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Aliases for CDAN1 Gene

Aliases for CDAN1 Gene

  • Codanin 1 2 3 5
  • Congenital Dyserythropoietic Anemia, Type I 2 3
  • Discs Lost Homolog 3
  • Codanin-1 3
  • PRO1295 3
  • CDAN1A 3
  • CDA1 3
  • CDAI 3
  • DLT 3

External Ids for CDAN1 Gene

Previous GeneCards Identifiers for CDAN1 Gene

  • GC15U990007
  • GC15M035911
  • GC15M040594
  • GC15M040731
  • GC15M040803
  • GC15M043015
  • GC15M019864

Summaries for CDAN1 Gene

Entrez Gene Summary for CDAN1 Gene

  • This gene encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to microtubule attachments. Mutations in this gene cause congenital dyserythropoietic anemia type I, a disease resulting in morphological and functional abnormalities of erythropoiesis. [provided by RefSeq, Jul 2009]

GeneCards Summary for CDAN1 Gene

CDAN1 (Codanin 1) is a Protein Coding gene. Diseases associated with CDAN1 include Anemia, Congenital Dyserythropoietic, Type Ia and Congenital Dyserythropoietic Anemia.

UniProtKB/Swiss-Prot for CDAN1 Gene

  • May act as a negative regulator of ASF1 in chromatin assembly.

Additional gene information for CDAN1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDAN1 Gene

Genomics for CDAN1 Gene

GeneHancer (GH) Regulatory Elements for CDAN1 Gene

Promoters and enhancers for CDAN1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J042735 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 673.6 +0.2 243 2.3 FOXA2 ARNT ARID4B SIN3A YY1 ZNF121 POLR2B GLIS2 ARID2 ZNF207 CDAN1 LRRC57 LOC105370795 LCMT2 ZSCAN29 VPS39 GANC CCNDBP1 ENSG00000274403
GH15J041772 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 25.8 +961.2 961221 6.4 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC SSRP1 ZNF610 MAPKBP1 JMJD7 MGA CDAN1 SPTBN5 VPS39 INO80 ENSG00000260814 JMJD7-PLA2G4B ENSG00000250379
GH15J043508 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.9 -772.9 -772912 3.5 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 TP53BP1 MAP1A GC15M043498 ZSCAN29 CTDSPL2 ADAL CDAN1 LRRC57 LCMT2 UBR1
GH15J042493 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 21.4 +241.9 241914 3.7 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 SLC30A9 SNAP23 LRRC57 CDAN1 GANC ZSCAN29 HAUS2 MGA LCMT2 LOC105370795 VPS39
GH15J042270 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 23.1 +463.5 463467 5.8 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 GANC TMEM87A LRRC57 CDAN1 MGA LOC105370795 RPAP1 VPS39 RPS3AP47 ENSG00000260814
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDAN1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDAN1 gene promoter:
  • PPAR-gamma2
  • PPAR-gamma1
  • Olf-1
  • RORalpha2
  • STAT3
  • p53
  • STAT5A
  • Cdc5
  • Pax-5
  • Cart-1

Genomic Locations for CDAN1 Gene

Genomic Locations for CDAN1 Gene
chr15:42,723,544-42,737,219
(GRCh38/hg38)
Size:
13,676 bases
Orientation:
Minus strand
chr15:43,015,757-43,029,417
(GRCh37/hg19)
Size:
13,661 bases
Orientation:
Minus strand

Genomic View for CDAN1 Gene

Genes around CDAN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDAN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDAN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDAN1 Gene

Proteins for CDAN1 Gene

  • Protein details for CDAN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWY9-CDAN1_HUMAN
    Recommended name:
    Codanin-1
    Protein Accession:
    Q8IWY9
    Secondary Accessions:
    • Q6NYD0
    • Q7Z7L5
    • Q969N3

    Protein attributes for CDAN1 Gene

    Size:
    1227 amino acids
    Molecular mass:
    134120 Da
    Quaternary structure:
    • Found in a cytosolic complex with ASF1A, ASF1B, IPO4 and histones H3.1 and H4.
    SequenceCaution:
    • Sequence=AAH52568.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAO14994.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAQ88832.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CDAN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDAN1 Gene

Post-translational modifications for CDAN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDAN1 Gene

No data available for DME Specific Peptides for CDAN1 Gene

Domains & Families for CDAN1 Gene

Gene Families for CDAN1 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CDAN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDAN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDAN1: view

No data available for UniProtKB/Swiss-Prot for CDAN1 Gene

Function for CDAN1 Gene

Molecular function for CDAN1 Gene

UniProtKB/Swiss-Prot Function:
May act as a negative regulator of ASF1 in chromatin assembly.

Phenotypes From GWAS Catalog for CDAN1 Gene

Gene Ontology (GO) - Molecular Function for CDAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17353931
genes like me logo Genes that share ontologies with CDAN1: view
genes like me logo Genes that share phenotypes with CDAN1: view

Human Phenotype Ontology for CDAN1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CDAN1 Gene

MGI Knock Outs for CDAN1:
  • Cdan1 Cdan1<tm1b(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for CDAN1

CRISPR Products

miRNA for CDAN1 Gene

miRTarBase miRNAs that target CDAN1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDAN1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CDAN1 Gene

Localization for CDAN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDAN1 Gene

Cytoplasm. Nucleus. Membrane; Multi-pass membrane protein. Note=Mainly detected as a cytoplasmic protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDAN1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 21364188
GO:0005737 cytoplasm IEA,IDA 22407294
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0012505 endomembrane system IDA,IEA 21364188
genes like me logo Genes that share ontologies with CDAN1: view

Pathways & Interactions for CDAN1 Gene

SuperPathways for CDAN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IMP 21364188
GO:0008104 protein localization IMP 21364188
GO:0008156 negative regulation of DNA replication IMP 22407294
GO:0031497 chromatin assembly IMP 22407294
genes like me logo Genes that share ontologies with CDAN1: view

No data available for Pathways by source and SIGNOR curated interactions for CDAN1 Gene

Drugs & Compounds for CDAN1 Gene

(1) Drugs for CDAN1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CDAN1: view

Transcripts for CDAN1 Gene

Unigene Clusters for CDAN1 Gene

Codanin 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDAN1

Alternative Splicing Database (ASD) splice patterns (SP) for CDAN1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
SP1: -
SP2:
SP3:
SP4:

ExUns: 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28
SP1:
SP2: -
SP3:
SP4:

Relevant External Links for CDAN1 Gene

GeneLoc Exon Structure for
CDAN1
ECgene alternative splicing isoforms for
CDAN1

Expression for CDAN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDAN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDAN1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (23.5), Adipocyte (18.2), Peripheral blood mononuclear cells (12.8), and CD8 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDAN1 Gene



NURSA nuclear receptor signaling pathways regulating expression of CDAN1 Gene:

CDAN1

SOURCE GeneReport for Unigene cluster for CDAN1 Gene:

Hs.599232

mRNA Expression by UniProt/SwissProt for CDAN1 Gene:

Q8IWY9-CDAN1_HUMAN
Tissue specificity: Ubiquitously expressed. Isoform 3 is not found in erythroid cells.

Evidence on tissue expression from TISSUES for CDAN1 Gene

  • Kidney(4.1)
  • Bone marrow(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CDAN1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • integumentary
  • lymphatic
  • nervous
  • respiratory
Regions:
Head and neck:
  • ear
  • eye
  • head
  • mouth
Thorax:
  • heart
  • lung
Abdomen:
  • kidney
  • liver
  • spleen
Pelvis:
  • placenta
  • uterus
General:
  • blood
  • blood vessel
  • bone marrow
  • red blood cell
  • skin
genes like me logo Genes that share expression patterns with CDAN1: view

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for CDAN1 Gene

Orthologs for CDAN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDAN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDAN1 34 33
  • 99.27 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CDAN1 34 33
  • 88.4 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CDAN1 34 33
  • 87.28 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cdan1 16 34 33
  • 86.62 (n)
rat
(Rattus norvegicus)
Mammalia Cdan1 33
  • 86.19 (n)
oppossum
(Monodelphis domestica)
Mammalia CDAN1 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDAN1 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDAN1 34 33
  • 62.79 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDAN1 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdan1 33
  • 58.58 (n)
zebrafish
(Danio rerio)
Actinopterygii cdan1 34 33
  • 55.09 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010055 33
  • 42.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta dlt 34 33
  • 40.96 (n)
OneToOne
Species where no ortholog for CDAN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDAN1 Gene

ENSEMBL:
Gene Tree for CDAN1 (if available)
TreeFam:
Gene Tree for CDAN1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDAN1: view image

Paralogs for CDAN1 Gene

No data available for Paralogs for CDAN1 Gene

Variants for CDAN1 Gene

Sequence variations from dbSNP and Humsavar for CDAN1 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1022603666 uncertain-significance, Congenital dyserythropoietic anemia 42,723,703(-) C/A 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs111961345 likely-benign, Congenital dyserythropoietic anemia 42,724,026(-) AAG/ 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs113313967 pathogenic, Congenital dyserythropoietic anemia, type I 42,731,206(-) C/T intron_variant
rs114208791 likely-benign, Congenital dyserythropoietic anemia 42,729,325(-) G/A coding_sequence_variant, genic_downstream_transcript_variant, non_coding_transcript_variant, synonymous_variant
rs114779238 benign, likely-benign, not provided, not specified, Congenital dyserythropoietic anemia 42,728,236(-) G/A coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CDAN1 Gene

Variant ID Type Subtype PubMed ID
nsv457122 CNV loss 19166990
nsv517553 CNV gain+loss 19592680
nsv528725 CNV gain 19592680
nsv569238 CNV loss 21841781
nsv952615 CNV deletion 24416366

Variation tolerance for CDAN1 Gene

Residual Variation Intolerance Score: 86.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.08; 99.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDAN1 Gene

Human Gene Mutation Database (HGMD)
CDAN1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDAN1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDAN1 Gene

Disorders for CDAN1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CDAN1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CDAN1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CDAN1_HUMAN
  • Anemia, congenital dyserythropoietic, 1A (CDAN1A) [MIM:224120]: An autosomal recessive blood disorder characterized by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis. It is occasionally associated with bone abnormalities, especially of the hands and feet (acrodysostosis), nail hypoplasia, and scoliosis. Ultrastructural features include internuclear chromatin bridges connecting some nearly completely separated erythroblasts and an abnormal appearance (spongy or Swiss-cheese appearance) of the heterochromatin in a high proportion of the erythroblasts. {ECO:0000269 PubMed:12434312}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for CDAN1

genes like me logo Genes that share disorders with CDAN1: view

No data available for Genatlas for CDAN1 Gene

Publications for CDAN1 Gene

  1. Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1. (PMID: 12434312) Dgany O … Tamary H (American journal of human genetics 2002) 2 3 4 22 58
  2. Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply. (PMID: 22407294) Ask K … Groth A (The EMBO journal 2012) 3 4 58
  3. Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1{alpha} localization in erythroblasts. (PMID: 21364188) Renella R … Wood WG (Blood 2011) 3 4 58
  4. Codanin-1, the protein encoded by the gene mutated in congenital dyserythropoietic anemia type I (CDAN1), is cell cycle-regulated. (PMID: 19336738) Noy-Lotan S … Tamary H (Haematologica 2009) 3 22 58
  5. Congenital dyserythropoietic anaemia, type I, in a Caucasian patient with retinal angioid streaks (homozygous Arg1042Trp mutation in codanin-1). (PMID: 18081704) Tamary H … Delaunay J (European journal of haematology 2008) 3 22 58

Products for CDAN1 Gene

Sources for CDAN1 Gene

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