2.3 SOX13 USF1 RB1 BACH1 ETS1 POLR2A NR2F6 SOX5 ZNF687 RNF2 ZBTB45 ZNF584 ZSCAN18 ENSG00000232098 ZNF8 ZNF544 TRIM28 ZNF329 ZNF497 ZNF324
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF497 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF497 gene promoter:
  • STAT3
  • TBP
  • Nkx5-1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • Pbx1a
  • RORalpha1
  • C/EBPalpha

Genomic Locations for ZNF497 Gene

Genomic Locations for ZNF497 Gene
8,492 bases
Minus strand
8,492 bases
Minus strand

Genomic View for ZNF497 Gene

Genes around ZNF497 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF497 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF497 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF497 Gene

Proteins for ZNF497 Gene

  • Protein details for ZNF497 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 497
    Protein Accession:
    Secondary Accessions:
    • Q05AG8
    • Q0VF48
    • Q6ZTD2
    • Q9UIA8

    Protein attributes for ZNF497 Gene

    498 amino acids
    Molecular mass:
    54721 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF497 Gene

Post-translational modifications for ZNF497 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF497 Gene

No data available for DME Specific Peptides for ZNF497 Gene

Domains & Families for ZNF497 Gene

Gene Families for ZNF497 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF497 Gene


Suggested Antigen Peptide Sequences for ZNF497 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF497: view

Function for ZNF497 Gene

Molecular function for ZNF497 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF497 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF497: view
genes like me logo Genes that share phenotypes with ZNF497: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF497 Gene

Localization for ZNF497 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF497 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF497 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF497 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF497: view

Pathways & Interactions for ZNF497 Gene

SuperPathways for ZNF497 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF497 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF497: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF497 Gene

Drugs & Compounds for ZNF497 Gene

No Compound Related Data Available

Transcripts for ZNF497 Gene

mRNA/cDNA for ZNF497 Gene

Unigene Clusters for ZNF497 Gene

Zinc finger protein 497:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF497 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: -
SP3: - -
SP4: - - -
SP5: - - - -

Relevant External Links for ZNF497 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF497 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF497 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF497 Gene:


SOURCE GeneReport for Unigene cluster for ZNF497 Gene:


Evidence on tissue expression from TISSUES for ZNF497 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF497: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF497 Gene

Orthologs for ZNF497 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF497 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF497 34 33
  • 99.46 (n)
(Monodelphis domestica)
Mammalia ZNF497 34
  • 56 (a)
(Canis familiaris)
Mammalia -- 34
  • 23 (a)
Species where no ortholog for ZNF497 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF497 Gene

Gene Tree for ZNF497 (if available)
Gene Tree for ZNF497 (if available)
Evolutionary constrained regions (ECRs) for ZNF497: view image

Paralogs for ZNF497 Gene

Paralogs for ZNF497 Gene

(500) SIMAP similar genes for ZNF497 Gene using alignment to 2 proteins:

  • ZN497_HUMAN
  • M0R159_HUMAN
genes like me logo Genes that share paralogs with ZNF497: view

Variants for ZNF497 Gene

Sequence variations from dbSNP and Humsavar for ZNF497 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000283645 -- 58,362,062(-) T/C intron_variant
rs1000479994 -- 58,356,961(-) C/G coding_sequence_variant, missense_variant
rs1000962708 -- 58,358,155(-) TCCACA/ intron_variant
rs1001078658 -- 58,357,856(-) C/T intron_variant
rs1001185552 -- 58,357,790(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF497 Gene

Variant ID Type Subtype PubMed ID
nsv515731 CNV gain+loss 19592680
nsv817878 CNV loss 17921354
nsv833887 CNV loss 17160897
nsv833888 CNV loss 17160897

Variation tolerance for ZNF497 Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.88; 83.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF497 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF497 Gene

Disorders for ZNF497 Gene

Additional Disease Information for ZNF497

No disorders were found for ZNF497 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF497 Gene

Publications for ZNF497 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for ZNF497 Gene

Sources for ZNF497 Gene

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