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Aliases for SLC25A10 Gene

Aliases for SLC25A10 Gene

  • Solute Carrier Family 25 Member 10 2 3 4 5
  • Solute Carrier Family 25 (Mitochondrial Carrier; Dicarboxylate Transporter), Member 10 2 3
  • DIC 3 4
  • Mitochondrial Dicarboxylate Carrier 3
  • Dicarboxylate Ion Carrier 3

External Ids for SLC25A10 Gene

Previous HGNC Symbols for SLC25A10 Gene

  • DIC

Previous GeneCards Identifiers for SLC25A10 Gene

  • GC17U990019
  • GC17P080239
  • GC17P080375
  • GC17P077289
  • GC17P079679
  • GC17P075125
  • GC17P079674

Summaries for SLC25A10 Gene

Entrez Gene Summary for SLC25A10 Gene

  • This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

GeneCards Summary for SLC25A10 Gene

SLC25A10 (Solute Carrier Family 25 Member 10) is a Protein Coding gene. Diseases associated with SLC25A10 include Retinitis Pigmentosa. Among its related pathways are Glycosaminoglycan metabolism and Proximal tubule bicarbonate reclamation. Gene Ontology (GO) annotations related to this gene include antiporter activity and phosphate ion transmembrane transporter activity. An important paralog of this gene is ENSG00000262660.

UniProtKB/Swiss-Prot for SLC25A10 Gene

  • Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.

Gene Wiki entry for SLC25A10 Gene

Additional gene information for SLC25A10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A10 Gene

Genomics for SLC25A10 Gene

GeneHancer (GH) Regulatory Elements for SLC25A10 Gene

Promoters and enhancers for SLC25A10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I081709 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.1 79 4.7 HNRNPUL1 PKNOX1 CLOCK FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 GC17M081707 SLC25A10 ARL16 HGS ALYREF ENSG00000260563 NARF-IT1 ENSG00000262652 TEPSIN CSNK1D
GH17I081990 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 7 +279.6 279610 2.9 FOXA2 MLX ZFP64 ARID4B DMAP1 BRCA1 ZNF48 ETS1 YY1 SLC30A9 GC17P081992 TBCD CCDC57 ASPSCR1 GPS1 CEP131 ENSG00000265678 ARL16 RFNG ENSG00000262877
GH17I082095 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.6 +389.6 389574 13.5 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 FASN CCDC57 TBCD ENSG00000262877 CEP131 LOC105371942 ALYREF WDR45B ARL16 DCXR
GH17I082608 Enhancer 0.5 dbSUPER 5.9 +897.3 897283 1.6 HDGF IKZF1 KLF7 IKZF2 PRDM1 ZNF558 WDR45B SLC25A10 ENSG00000261845 GC17M082606 FOXK2
GH17I081720 Enhancer 0.4 dbSUPER 6.3 +8.5 8528 1.4 POLR2A ZIC2 ARL16 CCDC137 NPLOC4 SLC25A10 GC17P081724 GC17M081707 ENSG00000262660
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC25A10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC25A10 gene promoter:

Genomic Locations for SLC25A10 Gene

Genomic Locations for SLC25A10 Gene
8,781 bases
Plus strand

Genomic View for SLC25A10 Gene

Genes around SLC25A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A10 Gene

Proteins for SLC25A10 Gene

  • Protein details for SLC25A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial dicarboxylate carrier
    Protein Accession:
    Secondary Accessions:
    • Q542Z3
    • Q96BA1
    • Q96IP1

    Protein attributes for SLC25A10 Gene

    287 amino acids
    Molecular mass:
    31282 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A10 Gene


neXtProt entry for SLC25A10 Gene

Post-translational modifications for SLC25A10 Gene

  • Ubiquitination at isoforms=2254
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC25A10 Gene

No data available for DME Specific Peptides for SLC25A10 Gene

Domains & Families for SLC25A10 Gene

Gene Families for SLC25A10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC25A10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A10: view

Function for SLC25A10 Gene

Molecular function for SLC25A10 Gene

UniProtKB/Swiss-Prot Function:
Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.

Phenotypes From GWAS Catalog for SLC25A10 Gene

Gene Ontology (GO) - Molecular Function for SLC25A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005310 dicarboxylic acid transmembrane transporter activity TAS --
GO:0005515 protein binding IPI 19060904
GO:0015116 sulfate transmembrane transporter activity IBA --
GO:0015117 thiosulfate transmembrane transporter activity IBA --
GO:0015131 oxaloacetate transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC25A10: view
genes like me logo Genes that share phenotypes with SLC25A10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A10

miRNA for SLC25A10 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A10 Gene

Localization for SLC25A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A10 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A10 gene
Compartment Confidence
mitochondrion 5
nucleus 5
plasma membrane 1
extracellular 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC25A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,HDA 21630459
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC25A10: view

Pathways & Interactions for SLC25A10 Gene

genes like me logo Genes that share pathways with SLC25A10: view

Pathways by source for SLC25A10 Gene

Gene Ontology (GO) - Biological Process for SLC25A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006094 gluconeogenesis TAS --
GO:0006810 transport IEA --
GO:0006811 ion transport TAS --
GO:0006835 dicarboxylic acid transport TAS 9733776
GO:0006839 mitochondrial transport IBA --
genes like me logo Genes that share ontologies with SLC25A10: view

No data available for SIGNOR curated interactions for SLC25A10 Gene

Drugs & Compounds for SLC25A10 Gene

(1) Drugs for SLC25A10 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Succinic acid Approved Nutra Full agonist, Agonist, Target 0
genes like me logo Genes that share compounds with SLC25A10: view

Transcripts for SLC25A10 Gene

Unigene Clusters for SLC25A10 Gene

Solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · 12b · 12c
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - - - -
SP6: - - -
SP7: -
SP8: - - -
SP9: - -

Relevant External Links for SLC25A10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC25A10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A10 Gene

mRNA differential expression in normal tissues according to GTEx for SLC25A10 Gene

This gene is overexpressed in Liver (x6.1) and Kidney - Cortex (x5.0).

Protein differential expression in normal tissues from HIPED for SLC25A10 Gene

This gene is overexpressed in Nasal epithelium (45.0) and Gallbladder (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC25A10 Gene

Protein tissue co-expression partners for SLC25A10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC25A10 Gene:


SOURCE GeneReport for Unigene cluster for SLC25A10 Gene:


mRNA Expression by UniProt/SwissProt for SLC25A10 Gene:

Tissue specificity: Present in high amounts in liver and kidney, and at lower levels in all the other tissues analyzed.

Evidence on tissue expression from TISSUES for SLC25A10 Gene

  • Skin(4.2)
  • Thyroid gland(4.1)
  • Kidney(2.1)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with SLC25A10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A10 Gene

Orthologs for SLC25A10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC25A10 33
  • 99.21 (n)
(Canis familiaris)
Mammalia SLC25A10 33
  • 88.4 (n)
-- 34
  • 54 (a)
(Mus musculus)
Mammalia Slc25a10 33 16 34
  • 86.55 (n)
(Bos Taurus)
Mammalia SLC25A10 33
  • 86.37 (n)
MRPL12 34
  • 55 (a)
(Rattus norvegicus)
Mammalia Slc25a10 33
  • 84.8 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 74 (a)
(Gallus gallus)
Aves SLC25A10 33
  • 81.16 (n)
-- 34
  • 56 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a10 33
  • 71.58 (n)
Str.15496 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.11739 33
(Danio rerio)
Actinopterygii CABZ01059390.1 34
  • 77 (a)
si:ch1073-100f3.2 34
  • 77 (a)
LOC100332610 33
  • 71.99 (n)
zgc56614 33
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH02431 35
  • 58 (a)
CG4323 35
  • 51 (a)
Dic3 34
  • 46 (a)
CG11196 35
  • 45 (a)
CG18363 35
  • 38 (a)
CG6893 34
  • 37 (a)
Dic4 34
  • 36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003073 33
  • 57.94 (n)
(Caenorhabditis elegans)
Secernentea K11G12.5 35 34
  • 59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIC1 33 34 36
  • 47.83 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01514 33
  • 53.09 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2426 34
  • 53 (a)
Species where no ortholog for SLC25A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A10 Gene

Gene Tree for SLC25A10 (if available)
Gene Tree for SLC25A10 (if available)

Paralogs for SLC25A10 Gene

(10) SIMAP similar genes for SLC25A10 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC25A10: view

Variants for SLC25A10 Gene

Sequence variations from dbSNP and Humsavar for SLC25A10 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs114621664 likely-pathogenic, Mitochondrial complex I deficiency 81,717,813(+) C/T coding_sequence_variant, missense_variant, synonymous_variant
rs200706742 likely-pathogenic, Mitochondrial complex I deficiency 81,719,939(+) G/A intron_variant
rs1000397725 -- 81,713,532(+) C/T intron_variant
rs1000407543 -- 81,713,193(+) TTTTTTT/TTTTTTTT intron_variant
rs1001330049 -- 81,713,948(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A10 Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV gain+loss 19812545
nsv428351 CNV gain 18775914
nsv470620 CNV loss 18288195
nsv828128 CNV loss 20364138
nsv952390 CNV deletion 24416366

Variation tolerance for SLC25A10 Gene

Residual Variation Intolerance Score: 61.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC25A10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A10 Gene

Disorders for SLC25A10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC25A10 Gene - From: GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa
  • rp
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC25A10

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC25A10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC25A10 Gene

Publications for SLC25A10 Gene

  1. Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family. (PMID: 10585886) Fiermonte G … Palmieri F (The Biochemical journal 1999) 3 4 22 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  4. Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis. (PMID: 16027120) Mizuarai S … Kotani H (The Journal of biological chemistry 2005) 3 25 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for SLC25A10 Gene

Sources for SLC25A10 Gene

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