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Aliases for NCAN Gene

Aliases for NCAN Gene

  • Neurocan 2 3 5
  • Chondroitin Sulfate Proteoglycan 3 2 4
  • Neurocan Proteoglycan 2 3
  • CSPG3 3 4
  • Chondroitin Sulfate Proteoglycan 3 (Neurocan) 3
  • Neurocan Core Protein 3
  • NEUR 4

External Ids for NCAN Gene

Previous HGNC Symbols for NCAN Gene

  • CSPG3

Previous GeneCards Identifiers for NCAN Gene

  • GC19P019183
  • GC19P019322
  • GC19P018887
  • GC19P019212
  • GC19P019213
  • GC19P019364
  • GC19P019368

Summaries for NCAN Gene

Entrez Gene Summary for NCAN Gene

  • Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration.[supplied by OMIM, Jul 2002]

GeneCards Summary for NCAN Gene

NCAN (Neurocan) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and extracellular matrix structural constituent. An important paralog of this gene is VCAN.

UniProtKB/Swiss-Prot for NCAN Gene

  • May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.

Gene Wiki entry for NCAN Gene

Additional gene information for NCAN Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCAN Gene

Genomics for NCAN Gene

GeneHancer (GH) Regulatory Elements for NCAN Gene

Promoters and enhancers for NCAN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I019211 Promoter 0.8 EPDnew 550.8 0.0 -25 0.1 MXI1 MAZ POLR2A NRF1 EZH2 NCAN NR2C2AP
GH19I018893 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 4.1 -317.2 -317167 3.2 HDAC1 CLOCK ARID4B SIN3A BMI1 ZNF48 RAD21 ZNF335 GLIS2 EGR1 GDF1 CERS1 TMEM59L CRTC1 HAPLN4 HOMER3 NCAN SUGP2 KLHL26 SLC25A42
GH19I019319 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 2.2 +108.9 108937 2.6 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A YY1 POLR2B ZNF766 ZNF213 MAU2 SUGP1 GATAD2A ATP13A1 ENSG00000268938 ZNF506 ZNF14 MEF2B NR2C2AP ENSG00000268030
GH19I019259 Enhancer 0.9 FANTOM5 ENCODE 1.7 +48.0 47968 0.2 USF1 NFYA MAX NFYC SP2 USF2 RFX5 SP1 RFXANK NFYB GDF1 NCAN SUGP2 ENSG00000280282 HAPLN4 ENSG00000267629
GH19I018892 Enhancer 0.4 FANTOM5 1.9 -319.4 -319441 0.3 ZMYM3 ZNF623 GDF1 NCAN CERS1 GC19M018886 ENSG00000269694
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NCAN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NCAN gene promoter:

Genomic Locations for NCAN Gene

Genomic Locations for NCAN Gene
chr19:19,211,964-19,252,252
(GRCh38/hg38)
Size:
40,289 bases
Orientation:
Plus strand
chr19:19,322,782-19,363,061
(GRCh37/hg19)

Genomic View for NCAN Gene

Genes around NCAN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCAN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCAN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCAN Gene

Proteins for NCAN Gene

  • Protein details for NCAN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14594-NCAN_HUMAN
    Recommended name:
    Neurocan core protein
    Protein Accession:
    O14594
    Secondary Accessions:
    • Q9UPK6

    Protein attributes for NCAN Gene

    Size:
    1321 amino acids
    Molecular mass:
    143093 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NCAN Gene

Post-translational modifications for NCAN Gene

Other Protein References for NCAN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NCAN Gene

Domains & Families for NCAN Gene

Gene Families for NCAN Gene

Suggested Antigen Peptide Sequences for NCAN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14594

UniProtKB/Swiss-Prot:

NCAN_HUMAN :
  • Belongs to the aggrecan/versican proteoglycan family.
Family:
  • Belongs to the aggrecan/versican proteoglycan family.
genes like me logo Genes that share domains with NCAN: view

Function for NCAN Gene

Molecular function for NCAN Gene

UniProtKB/Swiss-Prot Function:
May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.

Phenotypes From GWAS Catalog for NCAN Gene

Gene Ontology (GO) - Molecular Function for NCAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent IBA --
GO:0005509 calcium ion binding IEA --
GO:0005540 hyaluronic acid binding IBA --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with NCAN: view
genes like me logo Genes that share phenotypes with NCAN: view

Animal Models for NCAN Gene

MGI Knock Outs for NCAN:

Animal Model Products

  • Taconic Biosciences Mouse Models for NCAN

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCAN Gene

Localization for NCAN Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCAN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCAN gene
Compartment Confidence
extracellular 5
lysosome 4
golgi apparatus 4
plasma membrane 3
cytoskeleton 3
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NCAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IBA --
GO:0005796 Golgi lumen TAS --
GO:0043202 lysosomal lumen TAS --
genes like me logo Genes that share ontologies with NCAN: view

Pathways & Interactions for NCAN Gene

genes like me logo Genes that share pathways with NCAN: view

Gene Ontology (GO) - Biological Process for NCAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IBA --
GO:0007155 cell adhesion IEA --
GO:0007417 central nervous system development IBA --
GO:0030198 extracellular matrix organization TAS --
GO:0030203 glycosaminoglycan metabolic process TAS --
genes like me logo Genes that share ontologies with NCAN: view

No data available for SIGNOR curated interactions for NCAN Gene

Drugs & Compounds for NCAN Gene

(5) Drugs for NCAN Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronic acid Approved, Vet_approved Pharma Target, binder 535
Chondroitin sulfate Approved, Investigational Nutra 0
Beta-D-Glucose Experimental Pharma Target 0
Thiodigalactoside Experimental Pharma Target 0
Chondroitin Nutra 48
genes like me logo Genes that share compounds with NCAN: view

Transcripts for NCAN Gene

Unigene Clusters for NCAN Gene

Neurocan:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCAN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: -
SP2: -

Relevant External Links for NCAN Gene

GeneLoc Exon Structure for
NCAN
ECgene alternative splicing isoforms for
NCAN

Expression for NCAN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NCAN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NCAN Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.5), Brain - Amygdala (x6.4), Brain - Caudate (basal ganglia) (x6.1), Brain - Cortex (x5.7), Brain - Frontal Cortex (BA9) (x5.5), Brain - Putamen (basal ganglia) (x5.5), Brain - Anterior cingulate cortex (BA24) (x5.2), and Brain - Hippocampus (x4.6).

Protein differential expression in normal tissues from HIPED for NCAN Gene

This gene is overexpressed in Fetal Brain (23.5), Frontal cortex (14.2), Brain (11.3), and Vitreous humor (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NCAN Gene



Protein tissue co-expression partners for NCAN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NCAN Gene:

NCAN

SOURCE GeneReport for Unigene cluster for NCAN Gene:

Hs.169047

mRNA Expression by UniProt/SwissProt for NCAN Gene:

O14594-NCAN_HUMAN
Tissue specificity: Brain.

Evidence on tissue expression from TISSUES for NCAN Gene

  • Nervous system(4.6)
  • Heart(2)
genes like me logo Genes that share expression patterns with NCAN: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NCAN Gene

Orthologs for NCAN Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCAN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCAN 33 34
  • 99.27 (n)
dog
(Canis familiaris)
Mammalia NCAN 33 34
  • 83.59 (n)
cow
(Bos Taurus)
Mammalia NCAN 33 34
  • 82.44 (n)
mouse
(Mus musculus)
Mammalia Ncan 16 34 33
  • 73.91 (n)
rat
(Rattus norvegicus)
Mammalia LOC102550316 33
  • 73.52 (n)
oppossum
(Monodelphis domestica)
Mammalia NCAN 34
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCAN 34
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCAN 34
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ncanb 34
  • 38 (a)
OneToMany
ncana 34
  • 34 (a)
OneToMany
Dr.20279 33
Species where no ortholog for NCAN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCAN Gene

ENSEMBL:
Gene Tree for NCAN (if available)
TreeFam:
Gene Tree for NCAN (if available)

Paralogs for NCAN Gene

Paralogs for NCAN Gene

genes like me logo Genes that share paralogs with NCAN: view

Variants for NCAN Gene

Sequence variations from dbSNP and Humsavar for NCAN Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs146011974 uncertain-significance, Developmental dyslexia 19,233,884(+) G/A/T coding_sequence_variant, missense_variant
rs1000003668 -- 19,224,827(+) C/G intron_variant
rs1000047324 -- 19,214,450(+) G/T intron_variant
rs1000189112 -- 19,218,829(+) AAAAAA/AAAAAAA intron_variant
rs1000225425 -- 19,250,084(+) A/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for NCAN Gene

Variant ID Type Subtype PubMed ID
nsv1138677 CNV deletion 24896259
nsv1151217 CNV deletion 26484159

Variation tolerance for NCAN Gene

Residual Variation Intolerance Score: 6.15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.12; 69.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NCAN Gene

Human Gene Mutation Database (HGMD)
NCAN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCAN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCAN Gene

Disorders for NCAN Gene

Additional Disease Information for NCAN

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NCAN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCAN Gene

Publications for NCAN Gene

  1. Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder. (PMID: 21353194) Cichon S … Nöthen MM (American journal of human genetics 2011) 2 3 44 58
  2. Characterization of the human neurocan gene, CSPG3. (PMID: 9795216) Prange CK … Lennon GG (Gene 1998) 3 4 22 58
  3. Common variants at 30 loci contribute to polygenic dyslipidemia. (PMID: 19060906) Kathiresan S … Cupples LA (Nature genetics 2009) 3 44 58
  4. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (PMID: 19060911) Aulchenko YS … ENGAGE Consortium (Nature genetics 2009) 3 44 58
  5. Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study. (PMID: 19148283) Deo RC … Wilson JG (PLoS genetics 2009) 3 44 58

Products for NCAN Gene

Sources for NCAN Gene

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