Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LINGO2 Gene

Aliases for LINGO2 Gene

  • Leucine Rich Repeat And Ig Domain Containing 2 2 3 5
  • Leucine-Rich Repeat Neuronal Protein 6C 3 4
  • Leucine-Rich Repeat Neuronal Protein 3 3 4
  • Leucine Rich Repeat Neuronal 6C 2 3
  • LRRN6C 3 4
  • LERN3 3 4
  • Leucine-Rich Repeat And Immunoglobulin-Like Domain-Containing Nogo Receptor-Interacting Protein 2 3

External Ids for LINGO2 Gene

Previous HGNC Symbols for LINGO2 Gene

  • LRRN6C

Summaries for LINGO2 Gene

GeneCards Summary for LINGO2 Gene

LINGO2 (Leucine Rich Repeat And Ig Domain Containing 2) is a Protein Coding gene. Diseases associated with LINGO2 include Essential Tremor. An important paralog of this gene is LINGO1.

Additional gene information for LINGO2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LINGO2 Gene

Genomics for LINGO2 Gene

GeneHancer (GH) Regulatory Elements for LINGO2 Gene

Promoters and enhancers for LINGO2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J029211 Enhancer 0.9 Ensembl ENCODE 650.7 +1.1 1115 3.3 CTCF MXI1 SUZ12 MAX BACH1 SIN3A RAD21 E2F1 FOXM1 ZFHX2 LINGO2 GC09P029215 GC09M029212 PIR41773
GH09J029214 Enhancer 0.5 Ensembl ENCODE 650.7 -1.1 -1101 0.2 MXI1 LINGO2 GC09M029212 GC09P029215
GH09J028915 Enhancer 0.6 ENCODE 17.2 +298.3 298342 0.7 JUN CEBPB EP300 BRCA1 RFX5 SP1 JUND MAFF ATF3 ZBTB33 LINGO2 MIR873 GC09P029173
GH09J028969 Enhancer 0.7 ENCODE dbSUPER 9.4 +243.3 243298 2.9 SP1 USF1 NANOG POLR2A POU5F1 MAFK LINGO2 MIR873 GC09P029173
GH09J028956 Enhancer 0.4 ENCODE dbSUPER 14.8 +257.2 257151 0.9 LINGO2 MIR873 GC09P029173
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LINGO2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LINGO2 gene promoter:
  • HNF-1A
  • HNF-1
  • HFH-1
  • POU3F1
  • RORalpha1
  • S8
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3

Genomic Locations for LINGO2 Gene

Genomic Locations for LINGO2 Gene
chr9:27,937,617-29,213,981
(GRCh38/hg38)
Size:
1,276,365 bases
Orientation:
Minus strand
chr9:27,948,076-28,719,303
(GRCh37/hg19)
Size:
771,228 bases
Orientation:
Minus strand

Genomic View for LINGO2 Gene

Genes around LINGO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LINGO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LINGO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LINGO2 Gene

Proteins for LINGO2 Gene

  • Protein details for LINGO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L985-LIGO2_HUMAN
    Recommended name:
    Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2
    Protein Accession:
    Q7L985
    Secondary Accessions:
    • A8K4K7
    • B2RPM5
    • Q6ZMD0

    Protein attributes for LINGO2 Gene

    Size:
    606 amino acids
    Molecular mass:
    68066 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD18799.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LINGO2 Gene

Post-translational modifications for LINGO2 Gene

  • Glycosylation at isoforms=327, posLast=279279, isoforms=188, posLast=130130, and isoforms=38
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Boster Bio Antibodies for LINGO2

No data available for DME Specific Peptides for LINGO2 Gene

Domains & Families for LINGO2 Gene

Gene Families for LINGO2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for LINGO2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LINGO2: view

No data available for UniProtKB/Swiss-Prot for LINGO2 Gene

Function for LINGO2 Gene

Phenotypes From GWAS Catalog for LINGO2 Gene

genes like me logo Genes that share phenotypes with LINGO2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LINGO2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LINGO2 Gene

Localization for LINGO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LINGO2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LINGO2 gene
Compartment Confidence
extracellular 4
plasma membrane 3
nucleus 2
endoplasmic reticulum 2
cytosol 2

Gene Ontology (GO) - Cellular Components for LINGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LINGO2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LINGO2 Gene

Pathways & Interactions for LINGO2 Gene

SuperPathways for LINGO2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LINGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007409 NOT axonogenesis IBA --
GO:0051965 positive regulation of synapse assembly IEA --
genes like me logo Genes that share ontologies with LINGO2: view

No data available for Pathways by source and SIGNOR curated interactions for LINGO2 Gene

Drugs & Compounds for LINGO2 Gene

No Compound Related Data Available

Transcripts for LINGO2 Gene

mRNA/cDNA for LINGO2 Gene

(11) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LINGO2 Gene

Leucine rich repeat and Ig domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LINGO2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: - -
SP3: -

Relevant External Links for LINGO2 Gene

GeneLoc Exon Structure for
LINGO2
ECgene alternative splicing isoforms for
LINGO2

Expression for LINGO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LINGO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LINGO2 Gene

This gene is overexpressed in Uterus (x9.6), Brain - Hypothalamus (x5.3), Brain - Cortex (x5.0), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.0).

Protein differential expression in normal tissues from HIPED for LINGO2 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LINGO2 Gene



Protein tissue co-expression partners for LINGO2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LINGO2 Gene:

LINGO2

SOURCE GeneReport for Unigene cluster for LINGO2 Gene:

Hs.745029

Evidence on tissue expression from TISSUES for LINGO2 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with LINGO2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LINGO2 Gene

Orthologs for LINGO2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LINGO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LINGO2 34 33
  • 99.56 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LINGO2 34
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LINGO2 34 33
  • 92.68 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LINGO2 34 33
  • 92.19 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LINGO2 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lingo2 16 34 33
  • 91.75 (n)
rat
(Rattus norvegicus)
Mammalia Lingo2 33
  • 91.53 (n)
chicken
(Gallus gallus)
Aves LINGO2 34 33
  • 81.24 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LINGO2 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490134 33
  • 73.06 (n)
zebrafish
(Danio rerio)
Actinopterygii sc:d0348 33
  • 65.78 (n)
LINGO2 (2 of 2) 34
  • 62 (a)
OneToMany
lingo2 34
  • 52 (a)
OneToMany
Species where no ortholog for LINGO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LINGO2 Gene

ENSEMBL:
Gene Tree for LINGO2 (if available)
TreeFam:
Gene Tree for LINGO2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LINGO2: view image

Paralogs for LINGO2 Gene

(7) SIMAP similar genes for LINGO2 Gene using alignment to 2 proteins:

  • LIGO2_HUMAN
  • B7ZMN0_HUMAN
genes like me logo Genes that share paralogs with LINGO2: view

Variants for LINGO2 Gene

Sequence variations from dbSNP and Humsavar for LINGO2 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000000013 -- 28,142,146(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000000098 -- 28,005,993(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000002009 -- 27,974,029(-) T/C intron_variant
rs1000003690 -- 28,655,388(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000004046 -- 28,476,743(-) C/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LINGO2 Gene

Variant ID Type Subtype PubMed ID
dgv1214n67 CNV loss 20364138
dgv1215n67 CNV loss 20364138
dgv12622n54 CNV loss 21841781
dgv12623n54 CNV loss 21841781
dgv12624n54 CNV loss 21841781
dgv12625n54 CNV loss 21841781
dgv12626n54 CNV loss 21841781
dgv12627n54 CNV loss 21841781
dgv12628n54 CNV loss 21841781
dgv12629n54 CNV loss 21841781
dgv12630n54 CNV loss 21841781
dgv12631n54 CNV loss 21841781
dgv12632n54 CNV loss 21841781
dgv12633n54 CNV loss 21841781
dgv12634n54 CNV loss 21841781
dgv12635n54 CNV loss 21841781
dgv12636n54 CNV loss 21841781
dgv12637n54 CNV loss 21841781
dgv12638n54 CNV loss 21841781
dgv12639n54 CNV loss 21841781
dgv12640n54 CNV loss 21841781
dgv1333e199 CNV deletion 23128226
dgv1463e214 CNV loss 21293372
dgv1464e214 CNV gain 21293372
dgv1465e214 CNV loss 21293372
dgv1466e214 CNV loss 21293372
dgv193e180 CNV loss 20482838
dgv2143e212 CNV loss 25503493
dgv2144e212 CNV loss 25503493
dgv2145e212 CNV loss 25503493
dgv2146e212 CNV loss 25503493
dgv2147e212 CNV loss 25503493
dgv2148e212 CNV loss 25503493
dgv218n73 CNV deletion 24416366
dgv259e55 CNV loss 17911159
dgv263n6 CNV deletion 16902084
dgv3977n106 CNV deletion 24896259
dgv3978n106 CNV deletion 24896259
dgv3979n106 CNV deletion 24896259
dgv7490n100 CNV loss 25217958
dgv7491n100 CNV loss 25217958
dgv7492n100 CNV loss 25217958
dgv7493n100 CNV loss 25217958
dgv7494n100 CNV loss 25217958
dgv7495n100 CNV loss 25217958
dgv7496n100 CNV loss 25217958
dgv7497n100 CNV loss 25217958
dgv7498n100 CNV loss 25217958
dgv934n27 CNV loss 19166990
esv1000979 CNV insertion 20482838
esv1007916 CNV insertion 20482838
esv1051208 CNV insertion 17803354
esv1147897 CNV insertion 17803354
esv1148835 CNV deletion 17803354
esv1188668 CNV insertion 17803354
esv1324908 CNV deletion 17803354
esv1725580 CNV insertion 17803354
esv2112607 CNV deletion 18987734
esv22038 CNV loss 19812545
esv22492 CNV loss 19812545
esv2256172 CNV deletion 18987734
esv2272620 CNV deletion 18987734
esv23641 CNV loss 19812545
esv23647 CNV loss 19812545
esv2403327 CNV deletion 18987734
esv2405496 CNV deletion 18987734
esv2421503 CNV deletion 20811451
esv2422108 CNV deletion 20811451
esv2422138 CNV deletion 20811451
esv2422438 CNV deletion 17116639
esv2458446 CNV deletion 19546169
esv2525095 CNV deletion 19546169
esv25335 CNV loss 19812545
esv2569146 CNV deletion 19546169
esv2574493 CNV insertion 19546169
esv2656989 CNV deletion 23128226
esv2658304 CNV deletion 23128226
esv2660134 CNV deletion 23128226
esv2663352 CNV deletion 23128226
esv2666224 CNV deletion 23128226
esv2667408 CNV deletion 23128226
esv2668823 CNV deletion 23128226
esv2669206 CNV deletion 23128226
esv2673821 CNV deletion 23128226
esv2675156 CNV deletion 23128226
esv2675655 CNV deletion 23128226
esv2677715 CNV deletion 23128226
esv2677725 CNV deletion 23128226
esv27168 CNV loss 19812545
esv2738331 CNV deletion 23290073
esv2738332 CNV deletion 23290073
esv2738333 CNV deletion 23290073
esv2738334 CNV deletion 23290073
esv2738335 CNV deletion 23290073
esv2738336 CNV deletion 23290073
esv2738337 CNV deletion 23290073
esv2738338 CNV deletion 23290073
esv2738340 CNV deletion 23290073
esv2738341 CNV deletion 23290073
esv2738342 CNV deletion 23290073
esv2738343 CNV deletion 23290073
esv2738344 CNV deletion 23290073
esv2752295 CNV loss 17911159
esv2752296 CNV loss 17911159
esv2756 CNV loss 18987735
esv2759684 CNV loss 17122850
esv2759685 CNV loss 17122850
esv2761272 CNV loss 21179565
esv2761513 CNV loss 21179565
esv2761514 CNV gain 21179565
esv2761515 CNV loss 21179565
esv2764152 CNV loss 21179565
esv29910 CNV loss 19812545
esv3124542 CNV deletion 24192839
esv3302845 CNV tandem duplication 20981092
esv3303397 CNV mobile element insertion 20981092
esv3305726 CNV mobile element insertion 20981092
esv3306573 CNV mobile element insertion 20981092
esv3308340 CNV mobile element insertion 20981092
esv3310159 CNV mobile element insertion 20981092
esv3358017 CNV insertion 20981092
esv3366032 CNV insertion 20981092
esv3375039 CNV insertion 20981092
esv3379350 CNV duplication 20981092
esv3399774 CNV insertion 20981092
esv3405617 CNV insertion 20981092
esv34239 CNV loss 17911159
esv3544730 CNV deletion 23714750
esv3544736 CNV deletion 23714750
esv3544738 CNV deletion 23714750
esv3544739 CNV deletion 23714750
esv3544741 CNV deletion 23714750
esv3573191 CNV loss 25503493
esv3573205 CNV loss 25503493
esv3573206 CNV loss 25503493
esv3573207 CNV loss 25503493
esv3573210 CNV loss 25503493
esv3573212 CNV loss 25503493
esv3573213 CNV loss 25503493
esv3576644 CNV gain 25503493
esv3584905 CNV loss 24956385
esv3584906 CNV loss 24956385
esv3620143 CNV loss 21293372
esv3620144 CNV gain 21293372
esv3620145 CNV loss 21293372
esv3620146 CNV loss 21293372
esv3620147 CNV loss 21293372
esv3620149 CNV loss 21293372
esv3620150 CNV loss 21293372
esv3620151 CNV loss 21293372
esv3620152 CNV loss 21293372
esv3620154 CNV loss 21293372
esv3620155 CNV loss 21293372
esv3620156 CNV loss 21293372
esv3620157 CNV loss 21293372
esv3620165 CNV loss 21293372
esv3620166 CNV loss 21293372
esv3620167 CNV loss 21293372
esv3620171 CNV loss 21293372
esv3620174 CNV loss 21293372
esv3620175 CNV loss 21293372
esv3620176 CNV loss 21293372
esv3620177 CNV loss 21293372
esv3620180 CNV gain 21293372
esv3620181 CNV loss 21293372
esv3620182 CNV loss 21293372
esv3620183 CNV loss 21293372
esv3620184 CNV loss 21293372
esv3620185 CNV loss 21293372
esv3620186 CNV loss 21293372
esv3620187 CNV loss 21293372
esv3620189 CNV loss 21293372
esv3620190 CNV loss 21293372
esv3620191 CNV loss 21293372
esv3620192 CNV loss 21293372
esv3620194 CNV loss 21293372
esv3620196 CNV loss 21293372
esv3620197 CNV loss 21293372
esv3620198 CNV loss 21293372
esv3620199 CNV loss 21293372
esv3620200 CNV loss 21293372
esv3620201 CNV loss 21293372
esv3620202 CNV loss 21293372
esv3620204 CNV loss 21293372
esv3620205 CNV loss 21293372
esv3620208 CNV loss 21293372
esv3620209 CNV loss 21293372
esv3654 CNV loss 18987735
esv9636 CNV loss 19470904
esv989504 CNV insertion 20482838
esv998355 CNV deletion 20482838
nsv1015401 CNV loss 25217958
nsv1015607 CNV loss 25217958
nsv1016073 CNV loss 25217958
nsv1016325 CNV loss 25217958
nsv1016889 CNV loss 25217958
nsv1018692 CNV loss 25217958
nsv1020013 CNV loss 25217958
nsv1020624 CNV loss 25217958
nsv1021064 CNV loss 25217958
nsv1024649 CNV loss 25217958
nsv1025438 CNV loss 25217958
nsv1025477 CNV loss 25217958
nsv1026574 CNV loss 25217958
nsv1026780 CNV loss 25217958
nsv1027677 CNV loss 25217958
nsv1028989 CNV loss 25217958
nsv1029522 CNV loss 25217958
nsv1032757 CNV loss 25217958
nsv1033357 CNV loss 25217958
nsv1034663 CNV loss 25217958
nsv1034717 CNV loss 25217958
nsv1075613 CNV deletion 25765185
nsv1078055 CNV duplication 25765185
nsv1115167 CNV deletion 24896259
nsv1125024 CNV duplication 24896259
nsv1125967 CNV tandem duplication 24896259
nsv1129821 CNV tandem duplication 24896259
nsv1132188 CNV deletion 24896259
nsv1137434 CNV deletion 24896259
nsv1140511 CNV deletion 24896259
nsv1140965 CNV deletion 24896259
nsv1140966 CNV deletion 24896259
nsv1146308 CNV insertion 26484159
nsv1150274 CNV deletion 26484159
nsv1161853 OTHER complex 26073780
nsv415588 CNV deletion 16902084
nsv442141 CNV gain 18776908
nsv442540 CNV loss 18776908
nsv442541 CNV loss 18776908
nsv466346 CNV loss 19166990
nsv466347 CNV loss 19166990
nsv466352 CNV loss 19166990
nsv466356 CNV loss 19166990
nsv471295 CNV loss 18288195
nsv471296 CNV loss 18288195
nsv476688 CNV novel sequence insertion 20440878
nsv508540 CNV deletion 20534489
nsv511413 CNV gain 21212237
nsv515136 CNV loss 21397061
nsv515137 CNV loss 21397061
nsv515582 CNV loss 19592680
nsv515752 CNV loss 19592680
nsv517027 CNV loss 19592680
nsv517063 CNV gain+loss 19592680
nsv519040 CNV loss 19592680
nsv519211 CNV loss 19592680
nsv519569 CNV gain 19592680
nsv520823 CNV loss 19592680
nsv521408 CNV loss 19592680
nsv521666 CNV loss 19592680
nsv523230 CNV loss 19592680
nsv523607 CNV loss 19592680
nsv526322 CNV gain 19592680
nsv526640 CNV loss 19592680
nsv613950 CNV gain 21841781
nsv613953 CNV loss 21841781
nsv613954 CNV loss 21841781
nsv613965 CNV loss 21841781
nsv613971 CNV gain 21841781
nsv613975 CNV loss 21841781
nsv613976 CNV loss 21841781
nsv613977 CNV loss 21841781
nsv613978 CNV loss 21841781
nsv613979 CNV loss 21841781
nsv613980 CNV loss 21841781
nsv613981 CNV gain 21841781
nsv613982 CNV loss 21841781
nsv613983 CNV loss 21841781
nsv613985 CNV loss 21841781
nsv613988 CNV loss 21841781
nsv613989 CNV loss 21841781
nsv614001 CNV loss 21841781
nsv614004 CNV loss 21841781
nsv614010 CNV loss 21841781
nsv614011 CNV loss 21841781
nsv614039 CNV gain 21841781
nsv614055 CNV loss 21841781
nsv614056 CNV loss 21841781
nsv6513 CNV deletion 18451855
nsv6514 CNV insertion 18451855
nsv6515 CNV deletion 18451855
nsv6516 CNV insertion 18451855
nsv6517 CNV deletion 18451855
nsv818695 CNV loss 17921354
nsv819775 CNV loss 19587683
nsv820294 CNV loss 19587683
nsv820295 CNV loss 19587683
nsv824896 CNV loss 20364138
nsv831533 CNV gain 17160897
nsv8430 CNV loss 18304495
nsv8431 CNV loss 18304495
nsv968604 CNV duplication 23825009
nsv969768 CNV deletion 23825009
nsv969769 CNV duplication 23825009

Variation tolerance for LINGO2 Gene

Residual Variation Intolerance Score: 5.55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LINGO2 Gene

Human Gene Mutation Database (HGMD)
LINGO2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LINGO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LINGO2 Gene

Disorders for LINGO2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LINGO2 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
essential tremor
  • benign essential tremor
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LINGO2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LINGO2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LINGO2 Gene

Publications for LINGO2 Gene

  1. LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease. (PMID: 20369371) Vilariño-Güell C … Farrer MJ (Neurogenetics 2010) 3 44 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PMID: 20935630) Speliotes EK … Loos RJ (Nature genetics 2010) 3 44 58
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for LINGO2 Gene

Sources for LINGO2 Gene

Content
Loading form....