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Aliases for ADRA1A Gene

Aliases for ADRA1A Gene

  • Adrenoceptor Alpha 1A 2 3 5
  • Adrenergic, Alpha-1A-, Receptor 2 3
  • Alpha-1C Adrenergic Receptor 3 4
  • Alpha-1A Adrenoreceptor 3 4
  • Alpha-1A Adrenoceptor 3 4
  • ADRA1C 3 4
  • Alpha-1A Adrenergic Receptor 3
  • Alpha-Adrenergic Receptor 1c 4
  • G Protein Coupled Receptor 3
  • ADRA1L1 3

External Ids for ADRA1A Gene

Previous HGNC Symbols for ADRA1A Gene

  • ADRA1C

Previous GeneCards Identifiers for ADRA1A Gene

  • GC08M026378
  • GC08M027048
  • GC08M026627
  • GC08M026661
  • GC08M025150
  • GC08M026605

Summaries for ADRA1A Gene

Entrez Gene Summary for ADRA1A Gene

  • Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRA1A Gene

ADRA1A (Adrenoceptor Alpha 1A) is a Protein Coding gene. Diseases associated with ADRA1A include Horner's Syndrome and Ureter, Cancer Of. Among its related pathways are Monoamine GPCRs and AMP-activated Protein Kinase (AMPK) Signaling. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and alpha1-adrenergic receptor activity. An important paralog of this gene is ADRA1B.

UniProtKB/Swiss-Prot for ADRA1A Gene

  • This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.

Tocris Summary for ADRA1A Gene

  • Adrenergic alpha1 receptors (alpha1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha2A, alpha2B, alpha2C, beta1, beta2 and beta3. The adrenergic alpha1 receptors are further divided into three subtypes: alpha1A, alpha1B and alpha1D receptors.

Gene Wiki entry for ADRA1A Gene

Additional gene information for ADRA1A Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRA1A Gene

Genomics for ADRA1A Gene

GeneHancer (GH) Regulatory Elements for ADRA1A Gene

Promoters and enhancers for ADRA1A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J026865 Promoter 0.7 EPDnew 650.4 +5.3 5303 0.1 ZNF335 SUZ12 EZH2 ADRA1A COX6B1P4
GH08J026839 Enhancer 0.9 Ensembl ENCODE 29.3 +30.6 30608 2 TFAP4 FOXA2 MAX RAD21 ETS1 YY1 HNF4G GATAD2A RFX1 RXRA ADRA1A COX6B1P4
GH08J026861 Enhancer 0.6 FANTOM5 21.6 +9.8 9819 0.3 FOXA2 RXRA MAX REST RAD21 YY1 NR2F2 SP1 JUND ATF3 ADRA1A PTK2B COX6B1P4
GH08J027033 Enhancer 0.6 ENCODE 16.8 -162.6 -162561 0.1 ATF1 GABPA SP1 FOSL1 JUND POLR2A FOS FOSL2 CREM ADRA1A GC08M026972 MIR548H4
GH08J027359 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.6 -495.1 -495135 13.4 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A IRF4 YY1 ZNF766 PTK2B CLU ADRA1A EPHX2 MIR6842
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADRA1A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADRA1A gene promoter:
  • GATA-1
  • Nkx2-5
  • FOXJ2 (long isoform)
  • FOXJ2
  • AML1a
  • E47
  • CUTL1

Genomic Locations for ADRA1A Gene

Genomic Locations for ADRA1A Gene
128,162 bases
Minus strand
119,124 bases
Minus strand

Genomic View for ADRA1A Gene

Genes around ADRA1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRA1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRA1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA1A Gene

Proteins for ADRA1A Gene

  • Protein details for ADRA1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-1A adrenergic receptor
    Protein Accession:
    Secondary Accessions:
    • A8K0I3
    • B0ZBD1
    • B0ZBD2
    • B0ZBD4
    • B0ZBD5
    • B0ZBD6
    • B0ZBD8
    • B0ZBD9
    • O60451
    • Q13675
    • Q13729
    • Q4VBM7
    • Q6RUJ4
    • Q6RUJ5
    • Q6RUJ7
    • Q6RUJ8
    • Q6RUJ9
    • Q96RE8
    • Q9UD63
    • Q9UD67

    Protein attributes for ADRA1A Gene

    466 amino acids
    Molecular mass:
    51487 Da
    Quaternary structure:
    • Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes (PubMed:22120526). Interacts with CAVIN4 (PubMed:24567387).

    Alternative splice isoforms for ADRA1A Gene

neXtProt entry for ADRA1A Gene

Post-translational modifications for ADRA1A Gene

  • C-terminal Ser or Thr residues may be phosphorylated.
  • Glycosylation at Asn22, Asn13, and Asn7
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADRA1A Gene

Domains & Families for ADRA1A Gene

Gene Families for ADRA1A Gene

Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ADRA1A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.
genes like me logo Genes that share domains with ADRA1A: view

Function for ADRA1A Gene

Molecular function for ADRA1A Gene

UniProtKB/Swiss-Prot Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
GENATLAS Biochemistry:
adrenergic,alpha-1A,receptor,G protein coupled receptor superfamily,with four alternatively spliced isoforms,stimulating,acting through the phosphatidylinositol Ca2+ second messenger system

Phenotypes From GWAS Catalog for ADRA1A Gene

Gene Ontology (GO) - Molecular Function for ADRA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004935 adrenergic receptor activity IEA,IBA --
GO:0004937 alpha1-adrenergic receptor activity NAS,TAS 7737411
GO:0005515 protein binding IPI 24567387
genes like me logo Genes that share ontologies with ADRA1A: view
genes like me logo Genes that share phenotypes with ADRA1A: view

Animal Models for ADRA1A Gene

MGI Knock Outs for ADRA1A:

Animal Model Products

miRNA for ADRA1A Gene

miRTarBase miRNAs that target ADRA1A

Clone Products

  • R&D Systems cDNA Clones for ADRA1A (alpha-1A Adrenergic R/ADRA1A)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADRA1A Gene

Localization for ADRA1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA1A Gene

Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm. Membrane, caveola. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADRA1A gene
Compartment Confidence
plasma membrane 5
nucleus 5

Gene Ontology (GO) - Cellular Components for ADRA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 22120526
GO:0005737 cytoplasm IEA,IDA 24567387
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8396931
GO:0005901 caveola IEA --
genes like me logo Genes that share ontologies with ADRA1A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADRA1A Gene

Pathways & Interactions for ADRA1A Gene

genes like me logo Genes that share pathways with ADRA1A: view

Gene Ontology (GO) - Biological Process for ADRA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001985 negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure IEA --
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IBA --
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine IEA --
GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine IEA --
GO:0003084 positive regulation of systemic arterial blood pressure IEA --
genes like me logo Genes that share ontologies with ADRA1A: view

No data available for SIGNOR curated interactions for ADRA1A Gene

Drugs & Compounds for ADRA1A Gene

(273) Drugs for ADRA1A Gene - From: DrugBank, PharmGKB, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Prazosin Approved Pharma Inverse agonist, Antagonist, antagonist, Target 69
Alfuzosin Approved, Investigational Pharma antagonist, Target 52
Doxazosin Approved Pharma antagonist, Target 64
Terazosin Approved Pharma antagonist, Target α1-adrenergic receptor antagonist 23
Silodosin Approved Pharma Antagonist, Target, antagonist α1-adrenoceptor antagonist 23

(5) Additional Compounds for ADRA1A Gene - From: HMDB, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Promazine 5-sulfoxide
BMY 7378 dihydrochloride
Urapidil hydrochloride

(5) Tocris Compounds for ADRA1A Gene

Compound Action Cas Number
3-MPPI alpha1 ligand 133399-65-2
A 61603 hydrobromide alpha1A agonist 107756-30-9
BMY 7378 dihydrochloride Selective alpha1D antagonist 21102-95-4
Cirazoline hydrochloride Selective alpha1 agonist 40600-13-3
Urapidil hydrochloride alpha1 antagonist. Also 5-HT1A receptor agonist 64887-14-5
genes like me logo Genes that share compounds with ADRA1A: view

Transcripts for ADRA1A Gene

mRNA/cDNA for ADRA1A Gene

Unigene Clusters for ADRA1A Gene

Adrenoceptor alpha 1A:
Representative Sequences:

Clone Products

  • R&D Systems cDNA Clones for ADRA1A (alpha-1A Adrenergic R/ADRA1A)

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA1A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1: - - -
SP2: - -
SP3: - - - -
SP5: -

Relevant External Links for ADRA1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADRA1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADRA1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADRA1A Gene

This gene is overexpressed in Liver (x18.5) and Heart - Left Ventricle (x4.9).

Protein differential expression in normal tissues from HIPED for ADRA1A Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADRA1A Gene

Protein tissue co-expression partners for ADRA1A Gene

NURSA nuclear receptor signaling pathways regulating expression of ADRA1A Gene:


SOURCE GeneReport for Unigene cluster for ADRA1A Gene:


mRNA Expression by UniProt/SwissProt for ADRA1A Gene:

Tissue specificity: Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.

Evidence on tissue expression from TISSUES for ADRA1A Gene

  • Liver(4.5)
  • Heart(4.4)
  • Nervous system(4.3)
  • Blood(4.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with ADRA1A: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADRA1A Gene

Orthologs for ADRA1A Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA1A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADRA1A 34 33
  • 99.29 (n)
(Canis familiaris)
Mammalia ADRA1A 34 33
  • 91.85 (n)
(Bos Taurus)
Mammalia ADRA1A 34 33
  • 90.2 (n)
(Rattus norvegicus)
Mammalia Adra1a 33
  • 87.84 (n)
(Mus musculus)
Mammalia Adra1a 16 34 33
  • 87.12 (n)
(Ornithorhynchus anatinus)
Mammalia ADRA1A 34
  • 82 (a)
(Monodelphis domestica)
Mammalia ADRA1A 34
  • 78 (a)
(Gallus gallus)
Aves ADRA1A 34 33
  • 73.75 (n)
(Anolis carolinensis)
Reptilia ADRA1A 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492776 33
  • 65.52 (n)
(Danio rerio)
Actinopterygii LOC798498 33
  • 60.48 (n)
ADRA1A (2 of 2) 34
  • 54 (a)
adra1ab 34
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta Oamb 34 33
  • 55.94 (n)
DopR2 35
  • 44 (a)
CG7431 35
  • 41 (a)
5-HT1B 35
  • 38 (a)
DopR 35
  • 34 (a)
CG6989 35
  • 32 (a)
5-HT1A 35
  • 32 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPROAR1 33
  • 53.03 (n)
(Caenorhabditis elegans)
Secernentea dop-4 34 33
  • 46.51 (n)
C52B11.3 35
  • 38 (a)
Species where no ortholog for ADRA1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRA1A Gene

Gene Tree for ADRA1A (if available)
Gene Tree for ADRA1A (if available)
Evolutionary constrained regions (ECRs) for ADRA1A: view image

Paralogs for ADRA1A Gene

genes like me logo Genes that share paralogs with ADRA1A: view

Variants for ADRA1A Gene

Sequence variations from dbSNP and Humsavar for ADRA1A Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
VAR_035756 A breast cancer sample p.Gly40Trp
rs1000011190 -- 26,787,139(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000025875 -- 26,842,591(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000031923 -- 26,768,756(-) T/G downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000072785 -- 26,856,035(-) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADRA1A Gene

Variant ID Type Subtype PubMed ID
esv3616666 OTHER inversion 21293372
nsv527478 CNV gain 19592680
nsv610864 CNV loss 21841781

Variation tolerance for ADRA1A Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.12; 69.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADRA1A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA1A Gene

Disorders for ADRA1A Gene

MalaCards: The human disease database

(8) MalaCards diseases for ADRA1A Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
horner's syndrome
  • bernard horner syndrome
ureter, cancer of
  • ureter cancer
prostatic hypertrophy
  • prostatic hyperplasia
  • calculus of ureter
prostatic hyperplasia, benign
  • bph
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ADRA1A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ADRA1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADRA1A Gene

Publications for ADRA1A Gene

  1. Genetic variation in the autonomic nervous system affects mortality: a study of 1,095 trauma patients. (PMID: 19476811) Morris JA … Canter JA (Journal of the American College of Surgeons 2009) 3 22 44 58
  2. Polymorphisms in the alpha1A-adrenoceptor gene do not modify the short- and long-term efficacy of alpha1-adrenoceptor antagonists in the treatment of benign prostatic hyperplasia. (PMID: 16536786) Mochtar CA … Kiemeney LA (BJU international 2006) 3 22 44 58
  3. Polymorphisms in the promoter region of the alpha1A-adrenoceptor gene are associated with schizophrenia/schizoaffective disorder in a Spanish isolate population. (PMID: 16043131) Clark DA … Kerwin RW (Biological psychiatry 2005) 3 22 44 58
  4. Alpha 1A-adrenergic receptor polymorphism and vascular response. (PMID: 15179408) Sofowora GG … Stein CM (Clinical pharmacology and therapeutics 2004) 3 4 44 58
  5. The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics. (PMID: 15824464) Matayoshi T … Kawano Y (Hypertension research : official journal of the Japanese Society of Hypertension 2004) 3 22 44 58

Products for ADRA1A Gene

Sources for ADRA1A Gene

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