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Aliases for KLC3 Gene

Aliases for KLC3 Gene

  • Kinesin Light Chain 3 2 3 3 5
  • Kinesin Light Chain 2 3 4
  • KLC2L 3 4
  • KLC2 3 4
  • KLC2-Like 4
  • KNS2B 3
  • KLCt 3

External Ids for KLC3 Gene

Previous GeneCards Identifiers for KLC3 Gene

  • GC19P050538
  • GC19P045847
  • GC19P042276
  • GC19P045851

Summaries for KLC3 Gene

Entrez Gene Summary for KLC3 Gene

  • This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLC3 Gene

KLC3 (Kinesin Light Chain 3) is a Protein Coding gene. Diseases associated with KLC3 include Spastic Paraplegia, Optic Atrophy, And Neuropathy. Among its related pathways are Golgi-to-ER retrograde transport and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include microtubule binding and kinesin binding. An important paralog of this gene is KLC4.

UniProtKB/Swiss-Prot for KLC3 Gene

  • Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.

Gene Wiki entry for KLC3 Gene

Additional gene information for KLC3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLC3 Gene

Genomics for KLC3 Gene

GeneHancer (GH) Regulatory Elements for KLC3 Gene

Promoters and enhancers for KLC3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J045340 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 650.4 +7.4 7398 0.3 RB1 ZSCAN4 KLF17 KLF14 ZEB1 GLIS2 EGR1 EGR2 SP3 ZNF398 GC19P045339 KLC3 MARK4 GC19M045351
GH19J045320 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.4 -10.8 -10786 4.7 BCOR ZNF768 PTBP1 PKNOX1 ESRRA ZMYM3 ZNF335 ZNF121 ZFHX2 POLR2A CKM KLC3 MARK4 ERCC2 DMPK RTN2 PPM1N CD3EAP GC19M045307
GH19J045311 Enhancer 1 Ensembl ENCODE dbSUPER 12.7 -21.5 -21542 0.2 GATAD2A ZHX2 MNT KAT8 GABPA ZGPAT GABPB1 CREB1 CREM THAP11 KLC3 RPS16P9 EXOC3L2 MARK4 PPP1R13L CD3EAP GC19M045307 CKM
GH19J045401 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.5 +71.1 71138 6.2 CLOCK FEZF1 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D GLIS1 RCOR2 CD3EAP PPP1R13L CCDC61 ZNF180 CLASRP FBXO46 ENSG00000269148 ENSG00000268810 SYMPK IRF2BP1
GH19J046067 Enhancer 1.3 Ensembl ENCODE dbSUPER 6.9 +736.0 735988 3.2 FOXA2 FEZF1 GLIS2 FOS ATF7 SP3 TSHZ1 PPARG ZNF518A NFIL3 HIF3A IRF2BP1 LOC93429 IGFL3 KLC3 PIR33092 LOC400706 IGFL4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLC3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLC3 gene promoter:
  • MyoD
  • Roaz
  • FAC1
  • ITF-2
  • Tal-1beta
  • NRSF form 2
  • NRSF form 1

Genomic Locations for KLC3 Gene

Genomic Locations for KLC3 Gene
chr19:45,333,434-45,351,559
(GRCh38/hg38)
Size:
18,126 bases
Orientation:
Plus strand
chr19:45,836,692-45,854,778
(GRCh37/hg19)
Size:
18,087 bases
Orientation:
Plus strand

Genomic View for KLC3 Gene

Genes around KLC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLC3 Gene

Proteins for KLC3 Gene

  • Protein details for KLC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P597-KLC3_HUMAN
    Recommended name:
    Kinesin light chain 3
    Protein Accession:
    Q6P597
    Secondary Accessions:
    • A0AVM3
    • A2RUT6
    • Q6GMU2
    • Q8NAL1
    • Q8WWJ9

    Protein attributes for KLC3 Gene

    Size:
    504 amino acids
    Molecular mass:
    55364 Da
    Quaternary structure:
    • Oligomer composed of two heavy chains and two light chains. Associates with microtubulin in an ATP-dependent manner. Interacts with KIF5C. Interacts with ODF1 (By similarity). Interacts with LRGUK (By similarity).

    Alternative splice isoforms for KLC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLC3 Gene

Post-translational modifications for KLC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for KLC3
  • Boster Bio Antibodies for KLC3

No data available for DME Specific Peptides for KLC3 Gene

Domains & Families for KLC3 Gene

Gene Families for KLC3 Gene

Protein Domains for KLC3 Gene

Suggested Antigen Peptide Sequences for KLC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P597

UniProtKB/Swiss-Prot:

KLC3_HUMAN :
  • The heptad repeat (HR) motif is sufficient for interaction with kinesin heavy (KHL) chains and ODF1. The TPR region is involved in mitochondrial binding (By similarity).
  • Belongs to the kinesin light chain family.
Domain:
  • The heptad repeat (HR) motif is sufficient for interaction with kinesin heavy (KHL) chains and ODF1. The TPR region is involved in mitochondrial binding (By similarity).
Family:
  • Belongs to the kinesin light chain family.
genes like me logo Genes that share domains with KLC3: view

Function for KLC3 Gene

Molecular function for KLC3 Gene

UniProtKB/Swiss-Prot Function:
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.

Gene Ontology (GO) - Molecular Function for KLC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008017 microtubule binding IEA --
GO:0019894 kinesin binding IEA --
genes like me logo Genes that share ontologies with KLC3: view
genes like me logo Genes that share phenotypes with KLC3: view

Animal Model Products

miRNA for KLC3 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLC3 Gene

Localization for KLC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLC3 Gene

Cytoplasm, cytoskeleton. Note=In elongating spermatid tail midpiece, localized in outer dense fibers (ODFs) and associates with mitochondria. Also localizes to the manchette in elongating spermatids. {ECO:0000250 UniProtKB:Q68G30, ECO:0000250 UniProtKB:Q91W40}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLC3 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KLC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex IEA --
GO:0005874 microtubule IEA --
GO:0031514 motile cilium IEA --
genes like me logo Genes that share ontologies with KLC3: view

Pathways & Interactions for KLC3 Gene

genes like me logo Genes that share pathways with KLC3: view

Gene Ontology (GO) - Biological Process for KLC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008088 axo-dendritic transport IEA --
genes like me logo Genes that share ontologies with KLC3: view

No data available for SIGNOR curated interactions for KLC3 Gene

Drugs & Compounds for KLC3 Gene

(7) Drugs for KLC3 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2906
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 2100
Oxaliplatin Approved, Investigational Pharma Antitumor agent, Platinum 1560
platinum Investigational Pharma 0
GSK-923295 Investigational Pharma CENP-E inhibitor,small-molecule, Kinesin protein inhibitors 0
genes like me logo Genes that share compounds with KLC3: view

Transcripts for KLC3 Gene

Unigene Clusters for KLC3 Gene

Kinesin light chain 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLC3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5: -

Relevant External Links for KLC3 Gene

GeneLoc Exon Structure for
KLC3
ECgene alternative splicing isoforms for
KLC3

Expression for KLC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLC3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x16.7), Skin - Sun Exposed (Lower leg) (x15.9), and Esophagus - Mucosa (x4.8).

Protein differential expression in normal tissues from HIPED for KLC3 Gene

This gene is overexpressed in Cervix (30.3), Peripheral blood mononuclear cells (8.9), and Monocytes (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KLC3 Gene



NURSA nuclear receptor signaling pathways regulating expression of KLC3 Gene:

KLC3

SOURCE GeneReport for Unigene cluster for KLC3 Gene:

Hs.298079

Evidence on tissue expression from TISSUES for KLC3 Gene

  • Nervous system(4.3)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with KLC3: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLC3 Gene

Orthologs for KLC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLC3 34 33
  • 99.34 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KLC3 34 33
  • 89.07 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KLC3 34 33
  • 88.8 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Klc3 16 34 33
  • 85.69 (n)
rat
(Rattus norvegicus)
Mammalia Klc3 33
  • 83.9 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 3 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia KLC3 34
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii klc3 34
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Klc 34
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea klc-2 34
  • 43 (a)
ManyToMany
klc-1 34
  • 34 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
OneToMany
Species where no ortholog for KLC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KLC3 Gene

ENSEMBL:
Gene Tree for KLC3 (if available)
TreeFam:
Gene Tree for KLC3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KLC3: view image

Paralogs for KLC3 Gene

Paralogs for KLC3 Gene

(6) SIMAP similar genes for KLC3 Gene using alignment to 4 proteins:

  • KLC3_HUMAN
  • K7EL76_HUMAN
  • K7ELP9_HUMAN
  • K7ENJ3_HUMAN
genes like me logo Genes that share paralogs with KLC3: view

Variants for KLC3 Gene

Sequence variations from dbSNP and Humsavar for KLC3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs13181 benign, not-provided, not specified, Xeroderma pigmentosum, Non-small cell lung cancer, Osteosarcoma 45,351,661(+) T/A/G downstream_transcript_variant
rs140285667 uncertain-significance, Xeroderma pigmentosum 45,351,477(+) A/G 3_prime_UTR_variant
rs142103003 uncertain-significance, Xeroderma pigmentosum 45,351,457(+) C/T 3_prime_UTR_variant
rs200022901 uncertain-significance, Xeroderma pigmentosum 45,351,652(+) C/G downstream_transcript_variant
rs3916891 uncertain-significance, Xeroderma pigmentosum 45,351,458(+) C/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for KLC3 Gene

Variant ID Type Subtype PubMed ID
dgv1054e212 CNV gain 25503493
dgv29n64 CNV gain 17921354
dgv3606n100 CNV gain 25217958
esv3644502 CNV gain 21293372
esv3644503 CNV loss 21293372
esv3644504 CNV gain 21293372
nsv1063547 CNV gain 25217958
nsv1160648 CNV duplication 26073780
nsv442466 CNV gain 18776908
nsv458711 CNV gain 19166990
nsv470146 CNV loss 18288195
nsv476278 CNV novel sequence insertion 20440878
nsv579867 CNV gain 21841781
nsv579868 CNV gain 21841781
nsv833844 CNV loss 17160897
nsv833845 CNV loss 17160897

Variation tolerance for KLC3 Gene

Residual Variation Intolerance Score: 85.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 48.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLC3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLC3 Gene

Disorders for KLC3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLC3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spastic paraplegia, optic atrophy, and neuropathy
  • spoan
- elite association - COSMIC cancer census association via MalaCards
Search KLC3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KLC3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KLC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLC3 Gene

Publications for KLC3 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Sequence analysis of the ERCC2 gene regions in human, mouse, and hamster reveals three linked genes. (PMID: 8786141) Lamerdin JE … Carrano AV (Genomics 1996) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for KLC3 Gene

Sources for KLC3 Gene

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