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Aliases for CSRP2 Gene

Aliases for CSRP2 Gene

  • Cysteine And Glycine Rich Protein 2 2 3 5
  • Smooth Muscle Cell LIM Protein 3 4
  • LIM Domain Only Protein 5 3 4
  • Cysteine-Rich Protein 2 3 4
  • LMO-5 3 4
  • SmLIM 3 4
  • CRP2 3 4
  • LMO5 3 4
  • Cysteine And Glycine-Rich Protein 2 3
  • LIM Domain Only 5, Smooth Muscle 3
  • SMLIM 4

External Ids for CSRP2 Gene

Previous GeneCards Identifiers for CSRP2 Gene

  • GC12M077594
  • GC12M077185
  • GC12M075754
  • GC12M074305

Summaries for CSRP2 Gene

Entrez Gene Summary for CSRP2 Gene

  • CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for CSRP2 Gene

CSRP2 (Cysteine And Glycine Rich Protein 2) is a Protein Coding gene. Diseases associated with CSRP2 include Miller-Dieker Lissencephaly Syndrome. Among its related pathways are Immune response IL-23 signaling pathway and ATF-2 transcription factor network. An important paralog of this gene is CSRP1.

UniProtKB/Swiss-Prot for CSRP2 Gene

  • Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.

Gene Wiki entry for CSRP2 Gene

Additional gene information for CSRP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSRP2 Gene

Genomics for CSRP2 Gene

GeneHancer (GH) Regulatory Elements for CSRP2 Gene

Promoters and enhancers for CSRP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J076876 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 659.3 +0.4 411 4.6 PKNOX1 ATF1 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF121 GLIS2 ZNF143 CSRP2 ENSG00000257910
GH12J076302 Enhancer 0.9 ENCODE dbSUPER 5 +575.5 575517 2.4 BACH1 E4F1 IRF9 ZSCAN29 NFE2 STAT1 RFX1 CAVIN1 SMAD5 ZNF740 KRR1 RPL21P98 LINC02407 CSRP2 GC12M076305
GH12J076920 Enhancer 0.4 ENCODE 11 -41.6 -41635 1.1 RUNX3 SPI1 CSRP2 LOC727803
GH12J076862 Enhancer 0.6 Ensembl ENCODE 4.6 +13.7 13728 5.2 SRF POLR2A FOS ZDHHC17 CSRP2 ENSG00000257910
GH12J076857 Enhancer 0.2 FANTOM5 4.5 +21.6 21563 0.4 ZDHHC17 CSRP2 ENSG00000257910
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CSRP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CSRP2 gene promoter:
  • Elk-1
  • FOXO4
  • Meis-1b
  • Meis-1a
  • Meis-1
  • TBP
  • HOXA9
  • HOXA9B

Genomic Locations for CSRP2 Gene

Genomic Locations for CSRP2 Gene
chr12:76,858,715-76,879,060
(GRCh38/hg38)
Size:
20,346 bases
Orientation:
Minus strand
chr12:77,252,495-77,272,840
(GRCh37/hg19)
Size:
20,346 bases
Orientation:
Minus strand

Genomic View for CSRP2 Gene

Genes around CSRP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSRP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSRP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSRP2 Gene

Proteins for CSRP2 Gene

  • Protein details for CSRP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16527-CSRP2_HUMAN
    Recommended name:
    Cysteine and glycine-rich protein 2
    Protein Accession:
    Q16527
    Secondary Accessions:
    • Q93030

    Protein attributes for CSRP2 Gene

    Size:
    193 amino acids
    Molecular mass:
    20954 Da
    Quaternary structure:
    • Interacts with KAT14. The LIM domain 1 is necessary and sufficient for this interaction. Interacts with GLRX3 (By similarity).

neXtProt entry for CSRP2 Gene

Post-translational modifications for CSRP2 Gene

  • Ubiquitination at Lys69
  • Modification sites at PhosphoSitePlus

Other Protein References for CSRP2 Gene

No data available for DME Specific Peptides for CSRP2 Gene

Domains & Families for CSRP2 Gene

Gene Families for CSRP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CSRP2 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CSRP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CSRP2: view

No data available for UniProtKB/Swiss-Prot for CSRP2 Gene

Function for CSRP2 Gene

Molecular function for CSRP2 Gene

UniProtKB/Swiss-Prot Function:
Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.
GENATLAS Biochemistry:
cysteine and glycine rich protein 2,putatively involved in cellular growth control,likely involved in the determination of cell lineage and regulation of cell differentiation

Phenotypes From GWAS Catalog for CSRP2 Gene

Gene Ontology (GO) - Molecular Function for CSRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CSRP2: view
genes like me logo Genes that share phenotypes with CSRP2: view

Animal Models for CSRP2 Gene

MGI Knock Outs for CSRP2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSRP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSRP2 Gene

Localization for CSRP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSRP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSRP2 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CSRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 8626582
GO:0005925 focal adhesion HDA 21423176
genes like me logo Genes that share ontologies with CSRP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CSRP2 Gene

Pathways & Interactions for CSRP2 Gene

genes like me logo Genes that share pathways with CSRP2: view

Pathways by source for CSRP2 Gene

1 GeneGo (Thomson Reuters) pathway for CSRP2 Gene

Gene Ontology (GO) - Biological Process for CSRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation NAS 8626582
genes like me logo Genes that share ontologies with CSRP2: view

No data available for SIGNOR curated interactions for CSRP2 Gene

Drugs & Compounds for CSRP2 Gene

(1) Drugs for CSRP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CSRP2: view

Transcripts for CSRP2 Gene

mRNA/cDNA for CSRP2 Gene

Unigene Clusters for CSRP2 Gene

Cysteine and glycine-rich protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSRP2

Alternative Splicing Database (ASD) splice patterns (SP) for CSRP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: - -
SP3:

Relevant External Links for CSRP2 Gene

GeneLoc Exon Structure for
CSRP2
ECgene alternative splicing isoforms for
CSRP2

Expression for CSRP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CSRP2 Gene

mRNA differential expression in normal tissues according to GTEx for CSRP2 Gene

This gene is overexpressed in Artery - Tibial (x6.3) and Artery - Coronary (x4.3).

Protein differential expression in normal tissues from HIPED for CSRP2 Gene

This gene is overexpressed in Amniocyte (20.8), Placenta (11.2), and Uterus (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CSRP2 Gene



Protein tissue co-expression partners for CSRP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CSRP2 Gene:

CSRP2

SOURCE GeneReport for Unigene cluster for CSRP2 Gene:

Hs.530904

mRNA Expression by UniProt/SwissProt for CSRP2 Gene:

Q16527-CSRP2_HUMAN
Tissue specificity: Highly expressed in the aorta, but not in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for CSRP2 Gene

  • Nervous system(3.1)
  • Muscle(2.3)
  • Heart(2.2)
  • Kidney(2.1)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with CSRP2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CSRP2 Gene

Orthologs for CSRP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CSRP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSRP2 34 33
  • 99.65 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 97 (a)
OneToMany
-- 34
  • 96 (a)
OneToMany
cow
(Bos Taurus)
Mammalia CSRP2 34 33
  • 93.78 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csrp2 33
  • 93.61 (n)
mouse
(Mus musculus)
Mammalia Csrp2 16 34 33
  • 91.88 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CSRP2 34
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSRP2 34
  • 90 (a)
OneToOne
LOC475409 33
  • 85.26 (n)
chicken
(Gallus gallus)
Aves CSRP2 34 33
  • 82.21 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSRP2 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia csrp2 33
  • 78.82 (n)
Str.6131 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15138 33
zebrafish
(Danio rerio)
Actinopterygii csrp2 34 33
  • 75.99 (n)
OneToOne
zgc77740 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8116 33
fruit fly
(Drosophila melanogaster)
Insecta Mlp84B 34 35 33
  • 55.56 (n)
ManyToMany
Mlp60A 34
  • 20 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012305 33
  • 55.43 (n)
worm
(Caenorhabditis elegans)
Secernentea mlp-1 34 33
  • 50.83 (n)
OneToMany
Species where no ortholog for CSRP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSRP2 Gene

ENSEMBL:
Gene Tree for CSRP2 (if available)
TreeFam:
Gene Tree for CSRP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CSRP2: view image

Paralogs for CSRP2 Gene

Paralogs for CSRP2 Gene

(5) SIMAP similar genes for CSRP2 Gene using alignment to 3 proteins:

  • CSRP2_HUMAN
  • F8VQR7_HUMAN
  • F8VW96_HUMAN

Pseudogenes.org Pseudogenes for CSRP2 Gene

genes like me logo Genes that share paralogs with CSRP2: view

Variants for CSRP2 Gene

Sequence variations from dbSNP and Humsavar for CSRP2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000005269 -- 76,863,125(-) A/G intron_variant
rs1000172569 -- 76,874,639(-) T/A intron_variant
rs1000267545 -- 76,880,161(-) G/A upstream_transcript_variant
rs1000616247 -- 76,870,583(-) T/C intron_variant
rs1000626906 -- 76,876,057(-) T/G intron_variant

Variation tolerance for CSRP2 Gene

Residual Variation Intolerance Score: 36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CSRP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSRP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CSRP2 Gene

Disorders for CSRP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CSRP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
miller-dieker lissencephaly syndrome
  • mdls
- elite association - COSMIC cancer census association via MalaCards
Search CSRP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CSRP2

genes like me logo Genes that share disorders with CSRP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CSRP2 Gene

Publications for CSRP2 Gene

  1. Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2. (PMID: 9286703) Weiskirchen R … Bister K (Genomics 1997) 2 3 4 22 58
  2. The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP). (PMID: 10924333) Weiskirchen R … Gressner AM (Biochemical and biophysical research communications 2000) 3 4 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1. (PMID: 11672422) Weiskirchen R … Gressner AM (The Biochemical journal 2001) 3 22 58
  5. Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells. (PMID: 8626582) Jain MK … Lee ME (The Journal of biological chemistry 1996) 3 4 58

Products for CSRP2 Gene

Sources for CSRP2 Gene

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