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Aliases for C11orf65 Gene

Aliases for C11orf65 Gene

  • Chromosome 11 Open Reading Frame 65 2 3 5

External Ids for C11orf65 Gene

Previous GeneCards Identifiers for C11orf65 Gene

  • GC11M107708
  • GC11M108179
  • GC11M104179

Summaries for C11orf65 Gene

GeneCards Summary for C11orf65 Gene

C11orf65 (Chromosome 11 Open Reading Frame 65) is a Protein Coding gene.

Additional gene information for C11orf65 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf65 Gene

Genomics for C11orf65 Gene

GeneHancer (GH) Regulatory Elements for C11orf65 Gene

Promoters and enhancers for C11orf65 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I108465 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.3 261 2.7 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 C11orf65 NPAT KDELC2 DDX10 ACAT1 PIR35860
GH11I108219 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 4.9 +241.7 241686 12.2 MLX DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 NFYC NPAT ATM ACAT1 DDX10 KDELC2 CWF19L2 ENSG00000255467 C11orf65 GC11M108232 ENSG00000206967
GH11I108233 Enhancer 1.3 Ensembl ENCODE dbSUPER 7.9 +228.9 228942 11.1 FOXA2 BATF IRF4 ZNF48 RARA SMARCC2 ATF7 ETV6 BCLAF1 CREM ACAT1 ATM ENSG00000255467 DDX10 C11orf65 KDELC2 ENSG00000206967 GC11M108232 PIR35860
GH11I108246 Enhancer 0.6 dbSUPER 4.9 +220.5 220454 1.5 PAF1 CEBPB MAFG CEBPG ZNF316 MAFF EMSY MAFK ACAT1 ATM NPAT ENSG00000255467 DDX10 C11orf65 ENSG00000206967 GC11M108232 PIR35860
GH11I108215 Enhancer 0.5 dbSUPER 5.1 +251.1 251121 2.2 POLR2B EGR1 POLR2A SCRT2 ACAT1 ENSG00000255467 C11orf65 NPAT ATM
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C11orf65 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C11orf65 gene promoter:

Genomic Locations for C11orf65 Gene

Genomic Locations for C11orf65 Gene
159,029 bases
Minus strand

Genomic View for C11orf65 Gene

Genes around C11orf65 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf65 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf65 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf65 Gene

Proteins for C11orf65 Gene

  • Protein details for C11orf65 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C11orf65
    Protein Accession:
    Secondary Accessions:
    • B4DZU4
    • Q6PCA8

    Protein attributes for C11orf65 Gene

    313 amino acids
    Molecular mass:
    36720 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C11orf65 Gene


neXtProt entry for C11orf65 Gene

Post-translational modifications for C11orf65 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C11orf65 Gene

Domains & Families for C11orf65 Gene

Gene Families for C11orf65 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C11orf65 Gene


Suggested Antigen Peptide Sequences for C11orf65 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C11orf65: view

No data available for UniProtKB/Swiss-Prot for C11orf65 Gene

Function for C11orf65 Gene

Phenotypes From GWAS Catalog for C11orf65 Gene

Gene Ontology (GO) - Molecular Function for C11orf65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C11orf65: view
genes like me logo Genes that share phenotypes with C11orf65: view

miRNA for C11orf65 Gene

miRTarBase miRNAs that target C11orf65

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf65 Gene

Localization for C11orf65 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf65 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C11orf65 Gene

Pathways & Interactions for C11orf65 Gene

SuperPathways for C11orf65 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C11orf65 Gene


No data available for Pathways by source and SIGNOR curated interactions for C11orf65 Gene

Drugs & Compounds for C11orf65 Gene

(1) Drugs for C11orf65 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Metformin Approved Pharma AMP-activated protein kinase (AMPK) activator 1891
genes like me logo Genes that share compounds with C11orf65: view

Transcripts for C11orf65 Gene

mRNA/cDNA for C11orf65 Gene

Unigene Clusters for C11orf65 Gene

Chromosome 11 open reading frame 65:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf65 Gene

No ASD Table

Relevant External Links for C11orf65 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C11orf65 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C11orf65 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C11orf65 Gene

This gene is overexpressed in Testis (x22.8).

NURSA nuclear receptor signaling pathways regulating expression of C11orf65 Gene:


SOURCE GeneReport for Unigene cluster for C11orf65 Gene:

genes like me logo Genes that share expression patterns with C11orf65: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf65 Gene

Orthologs for C11orf65 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf65 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C11orf65 34
  • 100 (a)
C11H11orf65 33
  • 99.57 (n)
(Canis familiaris)
Mammalia C5H11orf65 33
  • 86.11 (n)
C11orf65 34
  • 81 (a)
(Bos Taurus)
Mammalia C15H11orf65 33
  • 85.04 (n)
(Mus musculus)
Mammalia 4930550C14Rik 33 16 34
  • 78.22 (n)
(Rattus norvegicus)
Mammalia RGD1311251 33
  • 77 (n)
(Ornithorhynchus anatinus)
Mammalia C11orf65 34
  • 53 (a)
(Monodelphis domestica)
Mammalia C11orf65 34
  • 50 (a)
(Anolis carolinensis)
Reptilia C11orf65 34
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490935 33
  • 59.25 (n)
(Danio rerio)
Actinopterygii gb:co360592 33
  • 57.12 (n)
C24H11orf65 34
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3681 34
  • 51 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13913 33
Species where no ortholog for C11orf65 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C11orf65 Gene

Gene Tree for C11orf65 (if available)
Gene Tree for C11orf65 (if available)

Paralogs for C11orf65 Gene Pseudogenes for C11orf65 Gene

genes like me logo Genes that share paralogs with C11orf65: view

No data available for Paralogs for C11orf65 Gene

Variants for C11orf65 Gene

Sequence variations from dbSNP and Humsavar for C11orf65 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1013290424 uncertain-significance, Ataxia-telangiectasia syndrome 108,353,879(-) A/C genic_downstream_transcript_variant, intron_variant
rs1018140779 likely-pathogenic, uncertain-significance, Ataxia-telangiectasia syndrome, not specified 108,329,097(-) C/G/T genic_downstream_transcript_variant, intron_variant
rs1026523956 uncertain-significance, Ataxia-telangiectasia syndrome 108,367,079(-) C/T genic_downstream_transcript_variant, intron_variant
rs1027959208 uncertain-significance, Ataxia-telangiectasia syndrome, not specified, Hereditary cancer-predisposing syndrome 108,332,791(-) A/G genic_downstream_transcript_variant, intron_variant
rs1038749014 uncertain-significance, Ataxia-telangiectasia syndrome 108,335,933(-) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf65 Gene

Variant ID Type Subtype PubMed ID
dgv2182n54 CNV gain 21841781
esv1612880 CNV insertion 17803354
esv21753 CNV gain 19812545
esv3627675 CNV gain 21293372
esv3627676 CNV loss 21293372
esv3627677 CNV loss 21293372
esv3892100 CNV loss 25118596
nsv832262 CNV loss 17160897
nsv832263 CNV gain 17160897

Variation tolerance for C11orf65 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C11orf65 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf65 Gene

Disorders for C11orf65 Gene

Additional Disease Information for C11orf65

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for C11orf65 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf65 Gene

Publications for C11orf65 Gene

  1. Does metformin work for everyone? A genome-wide association study for metformin response. (PMID: 21845381) Florez JC (Current diabetes reports 2011) 3 44 58
  2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for C11orf65 Gene

Sources for C11orf65 Gene

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