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Aliases for WFDC5 Gene

Aliases for WFDC5 Gene

  • WAP Four-Disulfide Core Domain 5 2 3 5
  • Putative Protease Inhibitor WAP1 3 4
  • P53-Responsive Gene 5 Protein 3 4
  • PRG5 3 4
  • WAP1 3 4
  • WAP Four-Disulfide Core Domain Protein 5 3
  • Protease Inhibitor WAP1 3
  • DJ211D12.5 3

External Ids for WFDC5 Gene

Previous GeneCards Identifiers for WFDC5 Gene

  • GC20M043426
  • GC20M044376
  • GC20M044423
  • GC20M043171
  • GC20M043738
  • GC20M040479

Summaries for WFDC5 Gene

Entrez Gene Summary for WFDC5 Gene

  • This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. Most WFDC proteins contain only one WFDC domain, and this encoded protein contains two WFDC domains. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. [provided by RefSeq, Jul 2008]

GeneCards Summary for WFDC5 Gene

WFDC5 (WAP Four-Disulfide Core Domain 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity.

UniProtKB/Swiss-Prot for WFDC5 Gene

  • Putative acid-stable proteinase inhibitor.

Gene Wiki entry for WFDC5 Gene

Additional gene information for WFDC5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFDC5 Gene

Genomics for WFDC5 Gene

GeneHancer (GH) Regulatory Elements for WFDC5 Gene

Promoters and enhancers for WFDC5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J045116 Promoter 0.7 EPDnew 650.7 +1.1 1145 0.1 ZNF335 GLIS2 GLIS1 WFDC5 KCNS1
GH20J045115 Enhancer 0.3 FANTOM5 652.4 +0.2 234 0.2 ZNF512 WFDC5 SLPI KCNS1
GH20J044965 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.4 +147.4 147395 7.5 CLOCK MLX DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SSRP1 STK4 PCIF1 SYS1 ENSG00000271984 PABPC1L DNTTIP1 OSER1 WFDC5 TOMM34 SERINC3
GH20J045293 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 9.8 -177.4 -177405 1.4 ATF1 SIN3A ZNF143 ATF7 DEK REST SMARCB1 SSRP1 MIER3 GMEB1 SLPI NCOA5 ZNF335 ZSWIM1 ZSWIM3 WFDC5 RNU6ATAC38P WFDC12 RBPJL MATN4
GH20J045068 Enhancer 1.4 Ensembl ENCODE dbSUPER 11 +45.6 45579 3.7 PKNOX1 ATF1 FEZF1 BRCA1 TCF12 GATA2 ATF7 FOS DEK NCOA1 KCNS1 ZNF335 PCIF1 ENSG00000271984 WFDC5 DNTTIP1 OSER1 STK4 PIR48188 ENSG00000252021
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WFDC5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WFDC5 gene promoter:
  • STAT1beta
  • STAT1alpha
  • STAT1
  • C/EBPalpha
  • NF-kappaB
  • NF-kappaB1
  • RelA
  • POU2F1
  • POU2F1a
  • AP-2alpha

Genomic Locations for WFDC5 Gene

Genomic Locations for WFDC5 Gene
6,870 bases
Minus strand
5,721 bases
Minus strand

Genomic View for WFDC5 Gene

Genes around WFDC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WFDC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WFDC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFDC5 Gene

Proteins for WFDC5 Gene

  • Protein details for WFDC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WAP four-disulfide core domain protein 5
    Protein Accession:
    Secondary Accessions:
    • Q5H981
    • Q6UWE4

    Protein attributes for WFDC5 Gene

    224 amino acids
    Molecular mass:
    24238 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WFDC5 Gene


neXtProt entry for WFDC5 Gene

Post-translational modifications for WFDC5 Gene

No Post-translational modifications

Other Protein References for WFDC5 Gene

No data available for DME Specific Peptides for WFDC5 Gene

Domains & Families for WFDC5 Gene

Gene Families for WFDC5 Gene

Protein Domains for WFDC5 Gene

Suggested Antigen Peptide Sequences for WFDC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WFDC5: view

No data available for UniProtKB/Swiss-Prot for WFDC5 Gene

Function for WFDC5 Gene

Molecular function for WFDC5 Gene

UniProtKB/Swiss-Prot Function:
Putative acid-stable proteinase inhibitor.
UniProtKB/Swiss-Prot Induction:
By p53/TP53.

Phenotypes From GWAS Catalog for WFDC5 Gene

Gene Ontology (GO) - Molecular Function for WFDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with WFDC5: view
genes like me logo Genes that share phenotypes with WFDC5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for WFDC5

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WFDC5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WFDC5 Gene

Localization for WFDC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFDC5 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WFDC5 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for WFDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with WFDC5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WFDC5 Gene

Pathways & Interactions for WFDC5 Gene

SuperPathways for WFDC5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WFDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with WFDC5: view

No data available for Pathways by source and SIGNOR curated interactions for WFDC5 Gene

Drugs & Compounds for WFDC5 Gene

No Compound Related Data Available

Transcripts for WFDC5 Gene

mRNA/cDNA for WFDC5 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WFDC5 Gene

WAP four-disulfide core domain 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WFDC5

Alternative Splicing Database (ASD) splice patterns (SP) for WFDC5 Gene

No ASD Table

Relevant External Links for WFDC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WFDC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WFDC5 Gene

mRNA differential expression in normal tissues according to GTEx for WFDC5 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x25.8) and Skin - Not Sun Exposed (Suprapubic) (x25.2).

NURSA nuclear receptor signaling pathways regulating expression of WFDC5 Gene:


SOURCE GeneReport for Unigene cluster for WFDC5 Gene:


Evidence on tissue expression from TISSUES for WFDC5 Gene

  • Skin(4.4)
genes like me logo Genes that share expression patterns with WFDC5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WFDC5 Gene

Orthologs for WFDC5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WFDC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WFDC5 34 33
  • 99.19 (n)
(Canis familiaris)
Mammalia WFDC5 34 33
  • 79.95 (n)
(Bos Taurus)
Mammalia WFDC5 34 33
  • 79.06 (n)
(Rattus norvegicus)
Mammalia Wfdc5 33
  • 76.96 (n)
(Mus musculus)
Mammalia Wfdc5 16 34 33
  • 74.53 (n)
(Monodelphis domestica)
Mammalia WFDC5 34
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia WFDC5 34
  • 62 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 36 (a)
-- 34
  • 34 (a)
-- 34
  • 32 (a)
-- 34
  • 31 (a)
-- 34
  • 28 (a)
Species where no ortholog for WFDC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WFDC5 Gene

Gene Tree for WFDC5 (if available)
Gene Tree for WFDC5 (if available)
Evolutionary constrained regions (ECRs) for WFDC5: view image

Paralogs for WFDC5 Gene

(1) SIMAP similar genes for WFDC5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WFDC5: view

No data available for Paralogs for WFDC5 Gene

Variants for WFDC5 Gene

Sequence variations from dbSNP and Humsavar for WFDC5 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000040854 -- 45,111,502(-) C/T intron_variant
rs1000165688 -- 45,116,974(-) T/C upstream_transcript_variant
rs1000967420 -- 45,117,454(-) C/T upstream_transcript_variant
rs1001082026 -- 45,117,093(-) G/A upstream_transcript_variant
rs1001844915 -- 45,110,400(-) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for WFDC5 Gene

Variant ID Type Subtype PubMed ID
nsv1056102 CNV loss 25217958

Variation tolerance for WFDC5 Gene

Residual Variation Intolerance Score: 53.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.54; 64.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WFDC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WFDC5 Gene

Disorders for WFDC5 Gene

Additional Disease Information for WFDC5

No disorders were found for WFDC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WFDC5 Gene

Publications for WFDC5 Gene

  1. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PMID: 12206714) Clauss A … Lundwall A (The Biochemical journal 2002) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  5. The whey acidic protein family: a new signature motif and three-dimensional structure by comparative modeling. (PMID: 10680116) Ranganathan S … Nicholas KR (Journal of molecular graphics & modelling 1999) 2 3 58

Products for WFDC5 Gene

Sources for WFDC5 Gene

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