Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IL34 Gene

Aliases for IL34 Gene

  • Interleukin 34 2 3 5
  • C16orf77 3 4
  • IL-34 3 4
  • Chromosome 16 Open Reading Frame 77 2
  • Interleukin-34 3

External Ids for IL34 Gene

Previous HGNC Symbols for IL34 Gene

  • C16orf77

Previous GeneCards Identifiers for IL34 Gene

  • GC16P069239
  • GC16P070680
  • GC16P056451

Summaries for IL34 Gene

Entrez Gene Summary for IL34 Gene

  • Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]

GeneCards Summary for IL34 Gene

IL34 (Interleukin 34) is a Protein Coding gene. Diseases associated with IL34 include Chronic Apical Periodontitis. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include cytokine activity and macrophage colony-stimulating factor receptor binding.

UniProtKB/Swiss-Prot for IL34 Gene

  • Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.

Gene Wiki entry for IL34 Gene

Additional gene information for IL34 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL34 Gene

Genomics for IL34 Gene

GeneHancer (GH) Regulatory Elements for IL34 Gene

Promoters and enhancers for IL34 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I070579 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.1 82 0.8 KLF1 MXI1 USF1 SAP130 MLX ARID4B SLC30A9 ZNF121 MAZ KLF11 IL34 LOC100506083 GC16P070621
GH16I070589 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 550.4 +11.2 11188 4.5 BCOR KLF1 ZNF362 JUN HLF ZMYM3 ZNF384 HMG20A ATF2 CREB1 IL34 PDXDC2P-NPIPB14P PDXDC2P COG4 SNORD111 AARS VAC14-AS1 DDX19B LOC100506083 NPIPB14P
GH16I070646 Promoter/Enhancer 1.3 EPDnew ENCODE dbSUPER 563.1 +66.8 66764 1.2 PKNOX1 RFX1 HLF EBF1 BMI1 NFIL3 NFIC SCRT2 PRDM1 IL34 EXOSC6 NPIPB14P ENSG00000279569 GC16P070621
GH16I070634 Enhancer 0.8 Ensembl ENCODE 12.8 +55.6 55635 1.7 BCOR SOX13 MTA2 JUN NR2F1 SIN3A ZMYM3 NR2F2 ZNF830 JUND EXOSC6 IL34 PDPR NPIPB14P VAC14 LOC100506083 GC16P070621 ENSG00000279569
GH16I070638 Enhancer 0.8 Ensembl ENCODE 11 +59.6 59631 1.1 GATAD2A CTCF FOXA3 BHLHE40 NR2F2 MITF ZNF316 SMAD4 FOS NR2F6 EXOSC6 IL34 PDXDC2P-NPIPB14P VAC14 GC16P070621 ENSG00000279569
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IL34 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IL34 gene promoter:

Genomic Locations for IL34 Gene

Genomic Locations for IL34 Gene
chr16:70,579,895-70,660,684
(GRCh38/hg38)
Size:
80,790 bases
Orientation:
Plus strand
chr16:70,613,798-70,694,585
(GRCh37/hg19)

Genomic View for IL34 Gene

Genes around IL34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL34 Gene

Proteins for IL34 Gene

  • Protein details for IL34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMJ4-IL34_HUMAN
    Recommended name:
    Interleukin-34
    Protein Accession:
    Q6ZMJ4
    Secondary Accessions:
    • B2RC28
    • B2Z4A8
    • B2ZC70
    • Q8N6L2

    Protein attributes for IL34 Gene

    Size:
    242 amino acids
    Molecular mass:
    27482 Da
    Quaternary structure:
    • Homodimer. Interacts with CSF1R.

    Three dimensional structures from OCA and Proteopedia for IL34 Gene

    Alternative splice isoforms for IL34 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL34 Gene

Post-translational modifications for IL34 Gene

Protein Products

No data available for DME Specific Peptides for IL34 Gene

Domains & Families for IL34 Gene

Gene Families for IL34 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for IL34 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZMJ4

UniProtKB/Swiss-Prot:

IL34_HUMAN :
  • Belongs to the IL-34 family.
Family:
  • Belongs to the IL-34 family.
genes like me logo Genes that share domains with IL34: view

Function for IL34 Gene

Molecular function for IL34 Gene

UniProtKB/Swiss-Prot Function:
Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.

Phenotypes From GWAS Catalog for IL34 Gene

Gene Ontology (GO) - Molecular Function for IL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005157 macrophage colony-stimulating factor receptor binding IDA 18467591
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with IL34: view
genes like me logo Genes that share phenotypes with IL34: view

Animal Models for IL34 Gene

MGI Knock Outs for IL34:
  • Il34 tm1b(EUCOMM)Wtsi
  • Il34 tm1a(EUCOMM)Wtsi

Animal Model Products

  • Taconic Biosciences Mouse Models for IL34

miRNA for IL34 Gene

miRTarBase miRNAs that target IL34

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL34 Gene

Localization for IL34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL34 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL34 gene
Compartment Confidence
extracellular 5
cytosol 1

Gene Ontology (GO) - Cellular Components for IL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 18467591
genes like me logo Genes that share ontologies with IL34: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL34 Gene

Pathways & Interactions for IL34 Gene

genes like me logo Genes that share pathways with IL34: view

Pathways by source for IL34 Gene

Gene Ontology (GO) - Biological Process for IL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IDA 18467591
GO:0002376 immune system process IEA --
GO:0006954 inflammatory response IEA --
GO:0008284 positive regulation of cell proliferation IDA 18467591
GO:0010469 regulation of receptor activity IEA --
genes like me logo Genes that share ontologies with IL34: view

No data available for SIGNOR curated interactions for IL34 Gene

Drugs & Compounds for IL34 Gene

No Compound Related Data Available

Transcripts for IL34 Gene

Unigene Clusters for IL34 Gene

Interleukin 34:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL34 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b
SP1: - -
SP2: - -
SP3:
SP4: - -

Relevant External Links for IL34 Gene

GeneLoc Exon Structure for
IL34
ECgene alternative splicing isoforms for
IL34

Expression for IL34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL34 Gene

mRNA differential expression in normal tissues according to GTEx for IL34 Gene

This gene is overexpressed in Spleen (x8.0), Nerve - Tibial (x6.2), Skin - Not Sun Exposed (Suprapubic) (x4.7), and Skin - Sun Exposed (Lower leg) (x4.5).

Protein differential expression in normal tissues from HIPED for IL34 Gene

This gene is overexpressed in Spleen (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL34 Gene



Protein tissue co-expression partners for IL34 Gene

NURSA nuclear receptor signaling pathways regulating expression of IL34 Gene:

IL34

SOURCE GeneReport for Unigene cluster for IL34 Gene:

Hs.461214

mRNA Expression by UniProt/SwissProt for IL34 Gene:

Q6ZMJ4-IL34_HUMAN
Tissue specificity: Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.

Evidence on tissue expression from TISSUES for IL34 Gene

  • Nervous system(4.5)
  • Spleen(2.6)
  • Skin(2)
genes like me logo Genes that share expression patterns with IL34: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL34 Gene

Orthologs for IL34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL34 33 34
  • 99.17 (n)
cow
(Bos Taurus)
Mammalia IL34 33 34
  • 83.92 (n)
dog
(Canis familiaris)
Mammalia IL34 33 34
  • 83.62 (n)
rat
(Rattus norvegicus)
Mammalia Il34 33
  • 79.87 (n)
mouse
(Mus musculus)
Mammalia Il34 33 16 34
  • 79.19 (n)
oppossum
(Monodelphis domestica)
Mammalia IL34 34
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL34 34
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL34 34
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia il34 33
  • 47.02 (n)
zebrafish
(Danio rerio)
Actinopterygii il34 34 34
  • 30 (a)
OneToMany
Species where no ortholog for IL34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL34 Gene

ENSEMBL:
Gene Tree for IL34 (if available)
TreeFam:
Gene Tree for IL34 (if available)

Paralogs for IL34 Gene

No data available for Paralogs for IL34 Gene

Variants for IL34 Gene

Sequence variations from dbSNP and Humsavar for IL34 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000016773 -- 70,644,894(+) G/C intron_variant
rs1000024057 -- 70,588,711(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000102642 -- 70,638,090(+) G/A intron_variant
rs1000134704 -- 70,628,148(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000209567 -- 70,622,816(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IL34 Gene

Variant ID Type Subtype PubMed ID
esv2660602 CNV deletion 23128226
esv26820 CNV loss 19812545
esv3553627 CNV deletion 23714750
esv3638957 CNV loss 21293372
esv3892881 CNV gain 25118596
esv3892883 CNV gain 25118596
nsv1117165 CNV tandem duplication 24896259
nsv1134560 CNV deletion 24896259
nsv471094 CNV loss 18288195
nsv517391 CNV loss 19592680
nsv572945 CNV gain 21841781
nsv572946 CNV loss 21841781
nsv7285 OTHER inversion 18451855

Variation tolerance for IL34 Gene

Residual Variation Intolerance Score: 78.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL34 Gene

Human Gene Mutation Database (HGMD)
IL34
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL34

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL34 Gene

Disorders for IL34 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IL34 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
chronic apical periodontitis
  • chronic apical periodontitis nos
- elite association - COSMIC cancer census association via MalaCards
Search IL34 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL34

genes like me logo Genes that share disorders with IL34: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL34 Gene

Publications for IL34 Gene

  1. Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. (PMID: 18467591) Lin H … Williams LT (Science (New York, N.Y.) 2008) 2 3 4 58
  2. Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells. (PMID: 20504948) Wei S … Stanley ER (Journal of leukocyte biology 2010) 3 4 58
  3. Bone Morphogenetic Protein 2 and Transforming Growth Factor β1 Inhibit the Expression of the Proinflammatory Cytokine IL-34 in Rheumatoid Arthritis Synovial Fibroblasts. (PMID: 27865758) Chemel M … Verrecchia F (The American journal of pathology 2017) 3 58
  4. Interleukin-34 inhibits hepatitis B virus replication in vitro and in vivo. (PMID: 28614380) Cheng ST … Chen J (PloS one 2017) 3 58
  5. miR-28-5p-IL-34-macrophage feedback loop modulates hepatocellular carcinoma metastasis. (PMID: 26754294) Zhou SL … Zhou J (Hepatology (Baltimore, Md.) 2016) 3 58

Products for IL34 Gene

Sources for IL34 Gene

Content
Loading form....